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Precise tuning of gene expression levels in mammalian cells.

Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V, Fulga TA.

Nat Commun. 2019 Feb 18;10(1):818. doi: 10.1038/s41467-019-08777-y.


NKG2A, a New Kid on the Immune Checkpoint Block.

Haanen JB, Cerundolo V.

Cell. 2018 Dec 13;175(7):1720-1722. doi: 10.1016/j.cell.2018.11.048.


Urothelial cancer: a narrative review of the role of novel immunotherapeutic agents with particular reference to the management of non-muscle-invasive disease.

Doyle E, Crew J, Mostafid H, Tuthill M, Cerundolo V, Gerristen W, Protheroe A.

BJU Int. 2018 Dec 7. doi: 10.1111/bju.14643. [Epub ahead of print] Review.


The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies.

Gibani MM, Voysey M, Jin C, Jones C, Thomaides-Brears H, Jones E, Baker P, Morgan M, Simmons A, Gordon MA, Cerundolo V, Pitzer VE, Angus B, Levine MM, Darton TC, Pollard AJ.

Clin Infect Dis. 2018 Sep 25. doi: 10.1093/cid/ciy670. [Epub ahead of print]


Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

Napolitani G, Kurupati P, Teng KWW, Gibani MM, Rei M, Aulicino A, Preciado-Llanes L, Wong MT, Becht E, Howson L, de Haas P, Salio M, Blohmke CJ, Olsen LR, Pinto DMS, Scifo L, Jones C, Dobinson H, Campbell D, Juel HB, Thomaides-Brears H, Pickard D, Bumann D, Baker S, Dougan G, Simmons A, Gordon MA, Newell EW, Pollard AJ, Cerundolo V.

Nat Immunol. 2018 Jul;19(7):742-754. doi: 10.1038/s41590-018-0133-z. Epub 2018 Jun 20.


Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to oncogene activation in melanocytes.

Kenyon A, Gavriouchkina D, Zorman J, Chong-Morrison V, Napolitani G, Cerundolo V, Sauka-Spengler T.

Dis Model Mech. 2018 Apr 6;11(4). pii: dmm030056. doi: 10.1242/dmm.030056.


Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

Temko D, Van Gool IC, Rayner E, Glaire M, Makino S, Brown M, Chegwidden L, Palles C, Depreeuw J, Beggs A, Stathopoulou C, Mason J, Baker AM, Williams M, Cerundolo V, Rei M, Taylor JC, Schuh A, Ahmed A, Amant F, Lambrechts D, Smit VT, Bosse T, Graham TA, Church DN, Tomlinson I.

J Pathol. 2018 Jul;245(3):283-296. doi: 10.1002/path.5081. Epub 2018 Apr 30.


MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

Howson LJ, Napolitani G, Shepherd D, Ghadbane H, Kurupati P, Preciado-Llanes L, Rei M, Dobinson HC, Gibani MM, Teng KWW, Newell EW, Veerapen N, Besra GS, Pollard AJ, Cerundolo V.

Nat Commun. 2018 Jan 17;9(1):253. doi: 10.1038/s41467-017-02540-x.


Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy.

Bedard M, Salio M, Cerundolo V.

Front Immunol. 2017 Dec 18;8:1829. doi: 10.3389/fimmu.2017.01829. eCollection 2017. Review.


Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.

Kurioka A, van Wilgenburg B, Javan RR, Hoyle R, van Tonder AJ, Harrold CL, Leng T, Howson LJ, Shepherd D, Cerundolo V, Brueggemann AB, Klenerman P.

J Infect Dis. 2018 Mar 5;217(6):988-999. doi: 10.1093/infdis/jix647.


Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.

Khatamzas E, Hipp MM, Gaughan D, Pichulik T, Leslie A, Fernandes RA, Muraro D, Booth S, Zausmer K, Sun MY, Kessler B, Rowland-Jones S, Cerundolo V, Simmons A.

EMBO J. 2017 Oct 16;36(20):2998-3011. doi: 10.15252/embj.201695364. Epub 2017 Sep 18.


Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.

Salio M, Gasser O, Gonzalez-Lopez C, Martens A, Veerapen N, Gileadi U, Verter JG, Napolitani G, Anderson R, Painter G, Besra GS, Hermans IF, Cerundolo V.

J Immunol. 2017 Oct 15;199(8):2631-2638. doi: 10.4049/jimmunol.1700615. Epub 2017 Sep 6.


Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum.

Kenyon A, Gavriouchkina D, Zorman J, Napolitani G, Cerundolo V, Sauka-Spengler T.

Sci Rep. 2017 Jul 26;7(1):6505. doi: 10.1038/s41598-017-06099-x.


Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.

Johnson LA, Banerji S, Lawrance W, Gileadi U, Prota G, Holder KA, Roshorm YM, Hanke T, Cerundolo V, Gale NW, Jackson DG.

Nat Immunol. 2017 Jul;18(7):762-770. doi: 10.1038/ni.3750. Epub 2017 May 15.


M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C; MOSAIC investigators, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP.

JCI Insight. 2017 Apr 6;2(7):e91868. doi: 10.1172/jci.insight.91868.


Modulation of cancer-specific immune responses by amino acid degrading enzymes.

Timosenko E, Hadjinicolaou AV, Cerundolo V.

Immunotherapy. 2017 Jan;9(1):83-97. doi: 10.2217/imt-2016-0118. Review.


Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.

Cheung KL, Jarrett R, Subramaniam S, Salimi M, Gutowska-Owsiak D, Chen YL, Hardman C, Xue L, Cerundolo V, Ogg G.

J Exp Med. 2016 Oct 17;213(11):2399-2412. Epub 2016 Sep 26.


Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.

Timosenko E, Ghadbane H, Silk JD, Shepherd D, Gileadi U, Howson LJ, Laynes R, Zhao Q, Strausberg RL, Olsen LR, Taylor S, Buffa FM, Boyd R, Cerundolo V.

Cancer Res. 2016 Nov 1;76(21):6193-6204. Epub 2016 Sep 20.


Erratum to: B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation.

Galson JD, Trück J, Clutterbuck EA, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Genome Med. 2016 Aug 3;8(1):81. No abstract available.


B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation.

Galson JD, Trück J, Clutterbuck EA, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Genome Med. 2016 Jun 16;8(1):68. doi: 10.1186/s13073-016-0322-z. Erratum in: Genome Med. 2016;8(1):81.


Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses.

Dölen Y, Kreutz M, Gileadi U, Tel J, Vasaturo A, van Dinther EA, van Hout-Kuijer MA, Cerundolo V, Figdor CG.

Oncoimmunology. 2015 Aug 12;5(1):e1068493. eCollection 2016.


Expansion of highly activated invariant natural killer T cells with altered phenotype in acute dengue infection.

Kamaladasa A, Wickramasinghe N, Adikari TN, Gomes L, Shyamali NL, Salio M, Cerundolo V, Ogg GS, Malavige GN.

Clin Exp Immunol. 2016 Aug;185(2):228-38. doi: 10.1111/cei.12778.


Non-glycosidic compounds can stimulate both human and mouse iNKT cells.

Jukes JP, Gileadi U, Ghadbane H, Yu TF, Shepherd D, Cox LR, Besra GS, Cerundolo V.

Eur J Immunol. 2016 May;46(5):1224-34. doi: 10.1002/eji.201546114. Epub 2016 Mar 1.


Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.

Jarrett R, Salio M, Lloyd-Lavery A, Subramaniam S, Bourgeois E, Archer C, Cheung KL, Hardman C, Chandler D, Salimi M, Gutowska-Owsiak D, de la Serna JB, Fallon PG, Jolin H, Mckenzie A, Dziembowski A, Podobas EI, Bal W, Johnson D, Moody DB, Cerundolo V, Ogg G.

Sci Transl Med. 2016 Feb 10;8(325):325ra18. doi: 10.1126/scitranslmed.aad6833.


Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.

Galson JD, Trück J, Fowler A, Clutterbuck EA, Münz M, Cerundolo V, Reinhard C, van der Most R, Pollard AJ, Lunter G, Kelly DF.

EBioMedicine. 2015 Nov 24;2(12):2070-9. doi: 10.1016/j.ebiom.2015.11.034. eCollection 2015 Dec.


The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.

Torreno-Pina JA, Manzo C, Salio M, Aichinger MC, Oddone A, Lakadamyali M, Shepherd D, Besra GS, Cerundolo V, Garcia-Parajo MF.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E772-81. doi: 10.1073/pnas.1514530113. Epub 2016 Jan 21.


Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.

Nakaya HI, Clutterbuck E, Kazmin D, Wang L, Cortese M, Bosinger SE, Patel NB, Zak DE, Aderem A, Dong T, Del Giudice G, Rappuoli R, Cerundolo V, Pollard AJ, Pulendran B, Siegrist CA.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1853-8. doi: 10.1073/pnas.1519690113. Epub 2016 Jan 11.


Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.


In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor Repertoire.

Galson JD, Trück J, Fowler A, Münz M, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Front Immunol. 2015 Oct 12;6:531. doi: 10.3389/fimmu.2015.00531. eCollection 2015.


Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals.

Subramaniam S, Aslam A, Misbah SA, Salio M, Cerundolo V, Moody DB, Ogg G.

Eur J Immunol. 2016 Jan;46(1):242-52. doi: 10.1002/eji.201545869. Epub 2015 Nov 17.


Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials.

Salio M, Cerundolo V.

Front Immunol. 2015 Jul 28;6:388. doi: 10.3389/fimmu.2015.00388. eCollection 2015. Review.


MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases.

Howson LJ, Salio M, Cerundolo V.

Front Immunol. 2015 Jun 16;6:303. doi: 10.3389/fimmu.2015.00303. eCollection 2015. Review.


Gaps in knowledge and prospects for research of adjuvanted vaccines.

Seder R, Reed SG, O'Hagan D, Malyala P, D'Oro U, Laera D, Abrignani S, Cerundolo V, Steinman L, Bertholet S.

Vaccine. 2015 Jun 8;33 Suppl 2:B40-3. doi: 10.1016/j.vaccine.2015.03.057.


BCR repertoire sequencing: different patterns of B-cell activation after two Meningococcal vaccines.

Galson JD, Clutterbuck EA, Trück J, Ramasamy MN, Münz M, Fowler A, Cerundolo V, Pollard AJ, Lunter G, Kelly DF.

Immunol Cell Biol. 2015 Nov;93(10):885-95. doi: 10.1038/icb.2015.57. Epub 2015 May 15.


The regulatory role of invariant NKT cells in tumor immunity.

McEwen-Smith RM, Salio M, Cerundolo V.

Cancer Immunol Res. 2015 May;3(5):425-35. doi: 10.1158/2326-6066.CIR-15-0062. Review.


The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes.

Hipp MM, Shepherd D, Booth S, Waithe D, Reis e Sousa C, Cerundolo V.

J Immunol. 2015 Jun 1;194(11):5417-25. doi: 10.4049/jimmunol.1402703. Epub 2015 Apr 27.


CD1d-dependent endogenous and exogenous lipid antigen presentation.

McEwen-Smith RM, Salio M, Cerundolo V.

Curr Opin Immunol. 2015 Jun;34:116-25. doi: 10.1016/j.coi.2015.03.004. Epub 2015 Mar 23. Review.


T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.

Brodovitch A, Shenderov E, Cerundolo V, Bongrand P, Pierres A, van der Merwe PA.

Eur J Immunol. 2015 Jun;45(6):1635-42. doi: 10.1002/eji.201445214. Epub 2015 Apr 21.


Autophagy Controls Acquisition of Aging Features in Macrophages.

Stranks AJ, Hansen AL, Panse I, Mortensen M, Ferguson DJ, Puleston DJ, Shenderov K, Watson AS, Veldhoen M, Phadwal K, Cerundolo V, Simon AK.

J Innate Immun. 2015;7(4):375-91. doi: 10.1159/000370112. Epub 2015 Mar 10.


NKT-dependent B-cell activation in Gaucher disease.

Salio M, Cerundolo V.

Blood. 2015 Feb 19;125(8):1200-2. doi: 10.1182/blood-2014-12-617514.


Bee venom processes human skin lipids for presentation by CD1a.

Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G.

J Exp Med. 2015 Feb 9;212(2):149-63. doi: 10.1084/jem.20141505. Epub 2015 Jan 12.


Classification of current anticancer immunotherapies.

Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, Apte RN, Aranda F, Ayyoub M, Beckhove P, Blay JY, Bracci L, Caignard A, Castelli C, Cavallo F, Celis E, Cerundolo V, Clayton A, Colombo MP, Coussens L, Dhodapkar MV, Eggermont AM, Fearon DT, Fridman WH, Fučíková J, Gabrilovich DI, Galon J, Garg A, Ghiringhelli F, Giaccone G, Gilboa E, Gnjatic S, Hoos A, Hosmalin A, Jäger D, Kalinski P, Kärre K, Kepp O, Kiessling R, Kirkwood JM, Klein E, Knuth A, Lewis CE, Liblau R, Lotze MT, Lugli E, Mach JP, Mattei F, Mavilio D, Melero I, Melief CJ, Mittendorf EA, Moretta L, Odunsi A, Okada H, Palucka AK, Peter ME, Pienta KJ, Porgador A, Prendergast GC, Rabinovich GA, Restifo NP, Rizvi N, Sautès-Fridman C, Schreiber H, Seliger B, Shiku H, Silva-Santos B, Smyth MJ, Speiser DE, Spisek R, Srivastava PK, Talmadge JE, Tartour E, Van Der Burg SH, Van Den Eynde BJ, Vile R, Wagner H, Weber JS, Whiteside TL, Wolchok JD, Zitvogel L, Zou W, Kroemer G.

Oncotarget. 2014 Dec 30;5(24):12472-508. Review.


Essential role for autophagy during invariant NKT cell development.

Salio M, Puleston DJ, Mathan TS, Shepherd D, Stranks AJ, Adamopoulou E, Veerapen N, Besra GS, Hollander GA, Simon AK, Cerundolo V.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15.


Autophagy is a critical regulator of memory CD8(+) T cell formation.

Puleston DJ, Zhang H, Powell TJ, Lipina E, Sims S, Panse I, Watson AS, Cerundolo V, Townsend AR, Klenerman P, Simon AK.

Elife. 2014 Nov 11;3. doi: 10.7554/eLife.03706.


NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus.

Chen JL, Dawoodji A, Tarlton A, Gnjatic S, Tajar A, Karydis I, Browning J, Pratap S, Verfaille C, Venhaus RR, Pan L, Altman DG, Cebon JS, Old LL, Nathan P, Ottensmeier C, Middleton M, Cerundolo V.

Int J Cancer. 2015 Mar 15;136(6):E590-601. doi: 10.1002/ijc.29118. Epub 2014 Aug 14.


High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.

Dawoodji A, Chen JL, Shepherd D, Dalin F, Tarlton A, Alimohammadi M, Penna-Martinez M, Meyer G, Mitchell AL, Gan EH, Bratland E, Bensing S, Husebye ES, Pearce SH, Badenhoop K, Kämpe O, Cerundolo V.

J Immunol. 2014 Sep 1;193(5):2118-26. doi: 10.4049/jimmunol.1400056. Epub 2014 Jul 25.


Biology of CD1- and MR1-restricted T cells.

Salio M, Silk JD, Jones EY, Cerundolo V.

Annu Rev Immunol. 2014;32:323-66. doi: 10.1146/annurev-immunol-032713-120243. Epub 2014 Jan 31. Review.


Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A.

J Immunol. 2014 Mar 1;192(5):2029-2033. doi: 10.4049/jimmunol.1302549. Epub 2014 Jan 31.


Combinatorial HLA-peptide bead libraries for high throughput identification of CD8⁺ T cell specificity.

Pan X, Huang LC, Dong T, Peng Y, Cerundolo V, McGowan S, Ogg G.

J Immunol Methods. 2014 Jan 31;403(1-2):72-8. doi: 10.1016/j.jim.2013.11.023. Epub 2013 Dec 3.


Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18.

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