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Items: 45

1.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group, Carel JC, Tubiana-Rufi N, Martinerie L, Poidvin A, JacqzAigrain E, Corvez L, Berruer V, Gautier JF, Baz B, Haddadi N, Andreelli F, Amouyal C, Jaqueminet S, Bourron O, Dasque E, Hartemann A, Lemoine-Yazigi A, Dubois-Laforgue D, Travert F, Feron M, Rolland P, Vignali V, Marre M, Chanson P, Briet C, Guillausseau PJ, Ait-Bachir L, Collet C, Beziaud F, Desforges-Bullet V, Petit-Aubert G, Christin-Maitre S, Fève B, Vatier C, Bourcigaux N, Lautridou C, Lahlou N, Bakouboula P, Elie C, Morel H, Treluyer JM, Gagnerault MC, Maillard C, Jones A.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
2.

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

Schwedhelm K, Thorpe J, Murray SA, Gavin M, Speake C, Greenbaum C, Cerosaletti K, Buckner J, Long SA.

Clin Immunol. 2017 Aug;181:67-74. doi: 10.1016/j.clim.2017.06.004. Epub 2017 Jun 20.

PMID:
28645874
3.

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.

Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, DeBerg HA, Dufort MJ, Murray SA, Israelsson E, Speake C, Gersuk VH, Eddy JA, Reijonen H, Greenbaum CJ, Kwok WW, Wambre E, Prlic M, Gottardo R, Nepom GT, Linsley PS.

J Immunol. 2017 Jul 1;199(1):323-335. doi: 10.4049/jimmunol.1700172. Epub 2017 May 31.

4.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.

5.

The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.

Dam EM, Habib T, Chen J, Funk A, Glukhova V, Davis-Pickett M, Wei S, James R, Buckner JH, Cerosaletti K.

Clin Immunol. 2016 Dec;173:171-180. doi: 10.1016/j.clim.2016.10.018. Epub 2016 Nov 2.

6.

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Hundhausen C, Roth A, Whalen E, Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH.

Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943.

7.

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF.

Nucleic Acids Res. 2015 Sep 30;43(17):8352-67. doi: 10.1093/nar/gkv754. Epub 2015 Aug 3.

8.

Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance.

Gupta S, Cerosaletti K, Long SA.

Clin Immunol. 2014 Apr;151(2):146-54. doi: 10.1016/j.clim.2014.02.007. Epub 2014 Feb 24. Review.

PMID:
24576418
9.

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

Cerosaletti K, Schneider A, Schwedhelm K, Frank I, Tatum M, Wei S, Whalen E, Greenbaum C, Kita M, Buckner J, Long SA.

PLoS One. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811. eCollection 2013.

10.

A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping.

Estorninho M, Gibson VB, Kronenberg-Versteeg D, Liu YF, Ni C, Cerosaletti K, Peakman M.

J Immunol. 2013 Dec 1;191(11):5430-40. doi: 10.4049/jimmunol.1300622. Epub 2013 Oct 25.

11.

In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling.

Schneider A, Long SA, Cerosaletti K, Ni CT, Samuels P, Kita M, Buckner JH.

Sci Transl Med. 2013 Jan 30;5(170):170ra15. doi: 10.1126/scitranslmed.3004970.

12.

NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks.

Wen J, Cerosaletti K, Schultz KJ, Wright JA, Concannon P.

Oncogene. 2013 Sep 12;32(37):4448-56. doi: 10.1038/onc.2012.443. Epub 2012 Nov 12.

13.

Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.

Cerosaletti K, Buckner JH.

Rev Diabet Stud. 2012 Winter;9(4):188-200. doi: 10.1900/RDS.2012.9.188. Epub 2012 Dec 28. Review.

14.

Ultra-sensitive detection of rare T cell clones.

Robins H, Desmarais C, Matthis J, Livingston R, Andriesen J, Reijonen H, Carlson C, Nepom G, Yee C, Cerosaletti K.

J Immunol Methods. 2012 Jan 31;375(1-2):14-9. doi: 10.1016/j.jim.2011.09.001. Epub 2011 Sep 10.

15.

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.

Long SA, Cerosaletti K, Wan JY, Ho JC, Tatum M, Wei S, Shilling HG, Buckner JH.

Genes Immun. 2011 Mar;12(2):116-25. doi: 10.1038/gene.2010.54. Epub 2010 Dec 23.

16.

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.

Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, Zhang ZY, Pihoker C, Sanda S, Greenbaum C, Buckner JH.

Diabetes. 2010 Feb;59(2):407-15. doi: 10.2337/db09-0694. Epub 2009 Oct 29.

17.

A novel mutation in a family with DNA ligase IV deficiency syndrome.

Unal S, Cerosaletti K, Uckan-Cetinkaya D, Cetin M, Gumruk F.

Pediatr Blood Cancer. 2009 Sep;53(3):482-4. doi: 10.1002/pbc.22031.

PMID:
19418549
18.

Nuclear export of NBN is required for normal cellular responses to radiation.

Vissinga CS, Yeo TC, Warren S, Brawley JV, Phillips J, Cerosaletti K, Concannon P.

Mol Cell Biol. 2009 Feb;29(4):1000-6. doi: 10.1128/MCB.01131-08. Epub 2008 Dec 15.

19.

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.

Stiff T, Cerosaletti K, Concannon P, O'Driscoll M, Jeggo PA.

Hum Mol Genet. 2008 Oct 15;17(20):3247-53. doi: 10.1093/hmg/ddn220. Epub 2008 Jul 28.

20.

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA.

EMBO J. 2006 Dec 13;25(24):5775-82. Epub 2006 Nov 23.

21.

Active role for nibrin in the kinetics of atm activation.

Cerosaletti K, Wright J, Concannon P.

Mol Cell Biol. 2006 Mar;26(5):1691-9.

22.

A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome.

Ben-Omran TI, Cerosaletti K, Concannon P, Weitzman S, Nezarati MM.

Am J Med Genet A. 2005 Sep 1;137A(3):283-7.

PMID:
16088910
23.

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

Cerosaletti K, Concannon P.

J Biol Chem. 2004 Sep 10;279(37):38813-9. Epub 2004 Jul 1.

24.

Functional delivery of large genomic DNA to human cells with a peptide-lipid vector.

White RE, Wade-Martins R, Hart SL, Frampton J, Huey B, Desai-Mehta A, Cerosaletti KM, Concannon P, James MR.

J Gene Med. 2003 Oct;5(10):883-892. doi: 10.1002/jgm.420.

PMID:
14533197
25.
26.

Medulloblastoma with adverse reaction to radiation therapy in nijmegen breakage syndrome.

Bakhshi S, Cerosaletti KM, Concannon P, Bawle EV, Fontanesi J, Gatti RA, Bhambhani K.

J Pediatr Hematol Oncol. 2003 Mar;25(3):248-51.

PMID:
12621246
27.

Mutations and molecular variants of the NBS1 gene in non-Hodgkin lymphoma.

Cerosaletti KM, Morrison VA, Sabath DE, Willerford DM, Concannon P.

Genes Chromosomes Cancer. 2002 Nov;35(3):282-6.

PMID:
12353271
28.

Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families.

Resnick IB, Kondratenko I, Togoev O, Vasserman N, Shagina I, Evgrafov O, Tverskaya S, Cerosaletti KM, Gatti RA, Concannon P.

J Pediatr. 2002 Mar;140(3):355-61.

PMID:
11953735
29.

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.

O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P.

Mol Cell. 2001 Dec;8(6):1175-85.

30.

Nijmegen breakage syndrome in a Dutch patient not resulting from a defect in NBS1.

Hiel JA, Weemaes CM, van Engelen BG, Smeets D, Ligtenberg M, van Der Burgt I, van Den Heuvel LP, Cerosaletti KM, Gabreëls FJ, Concannon P.

J Med Genet. 2001 Jun;38(6):E19. No abstract available.

31.

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization.

Desai-Mehta A, Cerosaletti KM, Concannon P.

Mol Cell Biol. 2001 Mar;21(6):2184-91.

32.

ATM-dependent phosphorylation of nibrin in response to radiation exposure.

Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K.

Nat Genet. 2000 May;25(1):115-9.

PMID:
10802669
33.

Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation.

Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, Concannon P.

Mutagenesis. 2000 May;15(3):281-6.

PMID:
10792024
34.

Fine localization of the Nijmegen breakage syndrome gene to 8q21: evidence for a common founder haplotype.

Cerosaletti KM, Lange E, Stringham HM, Weemaes CM, Smeets D, Sölder B, Belohradsky BH, Taylor AM, Karnes P, Elliott A, Komatsu K, Gatti RA, Boehnke M, Concannon P.

Am J Hum Genet. 1998 Jul;63(1):125-34.

35.

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.

Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanová E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A.

Cell. 1998 May 1;93(3):467-76.

36.
37.

Extinction of albumin gene expression in a panel of human chromosome 2 microcell hybrids.

Cerosaletti KM, Fournier RE.

Genomics. 1996 Feb 1;31(3):348-58.

PMID:
8838317
38.

Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1.

Hulsebos TJ, Cerosaletti KM, Fournier RE, Sinke RJ, Rocchi M, Marzella R, Jenkins NA, Gilbert DJ, Copeland NG.

Genomics. 1995 Aug 10;28(3):543-8.

PMID:
7490092
39.

The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes.

Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW.

Genomics. 1995 May 1;27(1):196-9.

PMID:
7665170
40.

Cloning mammary cell cDNAs from 17q12-q23 using interspecific somatic cell hybrids and subtractive hybridization.

Cerosaletti KM, Shapero MH, Fournier RE.

Genomics. 1995 Jan 1;25(1):226-37.

PMID:
7774923
41.

Two regions of the H-2 Dd promoter are responsive to dimethylsulfoxide in line 1 cells by a mechanism distinct from IFN-gamma.

Cerosaletti KM, Woodward JG, Lord EM, Frelinger JG.

J Immunol. 1992 Feb 15;148(4):1212-21.

PMID:
1737936
42.

Class-I MHC expression in the mouse lung carcinoma, line 1: a model for class-I inducible tumors.

Blieden TM, McAdam AJ, Foresman MD, Cerosaletti KM, Frelinger JG, Lord EM.

Int J Cancer Suppl. 1991;6:82-9.

PMID:
1906056
43.

Alteration of the metastatic potential of line 1 lung carcinoma cells: opposite effects of class I antigen induction by interferons versus DMSO or gene transfection.

Cerosaletti KM, Blieden TM, Harwell LW, Welsh KM, Frelinger JG, Lord EM.

Cell Immunol. 1990 May;127(2):299-310.

PMID:
1691690
44.

Molecular analysis of deficient class I H-2 antigen expression by mouse lung carcinoma cells.

Bahler DW, Cerosaletti KM, Lord EM, Frelinger JG.

J Immunol. 1988 Jun 1;140(11):4003-12.

PMID:
2453562
45.

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