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Items: 1 to 50 of 235


SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues.

Kishi JY, Lapan SW, Beliveau BJ, West ER, Zhu A, Sasaki HM, Saka SK, Wang Y, Cepko CL, Yin P.

Nat Methods. 2019 Jun;16(6):533-544. doi: 10.1038/s41592-019-0404-0. Epub 2019 May 20.


Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa.

Wang SK, Xue Y, Rana P, Hong CM, Cepko CL.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10140-10149. doi: 10.1073/pnas.1901787116. Epub 2019 Apr 29.


AAV cis-regulatory sequences are correlated with ocular toxicity.

Xiong W, Wu DM, Xue Y, Wang SK, Chung MJ, Ji X, Rana P, Zhao SR, Mai S, Cepko CL.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5785-5794. doi: 10.1073/pnas.1821000116. Epub 2019 Mar 4.


In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators.

Cheong SK, Xiong W, Strazzeri JM, Cepko CL, Williams DR, Merigan WH.

Adv Exp Med Biol. 2018;1074:135-144. doi: 10.1007/978-3-319-75402-4_17.


Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.

Guo N, Soden ME, Herber C, Kim MT, Besnard A, Lin P, Ma X, Cepko CL, Zweifel LS, Sahay A.

Nat Med. 2018 May;24(4):438-449. doi: 10.1038/nm.4491. Epub 2018 Mar 12.


Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain.

Tang JCY, Rudolph S, Cepko CL.

Methods Mol Biol. 2017;1642:109-126. doi: 10.1007/978-1-4939-7169-5_8.


Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina.

da Silva S, Cepko CL.

Dev Cell. 2017 Jul 10;42(1):68-81.e6. doi: 10.1016/j.devcel.2017.05.024. Epub 2017 Jun 22.


Glycolytic reliance promotes anabolism in photoreceptors.

Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL.

Elife. 2017 Jun 9;6. pii: e25946. doi: 10.7554/eLife.25946.


Epigenomics of Retinal Development in Mice and Humans.

Lonfat N, Cepko C.

Neuron. 2017 May 3;94(3):420-423. doi: 10.1016/j.neuron.2017.04.029.


The brain parenchyma has a type I interferon response that can limit virus spread.

Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O'Loughlin E, Madore C, Butovsky O, Cepko CL.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E95-E104. doi: 10.1073/pnas.1618157114. Epub 2016 Dec 15.


The origin and evolution of cell types.

Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, Pavlicev M, Schlosser G, Widder S, Laubichler MD, Wagner GP.

Nat Rev Genet. 2016 Dec;17(12):744-757. doi: 10.1038/nrg.2016.127. Epub 2016 Nov 7. Review.


Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.

Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR.

Cell. 2016 Aug 25;166(5):1308-1323.e30. doi: 10.1016/j.cell.2016.07.054.


Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies.

Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL.

Elife. 2016 May 20;5. pii: e15312. doi: 10.7554/eLife.15312.


Photoreceptor Fate Determination in the Vertebrate Retina.

Wang S, Cepko CL.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFe1-6. doi: 10.1167/iovs.15-17672.


Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors.

Beier KT, Mundell NA, Pan YA, Cepko CL.

Curr Protoc Neurosci. 2016 Jan 4;74:1.26.1-27. doi: 10.1002/0471142301.ns0126s74.


The Determination of Rod and Cone Photoreceptor Fate.

Cepko CL.

Annu Rev Vis Sci. 2015 Nov 24;1:211-234. doi: 10.1146/annurev-vision-090814-121657.


Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.

Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR.

Neuron. 2015 Sep 2;87(5):999-1007. doi: 10.1016/j.neuron.2015.07.030. Epub 2015 Aug 20.


Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries.

Mayer C, Jaglin XH, Cobbs LV, Bandler RC, Streicher C, Cepko CL, Hippenmeyer S, Fishell G.

Neuron. 2015 Sep 2;87(5):989-98. doi: 10.1016/j.neuron.2015.07.011. Epub 2015 Aug 20.


Cell type-specific manipulation with GFP-dependent Cre recombinase.

Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL.

Nat Neurosci. 2015 Sep;18(9):1334-41. doi: 10.1038/nn.4081. Epub 2015 Aug 10.


Neuroanatomy goes viral!

Nassi JJ, Cepko CL, Born RT, Beier KT.

Front Neuroanat. 2015 Jul 1;9:80. doi: 10.3389/fnana.2015.00080. eCollection 2015. Review.


Cell metabolism: Sugar for sight.

Cepko C, Punzo C.

Nature. 2015 Jun 25;522(7557):428-9. doi: 10.1038/522428a. No abstract available.


Embryonic Origin of Postnatal Neural Stem Cells.

Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A.

Cell. 2015 Jun 18;161(7):1644-55. doi: 10.1016/j.cell.2015.05.041.


Vision research special issue: Sight restoration: Prosthetics, optogenetics and gene therapy.

Fine I, Cepko CL, Landy MS.

Vision Res. 2015 Jun;111(Pt B):115-23. doi: 10.1016/j.visres.2015.04.012. Epub 2015 May 1. No abstract available.


Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors.

Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN.

J Virol. 2015 Jul;89(13):6711-24. doi: 10.1128/JVI.00709-15. Epub 2015 Apr 15.


NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.

Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL.

J Clin Invest. 2015 Apr;125(4):1433-45. doi: 10.1172/JCI79735. Epub 2015 Mar 23.


Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms.

Mundell NA, Beier KT, Pan YA, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL.

J Comp Neurol. 2015 Aug 1;523(11):1639-63. doi: 10.1002/cne.23761. Epub 2015 Apr 2.


A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina.

Wang S, Sengel C, Emerson MM, Cepko CL.

Dev Cell. 2014 Sep 8;30(5):513-27. doi: 10.1016/j.devcel.2014.07.018. Epub 2014 Aug 21.


Intrinsically different retinal progenitor cells produce specific types of progeny.

Cepko C.

Nat Rev Neurosci. 2014 Sep;15(9):615-27. doi: 10.1038/nrn3767. Epub 2014 Aug 6. Review.


The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.

Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN.

Exp Eye Res. 2014 Feb;119:106-10. doi: 10.1016/j.exer.2013.11.003. Epub 2013 Nov 15. Review.


A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation.

Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL.

Cell. 2013 Aug 15;154(4):928-39. doi: 10.1016/j.cell.2013.07.021.


Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library.

Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV.

PLoS One. 2013 Jul 25;8(7):e69314. doi: 10.1371/journal.pone.0069314. Print 2013.


Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.

Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL.

Dev Cell. 2013 Jul 15;26(1):59-72. doi: 10.1016/j.devcel.2013.06.005.


Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate.

Mizeracka K, DeMaso CR, Cepko CL.

Development. 2013 Aug;140(15):3188-97. doi: 10.1242/dev.090696. Epub 2013 Jul 3.


Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling.

Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL.

Dev Dyn. 2013 Oct;242(10):1147-59. doi: 10.1002/dvdy.24006. Epub 2013 Sep 2.


Retinal gene therapy coming of age.

Cepko CL, Vandenberghe LH.

Hum Gene Ther. 2013 Mar;24(3):242-4. doi: 10.1089/hum.2013.050. No abstract available.


Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo.

Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL.

Front Neural Circuits. 2013 Feb 7;7:11. doi: 10.3389/fncir.2013.00011. eCollection 2013.


Pseudotyped retroviruses for infecting axolotl in vivo and in vitro.

Whited JL, Tsai SL, Beier KT, White JN, Piekarski N, Hanken J, Cepko CL, Tabin CJ.

Development. 2013 Mar;140(5):1137-46. doi: 10.1242/dev.087734. Epub 2013 Jan 23.


Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry.

Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL.

J Neurosci. 2013 Jan 2;33(1):35-51. doi: 10.1523/JNEUROSCI.0245-12.2013.


Viral tracing of genetically defined neural circuitry.

Beier K, Cepko C.

J Vis Exp. 2012 Oct 17;(68). pii: 4253. doi: 10.3791/4253.


Gene expression changes within Müller glial cells in retinitis pigmentosa.

Roesch K, Stadler MB, Cepko CL.

Mol Vis. 2012;18:1197-214. Epub 2012 May 9.


Emerging gene therapies for retinal degenerations.

Cepko CL.

J Neurosci. 2012 May 9;32(19):6415-20. doi: 10.1523/JNEUROSCI.0295-12.2012. Review. No abstract available.


Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates.

Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7882-7. doi: 10.1073/pnas.1203138109. Epub 2012 Apr 27.


Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?

Punzo C, Xiong W, Cepko CL.

J Biol Chem. 2012 Jan 13;287(3):1642-8. doi: 10.1074/jbc.R111.304428. Epub 2011 Nov 10. Review.


Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors.

Emerson MM, Cepko CL.

Dev Biol. 2011 Dec 1;360(1):241-55. doi: 10.1016/j.ydbio.2011.09.012. Epub 2011 Sep 21.


Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation.

Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15231-6. doi: 10.1073/pnas.1104662108. Epub 2011 Sep 6.


Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors.

Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15414-9. doi: 10.1073/pnas.1110854108. Epub 2011 Aug 8. Erratum in: Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9219.


A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.

Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR.

Chem Biol. 2011 Jul 29;18(7):833-8. doi: 10.1016/j.chembiol.2011.07.003.


NeuroD factors regulate cell fate and neurite stratification in the developing retina.

Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL.

J Neurosci. 2011 May 18;31(20):7365-79. doi: 10.1523/JNEUROSCI.2555-10.2011.

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