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Items: 16

1.

Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):979-984. doi: 10.1016/j.bmcl.2017.12.015. Epub 2017 Dec 8.

PMID:
29254646
2.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD.

Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10.

3.

Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates.

Weldon SM, Cerny MA, Gueneva-Boucheva K, Cogan D, Guo X, Moss N, Parmentier JH, Richman JR, Reinhart GA, Brown NF.

J Pharmacol Exp Ther. 2016 Oct;359(1):142-50. doi: 10.1124/jpet.116.236463. Epub 2016 Aug 1.

4.

Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.

Cerny MA.

Drug Metab Dispos. 2016 Aug;44(8):1246-52. doi: 10.1124/dmd.116.070763. Epub 2016 Apr 15. Review.

5.

Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation.

Sadeque AJ, Palamar S, Usmani KA, Chen C, Cerny MA, Chen WG.

Drug Metab Dispos. 2016 Apr;44(4):570-5. doi: 10.1124/dmd.115.067397. Epub 2016 Jan 12.

6.

Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.

Cerny MA, Csengery A, Schmenk J, Frederick K.

J Steroid Biochem Mol Biol. 2015 Nov;154:197-205. doi: 10.1016/j.jsbmb.2015.08.004. Epub 2015 Aug 21.

PMID:
26303746
7.

Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.

Hutzler JM, Cerny MA, Yang YS, Asher C, Wong D, Frederick K, Gilpin K.

Drug Metab Dispos. 2014 Oct;42(10):1751-60. doi: 10.1124/dmd.114.059030. Epub 2014 Jul 17.

8.

G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.

Fryer RM, Ng KJ, Nodop Mazurek SG, Patnaude L, Skow DJ, Muthukumarana A, Gilpin KE, Dinallo RM, Kuzmich D, Lord J, Sanyal S, Yu H, Harcken C, Cerny MA, Hickey ER, Modis LK.

J Pharmacol Exp Ther. 2014 Mar;348(3):421-31. doi: 10.1124/jpet.113.210005. Epub 2014 Jan 7. Erratum in: J Pharmacol Exp Ther. 2014 Apr;349(1):174. Cerny, Matthew C [corrected to Cerny, Matthew A]. J Pharmacol Exp Ther. 2014 Mar;348(3):492.

9.

Progress towards clinically useful aldosterone synthase inhibitors.

Cerny MA.

Curr Top Med Chem. 2013;13(12):1385-401. Review.

PMID:
23688131
10.

Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.

Sadeque AJ, Usmani KA, Palamar S, Cerny MA, Chen WG.

Drug Metab Dispos. 2012 Apr;40(4):772-8. doi: 10.1124/dmd.111.043448. Epub 2012 Jan 18.

11.

Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.

Zhang J, Cerny MA, Lawson M, Mosadeghi R, Cashman JR.

J Biochem Mol Toxicol. 2007;21(4):206-15.

PMID:
17721934
12.

Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR.

J Med Chem. 2006 Nov 30;49(24):6987-7001.

PMID:
17125252
13.

Investigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3.

Borbás T, Zhang J, Cerny MA, Likó I, Cashman JR.

Drug Metab Dispos. 2006 Dec;34(12):1995-2002. Epub 2006 Sep 19.

15.

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.

Cerny MA, Hanzlik RP.

Arch Biochem Biophys. 2005 Apr 15;436(2):265-75.

PMID:
15797239
16.

1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard.

Lucas LH, Cerny MA, Koen YM, Hanzlik RP, Larive CK.

Anal Bioanal Chem. 2004 Oct;380(4):627-31. Epub 2004 Oct 7.

PMID:
15480583

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