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Items: 1 to 50 of 76

1.

De novo dNTP production is essential for normal postnatal murine heart development.

Tran P, Wanrooij PH, Lorenzon P, Sharma S, Thelander L, Nilsson AK, Olofsson AK, Medini P, von Hofsten J, Stål P, Chabes A.

J Biol Chem. 2019 Jul 12. pii: jbc.RA119.009492. doi: 10.1074/jbc.RA119.009492. [Epub ahead of print]

2.

Ribonucleotides in mitochondrial DNA.

Wanrooij PH, Chabes A.

FEBS Lett. 2019 Jul;593(13):1554-1565. doi: 10.1002/1873-3468.13440. Epub 2019 May 24. Review.

PMID:
31093968
3.

A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis.

Rentoft M, Svensson D, Sjödin A, Olason PI, Sjöström O, Nylander C, Osterman P, Sjögren R, Netotea S, Wibom C, Cederquist K, Chabes A, Trygg J, Melin BS, Johansson E.

PLoS One. 2019 Mar 27;14(3):e0213350. doi: 10.1371/journal.pone.0213350. eCollection 2019.

4.

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

Garbacz MA, Cox PB, Sharma S, Lujan SA, Chabes A, Kunkel TA.

Nucleic Acids Res. 2019 May 7;47(8):3986-3995. doi: 10.1093/nar/gkz048.

5.

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.

Xing X, Kane DP, Bulock CR, Moore EA, Sharma S, Chabes A, Shcherbakova PV.

Nat Commun. 2019 Jan 22;10(1):374. doi: 10.1038/s41467-018-08145-2.

6.

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance.

Schmidt TT, Sharma S, Reyes GX, Gries K, Gross M, Zhao B, Yuan JH, Wade R, Chabes A, Hombauer H.

Nucleic Acids Res. 2019 Jan 10;47(1):237-252. doi: 10.1093/nar/gky1154.

7.

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage.

Bacal J, Moriel-Carretero M, Pardo B, Barthe A, Sharma S, Chabes A, Lengronne A, Pasero P.

EMBO J. 2018 Nov 2;37(21). pii: e99319. doi: 10.15252/embj.201899319. Epub 2018 Aug 29.

PMID:
30158111
8.

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.

Yu C, Gan H, Serra-Cardona A, Zhang L, Gan S, Sharma S, Johansson E, Chabes A, Xu RM, Zhang Z.

Science. 2018 Sep 28;361(6409):1386-1389. doi: 10.1126/science.aat8849. Epub 2018 Aug 16.

9.

Rtt105 functions as a chaperone for replication protein A to preserve genome stability.

Li S, Xu Z, Xu J, Zuo L, Yu C, Zheng P, Gan H, Wang X, Li L, Sharma S, Chabes A, Li D, Wang S, Zheng S, Li J, Chen X, Sun Y, Xu D, Han J, Chan K, Qi Z, Feng J, Li Q.

EMBO J. 2018 Sep 3;37(17). pii: e99154. doi: 10.15252/embj.201899154. Epub 2018 Jul 31.

10.

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.

Lanz MC, Oberly S, Sanford EJ, Sharma S, Chabes A, Smolka MB.

Genes Dev. 2018 Jun 1;32(11-12):822-835. doi: 10.1101/gad.308148.117. Epub 2018 Jun 13.

11.

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae.

van Mourik PM, de Jong J, Sharma S, Kavšek A, Chabes A, Chang M.

G3 (Bethesda). 2018 Jul 31;8(8):2551-2558. doi: 10.1534/g3.118.200280.

12.

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P.

Nature. 2018 May;557(7703):57-61. doi: 10.1038/s41586-018-0050-1. Epub 2018 Apr 18.

PMID:
29670289
13.

Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.

Kong Z, Jia S, Chabes AL, Appelblad P, Lundmark R, Moritz T, Chabes A.

Nucleic Acids Res. 2018 Jun 20;46(11):e66. doi: 10.1093/nar/gky203.

14.

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.

Peng XP, Lim S, Li S, Marjavaara L, Chabes A, Zhao X.

PLoS Genet. 2018 Jan 23;14(1):e1007129. doi: 10.1371/journal.pgen.1007129. eCollection 2018 Jan.

15.

Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired.

Wanrooij PH, Engqvist MKM, Forslund JME, Navarrete C, Nilsson AK, Sedman J, Wanrooij S, Clausen AR, Chabes A.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12466-12471. doi: 10.1073/pnas.1713085114. Epub 2017 Nov 6.

16.

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.

Maicher A, Gazy I, Sharma S, Marjavaara L, Grinberg G, Shemesh K, Chabes A, Kupiec M.

PLoS Genet. 2017 Oct 25;13(10):e1007082. doi: 10.1371/journal.pgen.1007082. eCollection 2017 Oct.

17.

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.

Gan H, Yu C, Devbhandari S, Sharma S, Han J, Chabes A, Remus D, Zhang Z.

Mol Cell. 2017 Oct 19;68(2):446-455.e3. doi: 10.1016/j.molcel.2017.09.018. Epub 2017 Oct 12.

18.

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.

Garzón J, Rodríguez R, Kong Z, Chabes A, Rodríguez-Acebes S, Méndez J, Moreno S, García-Higuera I.

Oncogene. 2017 Oct 19;36(42):5808-5818. doi: 10.1038/onc.2017.186. Epub 2017 Jun 12.

PMID:
28604743
19.

Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.

Schmidt TT, Reyes G, Gries K, Ceylan CÜ, Sharma S, Meurer M, Knop M, Chabes A, Hombauer H.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4442-E4451. doi: 10.1073/pnas.1618714114. Epub 2017 Apr 17.

20.
21.

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

Kochenova OV, Bezalel-Buch R, Tran P, Makarova AV, Chabes A, Burgers PM, Shcherbakova PV.

Nucleic Acids Res. 2017 Feb 17;45(3):1200-1218. doi: 10.1093/nar/gkw1149.

22.

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase.

Liew LP, Lim ZY, Cohen M, Kong Z, Marjavaara L, Chabes A, Bell SD.

Cell Rep. 2016 Nov 1;17(6):1657-1670. doi: 10.1016/j.celrep.2016.10.024.

23.

The mutation spectrum in genomic late replication domains shapes mammalian GC content.

Kenigsberg E, Yehuda Y, Marjavaara L, Keszthelyi A, Chabes A, Tanay A, Simon I.

Nucleic Acids Res. 2016 May 19;44(9):4222-32. doi: 10.1093/nar/gkw268. Epub 2016 Apr 16.

24.

Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.

Rentoft M, Lindell K, Tran P, Chabes AL, Buckland RJ, Watt DL, Marjavaara L, Nilsson AK, Melin B, Trygg J, Johansson E, Chabes A.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4723-8. doi: 10.1073/pnas.1519128113. Epub 2016 Apr 11. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 25;:.

25.

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.

Watt DL, Buckland RJ, Lujan SA, Kunkel TA, Chabes A.

Nucleic Acids Res. 2016 Feb 29;44(4):1669-80. doi: 10.1093/nar/gkv1298. Epub 2015 Nov 24.

26.

S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.

Earp C, Rowbotham S, Merényi G, Chabes A, Cha RS.

Biol Open. 2015 Nov 24;4(12):1739-43. doi: 10.1242/bio.015347.

27.

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.

Jia S, Marjavaara L, Buckland R, Sharma S, Chabes A.

Methods Mol Biol. 2015;1300:113-21. doi: 10.1007/978-1-4939-2596-4_8.

PMID:
25916709
28.

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.

Barfeld SJ, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi KM, Rennie PS, Ceder Y, Chabes A, Visakorpi T, Mills IG.

Oncotarget. 2015 May 20;6(14):12587-602.

29.

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.

Mertz TM, Sharma S, Chabes A, Shcherbakova PV.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2467-76. doi: 10.1073/pnas.1422934112. Epub 2015 Mar 31.

30.

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.

Williams LN, Marjavaara L, Knowels GM, Schultz EM, Fox EJ, Chabes A, Herr AJ.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2457-66. doi: 10.1073/pnas.1422948112. Epub 2015 Mar 31.

31.

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Williams JS, Clausen AR, Lujan SA, Marjavaara L, Clark AB, Burgers PM, Chabes A, Kunkel TA.

Nat Struct Mol Biol. 2015 Apr;22(4):291-7. doi: 10.1038/nsmb.2989. Epub 2015 Mar 9.

32.

Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity.

Buckland RJ, Watt DL, Chittoor B, Nilsson AK, Kunkel TA, Chabes A.

PLoS Genet. 2014 Dec 4;10(12):e1004846. doi: 10.1371/journal.pgen.1004846. eCollection 2014 Dec.

33.

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

Yu C, Gan H, Han J, Zhou ZX, Jia S, Chabes A, Farrugia G, Ordog T, Zhang Z.

Mol Cell. 2014 Nov 20;56(4):551-63. doi: 10.1016/j.molcel.2014.09.017. Epub 2014 Oct 23. Erratum in: Mol Cell. 2014 Nov 20;56(4):609.

34.

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.

Lin CY, Wu MY, Gay S, Marjavaara L, Lai MS, Hsiao WC, Hung SH, Tseng HY, Wright DE, Wang CY, Hsu GS, Devys D, Chabes A, Kao CF.

PLoS Genet. 2014 Oct 2;10(10):e1004667. doi: 10.1371/journal.pgen.1004667. eCollection 2014 Oct.

36.

The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.

Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P.

Mol Cell. 2014 May 22;54(4):691-7. doi: 10.1016/j.molcel.2014.04.032.

37.

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups.

Rubinstein L, Ungar L, Harari Y, Babin V, Ben-Aroya S, Merenyi G, Marjavaara L, Chabes A, Kupiec M.

Nucleic Acids Res. 2014 Jun;42(10):6314-25. doi: 10.1093/nar/gku267. Epub 2014 Apr 11.

38.

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance.

Tsaponina O, Chabes A.

Nucleic Acids Res. 2013 Dec;41(22):10371-8. doi: 10.1093/nar/gkt820. Epub 2013 Sep 17.

39.

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Hoch NC, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD, Heierhorst J.

Mol Cell Biol. 2013 Aug;33(16):3202-13. doi: 10.1128/MCB.00474-13. Epub 2013 Jun 10.

40.

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.

Williams JS, Smith DJ, Marjavaara L, Lujan SA, Chabes A, Kunkel TA.

Mol Cell. 2013 Mar 7;49(5):1010-5. doi: 10.1016/j.molcel.2012.12.021. Epub 2013 Jan 31.

41.

Telomere length homeostasis responds to changes in intracellular dNTP pools.

Gupta A, Sharma S, Reichenbach P, Marjavaara L, Nilsson AK, Lingner J, Chabes A, Rothstein R, Chang M.

Genetics. 2013 Apr;193(4):1095-105. doi: 10.1534/genetics.112.149120. Epub 2013 Jan 18.

42.

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Sánchez A, Sharma S, Rozenzhak S, Roguev A, Krogan NJ, Chabes A, Russell P.

Mol Cell Biol. 2012 Nov;32(21):4445-54. doi: 10.1128/MCB.01062-12. Epub 2012 Aug 27.

43.

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.

Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou J, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K, Brown GW.

EMBO J. 2012 Feb 15;31(4):895-907. doi: 10.1038/emboj.2011.485. Epub 2012 Jan 10.

44.

dNTP pools determine fork progression and origin usage under replication stress.

Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P.

EMBO J. 2012 Feb 15;31(4):883-94. doi: 10.1038/emboj.2011.470. Epub 2012 Jan 10.

45.

Lesion bypass by S. cerevisiae Pol ζ alone.

Stone JE, Kumar D, Binz SK, Inase A, Iwai S, Chabes A, Burgers PM, Kunkel TA.

DNA Repair (Amst). 2011 Aug 15;10(8):826-34. doi: 10.1016/j.dnarep.2011.04.032. Epub 2011 May 31.

46.

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.

Tsaponina O, Barsoum E, Aström SU, Chabes A.

PLoS Genet. 2011 May;7(5):e1002061. doi: 10.1371/journal.pgen.1002061. Epub 2011 May 5.

47.

A top-down view on DNA replication and recombination from 9,000 feet above sea level.

Johansson E, Speck C, Chabes A.

Genome Biol. 2011;12(4):304. doi: 10.1186/gb-2011-12-4-304. Epub 2011 Apr 27.

48.

A common telomeric gene silencing assay is affected by nucleotide metabolism.

Rossmann MP, Luo W, Tsaponina O, Chabes A, Stillman B.

Mol Cell. 2011 Apr 8;42(1):127-36. doi: 10.1016/j.molcel.2011.03.007.

49.

Break-induced replication is highly inaccurate.

Deem A, Keszthelyi A, Blackgrove T, Vayl A, Coffey B, Mathur R, Chabes A, Malkova A.

PLoS Biol. 2011 Feb 15;9(2):e1000594. doi: 10.1371/journal.pbio.1000594.

50.

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Kumar D, Abdulovic AL, Viberg J, Nilsson AK, Kunkel TA, Chabes A.

Nucleic Acids Res. 2011 Mar;39(4):1360-71. doi: 10.1093/nar/gkq829. Epub 2010 Oct 20.

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