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Items: 41

1.

Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and Rhythm.

Moen JM, Matt MG, Ramirez C, Tarasov KV, Chakir K, Tarasova YS, Lukyanenko Y, Tsutsui K, Monfredi O, Morrell CH, Tagirova S, Yaniv Y, Huynh T, Pacak K, Ahmet I, Lakatta EG.

Front Neurosci. 2019 Jun 18;13:615. doi: 10.3389/fnins.2019.00615. eCollection 2019.

2.

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.

Vinogradova TM, Sirenko S, Lukyanenko YO, Yang D, Tarasov KV, Lyashkov AE, Varghese NJ, Li Y, Chakir K, Ziman B, Lakatta EG.

Circ Arrhythm Electrophysiol. 2018 Jun;11(6):e005896. doi: 10.1161/CIRCEP.117.005896.

3.

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA, Kwon C.

Cell Rep. 2017 Jan 10;18(2):571-582. doi: 10.1016/j.celrep.2016.12.040.

4.

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic-Banded Mini-Swine.

Hiemstra JA, Lee DI, Chakir K, Gutiérrez-Aguilar M, Marshall KD, Zgoda PJ, Cruz Rivera N, Dozier DG, Ferguson BS, Heublein DM, Burnett JC, Scherf C, Ivey JR, Minervini G, McDonald KS, Baines CP, Krenz M, Domeier TL, Emter CA.

J Am Heart Assoc. 2016 Apr 20;5(4):e003277. doi: 10.1161/JAHA.116.003277.

5.

Response to Letter Regarding Article, "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study".

Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S.

Circulation. 2016 Feb 9;133(6):e389-e390. doi: 10.1161/CIRCULATIONAHA.115.019228. No abstract available.

6.

Pacemaker-induced transient asynchrony suppresses heart failure progression.

Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA.

Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899.

7.

Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation.

Eskesen K, Olsen NT, Dimaano VL, Fritz-Hansen T, Sogaard P, Chakir K, Steenbergen C, Kass D, Abraham TP.

Springerplus. 2015 Oct 13;4:592. doi: 10.1186/s40064-015-1317-8. eCollection 2015.

8.

Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle.

Ramirez-Correa GA, Ma J, Slawson C, Zeidan Q, Lugo-Fagundo NS, Xu M, Shen X, Gao WD, Caceres V, Chakir K, DeVine L, Cole RN, Marchionni L, Paolocci N, Hart GW, Murphy AM.

Diabetes. 2015 Oct;64(10):3573-87. doi: 10.2337/db14-1107. Epub 2015 Jun 24.

9.

Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.

Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S.

Circulation. 2015 Jun 23;131(25):2202-2216. doi: 10.1161/CIRCULATIONAHA.114.013220. Epub 2015 May 20.

10.

[Nail psoriasis and silver: a magic ring…].

Hajji Ouafi FZ, Bouaddi M, Chakir K, Benzekri L, Hassam B.

Ann Dermatol Venereol. 2014 Jan;141(1):85. doi: 10.1016/j.annder.2013.09.161. Epub 2013 Oct 29. French. No abstract available.

PMID:
24461105
11.

Desmin modifications associate with amyloid-like oligomers deposition in heart failure.

Agnetti G, Halperin VL, Kirk JA, Chakir K, Guo Y, Lund L, Nicolini F, Gherli T, Guarnieri C, Caldarera CM, Tomaselli GF, Kass DA, Van Eyk JE.

Cardiovasc Res. 2014 Apr 1;102(1):24-34. doi: 10.1093/cvr/cvu003. Epub 2014 Jan 9.

12.

[Bullous contact dermatitis due to a black henna tattoo].

Chakir K, Hassam B.

Pan Afr Med J. 2013 Aug 27;15:148. doi: 10.11604/pamj.2013.15.148.3261. eCollection 2013. French. No abstract available.

13.

[Vegetating idiopathic pyoderma gangrenosum].

Chakir K, Hassam B.

Pan Afr Med J. 2014 Oct 14;19:144. doi: 10.11604/pamj.2014.19.144.3012. eCollection 2014. French. No abstract available.

14.

[Arteriovenous malformation of the scalp].

Chakir K, Benchikhi H.

Pan Afr Med J. 2013 Jul 10;15:93. doi: 10.11604/pamj.2013.15.93.2954. eCollection 2013. French. No abstract available.

15.

[Centro-facial granuloma revealing a tertiary syphilis].

Chakir K, Benchikhi H.

Pan Afr Med J. 2013 Jun 30;15:82. doi: 10.11604/pamj.2013.15.82.3011. eCollection 2013. French. No abstract available.

16.

[Phytophotodermatitis of an unusual location from seaweed].

Chakir K, Benchikh H.

Pan Afr Med J. 2013 Jun 20;15:58. doi: 10.11604/pamj.2013.15.58.2951. eCollection 2013. French. No abstract available.

17.

Hypertrophy signaling pathways in experimental chronic aortic regurgitation.

Olsen NT, Dimaano VL, Fritz-Hansen T, Sogaard P, Chakir K, Eskesen K, Steenbergen C, Kass DA, Abraham TP.

J Cardiovasc Transl Res. 2013 Oct;6(5):852-60. doi: 10.1007/s12265-013-9503-y. Epub 2013 Jul 26.

PMID:
23888404
18.

Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.

Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):546-54. doi: 10.1161/CIRCEP.113.000400. Epub 2013 May 6.

19.

Transcriptome, proteome, and metabolome in dyssynchronous heart failure and CRT.

Barth AS, Chakir K, Kass DA, Tomaselli GF.

J Cardiovasc Transl Res. 2012 Apr;5(2):180-7. doi: 10.1007/s12265-011-9339-2. Epub 2012 Feb 7. Review.

PMID:
22311562
20.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.

21.

Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA.

Sci Transl Med. 2011 Sep 14;3(100):100ra88. doi: 10.1126/scitranslmed.3001909.

22.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

23.

Rethinking Resynch: Exploring Mechanisms of Cardiac Resynchroniztion Beyond Wall Motion Control.

Chakir K, Kass DA.

Drug Discov Today Dis Mech. 2010 Summer;7(2):e103-e107.

24.

Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts.

Agnetti G, Kaludercic N, Kane LA, Elliott ST, Guo Y, Chakir K, Samantapudi D, Paolocci N, Tomaselli GF, Kass DA, Van Eyk JE.

Circ Cardiovasc Genet. 2010 Feb;3(1):78-87. doi: 10.1161/CIRCGENETICS.109.871236. Epub 2009 Nov 17.

25.

Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level.

Barth AS, Aiba T, Halperin V, DiSilvestre D, Chakir K, Colantuoni C, Tunin RS, Dimaano VL, Yu W, Abraham TP, Kass DA, Tomaselli GF.

Circ Cardiovasc Genet. 2009 Aug;2(4):371-8. doi: 10.1161/CIRCGENETICS.108.832345. Epub 2009 May 15.

26.

Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.

Chakir K, Daya SK, Aiba T, Tunin RS, Dimaano VL, Abraham TP, Jaques-Robinson KM, Lai EW, Pacak K, Zhu WZ, Xiao RP, Tomaselli GF, Kass DA.

Circulation. 2009 Mar 10;119(9):1231-40. doi: 10.1161/CIRCULATIONAHA.108.774752. Epub 2009 Feb 23. Erratum in: Circulation. 2009 May 19;119(19):e533. Jacques, Kathryn [corrected to Jaques-Robinson, Kathryn M].

27.

Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.

Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF.

Circulation. 2009 Mar 10;119(9):1220-30. doi: 10.1161/CIRCULATIONAHA.108.794834. Epub 2009 Feb 23.

28.

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.

Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA.

Circulation. 2008 May 20;117(20):2626-36. doi: 10.1161/CIRCULATIONAHA.107.737031. Epub 2008 May 12.

29.

Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization.

Chakir K, Daya SK, Tunin RS, Helm RH, Byrne MJ, Dimaano VL, Lardo AC, Abraham TP, Tomaselli GF, Kass DA.

Circulation. 2008 Mar 18;117(11):1369-77. doi: 10.1161/CIRCULATIONAHA.107.706291. Epub 2008 Mar 3.

PMID:
18316490
30.

Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol.

Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao RP, Abernethy DR.

Chirality. 2006 Nov;18(10):822-7.

PMID:
16917835
31.

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.

Zhu WZ, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, Hébert TE, Lakatta EG, Cheng H, Xiao RP.

Circ Res. 2005 Aug 5;97(3):244-51. Epub 2005 Jul 7.

PMID:
16002745
32.
33.

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90. Epub 2004 Nov 11.

PMID:
15539636
34.

Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.

Xiao RP, Zhu W, Zheng M, Chakir K, Bond R, Lakatta EG, Cheng H.

Trends Pharmacol Sci. 2004 Jul;25(7):358-65. Review. No abstract available.

PMID:
15219978
35.

The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.

Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP.

Mol Pharmacol. 2003 Nov;64(5):1048-58.

PMID:
14573753
36.

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.

Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H.

Circulation. 2003 Sep 30;108(13):1633-9. Epub 2003 Sep 15.

PMID:
12975249
37.

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP.

J Clin Invest. 2003 Mar;111(5):617-25.

38.

Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.

Yang D, Song LS, Zhu WZ, Chakir K, Wang W, Wu C, Wang Y, Xiao RP, Chen SR, Cheng H.

Circ Res. 2003 Apr 4;92(6):659-67. Epub 2003 Feb 27.

PMID:
12609973
39.

Two novel low-density lipoprotein receptor gene mutations (E397X and 347delGCC) in St. Petersburg familial hypercholesterolemia.

Chakir K, Ju MM, Shevtsov SP, Golubkov VI, Skobeleva NA, Shur YA, Zakharova FM, Lipovetskyi BM, Konstantinov VO, Denisenko AD, Gaitskhoki VS, Schwartz EI.

Mol Genet Metab. 1998 Dec;65(4):311-4. Erratum in: Mol Genet Metab. 2005 May;85(1):81. Kh, C [corrected to Chakir, K].

PMID:
9889019
40.

Prevalence of Lithuanian mutation among St. Petersburg Jews with familial hypercholesterolemia.

Mandelshtam M, Chakir K, Shevtsov S, Golubkov V, Skobeleva N, Lipovetsky B, Konstantinov V, Denisenko A, Gaitskhoki V, Schwartz E.

Hum Mutat. 1998;12(4):255-8.

PMID:
9744476
41.

Two novel slavic point mutations in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemia from St. Petersburg, Russia.

Chakir Kh, Skobeleva NA, Shevtsov SP, Konstantinov VO, Denisenko AD, Schwartz EI.

Mol Genet Metab. 1998 Jan;63(1):31-4.

PMID:
9538514

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