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Items: 1 to 50 of 271

1.

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse.

Riahi Y, Israeli T, Yeroslaviz R, Chimenez S, Avrahami D, Stolovich-Rain M, Alter I, Sebag M, Polin N, Bernal-Mizrachi E, Dor Y, Cerasi E, Leibowitz G.

Elife. 2018 Nov 9;7. pii: e38472. doi: 10.7554/eLife.38472.

2.

Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes.

Riahi Y, Israeli T, Cerasi E, Leibowitz G.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:95-103. doi: 10.1111/dom.13379. Review.

PMID:
30230182
3.

Opposing effects of intracellular versus extracellular adenine nucleotides on autophagy: implications for β-cell function.

Israeli T, Riahi Y, Saada A, Yefet D, Cerasi E, Tirosh B, Leibowitz G.

J Cell Sci. 2018 Aug 6;131(15). pii: jcs212969. doi: 10.1242/jcs.212969.

4.

A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.

Rozentul N, Avrahami Y, Shubely M, Levy L, Munder A, Cohen G, Cerasi E, Sasson S, Gruzman A.

Pharm Res. 2017 Dec;34(12):2873-2890. doi: 10.1007/s11095-017-2271-7. Epub 2017 Oct 5.

PMID:
28983714
5.

Alain Ktorza, PhD.

Thorens B, Accili D, Ahrén B, Boitard C, Seino S, Cerasi E.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:3. doi: 10.1111/dom.13036. No abstract available.

PMID:
28880483
6.

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Data Brief. 2017 Jul 28;14:329-336. doi: 10.1016/j.dib.2017.07.069. eCollection 2017 Oct.

7.

Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1900-1910. doi: 10.1016/j.bbamem.2017.06.013. Epub 2017 Jun 23.

8.

GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome.

Danielpur L, Sohn YS, Karmi O, Fogel C, Zinger A, Abu-Libdeh A, Israeli T, Riahi Y, Pappo O, Birk R, Zangen DH, Mittler R, Cabantchik ZI, Cerasi E, Nechushtai R, Leibowitz G.

J Clin Endocrinol Metab. 2016 Oct;101(10):3592-3599. Epub 2016 Jul 26.

PMID:
27459537
9.

Erratum to: Autophagy is a major regulator of beta cell insulin homeostasis.

Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G.

Diabetologia. 2016 Jul;59(7):1575-1576. doi: 10.1007/s00125-016-3986-4. No abstract available.

PMID:
27189065
10.

Autophagy is a major regulator of beta cell insulin homeostasis.

Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G.

Diabetologia. 2016 Jul;59(7):1480-1491. doi: 10.1007/s00125-016-3868-9. Epub 2016 Jan 30. Erratum in: Diabetologia. 2016 Jul;59(7):1575-6.

11.

The Islet and Metabolism Keep Time.

Thorens B, Accili D, Ahrén B, Cerasi E, Seino S, Boitard C.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:3-5. doi: 10.1111/dom.12547. No abstract available.

PMID:
26332961
12.

Donald F. Steiner: great scientist, close friend, real 'Mensch'.

Cerasi E, Seino S.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:1-2. doi: 10.1111/dom.12530. No abstract available.

PMID:
26332960
13.

Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner.

Riahi Y, Kaiser N, Cohen G, Abd-Elrahman I, Blum G, Shapira OM, Koler T, Simionescu M, Sima AV, Zarkovic N, Zarkovic K, Orioli M, Aldini G, Cerasi E, Leibowitz G, Sasson S.

J Cell Mol Med. 2015 Aug;19(8):1887-99. doi: 10.1111/jcmm.12561. Epub 2015 Mar 5.

14.

The mind and the belly: a glance at how the nervous system directs metabolism.

Accili D, Ahrén B, Boitard C, Seino S, Thorens B, Cerasi E.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:1-3. doi: 10.1111/dom.12353. No abstract available.

PMID:
25200289
15.

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation.

Pasternak L, Meltzer-Mats E, Babai-Shani G, Cohen G, Viskind O, Eckel J, Cerasi E, Sasson S, Gruzman A.

Chem Commun (Camb). 2014 Oct 4;50(76):11222-5. doi: 10.1039/c4cc03310h.

PMID:
25116279
16.

Shifting the paradigm of islet inflammation--good guy or bad guy?

Ahrén B, Accili D, Boitard C, Cerasi E, Thorens B, Seino S.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:4-9. doi: 10.1111/dom.12184. No abstract available.

17.

AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.

Wikstrom JD, Israeli T, Bachar-Wikstrom E, Swisa A, Ariav Y, Waiss M, Kaganovich D, Dor Y, Cerasi E, Leibowitz G.

Mol Endocrinol. 2013 Oct;27(10):1706-23. doi: 10.1210/me.2013-1109. Epub 2013 Aug 26.

18.

Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Meltzer-Mats E, Babai-Shani G, Pasternak L, Uritsky N, Getter T, Viskind O, Eckel J, Cerasi E, Senderowitz H, Sasson S, Gruzman A.

J Med Chem. 2013 Jul 11;56(13):5335-50. doi: 10.1021/jm4001488. Epub 2013 Jun 26.

PMID:
23750537
19.

Improvement of ER stress-induced diabetes by stimulating autophagy.

Bachar-Wikstrom E, Wikstrom JD, Kaiser N, Cerasi E, Leibowitz G.

Autophagy. 2013 Apr;9(4):626-8. doi: 10.4161/auto.23642. Epub 2013 Feb 4.

20.

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.

Bachar-Wikstrom E, Wikstrom JD, Ariav Y, Tirosh B, Kaiser N, Cerasi E, Leibowitz G.

Diabetes. 2013 Apr;62(4):1227-37. doi: 10.2337/db12-1474. Epub 2012 Dec 28.

21.

The hyperstimulated β-cell: prelude to diabetes?

Boitard C, Accili D, Ahrén B, Cerasi E, Seino S, Thorens B.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:iv-viii. doi: 10.1111/j.1463-1326.2012.01693.x. No abstract available.

PMID:
22928578
22.

Diet-induced diabetes in the sand rat (Psammomys obesus).

Kaiser N, Cerasi E, Leibowitz G.

Methods Mol Biol. 2012;933:89-102. doi: 10.1007/978-1-62703-068-7_7. Review.

PMID:
22893403
23.

AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.

Shaked M, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2011;6(12):e28804. doi: 10.1371/journal.pone.0028804. Epub 2011 Dec 14. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/23f84cc3-627d-4012-ae6f-f3291b2567d0.

24.

Long in the shade, glucagon re-occupies centre court.

Henquin JC, Accili D, Ahrén B, Boitard C, Seino S, Cerasi E.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:v-viii. doi: 10.1111/j.1463-1326.2011.01476.x. No abstract available.

PMID:
21824249
25.

Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice.

Gruzman A, Elgart A, Viskind O, Billauer H, Dotan S, Cohen G, Mishani E, Hoffman A, Cerasi E, Sasson S.

J Cell Mol Med. 2012 Mar;16(3):594-604. doi: 10.1111/j.1582-4934.2011.01340.x.

26.

β-Cell failure in type 2 diabetes.

Leibowitz G, Kaiser N, Cerasi E.

J Diabetes Investig. 2011 Apr 7;2(2):82-91. doi: 10.1111/j.2040-1124.2010.00094.x. Review.

27.

Glucose regulation of β-cell stress in type 2 diabetes.

Leibowitz G, Bachar E, Shaked M, Sinai A, Ketzinel-Gilad M, Cerasi E, Kaiser N.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:66-75. doi: 10.1111/j.1463-1326.2010.01280.x. Review.

PMID:
21029302
28.

What ails the β-cell?

Accili D, Ahrén B, Boitard C, Cerasi E, Henquin JC, Seino S.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:1-3. doi: 10.1111/j.1463-1326.2010.01296.x. No abstract available.

PMID:
21029293
29.

Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis.

Bachar E, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2010 Oct;53(10):2177-87. doi: 10.1007/s00125-010-1833-6. Epub 2010 Jul 2.

PMID:
20596694
30.

Balancing needs and means: the dilemma of the beta-cell in the modern world.

Leibowitz G, Kaiser N, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:1-9. doi: 10.1111/j.1463-1326.2009.01101.x. Review.

PMID:
19817783
31.

β-Cell research - A decade of rapid growth.

Ahrén B, Accili D, Boitard C, Efendic S, Henquin JC, Seino S, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:iv-ix. doi: 10.1111/j.1463-1326.2009.01143.x. No abstract available.

PMID:
19817782
32.

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2009;4(3):e4954. doi: 10.1371/journal.pone.0004954. Epub 2009 Mar 23.

33.

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2009 Apr;52(4):636-44. doi: 10.1007/s00125-009-1274-2. Epub 2009 Feb 13.

PMID:
19214472
34.

Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.

Gruzman A, Shamni O, Ben Yakir M, Sandovski D, Elgart A, Alpert E, Cohen G, Hoffman A, Katzhendler Y, Cerasi E, Sasson S.

J Med Chem. 2008 Dec 25;51(24):8096-108. doi: 10.1021/jm8008713.

PMID:
19049348
35.

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes.

Leibowitz G, Cerasi E, Ketzinel-Gilad M.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:157-69. doi: 10.1111/j.1463-1326.2008.00952.x. Review.

PMID:
18834443
36.

Pancreatic beta-cell mass or beta-cell function? That is the question!

Henquin JC, Cerasi E, Efendic S, Steiner DF, Boitard C.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:1-4. doi: 10.1111/j.1463-1326.2008.00968.x. No abstract available.

PMID:
18834427
37.

PKCepsilon mediates glucose-regulated insulin production in pancreatic beta-cells.

Warwar N, Dov A, Abramovitch E, Wu R, Jmoudiak M, Haber E, Cerasi E, Nesher R.

Biochim Biophys Acta. 2008 Oct;1783(10):1929-34. doi: 10.1016/j.bbamcr.2008.04.007. Epub 2008 Apr 29.

38.

[And what about diabetes?].

Cerasi E.

Bull Acad Natl Med. 2007 Apr-May;191(4-5):941-3; discussion 943. French.

PMID:
18225448
39.

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes.

Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz G.

Diabetes. 2008 Apr;57(4):945-57. doi: 10.2337/db07-0922. Epub 2008 Jan 3.

40.

[Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes].

Cerasi E, Ktorza A.

Med Sci (Paris). 2007 Oct;23(10):885-94. Review. French.

41.

Of mighty mice and diabetic men: animal models of islet dysfunction.

Efendic S, Boitard C, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:1-4. No abstract available.

PMID:
17919172
43.

Regulation of insulin secretion and proinsulin biosynthesis by succinate.

Attali V, Parnes M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Endocrinology. 2006 Nov;147(11):5110-8. Epub 2006 Aug 17.

PMID:
16916949
44.

Dynamics of glucose-induced localization of PKC isoenzymes in pancreatic beta-cells: diabetes-related changes in the GK rat.

Warwar N, Efendic S, Ostenson CG, Haber EP, Cerasi E, Nesher R.

Diabetes. 2006 Mar;55(3):590-9.

45.

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.

Kaiser N, Nesher R, Donath MY, Fraenkel M, Behar V, Magnan C, Ktorza A, Cerasi E, Leibowitz G.

Diabetes. 2005 Dec;54 Suppl 2:S137-44. Review.

46.

A tale of two cousins: type 1 and type 2 diabetes.

Boitard C, Efendic S, Ferrannini E, Henquin JC, Steiner DF, Cerasi E.

Diabetes. 2005 Dec;54 Suppl 2:S1-3. No abstract available.

47.

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years.

Alvarsson M, Wajngot A, Cerasi E, Efendic S.

Diabetologia. 2005 Nov;48(11):2262-8. Epub 2005 Sep 14.

PMID:
16160865
48.
49.

Mitochondrial regulation of insulin production in rat pancreatic islets.

Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N.

Diabetologia. 2005 Aug;48(8):1549-59. Epub 2005 Jun 29.

PMID:
15986240
50.

Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue.

Uçkaya G, Delagrange P, Chavanieu A, Grassy G, Berthault MF, Ktorza A, Cerasi E, Leibowitz G, Kaiser N.

J Endocrinol. 2005 Mar;184(3):505-13.

PMID:
15749809

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