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NCI Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions.

Kagan J, Moritz RL, Mazurchuck R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, Chee MS, Budnik BA, Yates JR, Chait BT, Moffitt JR, Smith RD, Srivastava S.

J Proteome Res. 2020 Mar 12. doi: 10.1021/acs.jproteome.0c00021. [Epub ahead of print]


Stepwise Promoter Melting by Bacterial RNA Polymerase.

Chen J, Chiu C, Gopalkrishnan S, Chen AY, Olinares PDB, Saecker RM, Winkelman JT, Maloney MF, Chait BT, Ross W, Gourse RL, Campbell EA, Darst SA.

Mol Cell. 2020 Mar 2. pii: S1097-2765(20)30110-6. doi: 10.1016/j.molcel.2020.02.017. [Epub ahead of print]


Structural basis of substrate recognition by a polypeptide processing and secretion transporter.

Kieuvongngam V, Olinares PDB, Palillo A, Oldham ML, Chait BT, Chen J.

Elife. 2020 Jan 14;9. pii: e51492. doi: 10.7554/eLife.51492.


Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.

Wieczorek M, Urnavicius L, Ti SC, Molloy KR, Chait BT, Kapoor TM.

Cell. 2020 Jan 9;180(1):165-175.e16. doi: 10.1016/j.cell.2019.12.007. Epub 2019 Dec 17.


Native Mass Spectrometry Analysis of Affinity-Captured Endogenous Yeast RNA Exosome Complexes.

Olinares PDB, Chait BT.

Methods Mol Biol. 2020;2062:357-382. doi: 10.1007/978-1-4939-9822-7_17.


Palaeoproteomics resolves sloth relationships.

Presslee S, Slater GJ, Pujos F, Forasiepi AM, Fischer R, Molloy K, Mackie M, Olsen JV, Kramarz A, Taglioretti M, Scaglia F, Lezcano M, Lanata JL, Southon J, Feranec R, Bloch J, Hajduk A, Martin FM, Salas Gismondi R, Reguero M, de Muizon C, Greenwood A, Chait BT, Penkman K, Collins M, MacPhee RDE.

Nat Ecol Evol. 2019 Jul;3(7):1121-1130. doi: 10.1038/s41559-019-0909-z. Epub 2019 Jun 6.


Interactions of nuclear transport factors and surface-conjugated FG nucleoporins: Insights and limitations.

Hayama R, Sorci M, Keating Iv JJ, Hecht LM, Plawsky JL, Belfort G, Chait BT, Rout MP.

PLoS One. 2019 Jun 6;14(6):e0217897. doi: 10.1371/journal.pone.0217897. eCollection 2019.


Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression.

Mayle R, Langston L, Molloy KR, Zhang D, Chait BT, O'Donnell ME.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):798-803. doi: 10.1073/pnas.1819107116. Epub 2018 Dec 31.


The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination.

Delgado-Benito V, Rosen DB, Wang Q, Gazumyan A, Pai JA, Oliveira TY, Sundaravinayagam D, Zhang W, Andreani M, Keller L, Kieffer-Kwon KR, Pękowska A, Jung S, Driesner M, Subbotin RI, Casellas R, Chait BT, Nussenzweig MC, Di Virgilio M.

Mol Cell. 2018 Nov 15;72(4):636-649.e8. doi: 10.1016/j.molcel.2018.08.042. Epub 2018 Oct 4.


Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Jishage M, Yu X, Shi Y, Ganesan SJ, Chen WY, Sali A, Chait BT, Asturias FJ, Roeder RG.

Nat Struct Mol Biol. 2018 Sep;25(9):859-867. doi: 10.1038/s41594-018-0118-5. Epub 2018 Sep 6.


Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J.

Nature. 2018 Jul;559(7712):61-66. doi: 10.1038/s41586-018-0237-5. Epub 2018 Jun 20.


Integrative structure and functional anatomy of a nuclear pore complex.

Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP.

Nature. 2018 Mar 22;555(7697):475-482. doi: 10.1038/nature26003. Epub 2018 Mar 14.


Modular assembly of the nucleolar pre-60S ribosomal subunit.

Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S.

Nature. 2018 Apr 5;556(7699):126-129. doi: 10.1038/nature26156. Epub 2018 Mar 5.


Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes.

Holden JM, Koreny L, Obado S, Ratushny AV, Chen WM, Bart JM, Navarro M, Chait BT, Aitchison JD, Rout MP, Field MC.

Mol Biol Cell. 2018 May 1;29(9):1100-1110. doi: 10.1091/mbc.E17-06-0430.


Dissection of affinity captured LINE-1 macromolecular complexes.

Taylor MS, Altukhov I, Molloy KR, Mita P, Jiang H, Adney EM, Wudzinska A, Badri S, Ischenko D, Eng G, Burns KH, Fenyö D, Chait BT, Alexeev D, Rout MP, Boeke JD, LaCava J.

Elife. 2018 Jan 8;7. pii: e30094. doi: 10.7554/eLife.30094.


A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Kleiner RE, Hang LE, Molloy KR, Chait BT, Kapoor TM.

Cell Chem Biol. 2018 Jan 18;25(1):110-120.e3. doi: 10.1016/j.chembiol.2017.10.001. Epub 2017 Nov 5.


The complete structure of the small-subunit processome.

Barandun J, Chaker-Margot M, Hunziker M, Molloy KR, Chait BT, Klinge S.

Nat Struct Mol Biol. 2017 Nov;24(11):944-953. doi: 10.1038/nsmb.3472. Epub 2017 Sep 25.


Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex.

Kang JY, Olinares PD, Chen J, Campbell EA, Mustaev A, Chait BT, Gottesman ME, Darst SA.

Elife. 2017 Mar 20;6. pii: e25478. doi: 10.7554/eLife.25478.


Lineage-specific proteins essential for endocytosis in trypanosomes.

Manna PT, Obado SO, Boehm C, Gadelha C, Sali A, Chait BT, Rout MP, Field MC.

J Cell Sci. 2017 Apr 15;130(8):1379-1392. doi: 10.1242/jcs.191478. Epub 2017 Feb 23.


The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis.

Boehm CM, Obado S, Gadelha C, Kaupisch A, Manna PT, Gould GW, Munson M, Chait BT, Rout MP, Field MC.

PLoS Pathog. 2017 Jan 23;13(1):e1006063. doi: 10.1371/journal.ppat.1006063. eCollection 2017 Jan.


Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.

Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW.

Cell Chem Biol. 2017 Jan 19;24(1):76-86. doi: 10.1016/j.chembiol.2016.12.008. Epub 2017 Jan 5.


The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators.

Orlova N, Gerding M, Ivashkiv O, Olinares PDB, Chait BT, Waldor MK, Jeruzalmi D.

Nucleic Acids Res. 2017 Apr 20;45(7):3724-3737. doi: 10.1093/nar/gkw1288.


Gel filtration of dilute human embryonic hemoglobins reveals basis for their increased oxygen binding.

Manning LR, Popowicz AM, Padovan JC, Chait BT, Manning JM.

Anal Biochem. 2017 Feb 15;519:38-41. doi: 10.1016/j.ab.2016.12.008. Epub 2016 Dec 11.


Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform.

Fernandez-Martinez J, Kim SJ, Shi Y, Upla P, Pellarin R, Gagnon M, Chemmama IE, Wang J, Nudelman I, Zhang W, Williams R, Rice WJ, Stokes DL, Zenklusen D, Chait BT, Sali A, Rout MP.

Cell. 2016 Nov 17;167(5):1215-1228.e25. doi: 10.1016/j.cell.2016.10.028. Epub 2016 Nov 10.


Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

Maishman L, Obado SO, Alsford S, Bart JM, Chen WM, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP, Field MC.

Nucleic Acids Res. 2016 Dec 15;44(22):10554-10570. Epub 2016 Sep 12.


Phosphorylation-Dependent Targeting of Tetrahymena HP1 to Condensed Chromatin.

Yale K, Tackett AJ, Neuman M, Bulley E, Chait BT, Wiley E.

mSphere. 2016 Aug 24;1(4). pii: e00142-16. doi: 10.1128/mSphere.00142-16. eCollection 2016 Jul-Aug.


HIV-host interactome revealed directly from infected cells.

Luo Y, Jacobs EY, Greco TM, Mohammed KD, Tong T, Keegan S, Binley JM, Cristea IM, Fenyö D, Rout MP, Chait BT, Muesing MA.

Nat Microbiol. 2016 Jul;1(7):16068. Epub 2016 May 23.


UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly.

Hunziker M, Barandun J, Petfalski E, Tan D, Delan-Forino C, Molloy KR, Kim KH, Dunn-Davies H, Shi Y, Chaker-Margot M, Chait BT, Walz T, Tollervey D, Klinge S.

Nat Commun. 2016 Jun 29;7:12090. doi: 10.1038/ncomms12090.


High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes.

Obado SO, Field MC, Chait BT, Rout MP.

Methods Mol Biol. 2016;1411:67-80. doi: 10.1007/978-1-4939-3530-7_3.


Revealing Higher Order Protein Structure Using Mass Spectrometry.

Chait BT, Cadene M, Olinares PD, Rout MP, Shi Y.

J Am Soc Mass Spectrom. 2016 Jun;27(6):952-65. doi: 10.1007/s13361-016-1385-1. Epub 2016 Apr 14.


Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA.

Rivera-Torres IO, Jin TB, Cadene M, Chait BT, Poget SF.

Sci Rep. 2016 Apr 5;6:23904. doi: 10.1038/srep23904.


Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex.

Obado SO, Brillantes M, Uryu K, Zhang W, Ketaren NE, Chait BT, Field MC, Rout MP.

PLoS Biol. 2016 Feb 18;14(2):e1002365. doi: 10.1371/journal.pbio.1002365. eCollection 2016 Feb.


Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis.

Lussignol M, Kopp M, Molloy K, Vizcay-Barrena G, Fleck RA, Dorner M, Bell KL, Chait BT, Rice CM, Catanese MT.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2484-9. doi: 10.1073/pnas.1518934113. Epub 2016 Feb 16.


Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies.

Kellner N, Schwarz J, Sturm M, Fernandez-Martinez J, Griesel S, Zhang W, Chait BT, Rout MP, Kück U, Hurt E.

Sci Rep. 2016 Feb 11;6:20937. doi: 10.1038/srep20937.


A Robust Workflow for Native Mass Spectrometric Analysis of Affinity-Isolated Endogenous Protein Assemblies.

Olinares PD, Dunn AD, Padovan JC, Fernandez-Martinez J, Rout MP, Chait BT.

Anal Chem. 2016 Mar 1;88(5):2799-807. doi: 10.1021/acs.analchem.5b04477. Epub 2016 Feb 18.


Optimizing selection of large animals for antibody production by screening immune response to standard vaccines.

Thompson MK, Fridy PC, Keegan S, Chait BT, Fenyö D, Rout MP.

J Immunol Methods. 2016 Mar;430:56-60. doi: 10.1016/j.jim.2016.01.006. Epub 2016 Jan 9.



Morris DH, Yip CK, Shi Y, Chait BT, Wang QJ.

Front Biol (Beijing). 2015 Oct;10(5):398-426. Epub 2015 Nov 4.


The architecture of a eukaryotic replisome.

Sun J, Shi Y, Georgescu RE, Yuan Z, Chait BT, Li H, O'Donnell ME.

Nat Struct Mol Biol. 2015 Dec;22(12):976-82. doi: 10.1038/nsmb.3113. Epub 2015 Nov 2.


Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.

LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM.

J Biol Chem. 2015 Dec 18;290(51):30390-405. doi: 10.1074/jbc.M115.689604. Epub 2015 Oct 16.


A strategy for dissecting the architectures of native macromolecular assemblies.

Shi Y, Pellarin R, Fridy PC, Fernandez-Martinez J, Thompson MK, Li Y, Wang QJ, Sali A, Rout MP, Chait BT.

Nat Methods. 2015 Dec;12(12):1135-8. doi: 10.1038/nmeth.3617. Epub 2015 Oct 5.


Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM.

Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7.


β-Lactoglobulin detected in human milk forms noncovalent complexes with maltooligosaccharides as revealed by chip-nanoelectrospray high-resolution tandem mass spectrometry.

Capitan F, Robu AC, Schiopu C, Ilie C, Chait BT, Przybylski M, Zamfir AD.

Amino Acids. 2015 Nov;47(11):2399-407. doi: 10.1007/s00726-015-2030-1. Epub 2015 Jun 27.


Rapid, optimized interactomic screening.

Hakhverdyan Z, Domanski M, Hough LE, Oroskar AA, Oroskar AR, Keegan S, Dilworth DJ, Molloy KR, Sherman V, Aitchison JD, Fenyö D, Chait BT, Jensen TH, Rout MP, LaCava J.

Nat Methods. 2015 Jun;12(6):553-60. doi: 10.1038/nmeth.3395. Epub 2015 May 4.


Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics.

Gadelha C, Zhang W, Chamberlain JW, Chait BT, Wickstead B, Field MC.

Mol Cell Proteomics. 2015 Jul;14(7):1911-26. doi: 10.1074/mcp.M114.047647. Epub 2015 Apr 30.


Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives.

LaCava J, Molloy KR, Taylor MS, Domanski M, Chait BT, Rout MP.

Biotechniques. 2015 Mar 1;58(3):103-19. doi: 10.2144/000114262. eCollection 2015 Mar.


Optimizing electrospray interfaces using slowly diverging conical duct (ConDuct) electrodes.

Krutchinsky AN, Padovan JC, Cohen H, Chait BT.

J Am Soc Mass Spectrom. 2015 Apr;26(4):659-67. doi: 10.1007/s13361-014-1063-0. Epub 2015 Feb 10.


Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.

Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A, Greengard P.

J Neurochem. 2015 Mar;132(6):677-86. doi: 10.1111/jnc.13038. Epub 2015 Mar 4.


Maximizing ion transmission from atmospheric pressure into the vacuum of mass spectrometers with a novel electrospray interface.

Krutchinsky AN, Padovan JC, Cohen H, Chait BT.

J Am Soc Mass Spectrom. 2015 Apr;26(4):649-58. doi: 10.1007/s13361-014-1062-1. Epub 2015 Jan 15.


Touching from a distance.

Holden JM, Koreny L, Kelly S, Chait BT, Rout MP, Field MC, Obado SO.

Nucleus. 2014 Jul-Aug;5(4):304-10. doi: 10.4161/nucl.32228.


Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Cevher MA, Shi Y, Li D, Chait BT, Malik S, Roeder RG.

Nat Struct Mol Biol. 2014 Dec;21(12):1028-34. doi: 10.1038/nsmb.2914. Epub 2014 Nov 10.

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