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Items: 1 to 50 of 277

1.

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.

Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA.

Cell Rep. 2019 Oct 1;29(1):76-88.e7. doi: 10.1016/j.celrep.2019.08.076.

2.

Starving the Devourer: Cutting Cancer Off from Its Favorite Foods.

Katt WP, Lukey MJ, Cerione RA.

Cell Chem Biol. 2019 Sep 19;26(9):1197-1199. doi: 10.1016/j.chembiol.2019.09.005.

PMID:
31539503
3.

Inhibition of cancer metabolism: a patent landscape.

Katt WP, Cerione RA.

Pharm Pat Anal. 2019 Jul;8(4):117-138. doi: 10.4155/ppa-2019-0012. Epub 2019 Aug 15.

PMID:
31414969
4.

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G.

Mol Cell. 2019 Aug 22;75(4):781-790.e3. doi: 10.1016/j.molcel.2019.06.007. Epub 2019 Jul 9.

PMID:
31300275
5.

New insights into extracellular vesicle biogenesis and function.

Latifkar A, Hur YH, Sanchez JC, Cerione RA, Antonyak MA.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs222406. doi: 10.1242/jcs.222406. Review.

PMID:
31263077
6.

Reconstitution of the Rhodopsin-Transducin Complex into Lipid Nanodiscs.

Gao Y, Erickson JW, Cerione RA, Ramachandran S.

Methods Mol Biol. 2019;2009:317-324. doi: 10.1007/978-1-4939-9532-5_24.

PMID:
31152414
7.

Purification of the Rhodopsin-Transducin Complex for Structural Studies.

Gao Y, Erickson JW, Cerione RA, Ramachandran S.

Methods Mol Biol. 2019;2009:307-315. doi: 10.1007/978-1-4939-9532-5_23.

PMID:
31152413
8.

Matrix stiffness regulates microvesicle-induced fibroblast activation.

Schwager SC, Bordeleau F, Zhang J, Antonyak MA, Cerione RA, Reinhart-King CA.

Am J Physiol Cell Physiol. 2019 Jul 1;317(1):C82-C92. doi: 10.1152/ajpcell.00418.2018. Epub 2019 Apr 24.

PMID:
31017799
9.

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.

Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA.

Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11.

PMID:
30982660
10.

Lipid-filled vesicles modulate macrophages.

Antonyak MA, Lukey MJ, Cerione RA.

Science. 2019 Mar 1;363(6430):931-932. doi: 10.1126/science.aaw6765. No abstract available.

PMID:
30819952
11.

Opening up about Tissue Transglutaminase: When Conformation Matters More than Enzymatic Activity.

Katt WP, Antonyak MA, Cerione RA.

Med One. 2018;3(6). pii: e180011. doi: 10.20900/mo.20180011. Epub 2018 Nov 22.

12.

Amorphous Quantum Nanomaterials.

Kohle FFE, Hinckley JA, Li S, Dhawan N, Katt WP, Erstling JA, Werner-Zwanziger U, Zwanziger J, Cerione RA, Wiesner UB.

Adv Mater. 2019 Feb;31(5):e1806993. doi: 10.1002/adma.201806993. Epub 2018 Dec 5.

PMID:
30516861
13.

A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cells.

Katt WP, Blobel NJ, Komarova S, Antonyak MA, Nakano I, Cerione RA.

Oncotarget. 2018 Sep 28;9(76):34379-34397. doi: 10.18632/oncotarget.26193. eCollection 2018 Sep 28.

14.

Probing the mechanisms of extracellular vesicle biogenesis and function in cancer.

Latifkar A, Cerione RA, Antonyak MA.

Biochem Soc Trans. 2018 Oct 19;46(5):1137-1146. doi: 10.1042/BST20180523. Epub 2018 Oct 8. Review.

PMID:
30301841
15.

Gain-of-function screen of α-transducin identifies an essential phenylalanine residue necessary for full effector activation.

Milano SK, Wang C, Erickson JW, Cerione RA, Ramachandran S.

J Biol Chem. 2018 Nov 16;293(46):17941-17952. doi: 10.1074/jbc.RA118.003746. Epub 2018 Sep 28.

PMID:
30266806
16.

Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.

Lukey MJ, Katt WP, Cerione RA.

Cancer Cell. 2018 May 14;33(5):795-797. doi: 10.1016/j.ccell.2018.04.009.

17.

The diamond anniversary of tissue transglutaminase: a protein of many talents.

Katt WP, Antonyak MA, Cerione RA.

Drug Discov Today. 2018 Mar;23(3):575-591. doi: 10.1016/j.drudis.2018.01.037. Epub 2018 Jan 31. Review.

18.

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.

Huang Q, Stalnecker C, Zhang C, McDermott LA, Iyer P, O'Neill J, Reimer S, Cerione RA, Katt WP.

J Biol Chem. 2018 Mar 9;293(10):3535-3545. doi: 10.1074/jbc.M117.810101. Epub 2018 Jan 9.

19.

The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression.

Yoo SM, Cerione RA, Antonyak MA.

Small GTPases. 2017 Oct 5:1-9. doi: 10.1080/21541248.2017.1362496. [Epub ahead of print]

PMID:
28981399
20.

Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.

Gao Y, Westfield G, Erickson JW, Cerione RA, Skiniotis G, Ramachandran S.

J Biol Chem. 2017 Aug 25;292(34):14280-14289. doi: 10.1074/jbc.M117.797100. Epub 2017 Jun 27.

21.

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.

22.

ALDH1A3 in CSCs.

Sullivan KE, Cerione RA, Wilson KF.

Aging (Albany NY). 2017 May 3;9(5):1351-1352. doi: 10.18632/aging.101236. No abstract available.

23.

The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells.

Sullivan KE, Rojas K, Cerione RA, Nakano I, Wilson KF.

Oncotarget. 2017 Apr 4;8(14):22325-22343. doi: 10.18632/oncotarget.16479.

24.

Glutamine Metabolism in Cancer: Understanding the Heterogeneity.

Cluntun AA, Lukey MJ, Cerione RA, Locasale JW.

Trends Cancer. 2017 Mar;3(3):169-180. doi: 10.1016/j.trecan.2017.01.005. Review.

25.

Balancing redox stress: anchorage-independent growth requires reductive carboxylation.

Stalnecker CA, Cluntun AA, Cerione RA.

Transl Cancer Res. 2016 Sep;5(Suppl 3):S433-S437. doi: 10.21037/tcr.2016.09.02. No abstract available.

26.

The experiences of a biochemist in the evolving world of G protein-dependent signaling.

Cerione RA.

Cell Signal. 2018 Jan;41:2-8. doi: 10.1016/j.cellsig.2017.02.016. Epub 2017 Feb 15.

27.

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.

Feng Q, Zhang C, Lum D, Druso JE, Blank B, Wilson KF, Welm A, Antonyak MA, Cerione RA.

Nat Commun. 2017 Feb 16;8:14450. doi: 10.1038/ncomms14450.

28.

Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.

Stalnecker CA, Erickson JW, Cerione RA.

J Biol Chem. 2017 Apr 14;292(15):6095-6107. doi: 10.1074/jbc.M116.758219. Epub 2017 Feb 14.

29.

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.

Katt WP, Lukey MJ, Cerione RA.

Future Med Chem. 2017 Jan;9(2):223-243. doi: 10.4155/fmc-2016-0190. Epub 2017 Jan 23. Review. Erratum in: Future Med Chem. 2017 Apr;9(5):527.

30.

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake.

French KC, Antonyak MA, Cerione RA.

Semin Cell Dev Biol. 2017 Jul;67:48-55. doi: 10.1016/j.semcdb.2017.01.002. Epub 2017 Jan 16. Review.

31.

Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.

Yoo SM, Latifkar A, Cerione RA, Antonyak MA.

J Biol Chem. 2017 Mar 3;292(9):3947-3957. doi: 10.1074/jbc.M116.769190. Epub 2017 Jan 18.

32.

Targeting amino acid metabolism for cancer therapy.

Lukey MJ, Katt WP, Cerione RA.

Drug Discov Today. 2017 May;22(5):796-804. doi: 10.1016/j.drudis.2016.12.003. Epub 2016 Dec 14. Review.

33.

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance.

Kreger BT, Johansen ER, Cerione RA, Antonyak MA.

Cancers (Basel). 2016 Dec 9;8(12). pii: E111.

34.

Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.

Song YH, Warncke C, Choi SJ, Choi S, Chiou AE, Ling L, Liu HY, Daniel S, Antonyak MA, Cerione RA, Fischbach C.

Matrix Biol. 2017 Jul;60-61:190-205. doi: 10.1016/j.matbio.2016.11.008. Epub 2016 Nov 29.

35.

The distinct traits of extracellular vesicles generated by transformed cells.

Antonyak MA, Cerione RA.

Small GTPases. 2018 Sep 3;9(5):427-432. doi: 10.1080/21541248.2016.1249044. Epub 2016 Nov 16.

36.

Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.

Bussche L, Rauner G, Antonyak M, Syracuse B, McDowell M, Brown AM, Cerione RA, Van de Walle GR.

J Biol Chem. 2016 Nov 18;291(47):24390-24405. Epub 2016 Oct 12.

37.

Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.

Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S.

J Biol Chem. 2016 Sep 30;291(40):20900-20910. Epub 2016 Aug 19.

38.

Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation.

Kreger BT, Dougherty AL, Greene KS, Cerione RA, Antonyak MA.

J Biol Chem. 2016 Sep 16;291(38):19774-85. doi: 10.1074/jbc.M116.725705. Epub 2016 Jul 20.

39.

Identifying the functional contribution of the defatty-acylase activity of SIRT6.

Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H.

Nat Chem Biol. 2016 Aug;12(8):614-20. doi: 10.1038/nchembio.2106. Epub 2016 Jun 20.

40.

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.

Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA.

Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.

41.

Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.

Desrochers LM, Antonyak MA, Cerione RA.

Dev Cell. 2016 May 23;37(4):301-309. doi: 10.1016/j.devcel.2016.04.019. Review.

42.

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.

Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA.

Nat Commun. 2016 Apr 18;7:11321. doi: 10.1038/ncomms11321.

43.

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.

Hall J, Prabhakar S, Balaj L, Lai CP, Cerione RA, Breakefield XO.

Cell Mol Neurobiol. 2016 Apr;36(3):417-27. doi: 10.1007/s10571-015-0309-0. Epub 2016 Mar 26. Review.

44.

An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.

Druso JE, Endo M, Lin MC, Peng X, Antonyak MA, Meller S, Cerione RA.

J Biol Chem. 2016 Apr 22;291(17):8886-95. doi: 10.1074/jbc.M115.694349. Epub 2016 Feb 24.

45.

The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability.

Singh G, Zhang J, Ma Y, Cerione RA, Antonyak MA.

J Biol Chem. 2016 Apr 22;291(17):9119-32. doi: 10.1074/jbc.M115.699108. Epub 2016 Feb 18.

46.

Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.

Bordeleau F, Chan B, Antonyak MA, Lampi MC, Cerione RA, Reinhart-King CA.

J Biomech. 2016 May 24;49(8):1272-1279. doi: 10.1016/j.jbiomech.2015.10.003. Epub 2015 Oct 9.

47.

Less than the sum of its parts, a leinamycin precursor has superior properties.

Katt WP, Cerione RA.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8164-5. doi: 10.1073/pnas.1510122112. Epub 2015 Jun 23. No abstract available.

48.

Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.

Choi HW, Tian M, Song F, Venereau E, Preti A, Park SW, Hamilton K, Swapna GV, Manohar M, Moreau M, Agresti A, Gorzanelli A, De Marchis F, Wang H, Antonyak M, Micikas RJ, Gentile DR, Cerione RA, Schroeder FC, Montelione GT, Bianchi ME, Klessig DF.

Mol Med. 2015 Jun 18;21:526-35. doi: 10.2119/molmed.2015.00148.

49.

Emerging picture of the distinct traits and functions of microvesicles and exosomes.

Antonyak MA, Cerione RA.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3589-90. doi: 10.1073/pnas.1502590112. Epub 2015 Mar 11. No abstract available.

50.

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.

Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9. doi: 10.1073/pnas.1414056112. Epub 2014 Dec 29.

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