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Items: 36


Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer.

Segal NH, He AR, Doi T, Levy R, Bhatia S, Pishvaian MJ, Cesari R, Chen Y, Davis CB, Huang B, Thall AD, Gopal AK.

Clin Cancer Res. 2018 Apr 15;24(8):1816-1823. doi: 10.1158/1078-0432.CCR-17-1922. Epub 2018 Mar 16.


Long-Term Follow-Up of Desmoid Fibromatosis Treated with PF-03084014, an Oral Gamma Secretase Inhibitor.

Villalobos VM, Hall F, Jimeno A, Gore L, Kern K, Cesari R, Huang B, Schowinsky JT, Blatchford PJ, Hoffner B, Elias A, Messersmith W.

Ann Surg Oncol. 2018 Mar;25(3):768-775. doi: 10.1245/s10434-017-6082-1. Epub 2017 Sep 8.


Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer.

Locatelli MA, Aftimos P, Dees EC, LoRusso PM, Pegram MD, Awada A, Huang B, Cesari R, Jiang Y, Shaik MN, Kern KA, Curigliano G.

Oncotarget. 2017 Jan 10;8(2):2320-2328. doi: 10.18632/oncotarget.13727.


A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.

Papayannidis C, DeAngelo DJ, Stock W, Huang B, Shaik MN, Cesari R, Zheng X, Reynolds JM, English PA, Ozeck M, Aster JC, Kuo F, Huang D, Lira PD, McLachlan KR, Kern KA, Garcia-Manero G, Martinelli G.

Blood Cancer J. 2015 Sep 25;5:e350. doi: 10.1038/bcj.2015.80. No abstract available.


A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors.

Wagner AJ, Messersmith WA, Shaik MN, Li S, Zheng X, McLachlan KR, Cesari R, Courtney R, Levin WJ, El-Khoueiry AB.

Clin Cancer Res. 2015 Mar 1;21(5):1044-51. doi: 10.1158/1078-0432.CCR-14-1116. Epub 2014 Nov 11.


A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.

Messersmith WA, Shapiro GI, Cleary JM, Jimeno A, Dasari A, Huang B, Shaik MN, Cesari R, Zheng X, Reynolds JM, English PA, McLachlan KR, Kern KA, LoRusso PM.

Clin Cancer Res. 2015 Jan 1;21(1):60-7. doi: 10.1158/1078-0432.CCR-14-0607. Epub 2014 Sep 17.


Sunitinib in combination with trastuzumab for the treatment of advanced breast cancer: activity and safety results from a phase II study.

Bachelot T, Garcia-Saenz JA, Verma S, Gutierrez M, Pivot X, Kozloff MF, Prady C, Huang X, Khosravan R, Wang Z, Cesari R, Tassell V, Kern KA, Blay JY, Lluch A.

BMC Cancer. 2014 Mar 7;14:166. doi: 10.1186/1471-2407-14-166.


Randomized phase II study of sunitinib versus standard of care for patients with previously treated advanced triple-negative breast cancer.

Curigliano G, Pivot X, Cortés J, Elias A, Cesari R, Khosravan R, Collier M, Huang X, Cataruozolo PE, Kern KA, Goldhirsch A.

Breast. 2013 Oct;22(5):650-6. doi: 10.1016/j.breast.2013.07.037. Epub 2013 Aug 17.


EPR and pulsed ENDOR study of intermediates from reactions of aromatic azides with group 13 metal trichlorides.

Bencivenni G, Cesari R, Nanni D, El Mkami H, Walton JC.

Beilstein J Org Chem. 2010 Aug 9;6:713-25. doi: 10.3762/bjoc.6.84.


EPR and ENDOR spectroscopic study of the reactions of aromatic azides with gallium trichloride.

Bencivenni G, Cesari R, Nanni D, El Mkami H, Walton JC.

Org Biomol Chem. 2010 Nov 21;8(22):5097-104. doi: 10.1039/c0ob00084a. Epub 2010 Aug 24.


Case report and surgical solution for a voluminous uterine leiomyoma in a woman with complicated Mayer-Rokitansky-Küster-Hauser syndrome.

Papa G, Andreotti M, Giannubilo SR, Cesari R, Ceré I, Tranquilli AL.

Fertil Steril. 2008 Nov;90(5):2014.e5-6. doi: 10.1016/j.fertnstert.2008.04.061.


HMGA1 protein is a novel target of the ATM kinase.

Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A.

Eur J Cancer. 2008 Nov;44(17):2668-79. doi: 10.1016/j.ejca.2008.07.033. Epub 2008 Sep 8.


In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia.

Miccio A, Cesari R, Lotti F, Rossi C, Sanvito F, Ponzoni M, Routledge SJ, Chow CM, Antoniou MN, Ferrari G.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10547-52. doi: 10.1073/pnas.0711666105. Epub 2008 Jul 23.


Tumor suppressor functions of ARLTS1 in lung cancers.

Yendamuri S, Trapasso F, Ferracin M, Cesari R, Sevignani C, Shimizu M, Rattan S, Kuroki T, Dumon KR, Bullrich F, Liu CG, Negrini M, Williams NN, Kaiser LR, Croce CM, Calin GA.

Cancer Res. 2007 Aug 15;67(16):7738-45.


Inactivation of the FHIT gene favors bladder cancer development.

Vecchione A, Sevignani C, Giarnieri E, Zanesi N, Ishii H, Cesari R, Fong LY, Gomella LG, Croce CM, Baffa R.

Clin Cancer Res. 2004 Nov 15;10(22):7607-12.


Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models.

Trapasso F, Sarti M, Cesari R, Yendamuri S, Dumon KR, Aqeilan RI, Pentimalli F, Infante L, Alder H, Abe N, Watanabe T, Viglietto G, Croce CM, Fusco A.

Cancer Gene Ther. 2004 Sep;11(9):633-41.


Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.

Trapasso F, Yendamuri S, Dumon KR, Iuliano R, Cesari R, Feig B, Seto R, Infante L, Ishii H, Vecchione A, During MJ, Croce CM, Fusco A.

Carcinogenesis. 2004 Nov;25(11):2107-14. Epub 2004 Jul 1.


Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer.

Picchio MC, Martin ES, Cesari R, Calin GA, Yendamuri S, Kuroki T, Pentimalli F, Sarti M, Yoder K, Kaiser LR, Fishel R, Croce CM.

Clin Cancer Res. 2004 Apr 15;10(8):2720-4.


The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.

Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM.

Clin Cancer Res. 2004 Apr 1;10(7):2459-65.


The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

Martin ES, Cesari R, Pentimalli F, Yoder K, Fishel R, Himelstein AL, Martin SE, Godwin AK, Negrini M, Croce CM.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11517-22. Epub 2003 Sep 22.


Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.

Cesari R, Martin ES, Calin GA, Pentimalli F, Bichi R, McAdams H, Trapasso F, Drusco A, Shimizu M, Masciullo V, D'Andrilli G, Scambia G, Picchio MC, Alder H, Godwin AK, Croce CM.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5956-61. Epub 2003 Apr 28.


[Pharmaco-economic evaluation of antibiotic therapy in a ward for infections diseases]

Sabbatani S, Cannella B, Fulgaro C, Pipitone E, Cesari R.

Infez Med. 2000;8(3):156-166. Italian.


Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.

Sevignani C, Calin GA, Cesari R, Sarti M, Ishii H, Yendamuri S, Vecchione A, Trapasso F, Croce CM.

Cancer Res. 2003 Mar 15;63(6):1183-7.


Lack of correlation between environmental or biological indicators of benzene exposure at parts per billion levels and micronuclei induction.

Violante FS, Sanguinetti G, Barbieri A, Accorsi A, Mattioli S, Cesari R, Fimognari C, Hrelia P.

Environ Res. 2003 Mar;91(3):135-42.


Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.

Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. Epub 2003 Feb 6.


Evolution of Antibiotic Use and Cost in Patients with Community-Acquired Pneumonia.

Sabbatani S, Cesari R, Pipitone E.

Clin Drug Investig. 2002 Sep;22(9):601-608. doi: 10.2165/00044011-200222090-00005.


Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression.

Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, Russo G, Hardy RR, Croce CM.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6955-60.


Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.

Fimognari C, Nüsse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P.

Carcinogenesis. 2002 Apr;23(4):581-6.


Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes.

Fimognari C, Nüsse M, Cesari R, Cantelli-Forti G, Hrelia P.

Mutat Res. 2001 Aug 22;495(1-2):1-9.


[The use of the Bullard laryngoscope].

Zocchi C, Spazzolini A, Cesari R, Buoncristiano M, Ravagnan R.

Minerva Anestesiol. 1992 Mar;58(3):135-7. Italian.


[Totally implantable system of venous access in patients with AIDS].

Zocchi C, Rapati D, Tagliabue L, Cesari R, Russo R, Ravagnan R.

Minerva Anestesiol. 1991 Sep;57(9):682-3. Italian. No abstract available.


[Electromyographic evaluation of muscle relaxation in leptonarcosis with depolarizing muscle relaxants in bolus].

Ravagnan R, Pelosi P, Zocchi C, Ravagnan I, Russo R, Cesari R.

Minerva Anestesiol. 1991 Sep;57(9):675-6. Italian. No abstract available.


[Kinetic study during amino acid infusion in catabolic patients. Comparison between two solutions].

Iapichino G, Radrizzani D, Veschi G, Bonetti G, Cesari R, Ciceri R, Guarnerio C, Quarenghi E, Rigoli A, Ronzoni G, et al.

Minerva Anestesiol. 1991 Mar;57(3):83-90. Italian.


The functional organization of thalamic afferents to the two subdivisions (areas 6a beta and 4 gamma) of cat motor cortex.

Cesari R, Michelini S, Spidalieri G, Vedovato M.

Arch Ital Biol. 1979 Jan;117(1):58-77. No abstract available.


Differential afferent organization of cytoarchitectonic subdivisions of cat motor cortex. Peripheral and cerebellar reactivities of neurones identified in area 6abeta.

Cesari R, Michelini S, Spidalieri G, Vedovato M.

Arch Ital Biol. 1977 Oct;115(4):386-408. No abstract available.


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