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Items: 40


Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.

Parveen N, Fernandez MC, Haynes AM, Zhang RL, Godornes BC, Centurion-Lara A, Giacani L.

Vaccine. 2019 Mar 22;37(13):1807-1818. doi: 10.1016/j.vaccine.2019.02.022. Epub 2019 Feb 20.


Sequencing of Treponema pallidum subsp. pallidum from isolate UZ1974 using Anti-Treponemal Antibodies Enrichment: First complete whole genome sequence obtained directly from human clinical material.

Grillová L, Giacani L, Mikalová L, Strouhal M, Strnadel R, Marra C, Centurion-Lara A, Poveda L, Russo G, Čejková D, Vašků V, Oppelt J, Šmajs D.

PLoS One. 2018 Aug 21;13(8):e0202619. doi: 10.1371/journal.pone.0202619. eCollection 2018.


Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster.

Arora N, Schuenemann VJ, Jäger G, Peltzer A, Seitz A, Herbig A, Strouhal M, Grillová L, Sánchez-Busó L, Kühnert D, Bos KI, Davis LR, Mikalová L, Bruisten S, Komericki P, French P, Grant PR, Pando MA, Vaulet LG, Fermepin MR, Martinez A, Centurion Lara A, Giacani L, Norris SJ, Šmajs D, Bosshard PP, González-Candelas F, Nieselt K, Krause J, Bagheri HC.

Nat Microbiol. 2016 Dec 5;2:16245. doi: 10.1038/nmicrobiol.2016.245.


Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence.

Chan K, Nasereddin T, Alter L, Centurion-Lara A, Giacani L, Parveen N.

Sci Rep. 2016 May 10;6:25593. doi: 10.1038/srep25593.


The molecular epidemiology of Treponema pallidum subspecies pallidum.

Ma DY, Giacani L, Centurión-Lara A.

Sex Health. 2015 Apr;12(2):141-7. doi: 10.1071/SH14197.


Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat.

Giacani L, Brandt SL, Ke W, Reid TB, Molini BJ, Iverson-Cabral S, Ciccarese G, Drago F, Lukehart SA, Centurion-Lara A.

Infect Immun. 2015 Jun;83(6):2275-89. doi: 10.1128/IAI.00360-15. Epub 2015 Mar 23.


Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes.

Staudová B, Strouhal M, Zobaníková M, Cejková D, Fulton LL, Chen L, Giacani L, Centurion-Lara A, Bruisten SM, Sodergren E, Weinstock GM, Smajs D.

PLoS Negl Trop Dis. 2014 Nov 6;8(11):e3261. doi: 10.1371/journal.pntd.0003261. eCollection 2014.


Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.

Giacani L, Iverson-Cabral SL, King JC, Molini BJ, Lukehart SA, Centurion-Lara A.

Genome Announc. 2014 Apr 17;2(2). pii: e00333-14. doi: 10.1128/genomeA.00333-14.


Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

Centurion-Lara A, Giacani L, Godornes C, Molini BJ, Brinck Reid T, Lukehart SA.

PLoS Negl Trop Dis. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222. Print 2013.


Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) regulon and its implications for pathogen persistence in the host and syphilis pathogenesis.

Giacani L, Denisenko O, Tompa M, Centurion-Lara A.

J Bacteriol. 2013 Feb;195(4):896-907. doi: 10.1128/JB.01973-12. Epub 2012 Dec 14.


Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

Giacani L, Chattopadhyay S, Centurion-Lara A, Jeffrey BM, Le HT, Molini BJ, Lukehart SA, Sokurenko EV, Rockey DD.

PLoS Negl Trop Dis. 2012;6(6):e1698. doi: 10.1371/journal.pntd.0001698. Epub 2012 Jun 12.


Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains.

Giacani L, Brandt SL, Puray-Chavez M, Reid TB, Godornes C, Molini BJ, Benzler M, Hartig JS, Lukehart SA, Centurion-Lara A.

J Bacteriol. 2012 Aug;194(16):4208-25. doi: 10.1128/JB.00863-12. Epub 2012 Jun 1.


Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.

Marra C, Sahi S, Tantalo L, Godornes C, Reid T, Behets F, Rompalo A, Klausner JD, Yin Y, Mulcahy F, Golden MR, Centurion-Lara A, Lukehart SA.

J Infect Dis. 2010 Nov 1;202(9):1380-8. doi: 10.1086/656533.


Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain.

Giacani L, Jeffrey BM, Molini BJ, Le HT, Lukehart SA, Centurion-Lara A, Rockey DD.

J Bacteriol. 2010 May;192(10):2645-6. doi: 10.1128/JB.00159-10. Epub 2010 Mar 26.


Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.

Giacani L, Molini BJ, Kim EY, Godornes BC, Leader BT, Tantalo LC, Centurion-Lara A, Lukehart SA.

J Immunol. 2010 Apr 1;184(7):3822-9. doi: 10.4049/jimmunol.0902788. Epub 2010 Feb 26.


TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum.

Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A.

Mol Microbiol. 2009 Jun;72(5):1087-99. doi: 10.1111/j.1365-2958.2009.06712.x. Epub 2009 Apr 30.


Evaluation of a joint Bioinformatics and Medical Informatics international course in Peru.

Curioso WH, Hansen JR, Centurion-Lara A, Garcia PJ, Wolf FM, Fuller S, Holmes KK, Kimball AM.

BMC Med Educ. 2008 Jan 14;8:1. doi: 10.1186/1472-6920-8-1.


Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum.

Giacani L, Lukehart S, Centurion-Lara A.

FEMS Immunol Med Microbiol. 2007 Nov;51(2):289-301. Epub 2007 Aug 7.


Quantitation of rabbit cytokine mRNA by real-time RT-PCR.

Godornes C, Leader BT, Molini BJ, Centurion-Lara A, Lukehart SA.

Cytokine. 2007 Apr;38(1):1-7. Epub 2007 May 22.


Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum.

Marra CM, Colina AP, Godornes C, Tantalo LC, Puray M, Centurion-Lara A, Lukehart SA.

J Infect Dis. 2006 Dec 15;194(12):1771-3. Epub 2006 Nov 3.


Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.

Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA.

Infect Immun. 2007 Jan;75(1):104-12. Epub 2006 Oct 9.


Molecular differentiation of Treponema pallidum subspecies.

Centurion-Lara A, Molini BJ, Godornes C, Sun E, Hevner K, Van Voorhis WC, Lukehart SA.

J Clin Microbiol. 2006 Sep;44(9):3377-80.


Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema.

Gray RR, Mulligan CJ, Molini BJ, Sun ES, Giacani L, Godornes C, Kitchen A, Lukehart SA, Centurion-Lara A.

Mol Biol Evol. 2006 Nov;23(11):2220-33. Epub 2006 Aug 22.


TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain.

LaFond RE, Centurion-Lara A, Godornes C, Van Voorhis WC, Lukehart SA.

Infect Immun. 2006 Mar;74(3):1896-906.


Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.

Giacani L, Sun ES, Hevner K, Molini BJ, Van Voorhis WC, Lukehart SA, Centurion-Lara A.

Infect Immun. 2004 Nov;72(11):6561-76.


Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity.

Sun ES, Molini BJ, Barrett LK, Centurion-Lara A, Lukehart SA, Van Voorhis WC.

Microbes Infect. 2004 Jul;6(8):725-37.


Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection.

Centurion-Lara A, LaFond RE, Hevner K, Godornes C, Molini BJ, Van Voorhis WC, Lukehart SA.

Mol Microbiol. 2004 Jun;52(6):1579-96.


Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.

LaFond RE, Centurion-Lara A, Godornes C, Rompalo AM, Van Voorhis WC, Lukehart SA.

J Bacteriol. 2003 Nov;185(21):6262-8.


Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.

Centurion-Lara A, Sun ES, Barrett LK, Castro C, Lukehart SA, Van Voorhis WC.

J Bacteriol. 2000 Apr;182(8):2332-5.


The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles.

Centurion-Lara A, Godornes C, Castro C, Van Voorhis WC, Lukehart SA.

Infect Immun. 2000 Feb;68(2):824-31.


Identification of Treponema pallidum subspecies pallidum in a 200-year-old skeletal specimen.

Kolman CJ, Centurion-Lara A, Lukehart SA, Owsley DW, Tuross N.

J Infect Dis. 1999 Dec;180(6):2060-3.


T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection.

Arroll TW, Centurion-Lara A, Lukehart SA, Van Voorhis WC.

Infect Immun. 1999 Sep;67(9):4757-63.


Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response.

Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA.

J Exp Med. 1999 Feb 15;189(4):647-56. Erratum in: J Exp Med 1999 Jun 7;189(11):following 1852.


Mechanisms of clearance of Treponema pallidum from the CSF in a nonhuman primate model.

Marra CM, Castro CD, Kuller L, Dukes AC, Centurion-Lara A, Morton WR, Lukehart SA.

Neurology. 1998 Oct;51(4):957-61.


The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes.

Centurion-Lara A, Castro C, Castillo R, Shaffer JM, Van Voorhis WC, Lukehart SA.

J Infect Dis. 1998 Apr;177(4):1036-40.


Detection of Treponema pallidum by a sensitive reverse transcriptase PCR.

Centurion-Lara A, Castro C, Shaffer JM, Van Voorhis WC, Marra CM, Lukehart SA.

J Clin Microbiol. 1997 Jun;35(6):1348-52.


Conservation of the 15-kilodalton lipoprotein among Treponema pallidum subspecies and strains and other pathogenic treponemes: genetic and antigenic analyses.

Centurion-Lara A, Arroll T, Castillo R, Shaffer JM, Castro C, Van Voorhis WC, Lukehart SA.

Infect Immun. 1997 Apr;65(4):1440-4.


Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes.

Centurion-Lara A, Castro C, van Voorhis WC, Lukehart SA.

FEMS Microbiol Lett. 1996 Oct 1;143(2-3):235-40.


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