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Functional characterization of an IFN-γ-like receptor on Entamoeba histolytica.

Pulido-Ortega J, Talamás-Rohana P, Muñoz-Ortega MH, Aldaba-Muruato LR, Martínez-Hernández SL, Campos-Esparza MDR, Cervantes-García D, Leon-Coria A, Moreau F, Chadee K, Ventura-Juárez J.

Infect Immun. 2019 Aug 19. pii: IAI.00540-19. doi: 10.1128/IAI.00540-19. [Epub ahead of print]


The delicate balance between Entamoeba histolytica, mucus and microbiota.

Leon-Coria A, Kumar M, Chadee K.

Gut Microbes. 2019 May 15:1-8. doi: 10.1080/19490976.2019.1614363. [Epub ahead of print]


Entamoeba histolytica Cyclooxygenase-Like Protein Regulates Cysteine Protease Expression and Virulence.

Shahi P, Moreau F, Chadee K.

Front Cell Infect Microbiol. 2019 Jan 9;8:447. doi: 10.3389/fcimb.2018.00447. eCollection 2018.


Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica.

Leon-Coria A, Kumar M, Moreau F, Chadee K.

PLoS Pathog. 2018 Nov 30;14(11):e1007466. doi: 10.1371/journal.ppat.1007466. eCollection 2018 Nov.


Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D.

Quach J, Moreau F, Sandall C, Chadee K.

Mucosal Immunol. 2019 Mar;12(2):323-339. doi: 10.1038/s41385-018-0101-9. Epub 2018 Oct 25.


Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency".

Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K.

Infect Immun. 2018 Sep 21;86(10). pii: e00564-18. doi: 10.1128/IAI.00564-18. Print 2018 Oct. No abstract available.


High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.

Tawiah A, Moreau F, Kumar M, Tiwari S, Falguera J, Chadee K.

Am J Pathol. 2018 Sep;188(9):2025-2041. doi: 10.1016/j.ajpath.2018.05.013. Epub 2018 Jun 20.


Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency.

Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K.

Infect Immun. 2018 Jun 21;86(7). pii: e00208-18. doi: 10.1128/IAI.00208-18. Print 2018 Jul. Erratum in: Infect Immun. 2018 Sep 21;86(10):.


High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.

Tawiah A, Cornick S, Moreau F, Gorman H, Kumar M, Tiwari S, Chadee K.

Am J Pathol. 2018 Jun;188(6):1354-1373. doi: 10.1016/j.ajpath.2018.02.007. Epub 2018 Mar 12.


VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica.

Cornick S, Moreau F, Gaisano HY, Chadee K.

Microb Cell. 2017 Nov 27;4(12):426-427. doi: 10.15698/mic2017.12.605.


Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense.

Cornick S, Moreau F, Gaisano HY, Chadee K.

MBio. 2017 Oct 3;8(5). pii: e01323-17. doi: 10.1128/mBio.01323-17.


The macrophage cytoskeleton acts as a contact sensor upon interaction with Entamoeba histolytica to trigger IL-1β secretion.

St-Pierre J, Moreau F, Cornick S, Quach J, Begum S, Aracely Fernandez L, Gorman H, Chadee K.

PLoS Pathog. 2017 Aug 24;13(8):e1006592. doi: 10.1371/journal.ppat.1006592. eCollection 2017 Aug.


Cysteine Protease-Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection.

Amat CB, Motta JP, Fekete E, Moreau F, Chadee K, Buret AG.

Am J Pathol. 2017 Nov;187(11):2486-2498. doi: 10.1016/j.ajpath.2017.07.009. Epub 2017 Aug 18.


Entamoeba histolytica: Host parasite interactions at the colonic epithelium.

Cornick S, Chadee K.

Tissue Barriers. 2017 Jan 2;5(1):e1283386. doi: 10.1080/21688370.2017.1283386.


MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis.

Cobo ER, Kissoon-Singh V, Moreau F, Holani R, Chadee K.

Infect Immun. 2017 Feb 23;85(3). pii: e00905-16. doi: 10.1128/IAI.00905-16. Print 2017 Mar.


Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.

Kumar M, Kissoon-Singh V, Coria AL, Moreau F, Chadee K.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G34-G45. doi: 10.1152/ajpgi.00298.2016. Epub 2016 Nov 17.


NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations.

Mortimer L, Moreau F, MacDonald JA, Chadee K.

Nat Immunol. 2016 Oct;17(10):1176-86. doi: 10.1038/ni.3538. Epub 2016 Aug 22.


Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin.

Cornick S, Moreau F, Chadee K.

PLoS Pathog. 2016 Apr 13;12(4):e1005579. doi: 10.1371/journal.ppat.1005579. eCollection 2016 Apr.


Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease.

Begum S, Quach J, Chadee K.

Front Microbiol. 2015 Dec 15;6:1394. doi: 10.3389/fmicb.2015.01394. eCollection 2015. Review.


The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction.

Mortimer L, Moreau F, Cornick S, Chadee K.

PLoS Pathog. 2015 May 8;11(5):e1004887. doi: 10.1371/journal.ppat.1004887. eCollection 2015 May.


Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.

Cobo ER, Kissoon-Singh V, Moreau F, Chadee K.

Mucosal Immunol. 2015 Nov;8(6):1360-72. doi: 10.1038/mi.2015.27. Epub 2015 Apr 29.


Roles and regulation of the mucus barrier in the gut.

Cornick S, Tawiah A, Chadee K.

Tissue Barriers. 2015 Apr 3;3(1-2):e982426. doi: 10.4161/21688370.2014.982426. eCollection 2015.


Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.

Lejeune M, Moreau F, Chadee K.

PLoS One. 2014 Nov 14;9(11):e113270. doi: 10.1371/journal.pone.0113270. eCollection 2014.


Invasive amoebiasis: a review of Entamoeba infections highlighted with case reports.

Skappak C, Akierman S, Belga S, Novak K, Chadee K, Urbanski SJ, Church D, Beck PL.

Can J Gastroenterol Hepatol. 2014 Jul-Aug;28(7):355-9. Review.


How the discovery of TNF-α has advanced gastrointestinal diseases and treatment regimes.

St-Pierre J, Chadee K.

Dig Dis Sci. 2014 Apr;59(4):712-5. doi: 10.1007/s10620-014-3042-5. Review. No abstract available.


The future for vaccine development against Entamoeba histolytica.

Quach J, St-Pierre J, Chadee K.

Hum Vaccin Immunother. 2014;10(6):1514-21. doi: 10.4161/hv.27796. Epub 2014 Feb 6. Review.


Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica.

Mortimer L, Moreau F, Cornick S, Chadee K.

Mucosal Immunol. 2014 Jul;7(4):829-41. doi: 10.1038/mi.2013.100. Epub 2013 Nov 20.


Entamoeba histolytica contains an occludin-like protein that can alter colonic epithelial barrier function.

Goplen M, Lejeune M, Cornick S, Moreau F, Chadee K.

PLoS One. 2013 Sep 13;8(9):e73339. doi: 10.1371/journal.pone.0073339. eCollection 2013.


Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4.

Dey I, Beck PL, Chadee K.

PLoS One. 2013 Apr 17;8(4):e61891. doi: 10.1371/journal.pone.0061891. Print 2013.


The probiotic mixture VSL#3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor.

Dharmani P, De Simone C, Chadee K.

PLoS One. 2013;8(3):e58671. doi: 10.1371/journal.pone.0058671. Epub 2013 Mar 6.


Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Kissoon-Singh V, Moreau F, Trusevych E, Chadee K.

Am J Pathol. 2013 Mar;182(3):852-65. doi: 10.1016/j.ajpath.2012.11.035. Epub 2013 Jan 26.


Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases.

Cobo ER, Chadee K.

Pathogens. 2013 Mar 19;2(1):177-92. doi: 10.3390/pathogens2010177. Review.


PPARγ is an E3 ligase that induces the degradation of NFκB/p65.

Hou Y, Moreau F, Chadee K.

Nat Commun. 2012;3:1300. doi: 10.1038/ncomms2270.


Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells.

Srivastava V, Dey I, Leung P, Chadee K.

Eur J Immunol. 2012 Apr;42(4):912-23. doi: 10.1002/eji.201141965.


Fusobacterium nucleatum: an emerging gut pathogen?

Allen-Vercoe E, Strauss J, Chadee K.

Gut Microbes. 2011 Sep 1;2(5):294-8. doi: 10.4161/gmic.2.5.18603. Epub 2011 Sep 1. Review.


Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis.

Dharmani P, Leung P, Chadee K.

PLoS One. 2011;6(9):e25058. doi: 10.1371/journal.pone.0025058. Epub 2011 Sep 19.


Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions.

Lejeune M, Moreau F, Chadee K.

Am J Pathol. 2011 Aug;179(2):807-18. doi: 10.1016/j.ajpath.2011.05.001. Epub 2011 May 31.


Entamoeba histolytica cathepsin-like enzymes : interactions with the host gut.

Kissoon-Singh V, Mortimer L, Chadee K.

Adv Exp Med Biol. 2011;712:62-83. doi: 10.1007/978-1-4419-8414-2_5. Review.


Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alpha.

Dharmani P, Strauss J, Ambrose C, Allen-Vercoe E, Chadee K.

Infect Immun. 2011 Jul;79(7):2597-607. doi: 10.1128/IAI.05118-11. Epub 2011 May 2.


Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair.

Wallace JL, Vong L, Dharmani P, Srivastava V, Chadee K.

Am J Pathol. 2011 Mar;178(3):1126-33. doi: 10.1016/j.ajpath.2010.11.048.


Entamoeba histolytica infection and secreted proteins proteolytically damage enteric neurons.

Lourenssen S, Houpt ER, Chadee K, Blennerhassett MG.

Infect Immun. 2010 Dec;78(12):5332-40. doi: 10.1128/IAI.00699-10. Epub 2010 Sep 20.


Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory responses.

Hou Y, Mortimer L, Chadee K.

J Biol Chem. 2010 Nov 12;285(46):35497-504. doi: 10.1074/jbc.M109.066035. Epub 2010 Sep 13.


Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity.

Lejeune M, Leung P, Beck PL, Chadee K.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1097-105. doi: 10.1152/ajpgi.00280.2010. Epub 2010 Sep 2.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.

Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL.

Gastroenterology. 2010 Jul;139(1):259-69.e3. doi: 10.1053/j.gastro.2010.03.045. Epub 2010 Mar 27.


The immunopathogenesis of Entamoeba histolytica.

Mortimer L, Chadee K.

Exp Parasitol. 2010 Nov;126(3):366-80. doi: 10.1016/j.exppara.2010.03.005. Epub 2010 Mar 19. Review.


Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.

Lejeune M, Rybicka JM, Chadee K.

Future Microbiol. 2009 Feb;4(1):105-18. doi: 10.2217/17460913.4.1.105. Review.


Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.

Dey I, Giembycz MA, Chadee K.

Br J Pharmacol. 2009 Feb;156(3):475-85. doi: 10.1111/j.1476-5381.2008.00056.x. Epub 2009 Jan 23.


Role of intestinal mucins in innate host defense mechanisms against pathogens.

Dharmani P, Srivastava V, Kissoon-Singh V, Chadee K.

J Innate Immun. 2009;1(2):123-35. doi: 10.1159/000163037. Epub 2008 Oct 8. Review.

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