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Items: 1 to 50 of 70

1.

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment.

Chodorge M, Celeste AJ, Grimsby J, Konkar A, Davidsson P, Fairman D, Jenkinson L, Naylor J, White N, Seaman JC, Dickson K, Kemp B, Spooner J, Rossy E, Hornigold DC, Trevaskis JL, Bond NJ, London TB, Buchanan A, Vaughan T, Rondinone CM, Osbourn JK.

Sci Rep. 2018 Dec 3;8(1):17545. doi: 10.1038/s41598-018-35869-4.

2.

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice.

Jouihan H, Will S, Guionaud S, Boland ML, Oldham S, Ravn P, Celeste A, Trevaskis JL.

Mol Metab. 2017 Nov;6(11):1360-1370. doi: 10.1016/j.molmet.2017.09.001. Epub 2017 Sep 14.

3.

Involvement of Stat1 in the phagocytosis of M. avium.

Dominici S, Schiavano GF, Magnani M, Buondelmonte C, Celeste AG, Brandi G.

Clin Dev Immunol. 2012;2012:652683. doi: 10.1155/2012/652683. Epub 2012 Jun 28.

4.

Novel therapeutics and targets for the treatment of diabetes.

Aicher TD, Boyd SA, McVean M, Celeste A.

Expert Rev Clin Pharmacol. 2010 Mar;3(2):209-29. doi: 10.1586/ecp.10.1.

PMID:
22111568
5.

Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy.

Kruhlak MJ, Celeste A, Nussenzweig A.

Methods Mol Biol. 2009;523:125-40. doi: 10.1007/978-1-59745-190-1_9.

PMID:
19381917
6.

Histone H2AX is integral to hypoxia-driven neovascularization.

Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.

Nat Med. 2009 May;15(5):553-8. doi: 10.1038/nm.1947. Epub 2009 Apr 19.

7.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.

Genes Dev. 2008 Aug 1;22(15):2048-61. doi: 10.1101/gad.476008.

8.

Angiogenesis, tumor necrosis factor-alpha and procoagulant factors in coronary artery giant aneurysm of a fatal infantile Kawasaki disease.

Pucci A, Martino S, Celeste A, Linari A, Tibaldi M, Camosso E, Muscio M, Barattia G, Riva C, Bartoloni G.

Cardiovasc Pathol. 2008 May-Jun;17(3):186-9. doi: 10.1016/j.carpath.2007.05.003. Epub 2007 Jul 5.

PMID:
18402791
9.

C-reactive protein and coronary composition in patients with percutaneous revascularization.

Pucci A, Brscic E, Tessitore E, Celeste A, Crudelini M, De Bernardi A, Alberti A, Biondi-Zoccai G, Sheiban I.

Eur J Clin Invest. 2008 May;38(5):281-9. doi: 10.1111/j.1365-2362.2008.01944.x. Epub 2008 Mar 20.

PMID:
18363718
10.

Using synthetic oligonucleotides as probes.

Duby A, Jacobs KA, Celeste A.

Curr Protoc Mol Biol. 2001 May;Chapter 6:Unit6.4. doi: 10.1002/0471142727.mb0604s09.

PMID:
18265259
11.

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.

Cell. 2007 Jul 13;130(1):63-75. Epub 2007 Jun 28.

12.

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.

Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A.

J Exp Med. 2007 May 14;204(5):1003-11. Epub 2007 May 3.

13.

In vivo coronary plaque histology in patients with stable and acute coronary syndromes: relationships with hyperlipidemic status and statin treatment.

Pucci A, Sheiban I, Formato L, Celeste A, Brscic E, Moretti C, De Bernardi A, Alberti A, Bergamasco L, Trevi G, Fuster V.

Atherosclerosis. 2007 Sep;194(1):189-95. Epub 2006 Sep 12.

PMID:
16970947
14.

Spatio-temporal dynamics of chromatin containing DNA breaks.

Kruhlak MJ, Celeste A, Nussenzweig A.

Cell Cycle. 2006 Sep;5(17):1910-2. Epub 2006 Sep 1.

PMID:
16929171
15.

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.

Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A.

Nature. 2006 Sep 14;443(7108):222-5. Epub 2006 Aug 13.

PMID:
16906133
16.

Oral manifestations of langerhans cell histiocytosis in a pediatric population: a clinical and histological study of 8 patients.

Mortellaro C, Pucci A, Palmeri A, Lucchina AG, Berta M, Celeste A, Costantino S, Del Prever AB, Forni M.

J Craniofac Surg. 2006 May;17(3):552-6.

PMID:
16770197
17.
18.

Papillary thyroid carcinoma presenting as a solitary soft tissue arm metastasis in an elderly hyperthyroid patient. Case report and review of the literature.

Pucci A, Suppo M, Lucchesi G, Celeste A, Viberti L, Pellerito R, Papotti M.

Virchows Arch. 2006 Jun;448(6):857-61. Epub 2006 Mar 28.

PMID:
16568308
19.

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.

Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A.

J Cell Biol. 2006 Mar 13;172(6):823-34. Epub 2006 Mar 6.

20.

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.

Mol Cell. 2006 Jan 20;21(2):187-200.

21.

Myostatin: a modulator of skeletal-muscle stem cells.

Walsh FS, Celeste AJ.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1513-7. Review.

PMID:
16246158
22.

Ku86 preserves chromatin integrity in cells adapted to high NaCl.

Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10730-5. Epub 2005 Jul 18.

23.

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.

Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.

PMID:
15965469
24.

Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

Tobin JF, Celeste AJ.

Curr Opin Pharmacol. 2005 Jun;5(3):328-32. Review.

PMID:
15907921
25.

Ablation of TrkA function in the immune system causes B cell abnormalities.

Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L.

Development. 2004 Oct;131(20):5185-95.

26.

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.

Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.

J Cell Biol. 2004 Sep 13;166(6):801-13.

27.

Effect of listeriolysin O-loaded erythrocytes on Mycobacterium avium replication within macrophages.

Rossi L, Brandi G, Malatesta M, Serafini S, Pierigé F, Celeste AG, Schiavano GF, Gazzanelli G, Magnani M.

J Antimicrob Chemother. 2004 May;53(5):863-6. Epub 2004 Mar 31.

PMID:
15056645
28.

Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.

Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L.

Mol Cell Biol. 2003 Oct;23(20):7230-42.

29.

Focusing on foci: H2AX and the recruitment of DNA-damage response factors.

Fernandez-Capetillo O, Celeste A, Nussenzweig A.

Cell Cycle. 2003 Sep-Oct;2(5):426-7. Review. No abstract available.

PMID:
12963833
30.

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.

Cell. 2003 Aug 8;114(3):371-383.

31.

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.

Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM.

Biochem Cell Biol. 2003 Jun;81(3):123-9. Review.

PMID:
12897845
32.

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A.

Nat Cell Biol. 2003 Jul;5(7):675-9.

PMID:
12792649
33.

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.

Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A.

Dev Cell. 2003 Apr;4(4):497-508.

34.

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.

J Biol Chem. 2003 May 30;278(22):20303-12. Epub 2003 Mar 25.

35.

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A.

Nat Cell Biol. 2002 Dec;4(12):993-7.

PMID:
12447390
36.

Preliminary investigations on vitellogenin m-RNA induction in some bioindicator Mediterranean fish species.

Canapa A, Barucca M, Celeste A, Olmo E, Regoli F.

Mar Environ Res. 2002 Sep-Dec;54(3-5):673-7.

PMID:
12408634
37.

Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Rossi L, Dominici S, Serafini S, Casabianca A, Cerasi A, Chiarantini L, Celeste AG, Cappellacci L, Franchetti P, Grifantini M, Magnani M.

J Antimicrob Chemother. 2002 Sep;50(3):365-74.

PMID:
12205061
38.

Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.

Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG.

J Biol Chem. 2002 Sep 6;277(36):33361-8. Epub 2002 Jun 25. Erratum in: J Biol Chem. 2003 May 2;278(18):16452.

39.

Genomic instability in mice lacking histone H2AX.

Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.

Science. 2002 May 3;296(5569):922-7. Epub 2002 Apr 4.

40.

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.

Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsuk M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.

Nature. 2001 Dec 6;414(6864):660-665. doi: 10.1038/414660a.

41.

Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages.

Schiavano GF, Celeste AG, Salvaggio L, Sisti M, Brandi G.

Int J Antimicrob Agents. 2001 Dec;18(6):525-30.

PMID:
11738339
42.

Transmission of Trichosporon asahii oesophagitis by a contaminated endoscope.

Lo Passo C, Pernice I, Celeste A, Perdichizzi G, Todaro-Luck F.

Mycoses. 2001;44(1-2):13-21.

PMID:
11398636
43.

Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.

Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C, Prasad SV, Skinner SS, Dunbar BS, Dube JL, Celeste AJ, Matzuk MM.

Mol Endocrinol. 2001 Jun;15(6):854-66.

PMID:
11376106
44.

Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.

Kumar A, Novoselov V, Celeste AJ, Wolfman NM, ten Dijke P, Kuehn MR.

J Biol Chem. 2001 Jan 5;276(1):656-61.

45.

Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells.

Ghosh-Choudhury N, Ghosh-Choudhury G, Celeste A, Ghosh PM, Moyer M, Abboud SL, Kreisberg J.

Biochim Biophys Acta. 2000 Jul 21;1497(2):186-96.

46.

Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation.

Ghosh-Choudhury N, Woodruff K, Qi W, Celeste A, Abboud SL, Ghosh Choudhury G.

Biochem Biophys Res Commun. 2000 Jun 16;272(3):705-11.

PMID:
10860819
47.

Inhibition of murine AIDS by alternate administration of azidothymidine and fludarabine monophosphate.

Fraternale A, Casabianca A, Tonelli A, Vallanti G, Chiarantini L, Brandi G, Celeste AG, Magnani M.

J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):209-20.

PMID:
10839656
48.

New treatment protocol including lympholytic and antiretroviral drugs to inhibit murine AIDS.

Fraternale A, Tonelli A, Casabianca A, Chiarantini L, Schiavano GF, Celeste AG, Magnani M.

J Acquir Immune Defic Syndr. 2000 Feb 1;23(2):107-13.

PMID:
10737424
49.

Bone morphogenetic protein-2 inhibits MAPK-dependent Elk-1 transactivation and DNA synthesis induced by EGF in mesangial cells.

Ghosh Choudhury G, Jin DC, Kim YSs, Celeste A, Ghosh-Choudhury N, Abboud HE.

Biochem Biophys Res Commun. 1999 May 10;258(2):490-6.

PMID:
10329414
50.

A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos.

Gamer LW, Wolfman NM, Celeste AJ, Hattersley G, Hewick R, Rosen V.

Dev Biol. 1999 Apr 1;208(1):222-32.

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