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Items: 28


Profiles of Radioresistance Mechanisms in Prostate Cancer.

Chaiswing L, Weiss HL, Jayswal RD, Clair DKS, Kyprianou N.

Crit Rev Oncog. 2018;23(1-2):39-67. doi: 10.1615/CritRevOncog.2018025946.


Extracellular redox state shift: A novel approach to target prostate cancer invasion.

Zhong W, Weiss HL, Jayswal RD, Hensley PJ, Downes LM, St Clair DK, Chaiswing L.

Free Radic Biol Med. 2018 Mar;117:99-109. doi: 10.1016/j.freeradbiomed.2018.01.023. Epub 2018 Feb 2.


Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.

Chaiswing L, St Clair WH, St Clair DK.

Antioxid Redox Signal. 2018 Feb 21. doi: 10.1089/ars.2017.7485. [Epub ahead of print]


Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury.

Yarana C, Carroll D, Chen J, Chaiswing L, Zhao Y, Noel T, Alstott M, Bae Y, Dressler EV, Moscow JA, Butterfield DA, Zhu H, St Clair DK.

Clin Cancer Res. 2018 Apr 1;24(7):1644-1653. doi: 10.1158/1078-0432.CCR-17-2046. Epub 2017 Oct 25.


A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.

Zhao Y, Carroll DW, You Y, Chaiswing L, Wen R, Batinic-Haberle I, Bondada S, Liang Y, St Clair DK.

Redox Biol. 2017 Aug;12:129-138. doi: 10.1016/j.redox.2017.02.005. Epub 2017 Feb 10.


Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy.

Xu B, Lefringhouse J, Liu Z, West D, Baldwin LA, Ou C, Chen L, Napier D, Chaiswing L, Brewer LD, St Clair D, Thibault O, van Nagell JR, Zhou BP, Drapkin R, Huang JA, Lu ML, Ueland FR, Yang XH.

Oncogenesis. 2017 Jan 30;6(1):e295. doi: 10.1038/oncsis.2016.86.


RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.

Wei X, Xu Y, Xu FF, Chaiswing L, Schnell D, Noel T, Wang C, Chen J, St Clair DK, St Clair WH.

Cancer Res. 2017 Mar 15;77(6):1345-1356. doi: 10.1158/0008-5472.CAN-16-0785. Epub 2017 Jan 20.


Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Latif AA, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St Clair DK.

Free Radic Biol Med. 2016 Feb;91:68-80. doi: 10.1016/j.freeradbiomed.2015.12.002. Epub 2015 Dec 9.


Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice.

Deng J, Coy D, Zhang W, Sunkara M, Morris AJ, Wang C, Chaiswing L, St Clair D, Vore M, Jungsuwadee P.

J Pharmacol Exp Ther. 2015 Nov;355(2):272-9. doi: 10.1124/jpet.115.225490. Epub 2015 Sep 9.


Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice.

Cole MP, Tangpong J, Oberley TD, Chaiswing L, Kiningham KK, St Clair DK.

PLoS One. 2014 Feb 25;9(2):e89251. doi: 10.1371/journal.pone.0089251. eCollection 2014.


Increasing discordant antioxidant protein levels and enzymatic activities contribute to increasing redox imbalance observed during human prostate cancer progression.

Chaiswing L, Zhong W, Oberley TD.

Free Radic Biol Med. 2014 Feb;67:342-52. doi: 10.1016/j.freeradbiomed.2013.11.006. Epub 2013 Nov 22.


KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.

Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH.

Cancer Res. 2013 Jul 15;73(14):4406-17. doi: 10.1158/0008-5472.CAN-12-4297. Epub 2013 May 14.


Distinct redox profiles of selected human prostate carcinoma cell lines: implications for rational design of redox therapy.

Chaiswing L, Zhong W, Oberley TD.

Cancers (Basel). 2011;3(3):3557-84. doi: 10.3390/cancers3033557.


Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance.

Chaiswing L, Zhong W, Liang Y, Jones DP, Oberley TD.

Free Radic Biol Med. 2012 Jan 15;52(2):452-61. doi: 10.1016/j.freeradbiomed.2011.10.489. Epub 2011 Nov 9.


Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.

Dhar SK, Tangpong J, Chaiswing L, Oberley TD, St Clair DK.

Cancer Res. 2011 Nov 1;71(21):6684-95. doi: 10.1158/0008-5472.CAN-11-1233. Epub 2011 Oct 18.


Extracellular/microenvironmental redox state.

Chaiswing L, Oberley TD.

Antioxid Redox Signal. 2010 Aug 15;13(4):449-65. doi: 10.1089/ars.2009.3020. Review.


Extracellular redox state regulates features associated with prostate cancer cell invasion.

Chaiswing L, Zhong W, Cullen JJ, Oberley LW, Oberley TD.

Cancer Res. 2008 Jul 15;68(14):5820-6. doi: 10.1158/0008-5472.CAN-08-0162.


Characterization of redox state of two human prostate carcinoma cell lines with different degrees of aggressiveness.

Chaiswing L, Bourdeau-Heller JM, Zhong W, Oberley TD.

Free Radic Biol Med. 2007 Jul 15;43(2):202-15. Epub 2007 Apr 10.


Ras mutation promotes p53 activation and apoptosis of skin keratinocytes.

Zhao Y, Chaiswing L, Bakthavatchalu V, Oberley TD, St Clair DK.

Carcinogenesis. 2006 Aug;27(8):1692-8. Epub 2006 Apr 12.


Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions.

Zhao Y, Wang LM, Chaiswing L, Yen HC, Oberley TD, Lien YC, Lin SM, Mattson MP, St Clair D.

Free Radic Biol Med. 2006 Apr 1;40(7):1234-41. Epub 2005 Dec 9.


The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity.

Cole MP, Chaiswing L, Oberley TD, Edelmann SE, Piascik MT, Lin SM, Kiningham KK, St Clair DK.

Cardiovasc Res. 2006 Jan;69(1):186-97. Epub 2005 Sep 12.


Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity.

Chaiswing L, Cole MP, Ittarat W, Szweda LI, St Clair DK, Oberley TD.

Mol Cancer Ther. 2005 Jul;4(7):1056-64.


p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.

Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St Clair DK.

Cancer Res. 2005 May 1;65(9):3745-50.


Modulation of skin tumorigenesis by SOD.

St Clair D, Zhao Y, Chaiswing L, Oberley T.

Biomed Pharmacother. 2005 May;59(4):209-14. Epub 2005 Mar 17. Review.


A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.

Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St Clair W, Epstein CJ, St Clair D.

Cancer Res. 2005 Feb 15;65(4):1401-5.


Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury.

Chaiswing L, Cole MP, St Clair DK, Ittarat W, Szweda LI, Oberley TD.

Toxicol Pathol. 2004 Sep-Oct;32(5):536-47.


Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model.

Zhao Y, Oberley TD, Chaiswing L, Lin SM, Epstein CJ, Huang TT, St Clair D.

Oncogene. 2002 May 30;21(24):3836-46.

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