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Quinazoline-based anti-virulence compounds selectively target Salmonella PhoP/PhoQ signal transduction system.

Carabajal MA, Asquith CRM, Laitinen T, Tizzard GJ, Yim L, Rial A, Chabalgoity JA, Zuercher WJ, García Véscovi E.

Antimicrob Agents Chemother. 2019 Oct 14. pii: AAC.01744-19. doi: 10.1128/AAC.01744-19. [Epub ahead of print]


Genome analysis of Salmonella enterica subsp. diarizonae isolates from invasive human infections reveals enrichment of virulence-related functions in lineage ST1256.

Giner-Lamia J, Vinuesa P, Betancor L, Silva C, Bisio J, Soleto L, Chabalgoity JA, Puente JL; Salmonella CYTED Network, García-Del Portillo F.

BMC Genomics. 2019 Jan 31;20(1):99. doi: 10.1186/s12864-018-5352-z.


Draft Genome Sequences of Two Multidrug-Resistant Salmonella enterica Serovar Typhimurium Clinical Isolates from Uruguay.

Cordeiro NF, D'Alessandro B, Iriarte A, Pickard D, Yim L, Chabalgoity JA, Betancor L, Vignoli R.

Microbiol Resour Announc. 2018 Aug 2;7(4). pii: e00917-18. doi: 10.1128/MRA.00917-18. eCollection 2018 Aug.


Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses.

Cibulski SP, Rivera-Patron M, Mourglia-Ettlin G, Casaravilla C, Yendo ACA, Fett-Neto AG, Chabalgoity JA, Moreno M, Roehe PM, Silveira F.

Sci Rep. 2018 Sep 11;8(1):13582. doi: 10.1038/s41598-018-31995-1.


Temporal evolution of anti-Clostridium antibody responses in sheep after vaccination with polyvalent clostridial vaccines.

Rossi A, Mónaco A, Guarnaschelli J, Silveira F, Iriarte A, Benecke AG, Chabalgoity JA.

Vet Immunol Immunopathol. 2018 Aug;202:46-51. doi: 10.1016/j.vetimm.2018.06.010. Epub 2018 Jun 18.


TLR7 agonist in combination with Salmonella as an effective antimelanoma immunotherapy.

Vola M, Mónaco A, Bascuas T, Rimsky G, Agorio CI, Chabalgoity JA, Moreno M.

Immunotherapy. 2018 Jun;10(8):665-679. doi: 10.2217/imt-2017-0188. Epub 2018 Mar 22.


A novel prophage identified in strains from Salmonella enterica serovar Enteritidis is a phylogenetic signature of the lineage ST-1974.

D'Alessandro B, Pérez Escanda V, Balestrazzi L, Iriarte A, Pickard D, Yim L, Chabalgoity JA, Betancor L.

Microb Genom. 2018 Mar;4(3). doi: 10.1099/mgen.0.000161. Epub 2018 Mar 6.


Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice.

Bascuas T, Moreno M, Grille S, Chabalgoity JA.

Front Immunol. 2018 Jan 23;9:7. doi: 10.3389/fimmu.2018.00007. eCollection 2018.


Characterization of Salmonella enterica isolates causing bacteremia in Lima, Peru, using multiple typing methods.

Silva C, Betancor L, García C, Astocondor L, Hinostroza N, Bisio J, Rivera J, Perezgasga L, Pérez Escanda V, Yim L, Jacobs J, García-Del Portillo F; SalmoIber CYTED Network, Chabalgoity JA, Puente JL.

PLoS One. 2017 Dec 21;12(12):e0189946. doi: 10.1371/journal.pone.0189946. eCollection 2017.


A Naturally Occurring Deletion in FliE from Salmonella enterica Serovar Dublin Results in an Aflagellate Phenotype and Defective Proinflammatory Properties.

Sasías S, Martínez-Sanguiné A, Betancor L, Martínez A, D'Alessandro B, Iriarte A, Chabalgoity JA, Yim L.

Infect Immun. 2017 Dec 19;86(1). pii: e00517-17. doi: 10.1128/IAI.00517-17. Print 2018 Jan.


Draft Genome Sequence of Salmonella enterica subsp. enterica Serovar Infantis Strain SPE101, Isolated from a Chronic Human Infection.

Iriarte A, Giner-Lamia J, Silva C, Betancor L, Astocondor L, Cestero JJ, Ochoa T, García C, Puente JL, Chabalgoity JA; SalmoIber CYTED Network, García-Del Portillo F.

Genome Announc. 2017 Jul 20;5(29). pii: e00679-17. doi: 10.1128/genomeA.00679-17.


Erratum: Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, Wigley P, Barquist L, Langridge GC, Feltwell T, Harris SR, Mather AE, Fookes M, Aslett M, Msefula C, Kariuki S, Maclennan CA, Onsare RS, Weill FX, Le Hello S, Smith AM, McClelland M, Desai P, Parry CM, Cheesbrough J, French N, Campos J, Chabalgoity JA, Betancor L, Hopkins KL, Nair S, Humphrey TJ, Lunguya O, Cogan TA, Tapia MD, Sow SO, Tennant SM, Bornstein K, Levine MM, Lacharme-Lora L, Everett DB, Kingsley RA, Parkhill J, Heyderman RS, Dougan G, Gordon MA, Thomson NR.

Nat Genet. 2017 Mar 30;49(4):651. doi: 10.1038/ng0417-651c. No abstract available.


A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario.

Bascuas T, Moreno M, Mónaco A, Reyes L, Paolino A, Oliver P, Kramer MG, Engler H, Pacheco JP, Grille S, Chabalgoity JA.

J Transl Med. 2016 Nov 22;14(1):323.


Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C.

Infect Immun. 2017 Jan 26;85(2). pii: e00806-16. doi: 10.1128/IAI.00806-16. Print 2017 Feb.


Intranasal administration of a polyvalent bacterial lysate induces self-restricted inflammation in the lungs and a Th1/Th17 memory signature.

Rial A, Ferrara F, Suárez N, Scavone P, Marqués JM, Chabalgoity JA.

Microbes Infect. 2016 Dec;18(12):747-757. doi: 10.1016/j.micinf.2016.10.006. Epub 2016 Oct 20.


Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, Wigley P, Barquist L, Langridge GC, Feltwell T, Harris SR, Mather AE, Fookes M, Aslett M, Msefula C, Kariuki S, Maclennan CA, Onsare RS, Weill FX, Le Hello S, Smith AM, McClelland M, Desai P, Parry CM, Cheesbrough J, French N, Campos J, Chabalgoity JA, Betancor L, Hopkins KL, Nair S, Humphrey TJ, Lunguya O, Cogan TA, Tapia MD, Sow SO, Tennant SM, Bornstein K, Levine MM, Lacharme-Lora L, Everett DB, Kingsley RA, Parkhill J, Heyderman RS, Dougan G, Gordon MA, Thomson NR.

Nat Genet. 2016 Oct;48(10):1211-1217. doi: 10.1038/ng.3644. Epub 2016 Aug 22. Erratum in: Nat Genet. 2017 Mar 30;49(4):651.


Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.

Muñoz-Wolf N, Rial A, Fougeron D, Tabareau J, Sirard JC, Chabalgoity JA.

Future Microbiol. 2016 Sep;11:1167-77. doi: 10.2217/fmb-2016-0045. Epub 2016 Aug 22.


A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections.

Porte R, Fougeron D, Muñoz-Wolf N, Tabareau J, Georgel AF, Wallet F, Paget C, Trottein F, Chabalgoity JA, Carnoy C, Sirard JC.

Antimicrob Agents Chemother. 2015 Oct;59(10):6064-72. doi: 10.1128/AAC.01210-15. Epub 2015 Jul 20.


Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain.

Rossotti MA, González-Techera A, Guarnaschelli J, Yim L, Camacho X, Fernández M, Cabral P, Leizagoyen C, Chabalgoity JA, González-Sapienza G.

MAbs. 2015;7(5):820-8. doi: 10.1080/19420862.2015.1068491.


Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.

Wong VK, Baker S, Pickard DJ, Parkhill J, Page AJ, Feasey NA, Kingsley RA, Thomson NR, Keane JA, Weill FX, Edwards DJ, Hawkey J, Harris SR, Mather AE, Cain AK, Hadfield J, Hart PJ, Thieu NT, Klemm EJ, Glinos DA, Breiman RF, Watson CH, Kariuki S, Gordon MA, Heyderman RS, Okoro C, Jacobs J, Lunguya O, Edmunds WJ, Msefula C, Chabalgoity JA, Kama M, Jenkins K, Dutta S, Marks F, Campos J, Thompson C, Obaro S, MacLennan CA, Dolecek C, Keddy KH, Smith AM, Parry CM, Karkey A, Mulholland EK, Campbell JI, Dongol S, Basnyat B, Dufour M, Bandaranayake D, Naseri TT, Singh SP, Hatta M, Newton P, Onsare RS, Isaia L, Dance D, Davong V, Thwaites G, Wijedoru L, Crump JA, De Pinna E, Nair S, Nilles EJ, Thanh DP, Turner P, Soeng S, Valcanis M, Powling J, Dimovski K, Hogg G, Farrar J, Holt KE, Dougan G.

Nat Genet. 2015 Jun;47(6):632-9. doi: 10.1038/ng.3281. Epub 2015 May 11.


Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.

Goñi F, Mathiason CK, Yim L, Wong K, Hayes-Klug J, Nalls A, Peyser D, Estevez V, Denkers N, Xu J, Osborn DA, Miller KV, Warren RJ, Brown DR, Chabalgoity JA, Hoover EA, Wisniewski T.

Vaccine. 2015 Jan 29;33(5):726-33. doi: 10.1016/j.vaccine.2014.11.035. Epub 2014 Dec 21.


Patterns of genome evolution that have accompanied host adaptation in Salmonella.

Langridge GC, Fookes M, Connor TR, Feltwell T, Feasey N, Parsons BN, Seth-Smith HM, Barquist L, Stedman A, Humphrey T, Wigley P, Peters SE, Maskell DJ, Corander J, Chabalgoity JA, Barrow P, Parkhill J, Dougan G, Thomson NR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):863-8. doi: 10.1073/pnas.1416707112. Epub 2014 Dec 22.


Sublingual immunotherapy as an alternative to induce protection against acute respiratory infections.

Muñoz-Wolf N, Rial A, Saavedra JM, Chabalgoity JA.

J Vis Exp. 2014 Aug 30;(90). doi: 10.3791/52036.


Synthesis of metallo-β-lactamase VIM-2 is associated with a fitness reduction in Salmonella enterica Serovar Typhimurium.

Cordeiro NF, Chabalgoity JA, Yim L, Vignoli R.

Antimicrob Agents Chemother. 2014 Nov;58(11):6528-35. doi: 10.1128/AAC.02847-14. Epub 2014 Aug 18.


Salmonella enterica serovar Typhimurium immunotherapy for B-cell lymphoma induces broad anti-tumour immunity with therapeutic effect.

Grille S, Moreno M, Bascuas T, Marqués JM, Muñoz N, Lens D, Chabalgoity JA.

Immunology. 2014 Nov;143(3):428-37. doi: 10.1111/imm.12320.


Native flagellin does not protect mice against an experimental Proteus mirabilis ascending urinary tract infection and neutralizes the protective effect of MrpA fimbrial protein.

Scavone P, Umpiérrez A, Rial A, Chabalgoity JA, Zunino P.

Antonie Van Leeuwenhoek. 2014 Jun;105(6):1139-48. doi: 10.1007/s10482-014-0175-7. Epub 2014 Apr 27.


Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection.

Van Maele L, Carnoy C, Cayet D, Ivanov S, Porte R, Deruy E, Chabalgoity JA, Renauld JC, Eberl G, Benecke AG, Trottein F, Faveeuw C, Sirard JC.

J Infect Dis. 2014 Aug 1;210(3):493-503. doi: 10.1093/infdis/jiu106. Epub 2014 Feb 26.


Repression of flagella is a common trait in field isolates of Salmonella enterica serovar Dublin and is associated with invasive human infections.

Yim L, Sasías S, Martínez A, Betancor L, Estevez V, Scavone P, Bielli A, Sirok A, Chabalgoity JA.

Infect Immun. 2014 Apr;82(4):1465-76. doi: 10.1128/IAI.01336-13. Epub 2014 Jan 13.


Generation and selection of anti-flagellin monoclonal antibodies useful for serotyping Salmonella enterica.

Hiriart Y, Serradell M, Martínez A, Sampaolesi S, Maciel DG, Chabalgoity JA, Yim L, Algorta G, Rumbo M.

Springerplus. 2013 Nov 28;2:640. doi: 10.1186/2193-1801-2-640. eCollection 2013.


Identification of the first blaCMY-2 gene in Salmonella enterica serovar Typhimurium isolates obtained from cases of paediatric diarrhoea illness detected in South America.

Cordeiro NF, Yim L, Betancor L, Cejas D, García-Fulgueiras V, Mota MI, Varela G, Anzalone L, Algorta G, Gutkind G, Ayala JA, Chabalgoity JA, Vignoli R.

J Glob Antimicrob Resist. 2013 Sep;1(3):143-148. doi: 10.1016/j.jgar.2013.04.003. Epub 2013 Jun 1.


Innate immune responses to Proteus mirabilis flagellin in the urinary tract.

Umpiérrez A, Scavone P, Romanin D, Marqués JM, Chabalgoity JA, Rumbo M, Zunino P.

Microbes Infect. 2013 Sep-Oct;15(10-11):688-96. doi: 10.1016/j.micinf.2013.06.007. Epub 2013 Jun 28.


[(99m)Tc(CO)(3)]-radiolabeled bevacizumab: in vitro and in vivo evaluation in a melanoma model.

Camacho X, García MF, Calzada V, Fernández M, Chabalgoity JA, Moreno M, Barbosa de Aguiar R, Alonso O, Gambini JP, Chammas R, Cabral P.

Oncology. 2013;84(4):200-9. doi: 10.1159/000338961. Epub 2013 Jan 15.


A therapeutic vaccine using Salmonella-modified tumor cells combined with interleukin-2 induces enhanced antitumor immunity in B-cell lymphoma.

Grille S, Moreno M, Brugnini A, Lens D, Chabalgoity JA.

Leuk Res. 2013 Mar;37(3):341-8. doi: 10.1016/j.leukres.2012.10.003. Epub 2012 Oct 26.


Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.

Ivanov S, Fontaine J, Paget C, Macho Fernandez E, Van Maele L, Renneson J, Maillet I, Wolf NM, Rial A, Léger H, Ryffel B, Frisch B, Chabalgoity JA, Sirard JC, Benecke A, Faveeuw C, Trottein F.

J Infect Dis. 2012 Sep 1;206(5):723-34. doi: 10.1093/infdis/jis413. Epub 2012 Jun 21.


Genomic Comparison of the Closely Related Salmonella enterica Serovars Enteritidis and Dublin.

Betancor L, Yim L, Martínez A, Fookes M, Sasias S, Schelotto F, Thomson N, Maskell D, Chabalgoity JA.

Open Microbiol J. 2012;6:5-13. doi: 10.2174/1874285801206010005. Epub 2012 Feb 10.


First human isolate of Salmonella enterica serotype Enteritidis harboring blaCTX-M-14 in South America.

Bado I, García-Fulgueiras V, Cordeiro NF, Betancor L, Caiata L, Seija V, Robino L, Algorta G, Chabalgoity JA, Ayala JA, Gutkind GO, Vignoli R.

Antimicrob Agents Chemother. 2012 Apr;56(4):2132-4. doi: 10.1128/AAC.05530-11. Epub 2012 Jan 30.


Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.

Marqués JM, Rial A, Muñoz N, Pellay FX, Van Maele L, Léger H, Camou T, Sirard JC, Benecke A, Chabalgoity JA.

Immunobiology. 2012 Apr;217(4):420-9. doi: 10.1016/j.imbio.2011.10.012. Epub 2011 Nov 23.


Echinococcus granulosus: different cytokine profiles are induced by single versus multiple experimental infections in dogs.

Rossi A, Marqués JM, Gavidia CM, Gonzalez AE, Carmona C, García HH, Chabalgoity JA.

Exp Parasitol. 2012 Feb;130(2):110-5. doi: 10.1016/j.exppara.2011.12.006. Epub 2011 Dec 19.


Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents.

Dapueto R, Castelli R, Fernández M, Chabalgoity JA, Moreno M, Gambini JP, Cabral P, Porcal W.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7102-6. doi: 10.1016/j.bmcl.2011.09.106. Epub 2011 Oct 1.


Naturally occurring motility-defective mutants of Salmonella enterica serovar Enteritidis isolated preferentially from nonhuman rather than human sources.

Yim L, Betancor L, Martínez A, Bryant C, Maskell D, Chabalgoity JA.

Appl Environ Microbiol. 2011 Nov;77(21):7740-8. doi: 10.1128/AEM.05318-11. Epub 2011 Sep 16.


Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior.

Mourglia-Ettlin G, Marqués JM, Chabalgoity JA, Dematteis S.

PLoS Negl Trop Dis. 2011 Aug;5(8):e1293. doi: 10.1371/journal.pntd.0001293. Epub 2011 Aug 30.


Development of 99mTc(CO)₃-dendrimer-FITC for cancer imaging.

Tassano MR, Audicio PF, Gambini JP, Fernandez M, Damian JP, Moreno M, Chabalgoity JA, Alonso O, Benech JC, Cabral P.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5598-601. doi: 10.1016/j.bmcl.2011.06.079. Epub 2011 Jun 30.


Differential phenotypic diversity among epidemic-spanning Salmonella enterica serovar enteritidis isolates from humans or animals.

Yim L, Betancor L, Martinez A, Giossa G, Bryant C, Maskell D, Chabalgoity JA.

Appl Environ Microbiol. 2010 Oct;76(20):6812-20. doi: 10.1128/AEM.00497-10. Epub 2010 Aug 27.


Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.

Muñoz N, Van Maele L, Marqués JM, Rial A, Sirard JC, Chabalgoity JA.

Infect Immun. 2010 Oct;78(10):4226-33. doi: 10.1128/IAI.00224-10. Epub 2010 Jul 19.


Prevalence of Salmonella enterica in poultry and eggs in Uruguay during an epidemic due to Salmonella enterica serovar Enteritidis.

Betancor L, Pereira M, Martinez A, Giossa G, Fookes M, Flores K, Barrios P, Repiso V, Vignoli R, Cordeiro N, Algorta G, Thomson N, Maskell D, Schelotto F, Chabalgoity JA.

J Clin Microbiol. 2010 Jul;48(7):2413-23. doi: 10.1128/JCM.02137-09. Epub 2010 May 19.


Salmonella as live trojan horse for vaccine development and cancer gene therapy.

Moreno M, Kramer MG, Yim L, Chabalgoity JA.

Curr Gene Ther. 2010 Feb;10(1):56-76. Review.


Genomic and phenotypic variation in epidemic-spanning Salmonella enterica serovar Enteritidis isolates.

Betancor L, Yim L, Fookes M, Martinez A, Thomson NR, Ivens A, Peters S, Bryant C, Algorta G, Kariuki S, Schelotto F, Maskell D, Dougan G, Chabalgoity JA.

BMC Microbiol. 2009 Nov 18;9:237. doi: 10.1186/1471-2180-9-237.


A B-cell lymphoma vaccine using a depot formulation of interleukin-2 induces potent antitumor immunity despite increased numbers of intratumoral regulatory T cells.

Grille S, Brugnini A, Nese M, Corley E, Falkenberg FW, Lens D, Chabalgoity JA.

Cancer Immunol Immunother. 2010 Apr;59(4):519-27. doi: 10.1007/s00262-009-0768-6. Epub 2009 Sep 19.


Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.

Thomson NR, Clayton DJ, Windhorst D, Vernikos G, Davidson S, Churcher C, Quail MA, Stevens M, Jones MA, Watson M, Barron A, Layton A, Pickard D, Kingsley RA, Bignell A, Clark L, Harris B, Ormond D, Abdellah Z, Brooks K, Cherevach I, Chillingworth T, Woodward J, Norberczak H, Lord A, Arrowsmith C, Jagels K, Moule S, Mungall K, Sanders M, Whitehead S, Chabalgoity JA, Maskell D, Humphrey T, Roberts M, Barrow PA, Dougan G, Parkhill J.

Genome Res. 2008 Oct;18(10):1624-37. doi: 10.1101/gr.077404.108. Epub 2008 Jun 26.

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