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Items: 28

1.

Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity.

Fonfria E, Elliott M, Beard M, Chaddock JA, Krupp J.

Toxins (Basel). 2018 Jul 4;10(7). pii: E278. doi: 10.3390/toxins10070278. Review.

2.

Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.

Masuyer G, Davies JR, Moore K, Chaddock JA, Ravi Acharya K.

Sci Rep. 2015 Sep 1;5:13397. doi: 10.1038/srep13397.

3.

Engineered botulinum neurotoxins as new therapeutics.

Masuyer G, Chaddock JA, Foster KA, Acharya KR.

Annu Rev Pharmacol Toxicol. 2014;54:27-51. doi: 10.1146/annurev-pharmtox-011613-135935. Epub 2013 Aug 30. Review.

PMID:
24016211
4.

Engineering botulinum neurotoxin domains for activation by toxin light chain.

Stancombe PR, Masuyer G, Birch-Machin I, Beard M, Foster KA, Chaddock JA, Acharya KR.

FEBS J. 2012 Feb;279(3):515-23. doi: 10.1111/j.1742-4658.2011.08444.x. Epub 2011 Dec 23.

5.

Structures of engineered Clostridium botulinum neurotoxin derivatives.

Masuyer G, Stancombe P, Chaddock JA, Acharya KR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1466-72. doi: 10.1107/S1744309111034671. Epub 2011 Nov 25.

6.

Engineering toxins for 21st century therapies.

Chaddock JA, Acharya KR.

FEBS J. 2011 Apr;278(6):899-904. doi: 10.1111/j.1742-4658.2011.08013.x. Epub 2011 Feb 3.

7.

Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B.

Masuyer G, Beard M, Cadd VA, Chaddock JA, Acharya KR.

J Struct Biol. 2011 Apr;174(1):52-7. doi: 10.1016/j.jsb.2010.11.010. Epub 2010 Nov 13.

PMID:
21078393
8.

Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A.

Masuyer G, Thiyagarajan N, James PL, Marks PM, Chaddock JA, Acharya KR.

Biochem Biophys Res Commun. 2009 Mar 27;381(1):50-3. doi: 10.1016/j.bbrc.2009.02.003. Epub 2009 Feb 8.

PMID:
19351593
9.

Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.

He Y, Elias CL, Huang YC, Gao X, Leung YM, Kang Y, Xie H, Chaddock JA, Tsushima RG, Gaisano HY.

Pancreas. 2008 Jan;36(1):10-7. doi: 10.1097/mpa.0b013e31812eee28.

PMID:
18192874
10.

Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics.

Foster KA, Adams EJ, Durose L, Cruttwell CJ, Marks E, Shone CC, Chaddock JA, Cox CL, Heaton C, Sutton JM, Wayne J, Alexander FC, Rogers DF.

Neurotox Res. 2006 Apr;9(2-3):101-7.

PMID:
16785105
11.

Clostridial neurotoxins: structure-function led design of new therapeutics.

Chaddock JA, Marks PM.

Cell Mol Life Sci. 2006 Mar;63(5):540-51. Review.

PMID:
16416025
12.

Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications.

Sutton JM, Wayne J, Scott-Tucker A, O'Brien SM, Marks PM, Alexander FC, Shone CC, Chaddock JA.

Protein Expr Purif. 2005 Mar;40(1):31-41.

PMID:
15721769
13.

Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose.

Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR.

Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16.

PMID:
15201215
14.

Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies.

Hall YH, Chaddock JA, Moulsdale HJ, Kirby ER, Alexander FC, Marks JD, Foster KA.

J Immunol Methods. 2004 May;288(1-2):55-60.

PMID:
15183085
15.

Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.

Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Duggan MJ, Quinn CP, Shone CC, Foster KA.

Mov Disord. 2004 Mar;19 Suppl 8:S42-7.

PMID:
15027053
16.

Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin.

Stancombe PR, Alexander FC, Ling R, Matheson MA, Shone CC, Chaddock JA.

Protein Expr Purif. 2003 Aug;30(2):283-92.

PMID:
12880778
17.

Botulinum and tetanus neurotoxins: structure, function and therapeutic utility.

Turton K, Chaddock JA, Acharya KR.

Trends Biochem Sci. 2002 Nov;27(11):552-8. Review.

PMID:
12417130
18.

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.

Chaddock JA, Herbert MH, Ling RJ, Alexander FC, Fooks SJ, Revell DF, Quinn CP, Shone CC, Foster KA.

Protein Expr Purif. 2002 Jul;25(2):219-28.

PMID:
12135553
19.

Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.

Duggan MJ, Quinn CP, Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Shone CC, Foster KA.

J Biol Chem. 2002 Sep 20;277(38):34846-52. Epub 2002 Jul 8.

20.
21.

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A.

Chaddock JA, Purkiss JR, Friis LM, Broadbridge JD, Duggan MJ, Fooks SJ, Shone CC, Quinn CP, Foster KA.

Infect Immun. 2000 May;68(5):2587-93.

22.

Restoration of lectin activity to a non-glycosylated ricin B chain mutant by the introduction of a novel N-glycosylation site.

Zhan J, de Sousa M, Chaddock JA, Roberts LM, Lord JM.

FEBS Lett. 1997 May 5;407(3):271-4.

23.

Ricin A chain fused to a chloroplast-targeting signal is unfolded on the chloroplast surface prior to import across the envelope membranes.

Walker D, Chaddock AM, Chaddock JA, Roberts LM, Lord JM, Robinson C.

J Biol Chem. 1996 Feb 23;271(8):4082-5.

24.

Major structural differences between pokeweed antiviral protein and ricin A-chain do not account for their differing ribosome specificity.

Chaddock JA, Monzingo AF, Robertus JD, Lord JM, Roberts LM.

Eur J Biochem. 1996 Jan 15;235(1-2):159-66.

25.

A hydrophobic region of ricin A chain which may have a role in membrane translocation can function as an efficient noncleaved signal peptide.

Chaddock JA, Roberts LM, Jungnickel B, Lord JM.

Biochem Biophys Res Commun. 1995 Dec 5;217(1):68-73.

PMID:
8526941
26.
27.

Mutagenesis and kinetic analysis of the active site Glu177 of ricin A-chain.

Chaddock JA, Roberts LM.

Protein Eng. 1993 Jun;6(4):425-31.

PMID:
8332600
28.

Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin.

Wales R, Chaddock JA, Roberts LM, Lord JM.

Exp Cell Res. 1992 Nov;203(1):1-4.

PMID:
1426032

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