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Items: 26

1.

The genetics of a pharma merger.

Sanseau P, Chabot-Fletcher M, Browne MJ.

Drug Discov Today. 2009 Apr;14(7-8):334-6. doi: 10.1016/j.drudis.2008.12.001. Epub 2009 Jan 21.

PMID:
19121408
2.

Second IRA West Coast Symposium: gene regulation in inflammation and bone erosion.

Chabot-Fletcher M.

Inflamm Res. 2000 Sep;49(9):435-7. No abstract available.

PMID:
11071115
3.

Decreased nuclear factor-kappaB DNA binding activity following permanent focal cerebral ischaemia in the rat.

Irving EA, Hadingham SJ, Roberts J, Gibbons M, Chabot-Fletcher M, Roshak A, Parsons AA.

Neurosci Lett. 2000 Jul 7;288(1):45-8.

PMID:
10869812
4.

Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells.

Gardner RC, Assinder SJ, Christie G, Mason GG, Markwell R, Wadsworth H, McLaughlin M, King R, Chabot-Fletcher MC, Breton JJ, Allsop D, Rivett AJ.

Biochem J. 2000 Mar 1;346 Pt 2:447-54.

5.

In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity.

Sarau HM, Foley JJ, Schmidt DB, Martin LD, Webb EF, Tzimas MN, Breton JJ, Chabot-Fletcher M, Underwood DC, Hay DW, Kingsbury WD, Chambers PA, Pendrak I, Jakas DR, Sathe GM, Van Horn S, Daines RA, Griswold DE.

Prostaglandins Leukot Essent Fatty Acids. 1999 Jul;61(1):55-64.

PMID:
10477044
6.

cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy.

Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, McQueney MS, Underwood DC, Rouanet S, Chabot-Fletcher M.

J Mol Cell Cardiol. 1999 Apr;31(4):705-19.

PMID:
10329199
7.

Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth.

Harrop JA, McDonnell PC, Brigham-Burke M, Lyn SD, Minton J, Tan KB, Dede K, Spampanato J, Silverman C, Hensley P, DiPrinzio R, Emery JG, Deen K, Eichman C, Chabot-Fletcher M, Truneh A, Young PR.

J Biol Chem. 1998 Oct 16;273(42):27548-56.

8.

Effect of staurosporine on transcription factor NF-kappaB in human keratinocytes.

Chabot-Fletcher M, Breton JJ.

Biochem Pharmacol. 1998 Jul 1;56(1):71-8.

PMID:
9698090
9.

Evaluation of the cutaneous anti-inflammatory activity of azaspiranes.

Griswold DE, Martin LD, Badger AM, Breton J, Chabot-Fletcher M.

Inflamm Res. 1998 Feb;47(2):56-61.

PMID:
9535542
10.

Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.

Roshak A, Jackson JR, Chabot-Fletcher M, Marshall LA.

J Pharmacol Exp Ther. 1997 Nov;283(2):955-61.

PMID:
9353419
11.
12.

A role for transcription factor NF-kappa B in inflammation.

Chabot-Fletcher M.

Inflamm Res. 1997 Jan;46(1):1-2. No abstract available.

PMID:
9117512
13.

Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.

Adams JL, Garigipati RS, Sorenson M, Schmidt SJ, Brian WR, Newton JF, Tyrrell KA, Garver E, Yodis LA, Chabot-Fletcher M, Tzimas M, Webb EF, Breton JJ, Griswold DE.

J Med Chem. 1996 Dec 20;39(26):5035-46.

PMID:
8978834
14.

Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation.

Roshak AK, Jackson JR, McGough K, Chabot-Fletcher M, Mochan E, Marshall LA.

J Biol Chem. 1996 Dec 6;271(49):31496-501.

15.

Production of biologically active human RelA (p65) in baculovirus-infected insect cells.

Chabot-Fletcher M, Ho ML, Breton JJ, Hanning CR, Amegadzie BY.

Cell Biol Int. 1996 Nov;20(11):777-9.

PMID:
8979371
16.

Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells.

Winkler JD, Eris T, Sung CM, Chabot-Fletcher M, Mayer RJ, Surette ME, Chilton FH.

J Pharmacol Exp Ther. 1996 Nov;279(2):956-66.

PMID:
8930205
17.

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL.

J Med Chem. 1996 Sep 27;39(20):3929-37.

PMID:
8831759
18.

Human keratinocytes lack the components to produce leukotriene B4.

Breton J, Woolf D, Young P, Chabot-Fletcher M.

J Invest Dermatol. 1996 Jan;106(1):162-7.

19.

Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.

Winkler JD, Fonteh AN, Sung CM, Heravi JD, Nixon AB, Chabot-Fletcher M, Griswold D, Marshall LA, Chilton FH.

J Pharmacol Exp Ther. 1995 Sep;274(3):1338-47.

PMID:
7562506
20.

SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock.

Marshall LA, Hall RH, Winkler JD, Badger A, Bolognese B, Roshak A, Flamberg PL, Sung CM, Chabot-Fletcher M, Adams JL, et al.

J Pharmacol Exp Ther. 1995 Sep;274(3):1254-62.

PMID:
7562496
21.

Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma.

Chabot-Fletcher MC, Underwood DC, Breton JJ, Adams JL, Kagey-Sobotka A, Griswold DE, Marshall LA, Sarau HM, Winkler JD, Hay DW.

J Pharmacol Exp Ther. 1995 Jun;273(3):1147-55.

PMID:
7791085
22.

Inhibition of CoA-independent transacylase reduces inflammatory lipid mediators.

Winkler JD, Fonteh AN, Sung CM, Huang L, Chabot-Fletcher M, Marshall LA, Chilton FH.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:89-91. Review. No abstract available.

PMID:
7732911
23.

Interleukin-8 production is regulated by protein kinase C in human keratinocytes.

Chabot-Fletcher M, Breton J, Lee J, Young P, Griswold DE.

J Invest Dermatol. 1994 Oct;103(4):509-15.

24.

Human keratinocytes possess an sn-2 acylhydrolase that is biochemically similar to the U937-derived 85-kDa phospholipase A2.

McCord M, Chabot-Fletcher M, Breton J, Marshall LA.

J Invest Dermatol. 1994 Jun;102(6):980-6.

25.

Use of a continuous assay of oxygen consumption to evaluate the pharmacology of 5-lipoxygenase inhibitors.

Breton J, Keller P, Chabot-Fletcher M, Hillegass L, DeWolf W Jr, Griswold D.

Prostaglandins Leukot Essent Fatty Acids. 1993 Dec;49(6):929-37.

PMID:
8140120
26.

Association between leukotriene B4-induced phospholipase D activation and degranulation of human neutrophils.

Zhou HL, Chabot-Fletcher M, Foley JJ, Sarau HM, Tzimas MN, Winkler JD, Torphy TJ.

Biochem Pharmacol. 1993 Jul 6;46(1):139-48.

PMID:
8394074

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