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Items: 23

1.

Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells.

Pouzolles M, Machado A, Guilbaud M, Irla M, Gailhac S, Barennes P, Cesana D, Calabria A, Benedicenti F, Sergé A, Raman I, Li QZ, Montini E, Klatzmann D, Adjali O, Taylor N, Zimmermann VS.

J Allergy Clin Immunol. 2019 Sep 9. pii: S0091-6749(19)31171-6. doi: 10.1016/j.jaci.2019.08.029. [Epub ahead of print]

PMID:
31513879
2.

Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates.

Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Peters R, Iannacone M, Cantore A, Naldini L.

Sci Transl Med. 2019 May 22;11(493). pii: eaav7325. doi: 10.1126/scitranslmed.aav7325.

PMID:
31118293
3.

Testicular microbiome in azoospermic men-first evidence of the impact of an altered microenvironment.

Alfano M, Ferrarese R, Locatelli I, Ventimiglia E, Ippolito S, Gallina P, Cesana D, Canducci F, Pagliardini L, Viganò P, Clementi M, Nebuloni M, Montorsi F, Salonia A.

Hum Reprod. 2018 Jul 1;33(7):1212-1217. doi: 10.1093/humrep/dey116.

4.

A PLAG1 mutation contributed to stature recovery in modern cattle.

Utsunomiya YT, Milanesi M, Utsunomiya ATH, Torrecilha RBP, Kim ES, Costa MS, Aguiar TS, Schroeder S, do Carmo AS, Carvalheiro R, Neves HHR, Padula RCM, Sussai TS, Zavarez LB, Cipriano RS, Caminhas MMT, Hambrecht G, Colli L, Eufemi E, Ajmone-Marsan P, Cesana D, Sannazaro M, Buora M, Morgante M, Liu G, Bickhart D, Van Tassell CP, Sölkner J, Sonstegard TS, Garcia JF.

Sci Rep. 2017 Dec 7;7(1):17140. doi: 10.1038/s41598-017-17127-1.

5.

HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells.

Cesana D, Santoni de Sio FR, Rudilosso L, Gallina P, Calabria A, Beretta S, Merelli I, Bruzzesi E, Passerini L, Nozza S, Vicenzi E, Poli G, Gregori S, Tambussi G, Montini E.

Nat Commun. 2017 Sep 8;8(1):498. doi: 10.1038/s41467-017-00609-1.

6.

Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation.

Scholz SJ, Fronza R, Bartholomä CC, Cesana D, Montini E, von Kalle C, Gil-Farina I, Schmidt M.

Hum Gene Ther. 2017 Oct;28(10):875-885. doi: 10.1089/hum.2017.162. Epub 2017 Aug 18.

PMID:
28825370
7.

VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites.

Calabria A, Leo S, Benedicenti F, Cesana D, Spinozzi G, Orsini M, Merella S, Stupka E, Zanetti G, Montini E.

Genome Med. 2014 Sep 3;6(9):67. doi: 10.1186/s13073-014-0067-5. eCollection 2014.

8.

Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.

Petrillo C, Cesana D, Piras F, Bartolaccini S, Naldini L, Montini E, Kajaste-Rudnitski A.

Mol Ther. 2015 Feb;23(2):352-62. doi: 10.1038/mt.2014.193. Epub 2014 Oct 1.

9.

Estimation of sex from the hyoid body in skeletal individuals from archeological sites.

D'Anastasio R, Viciano J, Di Nicola M, Cesana DT, Sciubba M, Del Cimmuto M, Paolucci A, Fazio A, Capasso L.

Homo. 2014 Aug;65(4):311-21. doi: 10.1016/j.jchb.2014.01.002. Epub 2014 Mar 15.

PMID:
24767538
10.

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo.

Cesana D, Ranzani M, Volpin M, Bartholomae C, Duros C, Artus A, Merella S, Benedicenti F, Sergi Sergi L, Sanvito F, Brombin C, Nonis A, Serio CD, Doglioni C, von Kalle C, Schmidt M, Cohen-Haguenauer O, Naldini L, Montini E.

Mol Ther. 2014 Apr;22(4):774-85. doi: 10.1038/mt.2014.3. Epub 2014 Jan 20.

11.

Micro-biomechanics of the Kebara 2 hyoid and its implications for speech in Neanderthals.

D'Anastasio R, Wroe S, Tuniz C, Mancini L, Cesana DT, Dreossi D, Ravichandiran M, Attard M, Parr WC, Agur A, Capasso L.

PLoS One. 2013 Dec 18;8(12):e82261. doi: 10.1371/journal.pone.0082261. eCollection 2013.

12.

Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity.

Catucci M, Zanoni I, Draghici E, Bosticardo M, Castiello MC, Venturini M, Cesana D, Montini E, Ponzoni M, Granucci F, Villa A.

Eur J Immunol. 2014 Apr;44(4):1039-45. doi: 10.1002/eji.201343935. Epub 2014 Jan 13.

13.

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.

Ranzani M, Cesana D, Bartholomae CC, Sanvito F, Pala M, Benedicenti F, Gallina P, Sergi LS, Merella S, Bulfone A, Doglioni C, von Kalle C, Kim YJ, Schmidt M, Tonon G, Naldini L, Montini E.

Nat Methods. 2013 Feb;10(2):155-61. doi: 10.1038/nmeth.2331. Epub 2013 Jan 13.

14.

The possible correlation between dental enamel hypoplasia and a historic natural disaster in the Roman population of Herculaneum (79 AD - central Italy).

D'Anastasio R, Cesana DT, Viciano J, Sciubba M, Nibaruta P, Capasso L.

Anthropol Anz. 2013;70(4):369-83.

PMID:
24620565
15.

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

Cesana D, Sgualdino J, Rudilosso L, Merella S, Naldini L, Montini E.

J Clin Invest. 2012 May;122(5):1667-76. doi: 10.1172/JCI62189. Epub 2012 Apr 23.

16.

Genotoxicity assay for gene therapy vectors in tumor prone Cdkn2a⁻/⁻ mice.

Montini E, Cesana D.

Methods Enzymol. 2012;507:171-85. doi: 10.1016/B978-0-12-386509-0.00009-0.

PMID:
22365774
17.

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Lombardo A, Cesana D, Genovese P, Di Stefano B, Provasi E, Colombo DF, Neri M, Magnani Z, Cantore A, Lo Riso P, Damo M, Pello OM, Holmes MC, Gregory PD, Gritti A, Broccoli V, Bonini C, Naldini L.

Nat Methods. 2011 Aug 21;8(10):861-9. doi: 10.1038/nmeth.1674.

PMID:
21857672
18.

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.

Biffi A, Bartolomae CC, Cesana D, Cartier N, Aubourg P, Ranzani M, Cesani M, Benedicenti F, Plati T, Rubagotti E, Merella S, Capotondo A, Sgualdino J, Zanetti G, von Kalle C, Schmidt M, Naldini L, Montini E.

Blood. 2011 May 19;117(20):5332-9. doi: 10.1182/blood-2010-09-306761. Epub 2011 Mar 14.

PMID:
21403130
19.

Lentiviral vector integration profiles differ in rodent postmitotic tissues.

Bartholomae CC, Arens A, Balaggan KS, Yáñez-Muñoz RJ, Montini E, Howe SJ, Paruzynski A, Korn B, Appelt JU, Macneil A, Cesana D, Abel U, Glimm H, Naldini L, Ali RR, Thrasher AJ, von Kalle C, Schmidt M.

Mol Ther. 2011 Apr;19(4):703-10. doi: 10.1038/mt.2011.19. Epub 2011 Mar 1.

20.

Comprehensive genomic access to vector integration in clinical gene therapy.

Gabriel R, Eckenberg R, Paruzynski A, Bartholomae CC, Nowrouzi A, Arens A, Howe SJ, Recchia A, Cattoglio C, Wang W, Faber K, Schwarzwaelder K, Kirsten R, Deichmann A, Ball CR, Balaggan KS, Yáñez-Muñoz RJ, Ali RR, Gaspar HB, Biasco L, Aiuti A, Cesana D, Montini E, Naldini L, Cohen-Haguenauer O, Mavilio F, Thrasher AJ, Glimm H, von Kalle C, Saurin W, Schmidt M.

Nat Med. 2009 Dec;15(12):1431-6. doi: 10.1038/nm.2057. Epub 2009 Nov 22.

PMID:
19966782
21.

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

Montini E, Cesana D, Schmidt M, Sanvito F, Bartholomae CC, Ranzani M, Benedicenti F, Sergi LS, Ambrosi A, Ponzoni M, Doglioni C, Di Serio C, von Kalle C, Naldini L.

J Clin Invest. 2009 Apr;119(4):964-75. doi: 10.1172/JCI37630. Epub 2009 Mar 23.

22.

Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells in vitro.

Calzavara E, Chiaramonte R, Cesana D, Basile A, Sherbet GV, Comi P.

J Cell Biochem. 2008 Apr 1;103(5):1405-12.

PMID:
17849443
23.

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration.

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, Doglioni C, von Kalle C, Naldini L.

Nat Biotechnol. 2006 Jun;24(6):687-96. Epub 2006 May 28.

PMID:
16732270

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