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Items: 28

1.

Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.

Petit D, Hitzenberger M, Lismont S, Zoltowska KM, Ryan NS, Mercken M, Bischoff F, Zacharias M, Chávez-Gutiérrez L.

EMBO J. 2019 Jun 17;38(12). pii: e101494. doi: 10.15252/embj.2019101494. Epub 2019 May 20.

2.

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium.

Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Erratum in: Brain. 2019 Jun 1;142(6):e25.

3.

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.

Voytyuk I, De Strooper B, Chávez-Gutiérrez L.

Biol Psychiatry. 2018 Feb 15;83(4):320-327. doi: 10.1016/j.biopsych.2017.08.001. Epub 2017 Aug 10. Review.

PMID:
28918941
4.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

5.

Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.

Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B.

EMBO Mol Med. 2017 Aug;9(8):1088-1099. doi: 10.15252/emmm.201707561.

6.

Identification and characterization of Nanobodies targeting the EphA4 receptor.

Schoonaert L, Rué L, Roucourt B, Timmers M, Little S, Chávez-Gutiérrez L, Dewilde M, Joyce P, Curnock A, Weber P, Haustraete J, Hassanzadeh-Ghassabeh G, De Strooper B, Van Den Bosch L, Van Damme P, Lemmens R, Robberecht W.

J Biol Chem. 2017 Jul 7;292(27):11452-11465. doi: 10.1074/jbc.M116.774141. Epub 2017 May 19.

7.

Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds.

Le Guennec K, Veugelen S, Quenez O, Szaruga M, Rousseau S, Nicolas G, Wallon D, Fluchere F, Frébourg T, De Strooper B, Campion D, Chávez-Gutiérrez L, Rovelet-Lecrux A.

Neurobiol Dis. 2017 Aug;104:97-103. doi: 10.1016/j.nbd.2017.04.020. Epub 2017 Apr 28.

PMID:
28461250
8.

Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins.

Veugelen S, Dewilde M, De Strooper B, Chávez-Gutiérrez L.

Methods Enzymol. 2017;584:59-97. doi: 10.1016/bs.mie.2016.10.029. Epub 2016 Dec 12. Review.

PMID:
28065273
9.

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Ryan NS, Nicholas JM, Weston PSJ, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, Fox NC.

Lancet Neurol. 2016 Dec;15(13):1326-1335. doi: 10.1016/S1474-4422(16)30193-4. Epub 2016 Oct 21.

10.

Probing γ-secretase-substrate interactions at the single amino acid residue level.

Chávez-Gutiérrez L, De Strooper B.

EMBO J. 2016 Aug 1;35(15):1597-9. doi: 10.15252/embj.201694978. Epub 2016 Jul 1. No abstract available.

11.

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B.

Neuron. 2016 Apr 20;90(2):410-6. doi: 10.1016/j.neuron.2016.03.010.

12.

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L.

J Exp Med. 2015 Nov 16;212(12):2003-13. doi: 10.1084/jem.20150892. Epub 2015 Oct 19.

13.

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease.

Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, Revesz T, Lashley T, Fox NC.

Neurobiol Aging. 2015 Dec;36(12):3140-3151. doi: 10.1016/j.neurobiolaging.2015.08.026. Epub 2015 Sep 4.

14.

The dynamic conformational landscape of gamma-secretase.

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L.

J Cell Sci. 2015 Feb 1;128(3):589-98.

15.

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

De Strooper B, Chávez Gutiérrez L.

Annu Rev Pharmacol Toxicol. 2015;55:419-37. doi: 10.1146/annurev-pharmtox-010814-124309. Epub 2014 Oct 1. Review.

PMID:
25292430
16.

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B.

J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13.

17.

Dissecting γ-secretase function.

Chávez-Gutiérrez L.

J Neurochem. 2013 Apr;125(1):1-3. doi: 10.1111/jnc.12077. No abstract available.

18.

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P.

Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022.

19.

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B.

EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13.

20.

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B.

EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2.

21.

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.

Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B.

J Biol Chem. 2011 Apr 8;286(14):12271-82. doi: 10.1074/jbc.M110.216978. Epub 2011 Feb 4.

22.

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B.

J Biol Chem. 2011 Mar 11;286(10):8677-87. doi: 10.1074/jbc.M110.194860. Epub 2011 Jan 5.

23.

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B.

J Biol Chem. 2008 Jul 18;283(29):20096-105. doi: 10.1074/jbc.M803040200. Epub 2008 May 23.

24.

Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.

de Gortari P, Vargas MA, Martínez A, García-Vázquez AI, Uribe RM, Chávez-Gutiérrez L, Magdaleno V, Boileau G, Charlí JL, Joseph-Bravo P.

J Mol Neurosci. 2007;33(3):252-61. Epub 2007 Apr 17.

PMID:
17952634
25.

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

Tolia A, Chávez-Gutiérrez L, De Strooper B.

J Biol Chem. 2006 Sep 15;281(37):27633-42. Epub 2006 Jul 14.

26.

Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

Chávez-Gutiérrez L, Matta-Camacho E, Osuna J, Horjales E, Joseph-Bravo P, Maigret B, Charli JL.

J Biol Chem. 2006 Jul 7;281(27):18581-90. Epub 2006 Apr 12.

27.

A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.

Chávez-Gutiérrez L, Bourdais J, Aranda G, Vargas MA, Matta-Camacho E, Ducancel F, Segovia L, Joseph-Bravo P, Charli JL.

J Neurochem. 2005 Feb;92(4):807-17.

28.

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