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Items: 40

1.

Correction: Cryo-EM in drug discovery.

Ceska T, Chung CW, Cooke R, Phillips C, Williams PA.

Biochem Soc Trans. 2019 Feb 28;47(1):487. doi: 10.1042/BST-2018-0267C_COR. No abstract available.

PMID:
30819927
2.

Cryo-EM in drug discovery.

Ceska T, Chung CW, Cooke R, Phillips C, Williams PA.

Biochem Soc Trans. 2019 Feb 28;47(1):281-293. doi: 10.1042/BST20180267. Epub 2019 Jan 15. Review. Erratum in: Biochem Soc Trans. 2019 Feb 28;47(1):487.

PMID:
30647139
3.

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.

Reuberson J, Horsley H, Franklin RJ, Ford D, Neuss J, Brookings D, Huang Q, Vanderhoydonck B, Gao LJ, Jang MY, Herdewijn P, Ghawalkar A, Fallah-Arani F, Khan AR, Henshall J, Jairaj M, Malcolm S, Ward E, Shuttleworth L, Lin Y, Li S, Louat T, Waer M, Herman J, Payne A, Ceska T, Doyle C, Pitt W, Calmiano M, Augustin M, Steinbacher S, Lammens A, Allen R.

J Med Chem. 2018 Aug 9;61(15):6705-6723. doi: 10.1021/acs.jmedchem.8b00521. Epub 2018 Jul 19.

PMID:
29952567
4.

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies AM, Allan EG, Keeble AH, Delgado J, Cossins BP, Mitropoulou AN, Pang MOY, Ceska T, Beavil AJ, Craggs G, Westwood M, Henry AJ, McDonnell JM, Sutton BJ.

J Biol Chem. 2017 Jun 16;292(24):9975-9987. doi: 10.1074/jbc.M117.776476. Epub 2017 Apr 24.

5.

Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.

Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2066-2071. doi: 10.1073/pnas.1621423114. Epub 2017 Feb 6.

6.

Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.

Liu X, Taylor RD, Griffin L, Coker SF, Adams R, Ceska T, Shi J, Lawson AD, Baker T.

Sci Rep. 2017 Jan 27;7:41306. doi: 10.1038/srep41306.

7.

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.

Adams R, Griffin L, Compson JE, Jairaj M, Baker T, Ceska T, West S, Zaccheo O, Davé E, Lawson AD, Humphreys DP, Heywood S.

MAbs. 2016 Oct;8(7):1336-1346. Epub 2016 Jun 17.

8.

Direct observation of DNA threading in flap endonuclease complexes.

AlMalki FA, Flemming CS, Zhang J, Feng M, Sedelnikova SE, Ceska T, Rafferty JB, Sayers JR, Artymiuk PJ.

Nat Struct Mol Biol. 2016 Jul;23(7):640-6. doi: 10.1038/nsmb.3241. Epub 2016 Jun 6.

9.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, Hodgson S, Bodkin MJ, Singh S, Law RJ, Biggin PC.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Aug;388(8):883-903. doi: 10.1007/s00210-015-1111-8. Epub 2015 Mar 14.

10.

Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.

Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP.

ChemMedChem. 2014 Apr;9(4):699-705. doi: 10.1002/cmdc.201300525. Epub 2014 Feb 6.

PMID:
24504667
11.

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.

Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GF, Hoogenraad CC, Capitani G, Kammerer RA.

Nature. 2014 Jan 2;505(7481):108-11. doi: 10.1038/nature12732. Epub 2013 Nov 17.

PMID:
24240280
12.

Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.

Holdsworth G, Slocombe P, Doyle C, Sweeney B, Veverka V, Le Riche K, Franklin RJ, Compson J, Brookings D, Turner J, Kennedy J, Garlish R, Shi J, Newnham L, McMillan D, Muzylak M, Carr MD, Henry AJ, Ceska T, Robinson MK.

J Biol Chem. 2012 Aug 3;287(32):26464-77. doi: 10.1074/jbc.M112.350108. Epub 2012 Jun 13.

13.

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting.

Meier C, Brookings DC, Ceska TA, Doyle C, Gong H, McMillan D, Saville GP, Mushtaq A, Knight D, Reich S, Pearl LH, Powell KA, Savva R, Allen RA.

J Struct Biol. 2012 Feb;177(2):329-34. doi: 10.1016/j.jsb.2012.01.002. Epub 2012 Jan 8.

PMID:
22245778
14.

Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.

Perry B, Alexander R, Bennett G, Buckley G, Ceska T, Crabbe T, Dale V, Gowers L, Horsley H, James L, Jenkins K, Crépy K, Kulisa C, Lightfoot H, Lock C, Mack S, Morgan T, Nicolas AL, Pitt W, Sabin V, Wright S.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4700-4. doi: 10.1016/j.bmcl.2008.06.104. Epub 2008 Jul 5.

PMID:
18644721
15.

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039. Epub 2008 Apr 22.

PMID:
18482836
16.

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Alam M, Beevers RE, Ceska T, Davenport RJ, Dickson KM, Fortunato M, Gowers L, Haughan AF, James LA, Jones MW, Kinsella N, Lowe C, Meissner JW, Nicolas AL, Perry BG, Phillips DJ, Pitt WR, Platt A, Ratcliffe AJ, Sharpe A, Tait LJ.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3463-7. Epub 2007 Mar 30.

PMID:
17459703
17.

Roles of divalent metal ions in flap endonuclease-substrate interactions.

Feng M, Patel D, Dervan JJ, Ceska T, Suck D, Haq I, Sayers JR.

Nat Struct Mol Biol. 2004 May;11(5):450-6. Epub 2004 Apr 11.

PMID:
15077103
18.

Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry.

Crump MP, Ceska TA, Spyracopoulos L, Henry A, Archibald SC, Alexander R, Taylor RJ, Findlow SC, O'Connell J, Robinson MK, Shock A.

Biochemistry. 2004 Mar 9;43(9):2394-404.

PMID:
14992576
19.

Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding.

Dervan JJ, Feng M, Patel D, Grasby JA, Artymiuk PJ, Ceska TA, Sayers JR.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8542-7.

20.

Recollections of the electron crystallographic heavy atom derivative search of purple membrane: the quest for EM structure determination.

Ceska TA.

J Struct Biol. 1999 Sep;127(2):135-40. Erratum in: J Struct Biol 2000 Feb;129(1):100.

PMID:
10527902
21.
22.

Structure-specific DNA cleavage by 5' nucleases.

Ceska TA, Sayers JR.

Trends Biochem Sci. 1998 Sep;23(9):331-6. Review.

PMID:
9787638
23.

[Recommendations for the diagnosis and therapy of hyperlipoproteinemias in adults prepared by the Czech Atherosclerosis Society].

Ceska T, Cílková R, Poledne R, Rosolová H, Soska V, Simon J, Sobra J, Vaverková H, Widimský J Jr, Widimský J Sr, Zadák Z.

Vnitr Lek. 1997 Sep;43(9):621-5. Czech. No abstract available.

PMID:
9750474
24.

Prokaryotic 5'-3' exonucleases share a common core structure with gamma-delta resolvase.

Artymiuk PJ, Ceska TA, Suck D, Sayers JR.

Nucleic Acids Res. 1997 Nov 1;25(21):4224-9.

25.

The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.

Brownlie P, Ceska T, Lamers M, Romier C, Stier G, Teo H, Suck D.

Structure. 1997 Apr 15;5(4):509-20.

26.

A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease.

Ceska TA, Sayers JR, Stier G, Suck D.

Nature. 1996 Jul 4;382(6586):90-3.

PMID:
8657312
27.

Electron-crystallographic refinement of the structure of bacteriorhodopsin.

Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R.

J Mol Biol. 1996 Jun 14;259(3):393-421.

PMID:
8676377
29.

Crystallization experiments with 2-enoyl-CoA hydratase, using an automated 'fast-screening' crystallization protocol.

Zeelen JP, Hiltunen JK, Ceska TA, Wierenga RK.

Acta Crystallogr D Biol Crystallogr. 1994 Jul 1;50(Pt 4):443-7.

PMID:
15299399
30.

Preliminary crystallographic studies on the D15 5' to 3' exonuclease from phage T5.

Ceska TA, Sayers JR, Eckstein F, Suck D.

J Mol Biol. 1993 Sep 5;233(1):179-82.

PMID:
8377188
31.
32.

Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex.

van der Oost J, Musacchio A, Pauptit RA, Ceska TA, Wierenga RK, Saraste M.

J Mol Biol. 1993 Feb 5;229(3):794-6.

PMID:
8433374
33.

An atomic model for the structure of bacteriorhodopsin, a seven-helix membrane protein.

Ceska TA, Henderson R, Baldwin JM, Zemlin F, Beckmann E, Downing K.

Acta Physiol Scand Suppl. 1992;607:31-40.

PMID:
1449073
34.

An atomic model for the structure of bacteriorhodopsin.

Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH.

Biochem Soc Trans. 1990 Oct;18(5):844. No abstract available.

PMID:
2083691
35.

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.

Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH.

J Mol Biol. 1990 Jun 20;213(4):899-929.

PMID:
2359127
36.
37.

High-voltage electron diffraction from bacteriorhodopsin (purple membrane) is measurably dynamical.

Glaeser RM, Ceska TA.

Acta Crystallogr A. 1989 Sep 1;45 ( Pt 9):620-8.

PMID:
2803666
38.

Electron diffraction analysis of the M412 intermediate of bacteriorhodopsin.

Glaeser RM, Baldwin J, Ceska TA, Henderson R.

Biophys J. 1986 Nov;50(5):913-20.

39.
40.

Structural changes in tubulin sheets upon removal of microtubule-associated proteins.

McEwen BF, Ceska TA, Crepeau RH, Edelstein SJ.

J Mol Biol. 1983 May 15;166(2):119-40.

PMID:
6854640

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