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Items: 1 to 50 of 83

1.

Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins.

Monteuuis G, Miścicka A, Świrski M, Zenad L, Niemitalo O, Wrobel L, Alam J, Chacinska A, Kastaniotis AJ, Kufel J.

Nucleic Acids Res. 2019 Jun 20;47(11):5777-5791. doi: 10.1093/nar/gkz301.

PMID:
31216041
2.

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.

Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A.

Mol Biol Cell. 2019 May 22:mbcE18100628. doi: 10.1091/mbc.E18-10-0628. [Epub ahead of print]

PMID:
31116686
3.

Mitochondrial stress-dependent regulation of cellular protein synthesis.

Topf U, Uszczynska-Ratajczak B, Chacinska A.

J Cell Sci. 2019 Apr 26;132(8). pii: jcs226258. doi: 10.1242/jcs.226258. Review.

PMID:
31028152
4.

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A.

EMBO Mol Med. 2019 May;11(5). pii: e9561. doi: 10.15252/emmm.201809561.

5.

A High-Resolution Luminescent Assay for Rapid and Continuous Monitoring of Protein Translocation across Biological Membranes.

Pereira GC, Allen WJ, Watkins DW, Buddrus L, Noone D, Liu X, Richardson AP, Chacinska A, Collinson I.

J Mol Biol. 2019 Apr 5;431(8):1689-1699. doi: 10.1016/j.jmb.2019.03.007. Epub 2019 Mar 13.

6.

Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Sokol AM, Uszczynska-Ratajczak B, Collins MM, Bazala M, Topf U, Lundegaard PR, Sugunan S, Guenther S, Kuenne C, Graumann J, Chan SSL, Stainier DYR, Chacinska A.

PLoS Genet. 2019 Jan 31;15(1):e1007972. doi: 10.1371/journal.pgen.1007972. eCollection 2019 Jan.

7.

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Sokol AM, Uszczynska-Ratajczak B, Collins MM, Bazala M, Topf U, Lundegaard PR, Sugunan S, Guenther S, Kuenne C, Graumann J, Chan SSL, Stainier DYR, Chacinska A.

PLoS Genet. 2018 Nov 20;14(11):e1007743. doi: 10.1371/journal.pgen.1007743. eCollection 2018 Nov. Erratum in: PLoS Genet. 2019 Jan 31;15(1):e1007972.

8.

Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane.

Schendzielorz AB, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, Chacinska A, Rehling P.

Nat Commun. 2018 Oct 2;9(1):4028. doi: 10.1038/s41467-018-06492-8.

9.

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins.

Kowalski L, Bragoszewski P, Khmelinskii A, Glow E, Knop M, Chacinska A.

BMC Biol. 2018 Jun 22;16(1):66. doi: 10.1186/s12915-018-0536-1.

10.

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B.

Nat Commun. 2018 Jan 22;9(1):324. doi: 10.1038/s41467-017-02694-8.

11.

Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography.

Gold VA, Chroscicki P, Bragoszewski P, Chacinska A.

EMBO Rep. 2017 Oct;18(10):1786-1800. doi: 10.15252/embr.201744261. Epub 2017 Aug 21.

12.

Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system.

Bragoszewski P, Turek M, Chacinska A.

Open Biol. 2017 Apr;7(4). pii: 170007. doi: 10.1098/rsob.170007. Review.

13.

Cell biology: Sort and destroy.

Chacinska A.

Nature. 2017 Mar 16;543(7645):324-325. doi: 10.1038/nature21892. Epub 2017 Mar 1. No abstract available.

PMID:
28241137
14.

[Mitochondrial proteins - import, export, degradation].

Wasilewski M, Chojnacka K, Chacińska A.

Postepy Biochem. 2016;62(2):94-102. Review. Polish.

15.

Protein trafficking at the crossroads to mitochondria.

Wasilewski M, Chojnacka K, Chacinska A.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):125-137. doi: 10.1016/j.bbamcr.2016.10.019. Epub 2016 Oct 31. Review.

16.

TIM29 is a subunit of the human carrier translocase required for protein transport.

Callegari S, Richter F, Chojnacka K, Jans DC, Lorenzi I, Pacheu-Grau D, Jakobs S, Lenz C, Urlaub H, Dudek J, Chacinska A, Rehling P.

FEBS Lett. 2016 Dec;590(23):4147-4158. doi: 10.1002/1873-3468.12450. Epub 2016 Oct 26.

17.

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

Wrobel L, Sokol AM, Chojnacka M, Chacinska A.

Sci Rep. 2016 Jun 6;6:27484. doi: 10.1038/srep27484.

18.

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis.

Topf U, Wrobel L, Chacinska A.

Trends Cell Biol. 2016 Aug;26(8):577-586. doi: 10.1016/j.tcb.2016.03.002. Epub 2016 Mar 19. Review.

PMID:
27004699
19.

Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential.

Turakhiya U, von der Malsburg K, Gold VAM, Guiard B, Chacinska A, van der Laan M, Ieva R.

J Mol Biol. 2016 Mar 27;428(6):1041-1052. doi: 10.1016/j.jmb.2016.01.020. Epub 2016 Jan 29.

PMID:
26827728
20.

The Oxidation Status of Mic19 Regulates MICOS Assembly.

Sakowska P, Jans DC, Mohanraj K, Riedel D, Jakobs S, Chacinska A.

Mol Cell Biol. 2015 Dec;35(24):4222-37. doi: 10.1128/MCB.00578-15. Epub 2015 Sep 28.

21.

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O.

Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16.

22.

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.

Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B, Chacinska A.

Nature. 2015 Aug 27;524(7566):485-8. doi: 10.1038/nature14951. Epub 2015 Aug 5.

PMID:
26245374
23.

Retro-translocation of mitochondrial intermembrane space proteins.

Bragoszewski P, Wasilewski M, Sakowska P, Gornicka A, Böttinger L, Qiu J, Wiedemann N, Chacinska A.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7713-8. doi: 10.1073/pnas.1504615112. Epub 2015 Jun 8.

24.

Mitochondrial translocation of APE1 relies on the MIA pathway.

Barchiesi A, Wasilewski M, Chacinska A, Tell G, Vascotto C.

Nucleic Acids Res. 2015 Jun 23;43(11):5451-64. doi: 10.1093/nar/gkv433. Epub 2015 May 8.

25.

Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System.

Chojnacka M, Gornicka A, Oeljeklaus S, Warscheid B, Chacinska A.

J Biol Chem. 2015 Jun 12;290(24):15304-12. doi: 10.1074/jbc.M115.645069. Epub 2015 Apr 27.

26.

Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.

Ieva R, Schrempp SG, Opaliński L, Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N, van der Laan M.

Mol Cell. 2014 Dec 4;56(5):641-52. doi: 10.1016/j.molcel.2014.10.010. Epub 2014 Nov 13.

27.

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria.

Gornicka A, Bragoszewski P, Chroscicki P, Wenz LS, Schulz C, Rehling P, Chacinska A.

Mol Biol Cell. 2014 Dec 15;25(25):3999-4009. doi: 10.1091/mbc.E14-06-1155. Epub 2014 Oct 15.

28.

Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.

Melin J, Schulz C, Wrobel L, Bernhard O, Chacinska A, Jahn O, Schmidt B, Rehling P.

Mol Cell Biol. 2014 Sep 15;34(18):3473-85. doi: 10.1128/MCB.00433-14. Epub 2014 Jul 7.

29.

Mitochondrial protein translocases for survival and wellbeing.

Sokol AM, Sztolsztener ME, Wasilewski M, Heinz E, Chacinska A.

FEBS Lett. 2014 Aug 1;588(15):2484-95. doi: 10.1016/j.febslet.2014.05.028. Epub 2014 May 24. Review.

30.

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J.

J Cell Biol. 2014 Mar 31;204(7):1083-6. doi: 10.1083/jcb.201401006.

31.

Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.

Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T.

Cell. 2013 Aug 1;154(3):596-608. doi: 10.1016/j.cell.2013.06.033.

32.

Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1.

Varabyova A, Topf U, Kwiatkowska P, Wrobel L, Kaus-Drobek M, Chacinska A.

FEBS J. 2013 Oct;280(20):4943-59. doi: 10.1111/febs.12409. Epub 2013 Jul 22.

33.

The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins.

Bragoszewski P, Gornicka A, Sztolsztener ME, Chacinska A.

Mol Cell Biol. 2013 Jun;33(11):2136-48. doi: 10.1128/MCB.01579-12. Epub 2013 Mar 18.

34.

Mitochondrial protein homeostasis.

Varabyova A, Stojanovski D, Chacinska A.

IUBMB Life. 2013 Mar;65(3):191-201. doi: 10.1002/iub.1122. Epub 2013 Jan 22. Review.

35.

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria.

Wrobel L, Trojanowska A, Sztolsztener ME, Chacinska A.

Mol Biol Cell. 2013 Mar;24(5):543-54. doi: 10.1091/mbc.E12-09-0649. Epub 2013 Jan 2.

36.

Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

Sztolsztener ME, Brewinska A, Guiard B, Chacinska A.

Traffic. 2013 Mar;14(3):309-20. doi: 10.1111/tra.12030. Epub 2012 Dec 16.

37.

Intermembrane space proteome of yeast mitochondria.

Vögtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C.

Mol Cell Proteomics. 2012 Dec;11(12):1840-52. doi: 10.1074/mcp.M112.021105. Epub 2012 Sep 15.

38.

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

Böttinger L, Gornicka A, Czerwik T, Bragoszewski P, Loniewska-Lwowska A, Schulze-Specking A, Truscott KN, Guiard B, Milenkovic D, Chacinska A.

Mol Biol Cell. 2012 Oct;23(20):3957-69. doi: 10.1091/mbc.E12-05-0358. Epub 2012 Aug 23.

39.

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane.

Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N, van der Laan M.

Mol Biol Cell. 2012 Oct;23(20):3948-56. doi: 10.1091/mbc.E12-04-0295. Epub 2012 Aug 23.

40.

The MIA pathway: a tight bond between protein transport and oxidative folding in mitochondria.

Stojanovski D, Bragoszewski P, Chacinska A.

Biochim Biophys Acta. 2012 Jul;1823(7):1142-50. doi: 10.1016/j.bbamcr.2012.04.014. Epub 2012 May 2. Review.

41.

Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex.

Schulz C, Lytovchenko O, Melin J, Chacinska A, Guiard B, Neumann P, Ficner R, Jahn O, Schmidt B, Rehling P.

J Cell Biol. 2011 Nov 14;195(4):643-56. doi: 10.1083/jcb.201105098. Epub 2011 Nov 7.

42.

Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.

von der Malsburg K, Müller JM, Bohnert M, Oeljeklaus S, Kwiatkowska P, Becker T, Loniewska-Lwowska A, Wiese S, Rao S, Milenkovic D, Hutu DP, Zerbes RM, Schulze-Specking A, Meyer HE, Martinou JC, Rospert S, Rehling P, Meisinger C, Veenhuis M, Warscheid B, van der Klei IJ, Pfanner N, Chacinska A, van der Laan M.

Dev Cell. 2011 Oct 18;21(4):694-707. doi: 10.1016/j.devcel.2011.08.026. Epub 2011 Sep 22.

43.

The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins.

Becker T, Wenz LS, Krüger V, Lehmann W, Müller JM, Goroncy L, Zufall N, Lithgow T, Guiard B, Chacinska A, Wagner R, Meisinger C, Pfanner N.

J Cell Biol. 2011 Aug 8;194(3):387-95. doi: 10.1083/jcb.201102044.

44.

Native techniques for analysis of mitochondrial protein import.

Vögtle FN, Schmidt O, Chacinska A, Pfanner N, Meisinger C.

Methods Mol Biol. 2010;619:425-36. doi: 10.1007/978-1-60327-412-8_26.

PMID:
20419426
45.

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Chacinska A, van der Laan M, Mehnert CS, Guiard B, Mick DU, Hutu DP, Truscott KN, Wiedemann N, Meisinger C, Pfanner N, Rehling P.

Mol Cell Biol. 2010 Jan;30(1):307-18. doi: 10.1128/MCB.00749-09.

46.

Importing mitochondrial proteins: machineries and mechanisms.

Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N.

Cell. 2009 Aug 21;138(4):628-44. doi: 10.1016/j.cell.2009.08.005. Review.

47.

Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria.

Milenkovic D, Ramming T, Müller JM, Wenz LS, Gebert N, Schulze-Specking A, Stojanovski D, Rospert S, Chacinska A.

Mol Biol Cell. 2009 May;20(10):2530-9. doi: 10.1091/mbc.E08-11-1108. Epub 2009 Mar 18.

48.

Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import.

Baker MJ, Webb CT, Stroud DA, Palmer CS, Frazier AE, Guiard B, Chacinska A, Gulbis JM, Ryan MT.

Mol Biol Cell. 2009 Feb;20(3):769-79. doi: 10.1091/mbc.E08-09-0903. Epub 2008 Nov 26.

49.

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase.

Stojanovski D, Milenkovic D, Müller JM, Gabriel K, Schulze-Specking A, Baker MJ, Ryan MT, Guiard B, Pfanner N, Chacinska A.

J Cell Biol. 2008 Oct 20;183(2):195-202. doi: 10.1083/jcb.200804095. Epub 2008 Oct 13.

50.

Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

Chacinska A, Guiard B, Müller JM, Schulze-Specking A, Gabriel K, Kutik S, Pfanner N.

J Biol Chem. 2008 Oct 31;283(44):29723-9. doi: 10.1074/jbc.M805356200. Epub 2008 Sep 8.

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