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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J, Headland SE, Blighe K, Ruscica M, Humby F, Lewis MJ, Kamphorst JJ, Bombardieri M, Pitzalis C, Mauro C.

Cell Metab. 2019 Oct 29. pii: S1550-4131(19)30559-5. doi: 10.1016/j.cmet.2019.10.004. [Epub ahead of print]


A four-step process for building sustainable access to diagnosis and treatment of Chagas disease.

Batista C, Forsyth CJ, Herazo R, Certo MP, Marchiol A.

Rev Panam Salud Publica. 2019 Sep 20;43:e74. doi: 10.26633/RPSP.2019.74. eCollection 2019.


Neuropeptides in Alzheimer's Disease: An Update.

Petrella C, Di Certo MG, Barbato C, Gabanella F, Ralli M, Greco A, Possenti R, Severini C.

Curr Alzheimer Res. 2019;16(6):544-558. doi: 10.2174/1567205016666190503152555.


Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects.

Cucchi D, Camacho-Muñoz D, Certo M, Niven J, Smith J, Nicolaou A, Mauro C.

Cardiovasc Res. 2019 Aug 10. pii: cvz208. doi: 10.1093/cvr/cvz208. [Epub ahead of print]


Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Leung WH, Gay J, Martin U, Garrett TE, Horton HM, Certo MT, Blazar BR, Morgan RA, Gregory PD, Jarjour J, Astrakhan A.

JCI Insight. 2019 Apr 30;5. pii: 124430. doi: 10.1172/jci.insight.124430.


Deep Venous Thrombosis and a Very Rare Finding: Inferior Vena Cava Infra-renal Segment Agenesis.

Leitão A, Esteves JM, Abreu JP, Pereira AF, Boncoraglio MT, Certo M, Ferreira RA.

Eur J Case Rep Intern Med. 2019 Mar 15;6(3):001063. doi: 10.12890/2019_001063. eCollection 2019.


Endoscopic Ultrasound-Guided Biliary Drainage in Two Patients with Difficult Biliary Access.

Libânio D, Giestas S, Martinez-Ares D, Ferreira F, Canena J, Certo M, Lopes L.

GE Port J Gastroenterol. 2018 Sep;25(5):258-263. doi: 10.1159/000485429. Epub 2017 Dec 20.


Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice.

Maiarù M, Leese C, Certo M, Echeverria-Altuna I, Mangione AS, Arsenault J, Davletov B, Hunt SP.

Sci Transl Med. 2018 Jul 18;10(450). pii: eaar7384. doi: 10.1126/scitranslmed.aar7384.


Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.

Pisani C, Strimpakos G, Gabanella F, Di Certo MG, Onori A, Severini C, Luvisetto S, Farioli-Vecchioli S, Carrozzo I, Esposito A, Canu T, Mattei E, Corbi N, Passananti C.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1172-1182. doi: 10.1016/j.bbadis.2018.01.030. Epub 2018 Jan 31.


Giant symptomatic rectal lipoma resected by endoscopic submucosal dissection.

Fernandes J, Libânio D, Giestas S, Araújo T, Martinez-Ares D, Certo M, Lopes L.

Endoscopy. 2018 Mar;50(3):E63-E64. doi: 10.1055/s-0043-123876. Epub 2017 Dec 21. No abstract available.


Reduction of the Harmonic Series Influences Musical Enjoyment With Cochlear Implants.

Nemer JS, Kohlberg GD, Mancuso DM, Griffin BM, Certo MV, Chen SY, Chun MB, Spitzer JB, Lalwani AK.

Otol Neurotol. 2017 Jan;38(1):31-37.


eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.

Pisani C, Onori A, Gabanella F, Delle Monache F, Borreca A, Ammassari-Teule M, Fanciulli M, Di Certo MG, Passananti C, Corbi N.

J Exp Clin Cancer Res. 2016 Sep 17;35(1):146. doi: 10.1186/s13046-016-0424-x.


Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence.

Zalcman G, Corbi N, Di Certo MG, Mattei E, Federman N, Romano A.

Neurosci Lett. 2016 Oct 6;632:169-74. doi: 10.1016/j.neulet.2016.08.055. Epub 2016 Aug 31.


Caspase-1-independent Maturation of IL-1β in Ischemic Brain Injury: is there a Role for Gelatinases?

Amantea D, Russo R, Certo M, Rombolà L, Adornetto A, Morrone LA, Corasaniti MT, Bagetta G.

Mini Rev Med Chem. 2016;16(9):729-37. Review.


Salient Features of Endonuclease Platforms for Therapeutic Genome Editing.

Certo MT, Morgan RA.

Mol Ther. 2016 Mar;24(3):422-9. doi: 10.1038/mt.2016.21. Epub 2016 Jan 22. Review.


SMN affects membrane remodelling and anchoring of the protein synthesis machinery.

Gabanella F, Pisani C, Borreca A, Farioli-Vecchioli S, Ciotti MT, Ingegnere T, Onori A, Ammassari-Teule M, Corbi N, Canu N, Monaco L, Passananti C, Di Certo MG.

J Cell Sci. 2016 Feb 15;129(4):804-16. doi: 10.1242/jcs.176750. Epub 2016 Jan 7.


Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke.

Certo M, Endo Y, Ohta K, Sakurada S, Bagetta G, Amantea D.

Pharmacol Res. 2015 Dec;102:298-307. doi: 10.1016/j.phrs.2015.10.009. Epub 2015 Nov 4.


Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype.

Amantea D, Certo M, Petrelli F, Tassorelli C, Micieli G, Corasaniti MT, Puccetti P, Fallarino F, Bagetta G.

Exp Neurol. 2016 Jan;275 Pt 1:116-25. doi: 10.1016/j.expneurol.2015.10.012. Epub 2015 Oct 27.


Drug repurposing and beyond: the fundamental role of pharmacology.

Amantea D, Certo M, Bagetta G.

Funct Neurol. 2015 Jan-Mar;30(1):79-81. No abstract available.


Pathways Implicated in Tadalafil Amelioration of Duchenne Muscular Dystrophy.

De Arcangelis V, Strimpakos G, Gabanella F, Corbi N, Luvisetto S, Magrelli A, Onori A, Passananti C, Pisani C, Rome S, Severini C, Naro F, Mattei E, Di Certo MG, Monaco L.

J Cell Physiol. 2016 Jan;231(1):224-32. doi: 10.1002/jcp.25075.


Rational modulation of the innate immune system for neuroprotection in ischemic stroke.

Amantea D, Micieli G, Tassorelli C, Cuartero MI, Ballesteros I, Certo M, Moro MA, Lizasoain I, Bagetta G.

Front Neurosci. 2015 Apr 29;9:147. doi: 10.3389/fnins.2015.00147. eCollection 2015. Review.


Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia.

Greco R, Tassorelli C, Mangione AS, Levandis G, Certo M, Nappi G, Bagetta G, Blandini F, Amantea D.

Eur J Pharmacol. 2014 Dec 5;744:91-7. doi: 10.1016/j.ejphar.2014.10.006. Epub 2014 Oct 15.


Reverberation time influences musical enjoyment with cochlear implants.

Certo MV, Kohlberg GD, Chari DA, Mancuso DM, Lalwani AK.

Otol Neurotol. 2015 Feb;36(2):e46-50. doi: 10.1097/MAO.0000000000000609.


Early reperfusion injury is associated to MMP2 and IL-1β elevation in cortical neurons of rats subjected to middle cerebral artery occlusion.

Amantea D, Certo M, Russo R, Bagetta G, Corasaniti MT, Tassorelli C.

Neuroscience. 2014 Sep 26;277:755-63. doi: 10.1016/j.neuroscience.2014.07.064. Epub 2014 Aug 7.


Design and analysis of site-specific single-strand nicking endonucleases for gene correction.

Metzger MJ, Certo MT.

Methods Mol Biol. 2014;1114:237-44. doi: 10.1007/978-1-62703-761-7_15.


Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.

Strimpakos G, Corbi N, Pisani C, Di Certo MG, Onori A, Luvisetto S, Severini C, Gabanella F, Monaco L, Mattei E, Passananti C.

J Cell Physiol. 2014 Sep;229(9):1283-91. doi: 10.1002/jcp.24567.


Understanding the multifaceted role of inflammatory mediators in ischemic stroke.

Amantea D, Tassorelli C, Petrelli F, Certo M, Bezzi P, Micieli G, Corasaniti MT, Bagetta G.

Curr Med Chem. 2014;21(18):2098-117. Review.


megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM.

Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26.


Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.

Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT.

Nucleic Acids Res. 2014 Jan;42(1):e4. doi: 10.1093/nar/gkt872. Epub 2013 Oct 10.


Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization.

Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M.

J Biol Chem. 2013 Aug 9;288(32):23348-57. doi: 10.1074/jbc.M113.465302. Epub 2013 Jun 24.


Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.

Pristerà A, Saraulli D, Farioli-Vecchioli S, Strimpakos G, Costanzi M, di Certo MG, Cannas S, Ciotti MT, Tirone F, Mattei E, Cestari V, Canu N.

Neurobiol Aging. 2013 Nov;34(11):2551-63. doi: 10.1016/j.neurobiolaging.2013.05.010. Epub 2013 Jun 12.


Age-related changes of hippocampal synaptic plasticity in AβPP-null mice are restored by NGF through p75NTR.

La Rosa LR, Matrone C, Ferraina C, Panico MB, Piccirilli S, Di Certo MG, Strimpakos G, Mercuri NB, Calissano P, D'Amelio M, Nisticò R.

J Alzheimers Dis. 2013;33(1):265-72. doi: 10.3233/JAD-2012-112108.


Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.

Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM.

Nat Methods. 2012 Oct;9(10):973-5. doi: 10.1038/nmeth.2177. Epub 2012 Sep 2.


Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice.

Cinque C, Pondiki S, Oddi D, Di Certo MG, Marinelli S, Troisi A, Moles A, D'Amato FR.

Transl Psychiatry. 2012 Aug 28;2:e155. doi: 10.1038/tp.2012.83.


Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.

Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK.

Nucleic Acids Res. 2012 Jul;40(12):5560-8. doi: 10.1093/nar/gks179. Epub 2012 Feb 28.


Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.

Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2012 Jun;40(11):4954-64. doi: 10.1093/nar/gkr1303. Epub 2012 Feb 14.


Tracking genome engineering outcome at individual DNA breakpoints.

Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM.

Nat Methods. 2011 Jul 10;8(8):671-6. doi: 10.1038/nmeth.1648.


The eEF1γ subunit contacts RNA polymerase II and binds vimentin promoter region.

Corbi N, Batassa EM, Pisani C, Onori A, Di Certo MG, Strimpakos G, Fanciulli M, Mattei E, Passananti C.

PLoS One. 2010 Dec 31;5(12):e14481. doi: 10.1371/journal.pone.0014481.


Imaging of pancreas transplantation and its complications.

França M, Certo M, Martins L, Varzim P, Teixeira M, Henriques AC, Ribeiro AM, Alves FC.

Insights Imaging. 2010 Nov;1(5-6):329-338. Epub 2010 Oct 1.


Angiomegaly and arterial aneurysms.

D'Andrea V, Cantisani V, Catania A, Todini A, Stio F, Di Matteo FM, Di Marco C, Greco R, Di Certo M, Guaitoli E, De Antoni E.

G Chir. 2010 Oct;31(10):429-32.


Elderly patient with acute, left lower abdominal pain: perforated jejunal diverticulitis (2010:7b).

França M, Certo M, Silva D, Peixoto C, Varzim P.

Eur Radiol. 2010 Oct;20(10):2541-5. doi: 10.1007/s00330-010-1726-6. Epub 2010 Sep 15.


Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene.

Passananti C, Corbi N, Onori A, Di Certo MG, Mattei E.

Methods Mol Biol. 2010;649:183-206. doi: 10.1007/978-1-60761-753-2_11.


The artificial gene Jazz, a transcriptional regulator of utrophin, corrects the dystrophic pathology in mdx mice.

Di Certo MG, Corbi N, Strimpakos G, Onori A, Luvisetto S, Severini C, Guglielmotti A, Batassa EM, Pisani C, Floridi A, Benassi B, Fanciulli M, Magrelli A, Mattei E, Passananti C.

Hum Mol Genet. 2010 Mar 1;19(5):752-60. doi: 10.1093/hmg/ddp539. Epub 2009 Dec 4.


High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.

Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2009 Nov;37(20):6871-80. doi: 10.1093/nar/gkp726. Epub 2009 Sep 8.


Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference.

Gasbarrini A, Corazza GR, Gasbarrini G, Montalto M, Di Stefano M, Basilisco G, Parodi A, Usai-Satta P, Vernia P, Anania C, Astegiano M, Barbara G, Benini L, Bonazzi P, Capurso G, Certo M, Colecchia A, Cuoco L, Di Sario A, Festi D, Lauritano C, Miceli E, Nardone G, Perri F, Portincasa P, Risicato R, Sorge M, Tursi A; 1st Rome H2-Breath Testing Consensus Conference Working Group.

Aliment Pharmacol Ther. 2009 Mar 30;29 Suppl 1:1-49. doi: 10.1111/j.1365-2036.2009.03951.x. Erratum in: Aliment Pharmacol Ther. 2010 Jan;31(1):166. Satta PU [corrected to Usai-Satta P].


Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation.

Desantis A, Onori A, Di Certo MG, Mattei E, Fanciulli M, Passananti C, Corbi N.

Neuromuscul Disord. 2009 Feb;19(2):158-62. doi: 10.1016/j.nmd.2008.11.005. Epub 2009 Jan 21.


Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.

Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.

Nucleic Acids Res. 2009 Feb;37(3):877-90. doi: 10.1093/nar/gkn1007. Epub 2008 Dec 22.


Delayed internalization and lack of recycling in a beta2-adrenergic receptor fused to the G protein alpha-subunit.

Di Certo MG, Batassa EM, Casella I, Serafino A, Floridi A, Passananti C, Molinari P, Mattei E.

BMC Cell Biol. 2008 Oct 7;9:56. doi: 10.1186/1471-2121-9-56.


The water immersion technique is easy to learn for routine use during EGD for duodenal villous evaluation: a single-center 2-year experience.

Cammarota G, Cesaro P, Cazzato A, Cianci R, Fedeli P, Ojetti V, Certo M, Sparano L, Giovannini S, Larocca LM, Vecchio FM, Gasbarrini G.

J Clin Gastroenterol. 2009 Mar;43(3):244-8. doi: 10.1097/MCG.0b013e318159c654.


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