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Items: 1 to 50 of 106

1.

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis.

Benitz S, Straub T, Mahajan UM, Mutter J, Czemmel S, Unruh T, Wingerath B, Deubler S, Fahr L, Cheng T, Nahnsen S, Bruns P, Kong B, Raulefs S, Ceyhan GO, Mayerle J, Steiger K, Esposito I, Kleeff J, Michalski CW, Regel I.

Gut. 2019 Apr 6. pii: gutjnl-2018-317208. doi: 10.1136/gutjnl-2018-317208. [Epub ahead of print]

PMID:
30954952
2.

Mortality and postoperative complications after different types of surgical reconstruction following pancreaticoduodenectomy-a systematic review with meta-analysis.

Schorn S, Demir IE, Vogel T, Schirren R, Reim D, Wilhelm D, Friess H, Ceyhan GO.

Langenbecks Arch Surg. 2019 Mar;404(2):141-157. doi: 10.1007/s00423-019-01762-5. Epub 2019 Feb 28.

PMID:
30820662
3.

Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling.

Alrawashdeh W, Jones R, Dumartin L, Radon TP, Cutillas PR, Feakins RM, Dmitrovic B, Demir IE, Ceyhan GO, Crnogorac-Jurcevic T.

Mol Oncol. 2019 May;13(5):1075-1091. doi: 10.1002/1878-0261.12463. Epub 2019 Mar 5.

4.

Borderline-resectable pancreatic adenocarcinoma: Contour irregularity of the venous confluence in pre-operative computed tomography predicts histopathological infiltration.

Kaissis GA, Lohöfer FK, Ziegelmayer S, Danner J, Jäger C, Schirren R, Ankerst D, Ceyhan GO, Friess H, Rummeny EJ, Weichert W, Braren RF.

PLoS One. 2019 Jan 2;14(1):e0208717. doi: 10.1371/journal.pone.0208717. eCollection 2019.

5.

Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment.

Cheng T, Zhang Z, Jian Z, Raulefs S, Schlitter AM, Steiger K, Maeritz N, Zhao Y, Shen S, Zou X, Ceyhan GO, Friess H, Kleeff J, Michalski CW, Kong B.

Int J Cancer. 2019 May 15;144(10):2529-2538. doi: 10.1002/ijc.31981. Epub 2018 Dec 12.

PMID:
30412288
6.

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.

Jian Z, Cheng T, Zhang Z, Raulefs S, Shi K, Steiger K, Maeritz N, Kleigrewe K, Hofmann T, Benitz S, Bruns P, Lamp D, Jastroch M, Akkan J, Jäger C, Huang P, Nie S, Shen S, Zou X, Ceyhan GO, Michalski CW, Friess H, Kleeff J, Kong B.

Cell Mol Gastroenterol Hepatol. 2018 Jul 26;6(4):429-449. doi: 10.1016/j.jcmgh.2018.07.003. eCollection 2018.

7.

Meta-analysis of the impact of neoadjuvant therapy on patterns of recurrence in pancreatic ductal adenocarcinoma.

Schorn S, Demir IE, Samm N, Scheufele F, Calavrezos L, Sargut M, Schirren RM, Friess H, Ceyhan GO.

BJS Open. 2018 Mar 30;2(2):52-61. doi: 10.1002/bjs5.46. eCollection 2018 Apr. Review.

8.

Pancreatic stump closure techniques and pancreatic fistula formation after distal pancreatectomy: Meta-analysis and single-center experience.

Tieftrunk E, Demir IE, Schorn S, Sargut M, Scheufele F, Calavrezos L, Schirren R, Friess H, Ceyhan GO.

PLoS One. 2018 Jun 13;13(6):e0197553. doi: 10.1371/journal.pone.0197553. eCollection 2018.

9.

Genetically induced vs. classical animal models of chronic pancreatitis: a critical comparison.

Klauss S, Schorn S, Teller S, Steenfadt H, Friess H, Ceyhan GO, Demir IE.

FASEB J. 2018 Jun 4:fj201800241RR. doi: 10.1096/fj.201800241RR. [Epub ahead of print]

PMID:
29863911
10.

Pain in pancreatic ductal adenocarcinoma: A multidisciplinary, International guideline for optimized management.

Drewes AM, Campbell CM, Ceyhan GO, Delhaye M, Garg PK, van Goor H, Laquente B, Morlion B, Olesen SS, Singh VK, Sjøgren P, Szigethy E, Windsor JA, Salvetti MG, Talukdar R.

Pancreatology. 2018 Jun;18(4):446-457. doi: 10.1016/j.pan.2018.04.008. Epub 2018 Apr 22. Review.

11.

European evidence-based guidelines on pancreatic cystic neoplasms.

European Study Group on Cystic Tumours of the Pancreas.

Gut. 2018 May;67(5):789-804. doi: 10.1136/gutjnl-2018-316027. Epub 2018 Mar 24.

12.

3D Cancer Migration Assay with Schwann Cells.

Fangmann L, Teller S, Stupakov P, Friess H, Ceyhan GO, Demir IE.

Methods Mol Biol. 2018;1739:317-325. doi: 10.1007/978-1-4939-7649-2_20.

PMID:
29546716
13.

The impact of surgically placed, intraperitoneal drainage on morbidity and mortality after pancreas resection- A systematic review & meta-analysis.

Schorn S, Nitsche U, Demir IE, Scheufele F, Tieftrunk E, Schirren R, Klauss S, Sargut M, Ceyhan GO, Friess H.

Pancreatology. 2018 Apr;18(3):334-345. doi: 10.1016/j.pan.2018.02.013. Epub 2018 Feb 23. Review.

PMID:
29534868
14.

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.

Buhner S, Hahne H, Hartwig K, Li Q, Vignali S, Ostertag D, Meng C, Hörmannsperger G, Braak B, Pehl C, Frieling T, Barbara G, De Giorgio R, Demir IE, Ceyhan GO, Zeller F, Boeckxstaens G, Haller D, Kuster B, Schemann M.

PLoS One. 2018 Mar 12;13(3):e0193943. doi: 10.1371/journal.pone.0193943. eCollection 2018.

15.

Risk of malignancy in resected pancreatic mucinous cystic neoplasms.

Keane MG, Shamali A, Nilsson LN, Antila A, Millastre Bocos J, Marijinissen Van Zanten M, Verdejo Gil C, Maisonneuve P, Vaalavuo Y, Hoskins T, Robinson S, Ceyhan GO, Abu Hilal M, Pereira SP, Laukkarinen J, Del Chiaro M.

Br J Surg. 2018 Mar;105(4):439-446. doi: 10.1002/bjs.10787.

PMID:
29488646
16.

Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer.

Mutgan AC, Besikcioglu HE, Wang S, Friess H, Ceyhan GO, Demir IE.

Mol Cancer. 2018 Feb 23;17(1):66. doi: 10.1186/s12943-018-0806-0. Review.

17.

bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)-the active metabolite of the laxatives bisacodyl and sodium picosulfate-enhances contractility and secretion in human intestine in vitro.

Krueger D, Demir IE, Ceyhan GO, Zeller F, Schemann M.

Neurogastroenterol Motil. 2018 Jul;30(7):e13311. doi: 10.1111/nmo.13311. Epub 2018 Feb 14.

PMID:
29441646
18.

Towards a neurobiological understanding of pain in chronic pancreatitis: mechanisms and implications for treatment.

Olesen SS, Krauss T, Demir IE, Wilder-Smith OH, Ceyhan GO, Pasricha PJ, Drewes AM.

Pain Rep. 2017 Oct 25;2(6):e625. doi: 10.1097/PR9.0000000000000625. eCollection 2017 Nov. Review.

19.

MTOR inhibitor-based combination therapies for pancreatic cancer.

Hassan Z, Schneeweis C, Wirth M, Veltkamp C, Dantes Z, Feuerecker B, Ceyhan GO, Knauer SK, Weichert W, Schmid RM, Stauber R, Arlt A, Krämer OH, Rad R, Reichert M, Saur D, Schneider G.

Br J Cancer. 2018 Feb 6;118(3):366-377. doi: 10.1038/bjc.2017.421. Epub 2018 Jan 2.

20.

Calcium Imaging of Nerve-Mast Cell Signaling in the Human Intestine.

Buhner S, Barki N, Greiter W, Giesbertz P, Demir IE, Ceyhan GO, Zeller F, Daniel H, Schemann M.

Front Physiol. 2017 Nov 29;8:971. doi: 10.3389/fphys.2017.00971. eCollection 2017.

21.

Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer.

Brooks J, Fleischmann-Mundt B, Woller N, Niemann J, Ribback S, Peters K, Demir IE, Armbrecht N, Ceyhan GO, Manns MP, Wirth TC, Kubicka S, Bernhardt G, Smyth MJ, Calvisi DF, Gürlevik E, Kühnel F.

Cancer Res. 2018 Jan 15;78(2):475-488. doi: 10.1158/0008-5472.CAN-17-2415. Epub 2017 Nov 27.

22.

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response.

Muckenhuber A, Berger AK, Schlitter AM, Steiger K, Konukiewitz B, Trumpp A, Eils R, Werner J, Friess H, Esposito I, Klöppel G, Ceyhan GO, Jesinghaus M, Denkert C, Bahra M, Stenzinger A, Sprick MR, Jäger D, Springfeld C, Weichert W.

Clin Cancer Res. 2018 Jan 15;24(2):351-359. doi: 10.1158/1078-0432.CCR-17-2180. Epub 2017 Nov 3.

23.

Meta-analysis of outcomes following resection of the primary tumour in patients presenting with metastatic colorectal cancer.

Nitsche U, Stöß C, Stecher L, Wilhelm D, Friess H, Ceyhan GO.

Br J Surg. 2018 Jun;105(7):784-796. doi: 10.1002/bjs.10682. Epub 2017 Oct 31.

PMID:
29088493
24.

Combining 18F-FDG positron emission tomography with Up-to-seven criteria for selecting suitable liver transplant patients with advanced hepatocellular carcinoma.

Kornberg A, Witt U, Schernhammer M, Kornberg J, Ceyhan GO, Mueller K, Friess H, Thrum K.

Sci Rep. 2017 Oct 26;7(1):14176. doi: 10.1038/s41598-017-14430-9.

25.

Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors - a multi-institutional study.

Sallinen VJ, Le Large TYS, Tieftrunk E, Galeev S, Kovalenko Z, Haugvik SP, Antila A, Franklin O, Martinez-Moneo E, Robinson SM, Panzuto F, Regenet N, Muffatti F, Partelli S, Wiese D, Ruszniewski P, Dousset B, Edwin B, Bartsch DK, Sauvanet A, Falconi M, Ceyhan GO, Gaujoux S; Pancreas 2000 research group.

HPB (Oxford). 2018 Mar;20(3):251-259. doi: 10.1016/j.hpb.2017.08.034. Epub 2017 Oct 5.

26.

Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial.

Diener MK, Hüttner FJ, Kieser M, Knebel P, Dörr-Harim C, Distler M, Grützmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Börner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Büchler MW; ChroPac Trial Group.

Lancet. 2017 Sep 9;390(10099):1027-1037. doi: 10.1016/S0140-6736(17)31960-8.

PMID:
28901935
27.

[Resection of main duct and mixed type IPMN ≥5 mm].

Ceyhan GO, Scheufele F, Friess H.

Chirurg. 2017 Nov;88(11):913-917. doi: 10.1007/s00104-017-0494-0. Review. German.

PMID:
28842734
28.

pT but not pN stage of the 8th TNM classification significantly improves prognostication in pancreatic ductal adenocarcinoma.

Schlitter AM, Jesinghaus M, Jäger C, Konukiewitz B, Muckenhuber A, Demir IE, Bahra M, Denkert C, Friess H, Kloeppel G, Ceyhan GO, Weichert W.

Eur J Cancer. 2017 Oct;84:121-129. doi: 10.1016/j.ejca.2017.06.034. Epub 2017 Aug 10.

PMID:
28802189
29.

Analysis of lifestyle factors in patients with concomitant chronic pancreatitis and liver cirrhosis.

Aghdassi AA, Schneider A, Kahl M, Schütte K, Kuliaviene I, Salacone P, Lutz J, Tukiainen E, Simon P, Schauer B, Uomo G, Hauge T, Ceyhan GO.

Pancreatology. 2017 Sep - Oct;17(5):698-705. doi: 10.1016/j.pan.2017.07.194. Epub 2017 Jul 31.

PMID:
28784575
30.

Guidelines for the understanding and management of pain in chronic pancreatitis.

Drewes AM, Bouwense SAW, Campbell CM, Ceyhan GO, Delhaye M, Demir IE, Garg PK, van Goor H, Halloran C, Isaji S, Neoptolemos JP, Olesen SS, Palermo T, Pasricha PJ, Sheel A, Shimosegawa T, Szigethy E, Whitcomb DC, Yadav D; Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis.

Pancreatology. 2017 Sep - Oct;17(5):720-731. doi: 10.1016/j.pan.2017.07.006. Epub 2017 Jul 13. Review.

31.

R0 Versus R1 Resection Matters after Pancreaticoduodenectomy, and Less after Distal or Total Pancreatectomy for Pancreatic Cancer.

Demir IE, Jäger C, Schlitter AM, Konukiewitz B, Stecher L, Schorn S, Tieftrunk E, Scheufele F, Calavrezos L, Schirren R, Esposito I, Weichert W, Friess H, Ceyhan GO.

Ann Surg. 2018 Dec;268(6):1058-1068. doi: 10.1097/SLA.0000000000002345.

PMID:
28692477
32.

Reply to Letter: "Neural Invasion Cannot be Controlled by Extended Surgery in Gastric Cancer".

Ceyhan GO.

Ann Surg. 2017 May;265(5):e68-e69. doi: 10.1097/SLA.0000000000001233. No abstract available.

PMID:
28394792
33.

Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients.

Ostertag D, Annahazi A, Krueger D, Michel K, Demir IE, Ceyhan GO, Zeller F, Schemann M.

Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13070. Epub 2017 Apr 4.

PMID:
28374503
34.

The impact of neoadjuvant therapy on the histopathological features of pancreatic ductal adenocarcinoma - A systematic review and meta-analysis.

Schorn S, Demir IE, Reyes CM, Saricaoglu C, Samm N, Schirren R, Tieftrunk E, Hartmann D, Friess H, Ceyhan GO.

Cancer Treat Rev. 2017 Apr;55:96-106. doi: 10.1016/j.ctrv.2017.03.003. Epub 2017 Mar 14. Review.

PMID:
28342938
35.

The influence of neural invasion on survival and tumor recurrence in pancreatic ductal adenocarcinoma - A systematic review and meta-analysis.

Schorn S, Demir IE, Haller B, Scheufele F, Reyes CM, Tieftrunk E, Sargut M, Goess R, Friess H, Ceyhan GO.

Surg Oncol. 2017 Mar;26(1):105-115. doi: 10.1016/j.suronc.2017.01.007. Epub 2017 Feb 2. Review.

PMID:
28317579
36.

Surveillance strategy for small asymptomatic non-functional pancreatic neuroendocrine tumors - a systematic review and meta-analysis.

Sallinen V, Le Large TY, Galeev S, Kovalenko Z, Tieftrunk E, Araujo R, Ceyhan GO, Gaujoux S.

HPB (Oxford). 2017 Apr;19(4):310-320. doi: 10.1016/j.hpb.2016.12.010. Epub 2017 Feb 21. Review.

37.

Embolization Therapy for Pancreas-Related Bleeding: A Retrospective Analysis With Focus on End-Organ Ischemia.

Wildgruber M, Huff M, Meier R, Ceyhan GO, Friess H, Wohlgemuth WA, Koehler M, Berger H.

Pancreas. 2017 Mar;46(3):e22-e23. doi: 10.1097/MPA.0000000000000766. No abstract available.

PMID:
28187112
38.

Effect of preoperative biliary drainage on bacterial flora in bile of patients with periampullary cancer.

Scheufele F, Aichinger L, Jäger C, Demir IE, Schorn S, Sargut M, Erkan M, Kleeff J, Friess H, Ceyhan GO.

Br J Surg. 2017 Jan;104(2):e182-e188. doi: 10.1002/bjs.10450.

PMID:
28121036
39.

Preoperative biliary stenting versus operation first in jaundiced patients due to malignant lesions in the pancreatic head: A meta-analysis of current literature.

Scheufele F, Schorn S, Demir IE, Sargut M, Tieftrunk E, Calavrezos L, Jäger C, Friess H, Ceyhan GO.

Surgery. 2017 Apr;161(4):939-950. doi: 10.1016/j.surg.2016.11.001. Epub 2016 Dec 30. Review.

PMID:
28043693
40.

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells.

Demir IE, Kujundzic K, Pfitzinger PL, Saricaoglu ÖC, Teller S, Kehl T, Reyes CM, Ertl LS, Miao Z, Schall TJ, Tieftrunk E, Haller B, Diakopoulos KN, Kurkowski MU, Lesina M, Krüger A, Algül H, Friess H, Ceyhan GO.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E85-E94. doi: 10.1073/pnas.1606909114. Epub 2016 Dec 16.

41.

In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis.

Cheng T, Jian Z, Li K, Raulefs S, Regel I, Shen S, Zou X, Ruland J, Ceyhan GO, Friess H, Michalski CW, Kleeff J, Kong B.

Oncogenesis. 2016 Dec 12;5(12):e278. doi: 10.1038/oncsis.2016.78.

42.

Anti-Hu antibodies activate enteric and sensory neurons.

Li Q, Michel K, Annahazi A, Demir IE, Ceyhan GO, Zeller F, Komorowski L, Stöcker W, Beyak MJ, Grundy D, Farrugia G, De Giorgio R, Schemann M.

Sci Rep. 2016 Dec 1;6:38216. doi: 10.1038/srep38216.

43.

Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer.

Demir IE, Ceyhan GO, Friess H.

Expert Opin Ther Targets. 2017 Jan;21(1):1-3. Epub 2016 Dec 6. No abstract available.

PMID:
27885875
44.

Prognostic Impact of Intraoperative Blood Loss in Liver Transplant Patients with Advanced Hepatocellular Carcinoma.

Kornberg A, Witt U, Kornberg J, Ceyhan GO, Mueller K, Friess H, Thrum K.

Anticancer Res. 2016 Oct;36(10):5355-5364. Epub 2016 Oct 10.

PMID:
27798899
45.

Nerve growth factor & TrkA as novel therapeutic targets in cancer.

Demir IE, Tieftrunk E, Schorn S, Friess H, Ceyhan GO.

Biochim Biophys Acta. 2016 Aug;1866(1):37-50. doi: 10.1016/j.bbcan.2016.05.003. Epub 2016 Jun 2. Review.

PMID:
27264679
46.

Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.

Gürlevik E, Fleischmann-Mundt B, Brooks J, Demir IE, Steiger K, Ribback S, Yevsa T, Woller N, Kloos A, Ostroumov D, Armbrecht N, Manns MP, Dombrowski F, Saborowski M, Kleine M, Wirth TC, Oettle H, Ceyhan GO, Esposito I, Calvisi DF, Kubicka S, Kühnel F.

Gastroenterology. 2016 Aug;151(2):338-350.e7. doi: 10.1053/j.gastro.2016.05.004. Epub 2016 May 20.

PMID:
27210037
47.

Pancreatic exocrine insufficiency after pancreatic surgery.

Goess R, Ceyhan GO, Friess H.

Panminerva Med. 2016 Jun;58(2):151-9. Epub 2016 Apr 8. Review.

PMID:
27058237
48.

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia.

Demir IE, Tieftrunk E, Schorn S, Saricaoglu ÖC, Pfitzinger PL, Teller S, Wang K, Waldbaur C, Kurkowski MU, Wörmann SM, Shaw VE, Kehl T, Laschinger M, Costello E, Algül H, Friess H, Ceyhan GO.

Gut. 2016 Jun;65(6):1001-14. doi: 10.1136/gutjnl-2015-309784. Epub 2016 Jan 13.

PMID:
26762195
49.

Neural influences on human intestinal epithelium in vitro.

Krueger D, Michel K, Zeller F, Demir IE, Ceyhan GO, Slotta-Huspenina J, Schemann M.

J Physiol. 2016 Jan 15;594(2):357-72. doi: 10.1113/JP271493. Epub 2015 Nov 23.

50.

Back pain as a potential indicator of local recurrence in pancreatic cancer.

Tieftrunk E, Demir IE, Friess H, Ceyhan GO.

J Surg Case Rep. 2015 Oct 12;2015(10). pii: rjv127. doi: 10.1093/jscr/rjv127.

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