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Items: 32


CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle.

Sarek G, Kotsantis P, Ruis P, Van Ly D, Margalef P, Borel V, Zheng XF, Flynn HR, Snijders AP, Chowdhury D, Cesare AJ, Boulton SJ.

Nature. 2019 Nov 13. doi: 10.1038/s41586-019-1744-8. [Epub ahead of print]


Telomerase promotes formation of a telomere protective complex in cancer cells.

Perera ON, Sobinoff AP, Teber ET, Harman A, Maritz MF, Yang SF, Pickett HA, Cesare AJ, Arthur JW, MacKenzie KL, Bryan TM.

Sci Adv. 2019 Oct 2;5(10):eaav4409. doi: 10.1126/sciadv.aav4409. eCollection 2019 Oct.


Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.

Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, Cesare AJ.

Nat Commun. 2019 Sep 17;10(1):4224. doi: 10.1038/s41467-019-12255-w.


The mTOR pathway: Implications for DNA replication.

Lamm N, Rogers S, Cesare AJ.

Prog Biophys Mol Biol. 2019 Oct;147:17-25. doi: 10.1016/j.pbiomolbio.2019.04.002. Epub 2019 Apr 13. Review.


Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.

Lou J, Scipioni L, Wright BK, Bartolec TK, Zhang J, Masamsetti VP, Gaus K, Gratton E, Cesare AJ, Hinde E.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7323-7332. doi: 10.1073/pnas.1814965116. Epub 2019 Mar 27.


Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency.

Han M, Napier CE, Frölich S, Teber E, Wong T, Noble JR, Choi EHY, Everett RD, Cesare AJ, Reddel RR.

J Cell Sci. 2019 Mar 14;132(5). pii: jcs222349. doi: 10.1242/jcs.222349.


Telomere Loop Dynamics in Chromosome End Protection.

Van Ly D, Low RRJ, Frölich S, Bartolec TK, Kafer GR, Pickett HA, Gaus K, Cesare AJ.

Mol Cell. 2018 Aug 16;71(4):510-525.e6. doi: 10.1016/j.molcel.2018.06.025. Epub 2018 Jul 19.


MASTL overexpression promotes chromosome instability and metastasis in breast cancer.

Rogers S, McCloy RA, Parker BL, Gallego-Ortega D, Law AMK, Chin VT, Conway JRW, Fey D, Millar EKA, O'Toole S, Deng N, Swarbrick A, Chastain PD, Cesare AJ, Timpson P, Caldon CE, Croucher DR, James DE, Watkins DN, Burgess A.

Oncogene. 2018 Aug;37(33):4518-4533. doi: 10.1038/s41388-018-0295-z. Epub 2018 May 10.


Visualization of Telomere Integrity and Function In Vitro and In Vivo Using Immunofluorescence Techniques.

Cesare AJ, Heaphy CM, O'Sullivan RJ.

Curr Protoc Cytom. 2015 Jul 1;73:12.40.1-31. doi: 10.1002/0471142956.cy1240s73.


Cell death during crisis is mediated by mitotic telomere deprotection.

Hayashi MT, Cesare AJ, Rivera T, Karlseder J.

Nature. 2015 Jun 25;522(7557):492-6. doi: 10.1038/nature14513.


A genomics approach identifies senescence-specific gene expression regulation.

Lackner DH, Hayashi MT, Cesare AJ, Karlseder J.

Aging Cell. 2014 Oct;13(5):946-50. doi: 10.1111/acel.12234. Epub 2014 May 23.


The telomere deprotection response is functionally distinct from the genomic DNA damage response.

Cesare AJ, Hayashi MT, Crabbe L, Karlseder J.

Mol Cell. 2013 Jul 25;51(2):141-55. doi: 10.1016/j.molcel.2013.06.006. Epub 2013 Jul 11.


Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.

Crabbe L, Cesare AJ, Kasuboski JM, Fitzpatrick JA, Karlseder J.

Cell Rep. 2012 Dec 27;2(6):1521-9. doi: 10.1016/j.celrep.2012.11.019. Epub 2012 Dec 20.


A three-state model of telomere control over human proliferative boundaries.

Cesare AJ, Karlseder J.

Curr Opin Cell Biol. 2012 Dec;24(6):731-8. doi: 10.1016/ Epub 2012 Sep 2. Review.


A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest.

Hayashi MT, Cesare AJ, Fitzpatrick JA, Lazzerini-Denchi E, Karlseder J.

Nat Struct Mol Biol. 2012 Mar 11;19(4):387-94. doi: 10.1038/nsmb.2245.


Five dysfunctional telomeres predict onset of senescence in human cells.

Kaul Z, Cesare AJ, Huschtscha LI, Neumann AA, Reddel RR.

EMBO Rep. 2011 Dec 23;13(1):52-9. doi: 10.1038/embor.2011.227.


Alternative lengthening of telomeres: models, mechanisms and implications.

Cesare AJ, Reddel RR.

Nat Rev Genet. 2010 May;11(5):319-30. doi: 10.1038/nrg2763. Epub 2010 Mar 30. Review.


Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

Cesare AJ, Kaul Z, Cohen SB, Napier CE, Pickett HA, Neumann AA, Reddel RR.

Nat Struct Mol Biol. 2009 Dec;16(12):1244-51. doi: 10.1038/nsmb.1725. Epub 2009 Nov 22.


Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.

Basenko EY, Cesare AJ, Iyer S, Griffith JD, McEachern MJ.

Nucleic Acids Res. 2010 Jan;38(1):182-9. doi: 10.1093/nar/gkp814. Epub 2009 Oct 25.


Control of telomere length by a trimming mechanism that involves generation of t-circles.

Pickett HA, Cesare AJ, Johnston RL, Neumann AA, Reddel RR.

EMBO J. 2009 Apr 8;28(7):799-809. doi: 10.1038/emboj.2009.42. Epub 2009 Feb 12.


Telomere uncapping and alternative lengthening of telomeres.

Cesare AJ, Reddel RR.

Mech Ageing Dev. 2008 Jan-Feb;129(1-2):99-108. doi: 10.1016/j.mad.2007.11.006. Epub 2007 Dec 8. Review.


Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.

Cesare AJ, Groff-Vindman C, Compton SA, McEachern MJ, Griffith JD.

Mol Cell Biol. 2008 Jan;28(1):20-9. Epub 2007 Oct 29.


Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.

Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR.

J Biol Chem. 2007 Oct 5;282(40):29314-22. Epub 2007 Aug 9.


The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats.

Fouché N, Cesare AJ, Willcox S, Ozgür S, Compton SA, Griffith JD.

J Biol Chem. 2006 Dec 8;281(49):37486-95. Epub 2006 Oct 18.


Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.

Martin M, Cho J, Cesare AJ, Griffith JD, Attardi G.

Cell. 2005 Dec 29;123(7):1227-40.


Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.

Groff-Vindman C, Cesare AJ, Natarajan S, Griffith JD, McEachern MJ.

Mol Cell Biol. 2005 Jun;25(11):4406-12.


Telomere looping in P. sativum (common garden pea).

Cesare AJ, Quinney N, Willcox S, Subramanian D, Griffith JD.

Plant J. 2003 Oct;36(2):271-9.


Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1633-8. Epub 2003 Feb 10.


Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.

Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS.

Am J Hum Genet. 2002 Aug;71(2):337-48. Epub 2002 Jul 3. Erratum in: Am J Hum Genet 2002 Oct;72(4):1007.

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