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Items: 15


Computational modelling prediction and clinical validation of impact of benralizumab on airway smooth muscle mass in asthma.

Chachi L, Diver S, Kaul H, Rebelatto MC, Boutrin A, Nisa P, Newbold P, Brightling C.

Eur Respir J. 2019 Nov 14;54(5). pii: 1900930. doi: 10.1183/13993003.00930-2019. Print 2019 Nov. No abstract available.


Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab.

George L, Wright A, Mistry V, Sutcliffe A, Chachi L, Haldar K, Ramsheh MY, Richardson M, van der Merwe R, Martin U, Newbold P, Brightling CE.

Int J Chron Obstruct Pulmon Dis. 2019 Jun 5;14:1177-1185. doi: 10.2147/COPD.S198302. eCollection 2019.


DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaao6451. doi: 10.1126/scitranslmed.aao6451.


Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors.

Chachi L, Alzahrani A, Koziol-White C, Biddle M, Bagadood R, Panettieri RA Jr, Bradding P, Amrani Y.

Clin Exp Immunol. 2018 Nov;194(2):253-258. doi: 10.1111/cei.13191. Epub 2018 Sep 30.


Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

Russell RJ, Chachi L, FitzGerald JM, Backer V, Olivenstein R, Titlestad IL, Ulrik CS, Harrison T, Singh D, Chaudhuri R, Leaker B, McGarvey L, Siddiqui S, Wang M, Braddock M, Nordenmark LH, Cohen D, Parikh H, Colice G, Brightling CE; MESOS study investigators.

Lancet Respir Med. 2018 Jul;6(7):499-510. doi: 10.1016/S2213-2600(18)30201-7. Epub 2018 May 21.


In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE.

Eur Respir J. 2018 May 24;51(5). pii: 1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May.


HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.

Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi ME, Challiss RAJ, Brightling CE, Saunders RM.

J Allergy Clin Immunol. 2017 Aug;140(2):584-587.e8. doi: 10.1016/j.jaci.2016.11.049. Epub 2017 Mar 1. No abstract available.


Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

Chachi L, Abbasian M, Gavrila A, Alzahrani A, Tliba O, Bradding P, Wardlaw AJ, Brightling C, Amrani Y.

Allergy. 2017 Jan;72(1):126-136. doi: 10.1111/all.13003. Epub 2016 Sep 15.


NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma.

Wan WY, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling CE.

Chest. 2016 Jun;149(6):1445-59. doi: 10.1016/j.chest.2016.01.024. Epub 2016 Feb 2.


Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors.

Lewis RJ, Chachi L, Newby C, Amrani Y, Bradding P.

J Immunol. 2016 Jan 1;196(1):55-63. doi: 10.4049/jimmunol.1402232. Epub 2015 Nov 25.


Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma.

Chachi L, Gavrila A, Tliba O, Amrani Y.

Clin Exp Allergy. 2015 Nov;45(11):1637-46. doi: 10.1111/cea.12577. Review.


Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells.

Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):728-37. doi: 10.1165/rcmb.2014-0477OC.


Mechanisms of glucocorticoid action and insensitivity in airways disease.

Boardman C, Chachi L, Gavrila A, Keenan CR, Perry MM, Xia YC, Meurs H, Sharma P.

Pulm Pharmacol Ther. 2014 Dec;29(2):129-43. doi: 10.1016/j.pupt.2014.08.008. Epub 2014 Sep 9. Review.


Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells.

Chachi L, Shikotra A, Duffy SM, Tliba O, Brightling C, Bradding P, Amrani Y.

J Immunol. 2013 Sep 1;191(5):2624-2636. doi: 10.4049/jimmunol.1300104. Epub 2013 Jul 31.


Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor.

Cruse G, Yang W, Duffy SM, Chachi L, Leyland M, Amrani Y, Bradding P.

J Allergy Clin Immunol. 2010 Jan;125(1):257-63.e1-5. doi: 10.1016/j.jaci.2009.08.020. Epub 2009 Oct 27.


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