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Items: 24

1.

An essential role for the Zn2+ transporter ZIP7 in B cell development.

Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S.

Nat Immunol. 2019 Mar;20(3):350-361. doi: 10.1038/s41590-018-0295-8. Epub 2019 Feb 4.

PMID:
30718914
2.

The α-cell in diabetes mellitus.

Gromada J, Chabosseau P, Rutter GA.

Nat Rev Endocrinol. 2018 Dec;14(12):694-704. doi: 10.1038/s41574-018-0097-y. Review.

PMID:
30310153
3.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23.

4.

Neuronatin regulates pancreatic β cell insulin content and secretion.

Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ.

J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9.

5.

Targeting GLP-1 receptor trafficking to improve agonist efficacy.

Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR.

Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2.

6.

Sensors for measuring subcellular zinc pools.

Chabosseau P, Woodier J, Cheung R, Rutter GA.

Metallomics. 2018 Feb 21;10(2):229-239. doi: 10.1039/c7mt00336f. Review.

PMID:
29431830
7.

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A.

Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28.

8.

Local and regional control of calcium dynamics in the pancreatic islet.

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Review.

9.

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice.

Mitchell RK, Nguyen-Tu MS, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GA.

J Biol Chem. 2017 May 26;292(21):8892-8906. doi: 10.1074/jbc.M117.784629. Epub 2017 Apr 4.

10.

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.

Perez Y, Shorer Z, Liani-Leibson K, Chabosseau P, Kadir R, Volodarsky M, Halperin D, Barber-Zucker S, Shalev H, Schreiber R, Gradstein L, Gurevich E, Zarivach R, Rutter GA, Landau D, Birk OS.

Brain. 2017 Apr 1;140(4):928-939. doi: 10.1093/brain/awx013.

11.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA.

Am J Hum Genet. 2017 Feb 2;100(2):238-256. doi: 10.1016/j.ajhg.2017.01.011. Epub 2017 Jan 26.

12.

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.

Solomou A, Philippe E, Chabosseau P, Migrenne-Li S, Gaitan J, Lang J, Magnan C, Rutter GA.

Nutr Metab (Lond). 2016 Jul 7;13:46. doi: 10.1186/s12986-016-0104-z. eCollection 2016.

13.

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

Mehta ZB, Fine N, Pullen TJ, Cane MC, Hu M, Chabosseau P, Meur G, Velayos-Baeza A, Monaco AP, Marselli L, Marchetti P, Rutter GA.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E488-507. doi: 10.1152/ajpendo.00074.2016. Epub 2016 Jun 21.

14.

Zinc and diabetes.

Chabosseau P, Rutter GA.

Arch Biochem Biophys. 2016 Dec 1;611:79-85. doi: 10.1016/j.abb.2016.05.022. Epub 2016 Jun 1. Review.

15.

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Martinez-Sanchez A, Pullen TJ, Chabosseau P, Zhang Q, Haythorne E, Cane MC, Nguyen-Tu MS, Sayers SR, Rutter GA.

Diabetes. 2016 May;65(5):1268-82. doi: 10.2337/db15-1240. Epub 2016 Feb 9.

16.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, Bellomo EA, Carzaniga R, Collinson LM, Li WH, Hodson DJ, Rutter GA.

Mol Endocrinol. 2016 Jan;30(1):77-91. doi: 10.1210/me.2015-1227. Epub 2015 Nov 19.

17.

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Rutter GA, Chabosseau P, Bellomo EA, Maret W, Mitchell RK, Hodson DJ, Solomou A, Hu M.

Proc Nutr Soc. 2016 Feb;75(1):61-72. Epub 2015 Sep 14.

PMID:
26365743
18.

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.

Zhao L, Oliver E, Maratou K, Atanur SS, Dubois OD, Cotroneo E, Chen CN, Wang L, Arce C, Chabosseau PL, Ponsa-Cobas J, Frid MG, Moyon B, Webster Z, Aldashev A, Ferrer J, Rutter GA, Stenmark KR, Aitman TJ, Wilkins MR.

Nature. 2015 Aug 20;524(7565):356-60. doi: 10.1038/nature14620. Epub 2015 Aug 10.

19.

eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging.

Hessels AM, Chabosseau P, Bakker MH, Engelen W, Rutter GA, Taylor KM, Merkx M.

ACS Chem Biol. 2015 Sep 18;10(9):2126-34. doi: 10.1021/acschembio.5b00211. Epub 2015 Jul 20.

20.

Divergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemia.

Mondragon A, Davidsson D, Kyriakoudi S, Bertling A, Gomes-Faria R, Cohen P, Rothery S, Chabosseau P, Rutter GA, da Silva Xavier G.

PLoS One. 2014 Aug 13;9(8):e104873. doi: 10.1371/journal.pone.0104873. eCollection 2014.

21.

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

Chabosseau P, Tuncay E, Meur G, Bellomo EA, Hessels A, Hughes S, Johnson PR, Bugliani M, Marchetti P, Turan B, Lyon AR, Merkx M, Rutter GA.

ACS Chem Biol. 2014 Sep 19;9(9):2111-20. doi: 10.1021/cb5004064. Epub 2014 Jul 17.

22.

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.

Chabosseau P, Buhagiar-Labarchède G, Onclercq-Delic R, Lambert S, Debatisse M, Brison O, Amor-Guéret M.

Nat Commun. 2011 Jun 28;2:368. doi: 10.1038/ncomms1363.

PMID:
21712816
23.

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.

Bellemer C, Chabosseau P, Gallardo F, Gleizes PE, Stahl G.

PLoS One. 2010 May 3;5(5):e10472. doi: 10.1371/journal.pone.0010472.

24.

The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.

Lahkim Bennani-Belhaj K, Rouzeau S, Buhagiar-Labarchède G, Chabosseau P, Onclercq-Delic R, Bayart E, Cordelières F, Couturier J, Amor-Guéret M.

Mol Cancer Res. 2010 Mar;8(3):385-94. doi: 10.1158/1541-7786.MCR-09-0534. Epub 2010 Mar 9.

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