Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 62

1.

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.

Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, Chinta SJ, Rajagopalan S, Rane A, Siddiqui A, Ellenbroek B, Messer J, Pähler A, Andersen JK, Wyler R, Cesura AM.

J Pharmacol Exp Ther. 2017 Sep;362(3):413-423. doi: 10.1124/jpet.117.241653. Epub 2017 Jun 22.

PMID:
28642233
2.

The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.

Milanesi E, Costantini P, Gambalunga A, Colonna R, Petronilli V, Cabrelle A, Semenzato G, Cesura AM, Pinard E, Bernardi P.

J Biol Chem. 2006 Apr 14;281(15):10066-72. Epub 2006 Feb 14.

3.

The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore.

Cesura AM, Pinard E, Schubenel R, Goetschy V, Friedlein A, Langen H, Polcic P, Forte MA, Bernardi P, Kemp JA.

J Biol Chem. 2003 Dec 12;278(50):49812-8. Epub 2003 Sep 2.

4.

Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.

Kolczewski S, Adam G, Cesura AM, Jenck F, Hennig M, Oberhauser T, Poli SM, Rössler F, Röver S, Wichmann J, Dautzenberg FM.

J Med Chem. 2003 Jan 16;46(2):255-64.

PMID:
12519064
5.

A preclinical re-evaluation of the safety profile of tolcapone.

Borroni E, Cesura AM, Gatti S, Gasser R.

Funct Neurol. 2001;16(4 Suppl):125-34. Review. No abstract available.

PMID:
11996507
6.

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.

Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ Jr, Wichmann J, Dautzenberg FM.

J Med Chem. 2000 Apr 6;43(7):1329-38.

PMID:
10753470
7.
8.

ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.

Röver S, Wichmann J, Jenck F, Adam G, Cesura AM.

Bioorg Med Chem Lett. 2000 Apr 17;10(8):831-4.

PMID:
10782696
9.

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

Jenck F, Wichmann J, Dautzenberg FM, Moreau JL, Ouagazzal AM, Martin JR, Lundstrom K, Cesura AM, Poli SM, Roever S, Kolczewski S, Adam G, Kilpatrick G.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43.

10.

8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists.

Wichmann J, Adam G, Röver S, Cesura AM, Dautzenberg FM, Jenck F.

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2343-8.

PMID:
10476866
11.

Lazabemide for the treatment of Alzheimer's disease: rationale and therapeutic perspectives.

Cesura AM, Borroni E, Gottowik J, Kuhn C, Malherbe P, Martin J, Richards JG.

Adv Neurol. 1999;80:521-8. Review. No abstract available.

PMID:
10410766
12.
13.

Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies.

Cesura AM, Gottowik J, Lang G, Malherbe P, Da Prada M.

J Neural Transm Suppl. 1998;52:189-200.

PMID:
9564619
14.

Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.

Richards JG, Saura J, Luque JM, Cesura AM, Gottowik J, Malherbe P, Borroni E, Gray J.

J Neural Transm Suppl. 1998;52:173-87. Review.

PMID:
9564618
15.

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

Röver S, Cesura AM, Huguenin P, Kettler R, Szente A.

J Med Chem. 1997 Dec 19;40(26):4378-85.

PMID:
9435907
16.

Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells.

Alberati-Giani D, Malherbe P, Ricciardi-Castagnoli P, Köhler C, Denis-Donini S, Cesura AM.

J Immunol. 1997 Jul 1;159(1):419-26.

PMID:
9200481
17.

Cloning and functional expression of human kynurenine 3-monooxygenase.

Alberati-Giani D, Cesura AM, Broger C, Warren WD, Röver S, Malherbe P.

FEBS Lett. 1997 Jun 30;410(2-3):407-12.

18.

Isolation and expression of a cDNA clone encoding human kynureninase.

Alberati-Giani D, Buchli R, Malherbe P, Broger C, Lang G, Köhler C, Lahm HW, Cesura AM.

Eur J Biochem. 1996 Jul 15;239(2):460-8.

19.

Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.

Cesura AM, Gottowik J, Lahm HW, Lang G, Imhof R, Malherbe P, Röthlisberger U, Da Prada M.

Eur J Biochem. 1996 Mar 15;236(3):996-1002.

20.

Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.

Alberati-Giani D, Ricciardi-Castagnoli P, Köhler C, Cesura AM.

J Neurochem. 1996 Mar;66(3):996-1004.

PMID:
8769859
21.

Molecular characterisation of kynurenine pathway enzymes. 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase.

Cesura AM, Alberati-Giani D, Buchli R, Broger C, Köhler C, Vilbois F, Lahm HW, Heitz MP, Malherbe P.

Adv Exp Med Biol. 1996;398:477-83. No abstract available.

PMID:
8906308
22.

Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells.

Alberati-Giani D, Ricciardi-Castagnoli P, Köhler C, Cesura AM.

Adv Exp Med Biol. 1996;398:171-5. No abstract available.

PMID:
8906262
23.

Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney.

Buchli R, Alberati-Giani D, Malherbe P, Köhler C, Broger C, Cesura AM.

J Biol Chem. 1995 Dec 8;270(49):29330-5.

24.

Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain.

Malherbe P, Alberati-Giani D, Köhler C, Cesura AM.

FEBS Lett. 1995 Jun 26;367(2):141-4.

25.

Structure/function relationships of mitochondrial monoamine oxidase A and B chimeric forms.

Gottowik J, Malherbe P, Lang G, Da Prada M, Cesura AM.

Eur J Biochem. 1995 Jun 15;230(3):934-42.

26.

Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase.

Alberati-Giani D, Malherbe P, Köhler C, Lang G, Kiefer V, Lahm HW, Cesura AM.

J Neurochem. 1995 Apr;64(4):1448-55.

PMID:
7891071
27.

The role of monoamine oxidase and catechol O-methyltransferase in dopaminergic neurotransmission.

Napolitano A, Cesura AM, Da Prada M.

J Neural Transm Suppl. 1995;45:35-45. Review.

PMID:
8748607
28.

Relevance of reversible inhibitors of monoamine oxidase type A and of reuptake inhibition for noradrenaline turnover.

Hartmann D, Cesura AM, Schmid-Burgk W, Amrein R.

Acta Psychiatr Scand Suppl. 1995;386:14-21.

PMID:
7717090
29.

Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.

Saura J, Luque JM, Cesura AM, Da Prada M, Chan-Palay V, Huber G, Löffler J, Richards JG.

Neuroscience. 1994 Sep;62(1):15-30.

PMID:
7816197
31.

Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase.

Malherbe P, Köhler C, Da Prada M, Lang G, Kiefer V, Schwarcz R, Lahm HW, Cesura AM.

J Biol Chem. 1994 May 13;269(19):13792-7.

32.
33.

Characterisation of wild-type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line.

Gottowik J, Cesura AM, Malherbe P, Lang G, Da Prada M.

FEBS Lett. 1993 Feb 8;317(1-2):152-6.

34.

The new generation of monoamine oxidase inhibitors.

Cesura AM, Pletscher A.

Prog Drug Res. 1992;38:171-297. Review.

PMID:
1609114
35.

Biochemistry and pharmacology of moclobemide, a prototype RIMA.

Haefely W, Burkard WP, Cesura AM, Kettler R, Lorez HP, Martin JR, Richards JG, Scherschlicht R, Da Prada M.

Psychopharmacology (Berl). 1992;106 Suppl:S6-14. Review.

PMID:
1546143
36.

Brain microdialysis in rats: a technique to reveal competition in vivo between endogenous dopamine and moclobemide, a RIMA antidepressant.

Colzi A, d'Agostini F, Cesura AM, Da Prada M.

Psychopharmacology (Berl). 1992;106 Suppl:S17-20.

PMID:
1546133
37.

Mode of action and characteristics of monoamine oxidase-A inhibition by moclobemide.

Cesura AM, Kettler R, Imhof R, Da Prada M.

Psychopharmacology (Berl). 1992;106 Suppl:S15-6.

PMID:
1546132
38.

Serotonin organelles of rabbit platelets contain synaptophysin.

Bähler M, Cesura AM, Fischer G, Kuhn H, Klein RL, Da Prada M.

Eur J Biochem. 1990 Dec 27;194(3):825-9.

39.
40.

Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A.

Cesura AM, Bös M, Galva MD, Imhof R, Da Prada M.

Mol Pharmacol. 1990 Mar;37(3):358-66.

PMID:
2314388
41.

Characterization of [3H]Ro 16-6491 binding to digitonin solubilized monoamine oxidase-B and purification of the enzyme from human platelets by affinity chromatography.

Cesura AM, Imhof R, Muggli-Maniglio D, Picotti GB, Da Prada M.

Biochem Pharmacol. 1990 Jan 1;39(1):216-20. No abstract available.

PMID:
2297358
42.

From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors.

Da Prada M, Kettler R, Keller HH, Cesura AM, Richards JG, Saura Marti J, Muggli-Maniglio D, Wyss PC, Kyburz E, Imhof R.

J Neural Transm Suppl. 1990;29:279-92. Review.

PMID:
2193111
43.

MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course.

Kettler R, Cesura AM, Dingemanse J, Da Prada M.

J Neural Transm Suppl. 1990;32:211-4.

PMID:
2089093
44.

Monoamine oxidase inhibition by moclobemide and 2-amino-ethyl carboxamide derivatives: mode of action and kinetic characteristics.

Cesura AM, Muggli-Maniglio D, Lang G, Imhof R, Da Prada M.

J Neural Transm Suppl. 1990;32:165-70.

PMID:
2089085
45.

[3H]Ro 19-6327: a reversible ligand and affinity labelling probe for monoamine oxidase-B.

Cesura AM, Galva MD, Imhof R, Kyburz E, Picotti GB, Da Prada M.

Eur J Pharmacol. 1989 Mar 29;162(3):457-65.

PMID:
2744079
46.

Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.

Cesura AM, Imhof R, Galva MD, Kettler R, Da Prada M.

Pharmacol Res Commun. 1988 Dec;20 Suppl 4:51-61. No abstract available.

PMID:
3244727
47.

Reversible, enzyme-activated monoamine oxidase inhibitors: new advances.

Da Prada M, Kettler R, Cesura AM, Richards JG.

Pharmacol Res Commun. 1988 Dec;20 Suppl 4:21-33. No abstract available.

PMID:
3149747
48.

[3H]Ro 16-6491, a selective probe for affinity labelling of monoamine oxidase type B in human brain and platelet membranes.

Cesura AM, Imhof R, Takacs B, Galva MD, Picotti GB, Da Prada M.

J Neurochem. 1988 Apr;50(4):1037-43.

PMID:
3126263
49.

Platelets as a model for neurones?

Da Prada M, Cesura AM, Launay JM, Richards JG.

Experientia. 1988 Feb 15;44(2):115-26. Review.

PMID:
2831073
50.

Serotonin and noradrenaline concentrations and serotonin uptake in platelets from hyperphenylalaninaemic patients.

Giovannini M, Valsasina R, Longhi R, Cesura AM, Galva MD, Riva E, Bondiolotti GP, Picotti GB.

J Inherit Metab Dis. 1988;11(3):285-90.

PMID:
3148070

Supplemental Content

Loading ...
Support Center