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Items: 1 to 50 of 98

1.

Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.

Verhey TB, Castellanos M, Chaconas G.

Mol Microbiol. 2019 Mar;111(3):750-763. doi: 10.1111/mmi.14189. Epub 2019 Jan 31.

PMID:
30580501
2.

A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat.

Castellanos M, Verhey TB, Chaconas G.

Mol Microbiol. 2018 Sep;109(5):710-721. doi: 10.1111/mmi.14071. Epub 2018 Sep 9.

PMID:
29995993
3.

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.

Verhey TB, Castellanos M, Chaconas G.

Cell Rep. 2018 May 29;23(9):2595-2605. doi: 10.1016/j.celrep.2018.04.117.

4.

Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline.

Verhey TB, Castellanos M, Chaconas G.

Mol Microbiol. 2018 May;108(4):461. doi: 10.1111/mmi.13969. No abstract available.

PMID:
29740915
5.

Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline.

Verhey TB, Castellanos M, Chaconas G.

Mol Microbiol. 2018 Jan;107(1):104-115. doi: 10.1111/mmi.13873. Epub 2017 Nov 17. Erratum in: Mol Microbiol. 2018 May;108(4):461.

6.

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein.

Kumar D, Ristow LC, Shi M, Mukherjee P, Caine JA, Lee WY, Kubes P, Coburn J, Chaconas G.

PLoS Pathog. 2015 Dec 18;11(12):e1005333. doi: 10.1371/journal.ppat.1005333. eCollection 2015 Dec.

7.

Hairpin Telomere Resolvases.

Kobryn K, Chaconas G.

Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.MDNA3-0023-2014. Review.

PMID:
26104454
8.

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.

Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13936-41. doi: 10.1073/pnas.1404769111. Epub 2014 Sep 9.

9.

Construction and characterization of a Borrelia burgdorferi strain with conditional expression of the essential telomere resolvase, ResT.

Bandy NJ, Salman-Dilgimen A, Chaconas G.

J Bacteriol. 2014 Jul;196(13):2396-404. doi: 10.1128/JB.01435-13. Epub 2014 Apr 18.

10.

HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.

Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G.

PLoS Pathog. 2013;9(12):e1003841. doi: 10.1371/journal.ppat.1003841. Epub 2013 Dec 19.

11.

Illuminating the roles of the Borrelia burgdorferi adhesins.

Coburn J, Leong J, Chaconas G.

Trends Microbiol. 2013 Aug;21(8):372-9. doi: 10.1016/j.tim.2013.06.005. Epub 2013 Jul 19. Review.

12.

Peaceful coexistence amongst Borrelia plasmids: getting by with a little help from their friends?

Chaconas G, Norris SJ.

Plasmid. 2013 Sep;70(2):161-7. doi: 10.1016/j.plasmid.2013.05.002. Epub 2013 May 30. Review.

13.

The nucleotide excision repair system of Borrelia burgdorferi is the sole pathway involved in repair of DNA damage by UV light.

Hardy PO, Chaconas G.

J Bacteriol. 2013 May;195(10):2220-31. doi: 10.1128/JB.00043-13. Epub 2013 Mar 8.

14.

Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete.

Walia R, Chaconas G.

PLoS One. 2013;8(2):e57792. doi: 10.1371/journal.pone.0057792. Epub 2013 Feb 28.

15.

Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity.

Lin T, Gao L, Zhang C, Odeh E, Jacobs MB, Coutte L, Chaconas G, Philipp MT, Norris SJ.

PLoS One. 2012;7(10):e47532. doi: 10.1371/journal.pone.0047532. Epub 2012 Oct 25.

16.

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G.

Mol Microbiol. 2012 Dec;86(5):1116-31. doi: 10.1111/mmi.12045. Epub 2012 Oct 24.

17.

CSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to mice.

Chaconas G.

Can J Microbiol. 2012 Mar;58(3):236-48. doi: 10.1139/w11-143. Epub 2012 Feb 17.

PMID:
22339274
18.

HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete.

Salman-Dilgimen A, Hardy PO, Dresser AR, Chaconas G.

PLoS One. 2011;6(7):e22168. doi: 10.1371/journal.pone.0022168. Epub 2011 Jul 26.

19.

Meeting report for mobile DNA 2010.

Chaconas G, Craig N, Curcio MJ, Deininger P, Feschotte C, Levin H, Rice PA, Voytas DF.

Mob DNA. 2010 Aug 24;1(1):20. doi: 10.1186/1759-8753-1-20.

20.

Structure, function, and evolution of linear replicons in Borrelia.

Chaconas G, Kobryn K.

Annu Rev Microbiol. 2010;64:185-202. doi: 10.1146/annurev.micro.112408.134037. Review.

PMID:
20536352
21.

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.

Lee WY, Moriarty TJ, Wong CH, Zhou H, Strieter RM, van Rooijen N, Chaconas G, Kubes P.

Nat Immunol. 2010 Apr;11(4):295-302. doi: 10.1038/ni.1855. Epub 2010 Mar 14.

22.

Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.

Dresser AR, Hardy PO, Chaconas G.

PLoS Pathog. 2009 Dec;5(12):e1000680. doi: 10.1371/journal.ppat.1000680. Epub 2009 Dec 4.

23.

High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete.

Lefas G, Chaconas G.

Antimicrob Agents Chemother. 2009 Oct;53(10):4441-9. doi: 10.1128/AAC.00529-09. Epub 2009 Jul 13.

24.

Identification of the determinant conferring permissive substrate usage in the telomere resolvase, ResT.

Moriarty TJ, Chaconas G.

J Biol Chem. 2009 Aug 28;284(35):23293-301. doi: 10.1074/jbc.M109.023549. Epub 2009 Jun 26.

25.

Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the lyme disease spirochete.

Tourand Y, Deneke J, Moriarty TJ, Chaconas G.

J Biol Chem. 2009 Mar 13;284(11):7264-72. doi: 10.1074/jbc.M808918200. Epub 2009 Jan 2.

26.

Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host.

Norman MU, Moriarty TJ, Dresser AR, Millen B, Kubes P, Chaconas G.

PLoS Pathog. 2008 Oct 3;4(10):e1000169. doi: 10.1371/journal.ppat.1000169.

27.

Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host.

Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G.

PLoS Pathog. 2008 Jun 20;4(6):e1000090. doi: 10.1371/journal.ppat.1000090.

28.

Purification and properties of the plasmid maintenance proteins from the Borrelia burgdorferi linear plasmid lp17.

Deneke J, Chaconas G.

J Bacteriol. 2008 Jun;190(11):3992-4000. doi: 10.1128/JB.00057-08. Epub 2008 Mar 28.

29.
30.
31.
32.

Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution.

Bankhead T, Kobryn K, Chaconas G.

Mol Microbiol. 2006 Nov;62(3):895-905. Epub 2006 Sep 25.

33.

Differential telomere processing by Borrelia telomere resolvases in vitro but not in vivo.

Tourand Y, Bankhead T, Wilson SL, Putteet-Driver AD, Barbour AG, Byram R, Rosa PA, Chaconas G.

J Bacteriol. 2006 Nov;188(21):7378-86. Epub 2006 Aug 25.

34.

Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end.

Chaconas G.

Mol Microbiol. 2005 Nov;58(3):625-35. Review.

35.
36.

Uncoupling the chemical steps of telomere resolution by ResT.

Kobryn K, Burgin AB, Chaconas G.

J Biol Chem. 2005 Jul 22;280(29):26788-95. Epub 2005 May 23.

38.

3D reconstruction of the Mu transposase and the Type 1 transpososome: a structural framework for Mu DNA transposition.

Yuan JF, Beniac DR, Chaconas G, Ottensmeyer FP.

Genes Dev. 2005 Apr 1;19(7):840-52. Epub 2005 Mar 17.

39.

Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases.

Deneke J, Burgin AB, Wilson SL, Chaconas G.

J Biol Chem. 2004 Dec 17;279(51):53699-706. Epub 2004 Oct 6.

40.

Mixing active-site components: a recipe for the unique enzymatic activity of a telomere resolvase.

Bankhead T, Chaconas G.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13768-73. Epub 2004 Sep 13.

41.

Effect of mutations in the C-terminal domain of Mu B on DNA binding and interactions with Mu A transposase.

Coros CJ, Sekino Y, Baker TA, Chaconas G.

J Biol Chem. 2003 Aug 15;278(33):31210-7. Epub 2003 Jun 5.

43.
44.
45.

ResT, a telomere resolvase encoded by the Lyme disease spirochete.

Kobryn K, Chaconas G.

Mol Cell. 2002 Jan;9(1):195-201.

46.

The circle is broken: telomere resolution in linear replicons.

Kobryn K, Chaconas G.

Curr Opin Microbiol. 2001 Oct;4(5):558-64. Review.

PMID:
11587933
47.

Effect of mutations in the Mu-host junction region on transpososome assembly.

Coros CJ, Chaconas G.

J Mol Biol. 2001 Jul 6;310(2):299-309.

PMID:
11428891
48.

Telomere resolution in the Lyme disease spirochete.

Chaconas G, Stewart PE, Tilly K, Bono JL, Rosa P.

EMBO J. 2001 Jun 15;20(12):3229-37.

49.

The solution structure of the C-terminal domain of the Mu B transposition protein.

Hung LH, Chaconas G, Shaw GS.

EMBO J. 2000 Nov 1;19(21):5625-34.

50.

Site-specific DNA binding and bending by the Borrelia burgdorferi Hbb protein.

Kobryn K, Naigamwalla DZ, Chaconas G.

Mol Microbiol. 2000 Jul;37(1):145-55.

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