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Items: 12


Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS.

Lin S, Dikler S, Blincoe WD, Ferguson RD, Sheridan RP, Peng Z, Conway DV, Zawatzky K, Wang H, Cernak T, Davies IW, DiRocco DA, Sheng H, Welch CJ, Dreher SD.

Science. 2018 Aug 10;361(6402). pii: eaar6236. doi: 10.1126/science.aar6236. Epub 2018 May 24.


Nanoscale synthesis and affinity ranking.

Gesmundo NJ, Sauvagnat B, Curran PJ, Richards MP, Andrews CL, Dandliker PJ, Cernak T.

Nature. 2018 May;557(7704):228-232. doi: 10.1038/s41586-018-0056-8. Epub 2018 Apr 23.


Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.

Cernak T, Dykstra KD, Tyagarajan S, Vachal P, Krska SW.

Chem Soc Rev. 2017 Mar 21;46(6):1760. doi: 10.1039/c7cs90023f.


Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Cernak T, Gesmundo NJ, Dykstra K, Yu Y, Wu Z, Shi ZC, Vachal P, Sperbeck D, He S, Murphy BA, Sonatore L, Williams S, Madeira M, Verras A, Reiter M, Lee CH, Cuff J, Sherer EC, Kuethe J, Goble S, Perrotto N, Pinto S, Shen DM, Nargund R, Balkovec J, DeVita RJ, Dreher SD.

J Med Chem. 2017 May 11;60(9):3594-3605. doi: 10.1021/acs.jmedchem.6b01543. Epub 2017 Mar 2.


Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods.

Kutchukian PS, Dropinski JF, Dykstra KD, Li B, DiRocco DA, Streckfuss EC, Campeau LC, Cernak T, Vachal P, Davies IW, Krska SW, Dreher SD.

Chem Sci. 2016 Apr 21;7(4):2604-2613. doi: 10.1039/c5sc04751j. Epub 2016 Jan 26.


The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.

Cernak T, Dykstra KD, Tyagarajan S, Vachal P, Krska SW.

Chem Soc Rev. 2016 Feb 7;45(3):546-76. doi: 10.1039/c5cs00628g. Epub 2015 Oct 28.


Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.

Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD.

Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20.


Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

He S, Hong Q, Lai Z, Yang DX, Ting PC, Kuethe JT, Cernak TA, Dykstra KD, Sperbeck DM, Wu Z, Yu Y, Yang GX, Jian T, Liu J, Guiadeen D, Krikorian AD, Sonatore LM, Wiltsie J, Liu J, Gorski JN, Chung CC, Gibson JT, Lisnock J, Xiao J, Wolff M, Tong SX, Madeira M, Karanam BV, Shen DM, Balkovec JM, Pinto S, Nargund RP, DeVita RJ.

ACS Med Chem Lett. 2014 Sep 8;5(10):1082-7. doi: 10.1021/ml5003426. eCollection 2014 Oct 9.


Profound methyl effects in drug discovery and a call for new C-H methylation reactions.

Schönherr H, Cernak T.

Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12256-67. doi: 10.1002/anie.201303207. Epub 2013 Oct 22. Review.


Stable 5-substituted cyclopentadienes for the Diels-Alder cycloaddition and their application to the synthesis of palau'amine.

Hudon J, Cernak TA, Ashenhurst JA, Gleason JL.

Angew Chem Int Ed Engl. 2008;47(46):8885-8. doi: 10.1002/anie.200803344. No abstract available.


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