Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 381


Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.

Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM.

Sci Transl Med. 2019 Sep 11;11(509). pii: eaaw8412. doi: 10.1126/scitranslmed.aaw8412.


Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice.

El Gabbas Z, Bezza K, Laadraoui J, Ait Laaradia M, Kebbou A, Oufquir S, Boukhira A, Aboufatima R, Chait A.

Evid Based Complement Alternat Med. 2019 Jun 24;2019:1702378. doi: 10.1155/2019/1702378. eCollection 2019.


Anti-aggregant effect of butanolic extract of Rubia tinctorum L on platelets in vitro and ex vivo.

Marhoume FZ, Laaradia MA, Zaid Y, Laadraoui J, Oufquir S, Aboufatima R, Chait A, Bagri A.

J Ethnopharmacol. 2019 Sep 15;241:111971. doi: 10.1016/j.jep.2019.111971. Epub 2019 May 30. No abstract available.


The Chylomicronemia Syndrome Is Most Often Multifactorial: A Narrative Review of Causes and Treatment.

Chait A, Eckel RH.

Ann Intern Med. 2019 May 7;170(9):626-634. doi: 10.7326/M19-0203. Epub 2019 Apr 30.


Clinical Validation of IsoPSA™, a Single Parameter, Structure Based Assay for Improved Detection of High Grade Prostate Cancer.

Stovsky M, Klein EA, Chait A, Manickam K, Stephenson AJ, Wagner M, Dineen M, Lotan Y, Partin A, Baniel J, Kestranek A, Gawande P, Boris Zaslavsky.

J Urol. 2019 Jun;201(6):1115-1120. doi: 10.1097/JU.0000000000000185.


Coping strategies among colorectal cancer patients undergoing surgery and the role of the surgeon in mitigating distress: A qualitative study.

Abelson JS, Chait A, Shen MJ, Charlson M, Dickerman A, Yeo H.

Surgery. 2019 Feb;165(2):461-468. doi: 10.1016/j.surg.2018.06.005. Epub 2018 Oct 11.


Effect of Artemisia herba-alba consumption during pregnancy on fertility, morphological and behaviors of mice offspring.

Laadraoui J, Aboufatima R, El Gabbas Z, Ferehan H, Bezza K, Ait Laaradia M, Marhoume F, Wakrim EM, Chait A.

J Ethnopharmacol. 2018 Nov 15;226:105-110. doi: 10.1016/j.jep.2018.08.017. Epub 2018 Aug 16.


Sources of distress among patients undergoing surgery for colorectal cancer: a qualitative study.

Abelson JS, Chait A, Shen MJ, Charlson M, Dickerman A, Yeo HL.

J Surg Res. 2018 Jun;226:140-149. doi: 10.1016/j.jss.2018.01.017. Epub 2018 Feb 22.


Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota.

den Hartigh LJ, Gao Z, Goodspeed L, Wang S, Das AK, Burant CF, Chait A, Blaser MJ.

J Nutr. 2018 Apr 1;148(4):562-572. doi: 10.1093/jn/nxy011. Erratum in: J Nutr. 2019 May 1;149(5):884.


Buthus lienhardi venom and pathophysiological effects at the histological, hematological, biochemical and motor skills levels.

Ait Laaradia M, El Hidan MA, Marhoume F, Bouimeja B, Oufquir S, Sokar Z, Boumezzough A, Chait A.

Toxicon. 2018 May;146:106-113. doi: 10.1016/j.toxicon.2018.03.001. Epub 2018 Mar 9.


A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome.

Kanter JE, Kramer F, Barnhart S, Duggan JM, Shimizu-Albergine M, Kothari V, Chait A, Bouman SD, Hamerman JA, Hansen BF, Olsen GS, Bornfeldt KE.

Diabetes. 2018 May;67(5):946-959. doi: 10.2337/db17-0744. Epub 2018 Feb 26.


Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr-/- Mice.

Subramanian S, Goodspeed L, Wang S, Ding Y, O'Brien KD, Getz GS, Chait A, Reardon CA.

Int J Mol Sci. 2018 Feb 8;19(2). pii: E510. doi: 10.3390/ijms19020510.


FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans.

Buntschuh I, Raps DA, Joseph I, Reid C, Chait A, Totanes R, Sawh M, Li C.

PLoS One. 2018 Jan 2;13(1):e0189320. doi: 10.1371/journal.pone.0189320. eCollection 2018.


Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats.

Laadraoui J, Bezza K, El Gabbas Z, Marhoume F, Wakrim EM, Ferehan H, Aboufatima R, Sokar Z, Kissani N, Chait A.

Epilepsy Behav. 2018 Feb;79:154-161. doi: 10.1016/j.yebeh.2017.11.026. Epub 2018 Jan 4.


Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein.

Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, De Beer FC, Webb NR.

J Lipid Res. 2018 Feb;59(2):339-347. doi: 10.1194/jlr.M080887. Epub 2017 Dec 15.


Anti-scorpion venom activity of Thapsia garganica methanolic extract: Histopathological and biochemical evidences.

Bouimeja B, El Hidan MA, Touloun O, Ait Laaradia M, Ait Dra L, El Khoudri N, Chait A, Boumezzough A.

J Ethnopharmacol. 2018 Jan 30;211:340-347. doi: 10.1016/j.jep.2017.10.003. Epub 2017 Oct 6.


Treatment of Dyslipidemia in Diabetes: Recent Advances and Remaining Questions.

Chait A, Goldberg I.

Curr Diab Rep. 2017 Sep 27;17(11):112. doi: 10.1007/s11892-017-0942-8. Review.


Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH.

Ioannou GN, Subramanian S, Chait A, Haigh WG, Yeh MM, Farrell GC, Lee SP, Savard C.

J Lipid Res. 2017 Jun;58(6):1067-1079. doi: 10.1194/jlr.M072454. Epub 2017 Apr 12.


The Single-parameter, Structure-based IsoPSA Assay Demonstrates Improved Diagnostic Accuracy for Detection of Any Prostate Cancer and High-grade Prostate Cancer Compared to a Concentration-based Assay of Total Prostate-specific Antigen: A Preliminary Report.

Klein EA, Chait A, Hafron JM, Kernen KM, Manickam K, Stephenson AJ, Wagner M, Zhu H, Kestranek A, Zaslavsky B, Stovsky M.

Eur Urol. 2017 Dec;72(6):942-949. doi: 10.1016/j.eururo.2017.03.025. Epub 2017 Apr 7.


Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice.

den Hartigh LJ, Wang S, Goodspeed L, Wietecha T, Houston B, Omer M, Ogimoto K, Subramanian S, Gowda GA, O'Brien KD, Kaiyala KJ, Morton GJ, Chait A.

PLoS One. 2017 Feb 28;12(2):e0172912. doi: 10.1371/journal.pone.0172912. eCollection 2017.


Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ.

J Immunol. 2016 Dec 15;197(12):4529-4534. Epub 2016 Nov 11.


Analytical applications of partitioning in aqueous two-phase systems: Exploring protein structural changes and protein-partner interactions in vitro and in vivo by solvent interaction analysis method.

Zaslavsky BY, Uversky VN, Chait A.

Biochim Biophys Acta. 2016 May;1864(5):622-44. doi: 10.1016/j.bbapap.2016.02.017. Epub 2016 Feb 23. Review.


Lipids, Lipoproteins, and Cardiovascular Disease: Clinical Pharmacology Now and in the Future.

Chait A, Eckel RH.

J Clin Endocrinol Metab. 2016 Mar;101(3):804-14. doi: 10.1210/jc.2015-3940. Epub 2016 Feb 23. Review.


Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Feb;126(2):796. doi: 10.1172/JCI86401. Epub 2016 Feb 1. No abstract available.


Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen.

Zaid Y, Marhoume F, Senhaji N, Kojok K, Boufous H, Naya A, Oudghiri M, Darif Y, Habti N, Zouine S, Mohamed F, Chait A, Bagri A.

J Toxicol Sci. 2016 Feb;41(1):123-8. doi: 10.2131/jts.41.123.


Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Jan;126(1):266-81. doi: 10.1172/JCI83475. Epub 2015 Dec 7. Erratum in: J Clin Invest. 2016 Feb;126(2):796.


Hypertriglyceridemia: Pathophysiology, Role of Genetics, Consequences, and Treatment.

Chait A, Subramanian S.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2019 Apr 23.


Solvent interaction analysis as a proteomic approach to structure-based biomarker discovery and clinical diagnostics.

Zaslavsky BY, Uversky VN, Chait A.

Expert Rev Proteomics. 2016;13(1):9-17. doi: 10.1586/14789450.2016.1116945. Epub 2015 Nov 26.


Behavioral, histopathological and biochemical impairments observed in mice envenomed by the scorpion: Hottentota gentili (Pallary, 1924).

El Hidan MA, Touloun O, El Hiba O, Chait A, Eddine Hafid J, Boumezzough A.

Toxicon. 2015 Sep;103:19-29. doi: 10.1016/j.toxicon.2015.06.013. Epub 2015 Jun 16.


Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet.

Montes VN, Subramanian S, Goodspeed L, Wang SA, Omer M, Bobik A, Teshigawara K, Nishibori M, Chait A.

Nutr Diabetes. 2015 Jun 15;5:e161. doi: 10.1038/nutd.2015.11.


Hospital revisit rate after a diagnosis of conversion disorder.

Merkler AE, Parikh NS, Chaudhry S, Chait A, Allen NC, Navi BB, Kamel H.

J Neurol Neurosurg Psychiatry. 2016 Apr;87(4):363-6. doi: 10.1136/jnnp-2014-310181. Epub 2015 Apr 8.


The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice.

Averill MM, Kim EJ, Goodspeed L, Wang S, Subramanian S, Den Hartigh LJ, Tang C, Ding Y, Reardon CA, Getz GS, Chait A.

PLoS One. 2014 Oct 6;9(10):e109252. doi: 10.1371/journal.pone.0109252. eCollection 2014.


Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.

den Hartigh LJ, Wang S, Goodspeed L, Ding Y, Averill M, Subramanian S, Wietecha T, O'Brien KD, Chait A.

PLoS One. 2014 Sep 24;9(9):e108564. doi: 10.1371/journal.pone.0108564. eCollection 2014.


Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice.

Wei H, Averill MM, McMillen TS, Dastvan F, Mitra P, Subramanian S, Tang C, Chait A, Leboeuf RC.

Nutr Diabetes. 2014 Feb 24;4:e108. doi: 10.1038/nutd.2014.4.


10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species.

den Hartigh LJ, Han CY, Wang S, Omer M, Chait A.

J Lipid Res. 2013 Nov;54(11):2964-78. doi: 10.1194/jlr.M035188. Epub 2013 Aug 17.


Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice.

Subramanian S, Turner MS, Ding Y, Goodspeed L, Wang S, Buckner JH, O'Brien K, Getz GS, Reardon CA, Chait A.

J Lipid Res. 2013 Oct;54(10):2831-41. doi: 10.1194/jlr.M041020. Epub 2013 Aug 6.


T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice.

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, Den Hartigh LJ, Averill MM, O'Brien KD, Ledbetter J, Chait A.

PLoS One. 2013 Jul 2;8(7):e67709. doi: 10.1371/journal.pone.0067709. Print 2013.


Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis.

Smits MM, Woudstra P, Utzschneider KM, Tong J, Gerchman F, Faulenbach M, Carr DB, Aston-Mourney K, Chait A, Knopp RH, Meigs JB, Boyko EJ, Kahn SE.

Ann Epidemiol. 2013 Jul;23(7):415-21. doi: 10.1016/j.annepidem.2013.03.001. Epub 2013 Mar 25.


Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1.

Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer M, Subramanian S, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A.

Circ Res. 2013 May 10;112(10):1345-54. doi: 10.1161/CIRCRESAHA.111.300581. Epub 2013 Mar 15.


VASP increases hepatic fatty acid oxidation by activating AMPK in mice.

Tateya S, Rizzo-De Leon N, Handa P, Cheng AM, Morgan-Stevenson V, Ogimoto K, Kanter JE, Bornfeldt KE, Daum G, Clowes AW, Chait A, Kim F.

Diabetes. 2013 Jun;62(6):1913-22. doi: 10.2337/db12-0325. Epub 2013 Jan 24.


Solvatochromic relationship: prediction of distribution of ionic solutes in aqueous two-phase systems.

Madeira PP, Bessa A, de Barros DP, Teixeira MA, Álvares-Ribeiro L, Aires-Barros MR, Rodrigues AE, Chait A, Zaslavsky BY.

J Chromatogr A. 2013 Jan 4;1271(1):10-6. doi: 10.1016/j.chroma.2012.11.028. Epub 2012 Nov 19.


High throughput characterization of structural differences between closely related proteins in solution.

Zaslavsky A, Madeira P, Breydo L, Uversky VN, Chait A, Zaslavsky B.

Biochim Biophys Acta. 2013 Feb;1834(2):583-92. doi: 10.1016/j.bbapap.2012.11.004. Epub 2012 Nov 19.


P-selectin glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction.

Lee WJ, Chait A, Kim F.

Diabetes. 2012 Dec;61(12):3070-1. doi: 10.2337/db12-1036. No abstract available.


Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation.

Umemoto T, Subramanian S, Ding Y, Goodspeed L, Wang S, Han CY, Teresa AS, Kim J, O'Brien KD, Chait A.

J Lipid Res. 2012 Nov;53(11):2380-9. doi: 10.1194/jlr.M029264. Epub 2012 Sep 6.


Treatment of maladaptive aggression in youth: CERT guidelines II. Treatments and ongoing management.

Scotto Rosato N, Correll CU, Pappadopulos E, Chait A, Crystal S, Jensen PS; Treatment of Maladaptive Aggressive in Youth Steering Committee.

Pediatrics. 2012 Jun;129(6):e1577-86. doi: 10.1542/peds.2010-1361. Epub 2012 May 28. Review.


Treatment of maladaptive aggression in youth: CERT guidelines I. Engagement, assessment, and management.

Knapp P, Chait A, Pappadopulos E, Crystal S, Jensen PS; T-MAY Steering Group.

Pediatrics. 2012 Jun;129(6):e1562-76. doi: 10.1542/peds.2010-1360. Epub 2012 May 28. Review.


Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J, O'Brien KD, Chait A.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1596-604. doi: 10.1161/ATVBAHA.112.249847. Epub 2012 May 10.


Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis.

Savard C, Tartaglione EV, Kuver R, Haigh WG, Farrell GC, Subramanian S, Chait A, Yeh MM, Quinn LS, Ioannou GN.

Hepatology. 2013 Jan;57(1):81-92. doi: 10.1002/hep.25789.


Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts.

Cheng AM, Handa P, Tateya S, Schwartz J, Tang C, Mitra P, Oram JF, Chait A, Kim F.

PLoS One. 2012;7(3):e33917. doi: 10.1371/journal.pone.0033917. Epub 2012 Mar 30.

Supplemental Content

Support Center