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Items: 1 to 50 of 67

1.

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.

Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N.

Nat Immunol. 2019 Nov;20(11):1435-1443. doi: 10.1038/s41590-019-0493-z. Epub 2019 Oct 7.

PMID:
31591569
2.

Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice.

Basso L, Benamar M, Mas-Orea X, Deraison C, Blanpied C, Cenac N, Saoudi A, Dietrich G.

Neurogastroenterol Motil. 2020 Feb;32(2):e13743. doi: 10.1111/nmo.13743. Epub 2019 Oct 7.

PMID:
31588671
3.

Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling.

Morello E, Pérez-Berezo T, Boisseau C, Baranek T, Guillon A, Bréa D, Lanotte P, Carpena X, Pietrancosta N, Hervé V, Ramphal R, Cenac N, Si-Tahar M.

Front Microbiol. 2019 Aug 14;10:1826. doi: 10.3389/fmicb.2019.01826. eCollection 2019.

4.

Polyunsaturated fatty acid metabolites: biosynthesis in Leishmania and role in parasite/host interaction.

Paloque L, Perez-Berezo T, Abot A, Dalloux-Chioccioli J, Bourgeade-Delmas S, Le Faouder P, Pujo J, Teste MA, François JM, Schebb NH, Mainka M, Rolland C, Blanpied C, Dietrich G, Bertrand-Michel J, Deraison C, Valentin A, Cenac N.

J Lipid Res. 2019 Mar;60(3):636-647. doi: 10.1194/jlr.M091736. Epub 2019 Jan 9.

PMID:
30626624
5.

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N.

Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.

6.

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

Paupert J, Espinosa E, Cenac N, Robert V, Laharrague P, Evrard SM, Casteilla L, Lorsignol A, Cousin B.

J Immunol. 2018 Dec 15;201(12):3815-3821. doi: 10.4049/jimmunol.1701751. Epub 2018 Nov 16.

7.

Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons.

Desormeaux C, Bautzova T, Garcia-Caraballo S, Rolland C, Barbaro MR, Brierley SM, Barbara G, Vergnolle N, Cenac N.

Pain. 2018 Jul;159(7):1257-1267. doi: 10.1097/j.pain.0000000000001208.

PMID:
29554016
8.

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.

Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G.

Pain. 2018 Feb;159(2):331-341. doi: 10.1097/j.pain.0000000000001103.

PMID:
29140925
9.

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917.

Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N.

Nat Commun. 2017 Nov 3;8(1):1314. doi: 10.1038/s41467-017-01403-9.

10.

FPR2: A Novel Promising Target for the Treatment of Influenza.

Alessi MC, Cenac N, Si-Tahar M, Riteau B.

Front Microbiol. 2017 Sep 5;8:1719. doi: 10.3389/fmicb.2017.01719. eCollection 2017. Review.

11.

Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.

Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N, Blanchard N.

Parasite Immunol. 2017 Nov;39(11). doi: 10.1111/pim.12489. Epub 2017 Sep 27.

12.

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13148. Epub 2017 Jul 11.

PMID:
28695708
13.

T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice.

Basso L, Garnier L, Bessac A, Boué J, Blanpied C, Cenac N, Laffont S, Dietrich G.

J Gastroenterol. 2018 Feb;53(2):215-226. doi: 10.1007/s00535-017-1341-2. Epub 2017 Apr 19.

PMID:
28424989
14.

Epithelial expression and function of trypsin-3 in irritable bowel syndrome.

Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Vanden Berghe P, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N.

Gut. 2017 Oct;66(10):1767-1778. doi: 10.1136/gutjnl-2016-312094. Epub 2017 Jan 17.

15.

Different activation signals induce distinct mast cell degranulation strategies.

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ.

J Clin Invest. 2016 Oct 3;126(10):3981-3998. doi: 10.1172/JCI85538. Epub 2016 Sep 19.

16.

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice.

Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O.

Circ Res. 2016 Oct 14;119(9):1030-1038. Epub 2016 Aug 16.

PMID:
27531933
17.

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

Henry CO, Dalloneau E, Pérez-Berezo MT, Plata C, Wu Y, Guillon A, Morello E, Aimar RF, Potier-Cartereau M, Esnard F, Coraux C, Börnchen C, Kiefmann R, Vandier C, Touqui L, Valverde MA, Cenac N, Si-Tahar M.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L664-75. doi: 10.1152/ajplung.00442.2015. Epub 2016 Aug 5.

18.

PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.

Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G221-36. doi: 10.1152/ajpgi.00328.2015. Epub 2016 Jun 16.

19.

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.

Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.

Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.

20.

PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.

Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S.

PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016 Apr.

21.

Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.

Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.

J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.

PMID:
27034344
22.

Apelin targets gut contraction to control glucose metabolism via the brain.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.

Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12.

23.

A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice.

Cenac N, Castro M, Desormeaux C, Colin P, Sie M, Ranger M, Vergnolle N.

Eur J Pain. 2016 May;20(5):723-30. doi: 10.1002/ejp.798. Epub 2015 Nov 6.

PMID:
26541237
24.

Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.

Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.

Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.

PMID:
26433161
25.

Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response.

Federici Canova D, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB, Perretti M.

J Control Release. 2015 Nov 10;217:284-92. doi: 10.1016/j.jconrel.2015.09.021. Epub 2015 Sep 16.

26.

Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures.

Leghmar K, Cenac N, Rolland M, Martin H, Rauwel B, Bertrand-Michel J, Le Faouder P, Bénard M, Casper C, Davrinche C, Fournier T, Chavanas S.

PLoS One. 2015 Jul 14;10(7):e0132627. doi: 10.1371/journal.pone.0132627. eCollection 2015.

27.

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.

Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.

Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.

PMID:
25911511
28.

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18685-90. doi: 10.1073/pnas.1410938111. Epub 2014 Dec 15.

29.

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N.

Br J Pharmacol. 2015 Feb;172(3):910-23. doi: 10.1111/bph.12957. Epub 2014 Dec 15.

30.

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.

Fichna J, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Cenac N, Sałaga M, Timmermans JP, Vergnolle N, Małecka-Panas E, Krajewska WM, Storr M.

Neurogastroenterol Motil. 2014 Nov;26(11):1539-50. doi: 10.1111/nmo.12390. Epub 2014 Jul 15.

PMID:
25041572
31.

Protease-activated receptors as therapeutic targets in visceral pain.

Cenac N.

Curr Neuropharmacol. 2013 Dec;11(6):598-605. doi: 10.2174/1570159X113119990039.

32.

Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability.

Ochoa-Cortes F, Guerrero-Alba R, Valdez-Morales EE, Spreadbury I, Barajas-Lopez C, Castro M, Bertrand J, Cenac N, Vergnolle N, Vanner SJ.

Neurogastroenterol Motil. 2014 Mar;26(3):334-45. doi: 10.1111/nmo.12268. Epub 2013 Nov 29.

PMID:
24286174
33.

Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.

Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.

PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.

34.

Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.

Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.

Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.

PMID:
24055279
35.

LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.

Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15.

PMID:
23831705
36.

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.

Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.

Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.

37.

Inhibition of sensory afferents activation and visceral pain by a brominated algal diterpene.

Chatter R, Cenac N, Roussis V, Kharrat R, Vergnolle N.

Neurogastroenterol Motil. 2012 Jul;24(7):e336-43. doi: 10.1111/j.1365-2982.2012.01940.x.

PMID:
22709240
38.

Role of transient receptor potential vanilloid 4 in rat joint inflammation.

Denadai-Souza A, Martin L, de Paula MA, de Avellar MC, Muscará MN, Vergnolle N, Cenac N.

Arthritis Rheum. 2012 Jun;64(6):1848-58. doi: 10.1002/art.34345. Epub 2011 Dec 19.

39.

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.

Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N.

Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.

40.

Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.

Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M, McDonald T, Spreadbury I, Cenac N, Cattaruzza F, Hurlbut D, Vanner S, Bunnett N, Vergnolle N, Vanner S.

Gastroenterology. 2011 Dec;141(6):2098-2108.e5. doi: 10.1053/j.gastro.2011.08.006. Epub 2011 Aug 19.

PMID:
21856270
41.

Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.

Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.

PMID:
21199654
42.

Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice.

D'Aldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K, Selves J, Alric L, Vinel JP, Vergnolle N.

Gastroenterology. 2011 Jan;140(1):275-85. doi: 10.1053/j.gastro.2010.09.045. Epub 2010 Oct 1.

PMID:
20888819
43.

PAR(2) and temporomandibular joint inflammation in the rat.

Denadai-Souza A, Cenac N, Casatti CA, Câmara PR, Yshii LM, Costa SK, Vergnolle N, Muscará MN.

J Dent Res. 2010 Oct;89(10):1123-8. doi: 10.1177/0022034510375284. Epub 2010 Jul 22.

PMID:
20651095
44.

Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.

Cenac N, Altier C, Motta JP, d'Aldebert E, Galeano S, Zamponi GW, Vergnolle N.

Gut. 2010 Apr;59(4):481-8. doi: 10.1136/gut.2009.192567.

PMID:
20332520
45.

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.

Vergnolle N, Cenac N, Altier C, Cellars L, Chapman K, Zamponi GW, Materazzi S, Nassini R, Liedtke W, Cattaruzza F, Grady EF, Geppetti P, Bunnett NW.

Br J Pharmacol. 2010 Mar;159(5):1161-73. doi: 10.1111/j.1476-5381.2009.00590.x. Epub 2010 Feb 5.

46.

Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.

Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N.

J Immunol. 2010 Mar 1;184(5):2702-9. doi: 10.4049/jimmunol.0902171. Epub 2010 Jan 29.

47.

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.

Martin L, Augé C, Boué J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.

Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.

PMID:
19674841
48.

Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition.

Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N.

Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. doi: 10.1111/j.1472-8206.2009.00686.x. Epub 2009 Jun 8.

PMID:
19515068
49.

Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.

Prat CM, Schmid S, Farrugia F, Cenac N, Le Masson G, Schwemmle M, Gonzalez-Dunia D.

PLoS Pathog. 2009 May;5(5):e1000425. doi: 10.1371/journal.ppat.1000425. Epub 2009 May 8.

50.

Protease-activated receptor-4 (PAR 4): a role as inhibitor of visceral pain and hypersensitivity.

Augé C, Balz-Hara D, Steinhoff M, Vergnolle N, Cenac N.

Neurogastroenterol Motil. 2009 Nov;21(11):1189-e107. doi: 10.1111/j.1365-2982.2009.01310.x. Epub 2009 Apr 20.

PMID:
19413681

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