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Semi-continuous multi-step synthesis of lamivudine.

Mandala D, Chada S, Watts P.

Org Biomol Chem. 2017 Apr 18;15(16):3444-3454. doi: 10.1039/c7ob00480j.


Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity.

Panneerselvam J, Shanker M, Jin J, Branch CD, Muralidharan R, Zhao YD, Chada S, Munshi A, Ramesh R.

Oncotarget. 2015 Jun 30;6(18):16271-86.


A study to evaluate the effect of ratio of donor kidney weight to recipient body weight on renal graft function.

Dar TI, Tyagi V, Pahwa M, Chada S, Jauhari H, Sharma N.

Urol Ann. 2014 Apr;6(2):139-41. doi: 10.4103/0974-7796.130644.


Robotic assisted excision of retrovesical angiomyxoma in a male patient.

Tyagi V, Dar TI, Durani AM, Chada S.

J Minim Access Surg. 2014 Apr;10(2):84-6. doi: 10.4103/0972-9941.129958.


Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma.

Zhang Z, Kawamura K, Jiang Y, Shingyoji M, Ma G, Li Q, Hu J, Qi Y, Liu H, Zhang F, Kang S, Shan B, Wang S, Chada S, Tagawa M.

Cancer Gene Ther. 2013 Dec;20(12):663-70. doi: 10.1038/cgt.2013.66. Epub 2013 Nov 22.


Combination of asystole and sinus arrest with junctional escape rhythm seen in Takotsubo cardiomyopathy: A case report.

Mastrine L, Chada S, Enakpene E, Hollander G.

J Cardiol Cases. 2013 Aug 31;8(4):125-128. doi: 10.1016/j.jccase.2013.06.005. eCollection 2013 Oct.


Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects.

Nagakawa H, Shimozato O, Yu L, Wada A, Kawamura K, Li Q, Chada S, Tada Y, Takiguchi Y, Tatsumi K, Tagawa M.

Cell Immunol. 2012 Jan-Feb;275(1-2):90-7. doi: 10.1016/j.cellimm.2012.02.010. Epub 2012 Mar 14.


MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.

Valero V 3rd, Wingate H, Chada S, Liu Y, Palalon F, Mills G, Keyomarsi K, Hunt KK.

Cancer Gene Ther. 2011 Jul;18(7):510-9. doi: 10.1038/cgt.2011.20. Epub 2011 May 6.


Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer.

Ramesh R, Ioannides CG, Roth JA, Chada S.

Methods Mol Biol. 2010;651:241-70. doi: 10.1007/978-1-60761-786-0_14.


IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytes.

Poindexter NJ, Williams RR, Powis G, Jen E, Caudle AS, Chada S, Grimm EA.

Exp Dermatol. 2010 Aug;19(8):714-22. doi: 10.1111/j.1600-0625.2010.01077.x.


Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck.

Nemunaitis J, Clayman G, Agarwala SS, Hrushesky W, Wells JR, Moore C, Hamm J, Yoo G, Baselga J, Murphy BA, Menander KA, Licato LL, Chada S, Gibbons RD, Olivier M, Hainaut P, Roth JA, Sobol RE, Goodwin WJ.

Clin Cancer Res. 2009 Dec 15;15(24):7719-7725.


Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.

Fuson KL, Zheng M, Craxton M, Pataer A, Ramesh R, Chada S, Sutton RB.

J Biol Chem. 2009 Oct 30;284(44):30526-33. doi: 10.1074/jbc.M109.036061. Epub 2009 Sep 4.


Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.

Zheng M, Bocangel D, Ramesh R, Ekmekcioglu S, Poindexter N, Grimm EA, Chada S.

Mol Cancer Ther. 2008 Dec;7(12):3842-51. doi: 10.1158/1535-7163.MCT-08-0516. Epub 2008 Dec 3.


Phase I study of adenovirus p53 administered by bronchoalveolar lavage in patients with bronchioloalveolar cell lung carcinoma: ECOG 6597.

Keedy V, Wang W, Schiller J, Chada S, Slovis B, Coffee K, Worrell J, Thet LA, Johnson DH, Carbone DP.

J Clin Oncol. 2008 Sep 1;26(25):4166-71. doi: 10.1200/JCO.2007.15.6927.


Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.

Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG.

Mol Cancer Ther. 2008 Aug;7(8):2528-35. doi: 10.1158/1535-7163.MCT-08-0083.


Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.

Ekmekcioglu S, Mumm JB, Udtha M, Chada S, Grimm EA.

Cytokine. 2008 Jul;43(1):34-44. doi: 10.1016/j.cyto.2008.04.010. Epub 2008 Jun 3.


Development of Ad-mda7/IL-24-resistant lung cancer cell lines.

Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG.

Cancer Biol Ther. 2008 Jan;7(1):103-8. Epub 2007 Oct 13.


Cancer targeting using tumor suppressor genes.

Chada S, Menander KB, Bocangel D, Roth JA, Ramesh R.

Front Biosci. 2008 Jan 1;13:1959-67. Review.


mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R, Barral P, Lee SG, Wang D, Vozhilla N, Park ES, Chatman L, Boukerche H, Ramesh R, Inoue S, Chada S, Li R, De Pass AL, Mahasreshti PJ, Dmitriev IP, Curiel DT, Yacoub A, Grant S, Dent P, Senzer N, Nemunaitis JJ, Fisher PB.

Int J Oncol. 2007 Nov;31(5):985-1007. Review.


p53 therapy in a patient with Li-Fraumeni syndrome.

Senzer N, Nemunaitis J, Nemunaitis M, Lamont J, Gore M, Gabra H, Eeles R, Sodha N, Lynch FJ, Zumstein LA, Menander KB, Sobol RE, Chada S.

Mol Cancer Ther. 2007 May;6(5):1478-82. Epub 2007 May 4.


Vitamin E succinate in combination with mda-7 results in enhanced human ovarian tumor cell killing through modulation of extrinsic and intrinsic apoptotic pathways.

Shanker M, Gopalan B, Patel S, Bocangel D, Chada S, Ramesh R.

Cancer Lett. 2007 Sep 8;254(2):217-26. Epub 2007 Apr 20.


MDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo.

Gopalan B, Shanker M, Chada S, Ramesh R.

Mol Cancer. 2007 Feb 2;6:11.


Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes.

Mumm JB, Ekmekcioglu S, Poindexter NJ, Chada S, Grimm EA.

J Interferon Cytokine Res. 2006 Dec;26(12):877-86.


mda-7 In combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft.

Inoue S, Hartman A, Branch CD, Bucana CD, Bekele BN, Stephens LC, Chada S, Ramesh R.

Mol Ther. 2007 Feb;15(2):287-94.


Apoptin studies illuminate intersection between lipidomics and tumor suppressors.

Chada S, Ramesh R.

Mol Ther. 2007 Jan;15(1):7-9. No abstract available.


Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue.

Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG.

Cancer Gene Ther. 2007 Jan;14(1):12-8. Epub 2006 Oct 6.


Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress.

Kokkinakis DM, Brickner AG, Kirkwood JM, Liu X, Goldwasser JE, Kastrama A, Sander C, Bocangel D, Chada S.

Mol Cancer Res. 2006 Aug;4(8):575-89.


Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells.

Bocangel D, Zheng M, Mhashilkar A, Liu Y, Ramesh R, Hunt KK, Chada S.

Cancer Gene Ther. 2006 Oct;13(10):958-68. Epub 2006 Jun 16.


Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10.

Zheng M, Bocangel D, Doneske B, Mhashilkar A, Ramesh R, Hunt KK, Ekmekcioglu S, Sutton RB, Poindexter N, Grimm EA, Chada S.

Cancer Immunol Immunother. 2007 Feb;56(2):205-15. Epub 2006 May 19.


Melanoma differentiation-associated gene-7 (mda-7)/interleukin (IL)-24 induces anticancer immunity in a syngeneic murine model.

Miyahara R, Banerjee S, Kawano K, Efferson C, Tsuda N, Miyahara Y, Ioannides CG, Chada S, Ramesh R.

Cancer Gene Ther. 2006 Aug;13(8):753-61. Epub 2006 Mar 10.


Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer.

Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T, Yoshimura K, Sato T, Eto Y, Chada S, Nakamura H, Kato H.

J Clin Oncol. 2006 Apr 10;24(11):1689-99. Epub 2006 Feb 27.


MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic.

Inoue S, Shanker M, Miyahara R, Gopalan B, Patel S, Oida Y, Branch CD, Munshi A, Meyn RE, Andreeff M, Tanaka F, Mhashilkar AM, Chada S, Ramesh R.

Curr Gene Ther. 2006 Feb;6(1):73-91. Review.


Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer.

Antonia SJ, Mirza N, Fricke I, Chiappori A, Thompson P, Williams N, Bepler G, Simon G, Janssen W, Lee JH, Menander K, Chada S, Gabrilovich DI.

Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):878-87.


mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.

Chada S, Mhashilkar AM, Liu Y, Nishikawa T, Bocangel D, Zheng M, Vorburger SA, Pataer A, Swisher SG, Ramesh R, Kawase K, Meyn RE, Hunt KK.

Cancer Gene Ther. 2006 May;13(5):490-502.


Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.

Mahasreshti PJ, Kataram M, Wu H, Yalavarthy LP, Carey D, Fisher PB, Chada S, Alvarez RD, Haisma HJ, Dent P, Curiel DT.

Gynecol Oncol. 2006 Mar;100(3):521-32. Epub 2005 Oct 12.


Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells.

Suh YJ, Chada S, McKenzie T, Liu Y, Swisher SG, Lucci A, Hunt KK.

Surgery. 2005 Sep;138(3):422-30.


Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells.

Poindexter NJ, Walch ET, Chada S, Grimm EA.

J Leukoc Biol. 2005 Sep;78(3):745-52. Epub 2005 Jul 6.


Housekeeping genes in cancer: normalization of array data.

Khimani AH, Mhashilkar AM, Mikulskis A, O'Malley M, Liao J, Golenko EE, Mayer P, Chada S, Killian JB, Lott ST.

Biotechniques. 2005 May;38(5):739-45.


Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

Pataer A, Vorburger SA, Chada S, Balachandran S, Barber GN, Roth JA, Hunt KK, Swisher SG.

Mol Ther. 2005 May;11(5):717-23.


Activation of the Fas-FasL signaling pathway by MDA-7/IL-24 kills human ovarian cancer cells.

Gopalan B, Litvak A, Sharma S, Mhashilkar AM, Chada S, Ramesh R.

Cancer Res. 2005 Apr 15;65(8):3017-24.


Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.

Oida Y, Gopalan B, Miyahara R, Inoue S, Branch CD, Mhashilkar AM, Lin E, Bekele BN, Roth JA, Chada S, Ramesh R.

Mol Cancer Ther. 2005 Feb;4(2):291-304.


Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery.

Ramesh R, Ito I, Saito Y, Wu Z, Mhashikar AM, Wilson DR, Branch CD, Roth JA, Chada S.

DNA Cell Biol. 2004 Dec;23(12):850-7.


Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.

Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S.

Mol Ther. 2005 Jan;11(1):160-72.


Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.

Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, Mhashilkar A, Parker K, Vukelja S, Richards D, Hood J, Coffee K, Nemunaitis J.

Mol Ther. 2005 Jan;11(1):149-59.


Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated -7 (mda-7)/interleukin-24 (IL-24) gene.

Saito Y, Miyahara R, Gopalan B, Litvak A, Inoue S, Shanker M, Branch CD, Mhashilkar AM, Roth JA, Chada S, Ramesh R.

Cancer Gene Ther. 2005 Mar;12(3):238-47. Erratum in: Cancer Gene Ther. 2005 Mar;12(3):340.


Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism.

Chada S, Mhashilkar AM, Ramesh R, Mumm JB, Sutton RB, Bocangel D, Zheng M, Grimm EA, Ekmekcioglu S.

Mol Ther. 2004 Dec;10(6):1085-95.

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