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Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.

Fox BA, Guevara RB, Rommereim LM, Falla A, Bellini V, Pètre G, Rak C, Cantillana V, Dubremetz JF, Cesbron-Delauw MF, Taylor GA, Mercier C, Bzik DJ.

MBio. 2019 Jul 2;10(4). pii: e00589-19. doi: 10.1128/mBio.00589-19.


Toxoplasma Hypervirulence in the Rat Model Parallels Human Infection and Is Modulated by the Toxo1 Locus.

Loeuillet C, Mondon A, Kamche S, Curri V, Boutonnat J, Cavaillès P, Cesbron-Delauw MF.

Front Cell Infect Microbiol. 2019 May 1;9:134. doi: 10.3389/fcimb.2019.00134. eCollection 2019.


High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds.

Touquet B, Pelissier L, Cavailles P, Yi W, Bellini V, Mercier C, Cesbron-Delauw MF, Boumendjel A, Aldebert D.

PLoS One. 2018 Aug 29;13(8):e0201678. doi: 10.1371/journal.pone.0201678. eCollection 2018.


Determination of a Key Antigen for Immunological Intervention To Target the Latent Stage of Toxoplasma gondii.

Sa Q, Ochiai E, Tiwari A, Mullins J, Shastri N, Mercier C, Cesbron-Delauw MF, Suzuki Y.

J Immunol. 2017 Jun 1;198(11):4425-4434. doi: 10.4049/jimmunol.1700062. Epub 2017 Apr 26.


Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

Amiar S, MacRae JI, Callahan DL, Dubois D, van Dooren GG, Shears MJ, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y, Botté CY.

PLoS Pathog. 2016 Aug 4;12(8):e1005765. doi: 10.1371/journal.ppat.1005765. eCollection 2016 Aug.


Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii.

Rommereim LM, Bellini V, Fox BA, Pètre G, Rak C, Touquet B, Aldebert D, Dubremetz JF, Cesbron-Delauw MF, Mercier C, Bzik DJ.

PLoS One. 2016 Jul 26;11(7):e0159306. doi: 10.1371/journal.pone.0159306. eCollection 2016.


Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.

Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N.

Cell Rep. 2015 Dec 15;13(10):2273-86. doi: 10.1016/j.celrep.2015.11.001. Epub 2015 Nov 25.


Toxoplasma secretory granules: one population or more?

Mercier C, Cesbron-Delauw MF.

Trends Parasitol. 2015 Nov;31(11):604. doi: 10.1016/ Epub 2015 Mar 12. No abstract available.


Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6.

Bittame A, Effantin G, Pètre G, Ruffiot P, Travier L, Schoehn G, Weissenhorn W, Cesbron-Delauw MF, Gagnon J, Mercier C.

Biochem Biophys Res Commun. 2015 Mar 27;459(1):107-12. doi: 10.1016/j.bbrc.2015.02.078. Epub 2015 Feb 21.


Toxoplasma secretory granules: one population or more?

Mercier C, Cesbron-Delauw MF.

Trends Parasitol. 2015 Feb;31(2):60-71. doi: 10.1016/ Epub 2015 Jan 15. Review. Erratum in: Trends Parasitol. 2015 Nov;31(11):604. Trends Parasitol. 2015 Nov;31(11):604.


A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.

Cavailles P, Flori P, Papapietro O, Bisanz C, Lagrange D, Pilloux L, Massera C, Cristinelli S, Jublot D, Bastien O, Loeuillet C, Aldebert D, Touquet B, Fournié GJ, Cesbron-Delauw MF.

PLoS Pathog. 2014 Apr 3;10(4):e1004005. doi: 10.1371/journal.ppat.1004005. eCollection 2014 Apr.


ALOX12 in human toxoplasmosis.

Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R.

Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31.


Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.

Saïdani N, Botté CY, Deligny M, Bonneau AL, Reader J, Lasselin R, Merer G, Niepceron A, Brossier F, Cintrat JC, Rousseau B, Birkholtz LM, Cesbron-Delauw MF, Dubremetz JF, Mercier C, Vial H, Lopez R, Maréchal E.

Antimicrob Agents Chemother. 2014 May;58(5):2586-97. doi: 10.1128/AAC.01445-13. Epub 2014 Feb 18.


A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cells' migration.

Persat F, Mercier C, Ficheux D, Colomb E, Trouillet S, Bendridi N, Musset K, Loeuillet C, Cesbron-Delauw MF, Vincent C.

J Leukoc Biol. 2012 Dec;92(6):1241-50. doi: 10.1189/jlb.1211600. Epub 2012 Oct 2.


Toxoplasma gondii secretory proteins bind to sulfated heparin structures.

Azzouz N, Kamena F, Laurino P, Kikkeri R, Mercier C, Cesbron-Delauw MF, Dubremetz JF, De Cola L, Seeberger PH.

Glycobiology. 2013 Jan;23(1):106-20. doi: 10.1093/glycob/cws134. Epub 2012 Sep 20.


Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection.

Hester J, Mullins J, Sa Q, Payne L, Mercier C, Cesbron-Delauw MF, Suzuki Y.

Infect Immun. 2012 Oct;80(10):3611-20. doi: 10.1128/IAI.00604-12. Epub 2012 Jul 30.


Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.

Camara D, Bisanz C, Barette C, Van Daele J, Human E, Barnard B, Van der Straeten D, Stove CP, Lambert WE, Douce R, Maréchal E, Birkholtz LM, Cesbron-Delauw MF, Dumas R, Rébeillé F.

J Biol Chem. 2012 Jun 22;287(26):22367-76. doi: 10.1074/jbc.M112.365833. Epub 2012 May 10.


Development of high-throughput methods to quantify cysts of Toxoplasma gondii.

Aldebert D, Hypolite M, Cavailles P, Touquet B, Flori P, Loeuillet C, Cesbron-Delauw MF.

Cytometry A. 2011 Nov;79(11):952-8. doi: 10.1002/cyto.a.21138. Epub 2011 Sep 8.


Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.

Fox BA, Falla A, Rommereim LM, Tomita T, Gigley JP, Mercier C, Cesbron-Delauw MF, Weiss LM, Bzik DJ.

Eukaryot Cell. 2011 Sep;10(9):1193-206. doi: 10.1128/EC.00297-10. Epub 2011 Apr 29.


NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.

Witola WH, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, Cavailles P, Bisanz C, Cesbron-Delauw MF, Fournié GJ, McLeod R.

Infect Immun. 2011 Feb;79(2):756-66. doi: 10.1128/IAI.00898-10. Epub 2010 Nov 22.


Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model.

Loeuillet C, Lemaire-Vieille C, Naquet P, Cesbron-Delauw MF, Gagnon J, Cesbron JY.

PLoS One. 2010 Oct 5;5(10). pii: e13166. doi: 10.1371/journal.pone.0013166.


Sex effect in mouse and human prion disease.

Loeuillet C, Boelle PY, Lemaire-Vieille C, Baldazza M, Naquet P, Chambon P, Cesbron-Delauw MF, Valleron AJ, Gagnon J, Cesbron JY.

J Infect Dis. 2010 Aug 15;202(4):648-54. doi: 10.1086/654818.


Post-translational membrane sorting of the Toxoplasma gondii GRA6 protein into the parasite-containing vacuole is driven by its N-terminal domain.

Gendrin C, Bittame A, Mercier C, Cesbron-Delauw MF.

Int J Parasitol. 2010 Sep;40(11):1325-34. doi: 10.1016/j.ijpara.2010.03.014. Epub 2010 Apr 24.


Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole.

Gendrin C, Mercier C, Braun L, Musset K, Dubremetz JF, Cesbron-Delauw MF.

Traffic. 2008 Sep;9(10):1665-80. doi: 10.1111/j.1600-0854.2008.00793.x. Epub 2008 Jul 9.


Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America.

Morisset S, Peyron F, Lobry JR, Garweg J, Ferrandiz J, Musset K, Gomez-Marin JE, de la Torre A, Demar M, Carme B, Mercier C, Garin JF, Cesbron-Delauw MF.

Microbes Infect. 2008 Jun;10(7):742-7. doi: 10.1016/j.micinf.2008.04.001. Epub 2008 Apr 9.


Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole.

Cesbron-Delauw MF, Gendrin C, Travier L, Ruffiot P, Mercier C.

Traffic. 2008 May;9(5):657-64. doi: 10.1111/j.1600-0854.2008.00728.x. Epub 2008 Feb 24. Review.


Serodiagnosis of recently acquired Toxoplasma gondii infection in pregnant women using enzyme-linked immunosorbent assays with a recombinant dense granule GRA6 protein.

Golkar M, Azadmanesh K, Khalili G, Khoshkholgh-Sima B, Babaie J, Mercier C, Brenier-Pinchart MP, Fricker-Hidalgo H, Pelloux H, Cesbron-Delauw MF.

Diagn Microbiol Infect Dis. 2008 May;61(1):31-9. doi: 10.1016/j.diagmicrobio.2007.09.003. Epub 2008 Jan 31.


Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii.

Botté C, Saïdani N, Mondragon R, Mondragón M, Isaac G, Mui E, McLeod R, Dubremetz JF, Vial H, Welti R, Cesbron-Delauw MF, Mercier C, Maréchal E.

J Lipid Res. 2008 Apr;49(4):746-62. doi: 10.1194/jlr.M700476-JLR200. Epub 2008 Jan 8.


Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole.

Travier L, Mondragon R, Dubremetz JF, Musset K, Mondragon M, Gonzalez S, Cesbron-Delauw MF, Mercier C.

Int J Parasitol. 2008 Jun;38(7):757-73. Epub 2007 Nov 1.


Purification of Toxoplasma dense granule proteins reveals that they are in complexes throughout the secretory pathway.

Braun L, Travier L, Kieffer S, Musset K, Garin J, Mercier C, Cesbron-Delauw MF.

Mol Biochem Parasitol. 2008 Jan;157(1):13-21. Epub 2007 Sep 16.


Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line.

Aldebert D, Durand F, Mercier C, Brenier-Pinchart MP, Cesbron-Delauw MF, Pelloux H.

Cytokine. 2007 Mar;37(3):206-11. Epub 2007 May 23.


The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women.

Golkar M, Rafati S, Abdel-Latif MS, Brenier-Pinchart MP, Fricker-Hidalgo H, Sima BK, Babaie J, Pelloux H, Cesbron-Delauw MF, Mercier C.

Diagn Microbiol Infect Dis. 2007 Aug;58(4):419-26. Epub 2007 May 16.


Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice.

Golkar M, Shokrgozar MA, Rafati S, Musset K, Assmar M, Sadaie R, Cesbron-Delauw MF, Mercier C.

Vaccine. 2007 May 22;25(21):4301-11. Epub 2007 Mar 9.


Toxoplasma gondii in human astrocytes in vitro: interleukin (IL)-12 and IL-10 do not influence cystogenesis.

Estran C, Brenier-Pinchart MP, Pelletier L, Cesbron-Delauw MF, Pelloux H.

J Parasitol. 2006 Oct;92(5):1108-10.


[The rat Toxo1 locus controls the outcome of the toxoplasmic infection according to a mendelian mode].

Cavaillès P, Bisanz C, Papapietro O, Colacios C, Sergent V, Pipy B, Saoudi A, Cesbron-Delauw MF, Fournié GJ.

Med Sci (Paris). 2006 Aug-Sep;22(8-9):679-80. French. No abstract available.


Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America).

Peyron F, Lobry JR, Musset K, Ferrandiz J, Gomez-Marin JE, Petersen E, Meroni V, Rausher B, Mercier C, Picot S, Cesbron-Delauw MF.

Microbes Infect. 2006 Aug;8(9-10):2333-40. Epub 2006 Jul 28.


The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.

Cavaillès P, Sergent V, Bisanz C, Papapietro O, Colacios C, Mas M, Subra JF, Lagrange D, Calise M, Appolinaire S, Faraut T, Druet P, Saoudi A, Bessieres MH, Pipy B, Cesbron-Delauw MF, Fournié GJ.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):744-9. Epub 2006 Jan 6.


T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis.

Prigione I, Chiesa S, Taverna P, Ceccarelli R, Frulio R, Morandi F, Bocca P, Cesbron-Delauw MF, Pistoia V.

Microbes Infect. 2006 Feb;8(2):552-60. Epub 2005 Oct 21.


Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii.

Saksouk N, Bhatti MM, Kieffer S, Smith AT, Musset K, Garin J, Sullivan WJ Jr, Cesbron-Delauw MF, Hakimi MA.

Mol Cell Biol. 2005 Dec;25(23):10301-14.


Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors.

Bisanz C, Bastien O, Grando D, Jouhet J, Maréchal E, Cesbron-Delauw MF.

Biochem J. 2006 Feb 15;394(Pt 1):197-205.


The Toxoplasma surface protein SAG1 triggers efficient in vitro secretion of chemokine ligand 2 (CCL2) from human fibroblasts.

Brenier-Pinchart MP, Villena I, Mercier C, Durand F, Simon J, Cesbron-Delauw MF, Pelloux H.

Microbes Infect. 2006 Jan;8(1):254-61. Epub 2005 Sep 13.


Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells.

Sergent V, Cautain B, Khalife J, Deslée D, Bastien P, Dao A, Dubremetz JF, Fournié GJ, Saoudi A, Cesbron-Delauw MF.

Infect Immun. 2005 Oct;73(10):6990-7.


GRA9, a new Toxoplasma gondii dense granule protein associated with the intravacuolar network of tubular membranes.

Adjogble KD, Mercier C, Dubremetz JF, Hucke C, Mackenzie CR, Cesbron-Delauw MF, Däubener W.

Int J Parasitol. 2004 Oct;34(11):1255-64.


Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins.

Mercier C, Dubremetz JF, Rauscher B, Lecordier L, Sibley LD, Cesbron-Delauw MF.

Mol Biol Cell. 2002 Jul;13(7):2397-409.


Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii.

Azzouz N, Rauscher B, Gerold P, Cesbron-Delauw MF, Dubremetz JF, Schwarz RT.

Int J Parasitol. 2002 Jun;32(6):677-84.


Toxoplasma gondii-infected human myeloid dendritic cells induce T-lymphocyte dysfunction and contact-dependent apoptosis.

Wei S, Marches F, Borvak J, Zou W, Channon J, White M, Radke J, Cesbron-Delauw MF, Curiel TJ.

Infect Immun. 2002 Apr;70(4):1750-60.


Lack of expression of the dense granule protein GRA5 does not affect the development of Toxoplasma tachyzoites.

Mercier C, Rauscher B, Lecordier L, Deslée D, Dubremetz JF, Cesbron-Delauw MF.

Mol Biochem Parasitol. 2001 Sep 3;116(2):247-51. No abstract available.


The apicoplast: a new member of the plastid family.

Maréchal E, Cesbron-Delauw MF.

Trends Plant Sci. 2001 May;6(5):200-5. Review.


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