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Items: 50

1.

X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors.

Cendron L, Quotadamo A, Maso L, Bellio P, Montanari M, Celenza G, Venturelli A, Costi MP, Tondi D.

ACS Med Chem Lett. 2019 Mar 27;10(4):650-655. doi: 10.1021/acsmedchemlett.8b00607. eCollection 2019 Apr 11.

PMID:
30996812
2.

Kinetic Profile and Molecular Dynamic Studies Show that Y229W Substitution in an NDM-1/L209F Variant Restores the Hydrolytic Activity of the Enzyme toward Penicillins, Cephalosporins, and Carbapenems.

Piccirilli A, Brisdelli F, Aschi M, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02270-18. doi: 10.1128/AAC.02270-18. Print 2019 Apr.

PMID:
30917978
3.

Tebuconazole and Econazole Act Synergistically in Mediating Mitochondrial Stress, Energy Imbalance, and Sequential Activation of Autophagy and Apoptosis in Mouse Sertoli TM4 Cells: Possible Role of AMPK/ULK1 Axis.

Petricca S, Flati V, Celenza G, Di Gregorio J, Lizzi AR, Luzi C, Cristiano L, Cinque B, Rossi G, Festuccia C, Iorio R.

Toxicol Sci. 2019 May 1;169(1):209-223. doi: 10.1093/toxsci/kfz031.

PMID:
30698772
4.

First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase.

Spyrakis F, Bellio P, Quotadamo A, Linciano P, Benedetti P, D'Arrigo G, Baroni M, Cendron L, Celenza G, Tondi D.

J Comput Aided Mol Des. 2019 Feb;33(2):295-305. doi: 10.1007/s10822-018-0182-2. Epub 2019 Jan 2.

PMID:
30603820
5.

Oxaprozin: A new hope in the modulation of matrix metalloproteinase 9 activity.

Ianni A, Celenza G, Franceschini N.

Chem Biol Drug Des. 2019 May;93(5):811-817. doi: 10.1111/cbdd.13468. Epub 2019 Jan 11.

PMID:
30582279
6.

In silico identification and experimental validation of hits active against KPC-2 β-lactamase.

Klein R, Linciano P, Celenza G, Bellio P, Papaioannou S, Blazquez J, Cendron L, Brenk R, Tondi D.

PLoS One. 2018 Nov 29;13(11):e0203241. doi: 10.1371/journal.pone.0203241. eCollection 2018.

7.

Cerium oxide nanoparticles as potential antibiotic adjuvant. Effects of CeO2 nanoparticles on bacterial outer membrane permeability.

Bellio P, Luzi C, Mancini A, Cracchiolo S, Passacantando M, Di Pietro L, Perilli M, Amicosante G, Santucci S, Celenza G.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2428-2435. doi: 10.1016/j.bbamem.2018.07.002. Epub 2018 Jul 17.

PMID:
30026034
8.

Thymus lanceolatus ethanolic extract protects human cells from t-BHP induced oxidative damage.

Caprioli G, Maggi F, Bendif H, Miara MD, Cinque B, Lizzi AR, Brisdelli F, Celenza G.

Food Funct. 2018 Jul 17;9(7):3665-3672. doi: 10.1039/c8fo00568k.

PMID:
29932202
9.

A Kinetic Study of the Replacement by Site Saturation Mutagenesis of Residue 119 in NDM-1 Metallo-β-Lactamase.

Marcoccia F, Mercuri PS, Galleni M, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02541-17. doi: 10.1128/AAC.02541-17. Print 2018 Aug.

10.

Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance.

Celenza G, Vicario M, Bellio P, Linciano P, Perilli M, Oliver A, Blazquez J, Cendron L, Tondi D.

ChemMedChem. 2018 Apr 6;13(7):713-724. doi: 10.1002/cmdc.201700788. Epub 2018 Feb 20.

PMID:
29356380
11.

Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1.

Spyrakis F, Celenza G, Marcoccia F, Santucci M, Cross S, Bellio P, Cendron L, Perilli M, Tondi D.

ACS Med Chem Lett. 2017 Nov 26;9(1):45-50. doi: 10.1021/acsmedchemlett.7b00428. eCollection 2018 Jan 11.

12.

Interaction of carbapenems and β-lactamase inhibitors towards CTX-M-15 and CTX-M-15G238C mutant.

Sabatini A, Brisdelli F, Celenza G, Marcoccia F, Colapietro M, Tavío MM, Piccirilli A, Amicosante G, Perilli M.

J Glob Antimicrob Resist. 2017 Sep;10:95-100. doi: 10.1016/j.jgar.2017.04.004. Epub 2017 Jul 12.

PMID:
28711560
13.

SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein.

Bellio P, Di Pietro L, Mancini A, Piovano M, Nicoletti M, Brisdelli F, Tondi D, Cendron L, Franceschini N, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2017 Jun 15;29:11-18. doi: 10.1016/j.phymed.2017.04.001. Epub 2017 Apr 8.

PMID:
28515022
14.

Polar constituents, protection against reactive oxygen species, and nutritional value of Chinese artichoke (Stachys affinis Bunge).

Venditti A, Frezza C, Celona D, Bianco A, Serafini M, Cianfaglione K, Fiorini D, Ferraro S, Maggi F, Lizzi AR, Celenza G.

Food Chem. 2017 Apr 15;221:473-481. doi: 10.1016/j.foodchem.2016.10.096. Epub 2016 Oct 24.

PMID:
27979230
15.

Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro.

Brisdelli F, Perilli M, Sellitri D, Bellio P, Bozzi A, Amicosante G, Nicoletti M, Piovano M, Celenza G.

Life Sci. 2016 Aug 1;158:89-97. doi: 10.1016/j.lfs.2016.06.023. Epub 2016 Jun 27.

PMID:
27363900
16.

BlaB-15, a new BlaB metallo-β-lactamase variant found in an Elizabethkingia miricola clinical isolate.

Colapietro M, Endimiani A, Sabatini A, Marcoccia F, Celenza G, Segatore B, Amicosante G, Perilli M.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):195-7. doi: 10.1016/j.diagmicrobio.2015.11.016. Epub 2015 Nov 17.

PMID:
27033632
17.

Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems.

Bottoni C, Perilli M, Marcoccia F, Piccirilli A, Pellegrini C, Colapietro M, Sabatini A, Celenza G, Kerff F, Amicosante G, Galleni M, Mercuri PS.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3123-6. doi: 10.1128/AAC.01703-15. Print 2016 May.

18.

Kinetic Study of Laboratory Mutants of NDM-1 Metallo-β-Lactamase and the Importance of an Isoleucine at Position 35.

Marcoccia F, Bottoni C, Sabatini A, Colapietro M, Mercuri PS, Galleni M, Kerff F, Matagne A, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2366-72. doi: 10.1128/AAC.00531-15. Print 2016 Apr.

19.

Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy.

Bottoni C, Marcoccia F, Compagnoni C, Colapietro M, Sabatini A, Celenza G, Segatore B, Maturo MG, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2015 Aug;59(8):4990-3. doi: 10.1128/AAC.00628-15. Epub 2015 May 18.

20.

Interaction between lichen secondary metabolites and antibiotics against clinical isolates methicillin-resistant Staphylococcus aureus strains.

Bellio P, Segatore B, Mancini A, Di Pietro L, Bottoni C, Sabatini A, Brisdelli F, Piovano M, Nicoletti M, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2015 Feb 15;22(2):223-30. doi: 10.1016/j.phymed.2014.12.005. Epub 2014 Dec 19.

PMID:
25765826
21.

The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis.

Capannolo M, Fasciani I, Romeo S, Aloisi G, Rossi M, Bellio P, Celenza G, Cinque B, Cifone MG, Scarselli M, Maggio R.

Eur Neuropsychopharmacol. 2015 Mar;25(3):413-24. doi: 10.1016/j.euroneuro.2014.12.002. Epub 2014 Dec 18.

PMID:
25554564
22.

OXA-23 carbapenemase in multidrug-resistant Acinetobacter baumannii ST2 type: first identification in L'Aquila Hospital (Italy).

Perilli M, Sabatini A, Pontieri E, Celenza G, Segatore B, Bottoni C, Bellio P, Mancini A, Marcoccia F, Brisdelli F, Amicosante G.

Microb Drug Resist. 2015 Feb;21(1):97-101. doi: 10.1089/mdr.2014.0056. Epub 2014 Oct 2.

PMID:
25275951
23.

Kinetic study of the effect of histidines 240 and 164 on TEM-149 enzyme probed by β-lactam inhibitors.

Perilli M, Mancini A, Celenza G, Bottoni C, Bellio P, Sabatini A, Di Pietro L, Brisdelli F, Segatore B, Amicosante G.

Antimicrob Agents Chemother. 2014 Oct;58(10):6294-6. doi: 10.1128/AAC.02950-14. Epub 2014 Aug 4.

24.

Emergence of blaKPC-3-Tn4401a in Klebsiella pneumoniae ST512 in the municipal wastewater treatment plant and in the university hospital of a town in central Italy.

Perilli M, Bottoni C, Pontieri E, Segatore B, Celenza G, Setacci D, Bellio P, Strom R, Amicosante G.

J Glob Antimicrob Resist. 2013 Dec;1(4):217-220. doi: 10.1016/j.jgar.2013.07.002. Epub 2013 Aug 20.

PMID:
27873616
25.

Curcumin inhibits the SOS response induced by levofloxacin in Escherichia coli.

Bellio P, Brisdelli F, Perilli M, Sabatini A, Bottoni C, Segatore B, Setacci D, Amicosante G, Celenza G.

Phytomedicine. 2014 Mar 15;21(4):430-4. doi: 10.1016/j.phymed.2013.10.011. Epub 2013 Nov 17.

PMID:
24252336
26.

Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses.

Napolitano M, Dolce A, Celenza G, Grandone E, Perilli MG, Siragusa S, Carta G, Orecchioni A, Mariani G.

Ann Hematol. 2014 Apr;93(4):557-63. doi: 10.1007/s00277-013-1901-3. Epub 2013 Sep 19.

PMID:
24048634
27.

R164H and V240H replacements by site-directed mutagenesis of TEM-149 extended-spectrum β-lactamase: kinetic analysis of TEM-149H240 and TEM-149H164-H240 laboratory mutants.

Perilli M, Celenza G, Mercuri PS, Galleni M, Pellegrini C, Segatore B, Amicosante G.

Antimicrob Agents Chemother. 2013 Feb;57(2):1047-9. doi: 10.1128/AAC.01268-12. Epub 2012 Nov 26.

28.

Carbapenem-resistant Klebsiella pneumoniae harbouring blaKPC-3 and blaVIM-2 from central Italy.

Perilli M, Bottoni C, Grimaldi A, Segatore B, Celenza G, Mariani M, Bellio P, Frascaria P, Amicosante G.

Diagn Microbiol Infect Dis. 2013 Feb;75(2):218-21. doi: 10.1016/j.diagmicrobio.2012.10.008. Epub 2012 Nov 13.

PMID:
23153971
29.

Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci.

Celenza G, Segatore B, Setacci D, Perilli M, Brisdelli F, Bellio P, Piovano M, Garbarino JA, Amicosante G, Nicoletti M.

Nat Prod Res. 2013;27(17):1528-31. doi: 10.1080/14786419.2012.730043. Epub 2012 Oct 2.

PMID:
23030591
30.

Chromosomal blaCTX-M-₁₅ associated with ISEcp1 in Proteus mirabilis and Morganella morganii isolated at the Military Hospital of Tunis, Tunisia.

Mahrouki S, Belhadj O, Chihi H, Mohamed BM, Celenza G, Amicosante G, Perilli M.

J Med Microbiol. 2012 Sep;61(Pt 9):1286-9. doi: 10.1099/jmm.0.039487-0. Epub 2012 Jun 8.

PMID:
22683657
31.

Cytotoxic activity and antioxidant capacity of purified lichen metabolites: an in vitro study.

Brisdelli F, Perilli M, Sellitri D, Piovano M, Garbarino JA, Nicoletti M, Bozzi A, Amicosante G, Celenza G.

Phytother Res. 2013 Mar;27(3):431-7. doi: 10.1002/ptr.4739. Epub 2012 May 25.

PMID:
22628260
32.

In vitro antimicrobial activity of pannarin alone and in combination with antibiotics against methicillin-resistant Staphylococcus aureus clinical isolates.

Celenza G, Segatore B, Setacci D, Bellio P, Brisdelli F, Piovano M, Garbarino JA, Nicoletti M, Perilli M, Amicosante G.

Phytomedicine. 2012 May 15;19(7):596-602. doi: 10.1016/j.phymed.2012.02.010. Epub 2012 Mar 27.

PMID:
22459282
33.

In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods.

Segatore B, Bellio P, Setacci D, Brisdelli F, Piovano M, Garbarino JA, Nicoletti M, Amicosante G, Perilli M, Celenza G.

Phytomedicine. 2012 Feb 15;19(3-4):341-7. doi: 10.1016/j.phymed.2011.10.012. Epub 2011 Nov 25.

PMID:
22119041
34.

Persistence of TEM-52/TEM-92 and SHV-12 extended-spectrum β-lactamases in clinical isolates of Enterobacteriaceae in Italy.

Perilli M, Segatore B, Mugnaioli C, Celenza G, Rossolini GM, Stefani S, Luzzaro F, Pini B, Amicosante G.

Microb Drug Resist. 2011 Dec;17(4):521-4. doi: 10.1089/mdr.2011.0059. Epub 2011 Oct 4.

PMID:
21970626
35.

First report from Italy of blaVIM-1 and blaTEM-1 genes in Pseudomonas putida and Acinetobacter baumannii isolated from wastewater.

Perilli M, Pellegrini C, Celenza G, Bellio P, Segatore B, Amicosante G.

J Chemother. 2011 Jun;23(3):181-2. No abstract available.

PMID:
21742591
36.

Occurrence of class 1 and 2 integrons in resistant Enterobacteriaceae collected from a urban wastewater treatment plant: first report from central Italy.

Pellegrini C, Celenza G, Segatore B, Bellio P, Setacci D, Amicosante G, Perilli M.

Microb Drug Resist. 2011 Jun;17(2):229-34. doi: 10.1089/mdr.2010.0117. Epub 2011 Jan 26.

PMID:
21268680
37.

QnrB9 in association with TEM-116 extended-spectrum beta-lactamase in Citrobacter freundii isolated from sewage effluent: first report from Italy.

Forcella C, Pellegrini C, Celenza G, Segatore B, Calabrese R, Tavio MM, Amicosante G, Perilli M.

J Chemother. 2010 Aug;22(4):243-5.

PMID:
20685627
38.

Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location.

Pellegrini C, Mercuri PS, Celenza G, Galleni M, Segatore B, Sacchetti E, Volpe R, Amicosante G, Perilli M.

J Antimicrob Chemother. 2009 May;63(5):901-8. doi: 10.1093/jac/dkp061. Epub 2009 Mar 6.

PMID:
19270313
39.

Evidence for qnrB1 and aac(6')-Ib-cr in CTX-M-15-producing uropathogenic Enterobacteriaceae in an Italian teaching hospital.

Perilli M, Forcella C, Celenza G, Frascaria P, Segatore B, Pellegrini C, Amicosante G.

Diagn Microbiol Infect Dis. 2009 May;64(1):90-3. doi: 10.1016/j.diagmicrobio.2009.01.009. Epub 2009 Feb 26.

PMID:
19249178
40.

A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.

Lee M, Celenza G, Boggess B, Blase J, Shi Q, Toth M, Bernardo MM, Wolter WR, Suckow MA, Hesek D, Noll BC, Fridman R, Mobashery S, Chang M.

Chem Biol Drug Des. 2009 Feb;73(2):189-202. doi: 10.1111/j.1747-0285.2008.00750.x.

41.

Natural D240G Toho-1 mutant conferring resistance to ceftazidime: biochemical characterization of CTX-M-43.

Celenza G, Luzi C, Aschi M, Segatore B, Setacci D, Pellegrini C, Forcella C, Amicosante G, Perilli M.

J Antimicrob Chemother. 2008 Nov;62(5):991-7. doi: 10.1093/jac/dkn339. Epub 2008 Aug 27.

PMID:
18755695
42.

Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor.

Celenza G, Villegas-Estrada A, Lee M, Boggess B, Forbes C, Wolter WR, Suckow MA, Mobashery S, Chang M.

Chem Biol Drug Des. 2008 Mar;71(3):187-96. doi: 10.1111/j.1747-0277.2008.00632.x.

PMID:
18221479
43.

E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.

Perilli M, Celenza G, De Santis F, Pellegrini C, Forcella C, Rossolini GM, Stefani S, Amicosante G.

Antimicrob Agents Chemother. 2008 Mar;52(3):915-9. Epub 2007 Dec 26.

44.

Metabolism of a highly selective gelatinase inhibitor generates active metabolite.

Lee M, Villegas-Estrada A, Celenza G, Boggess B, Toth M, Kreitinger G, Forbes C, Fridman R, Mobashery S, Chang M.

Chem Biol Drug Des. 2007 Nov;70(5):371-82. Epub 2007 Oct 10.

PMID:
17927722
45.

Biochemical analysis of TEM-134, a new TEM-type extended-spectrum beta-lactamase variant produced in a Citrobacter koseri clinical isolate from an Italian hospital.

Perilli M, Celenza G, Fiore M, Segatore B, Pellegrini C, Luzzaro F, Rossolini GM, Amicosante G.

J Antimicrob Chemother. 2007 Oct;60(4):877-80. Epub 2007 Aug 2.

PMID:
17673478
46.

An in vitro investigation of levofloxacin and ciprofloxacin against clinical isolates of Pseudomonas aeruginosa.

Segatore B, Perilli M, Larosa M, Setacci D, Celenza G, Amicosante G.

Int J Antimicrob Agents. 2007 Oct;30(4):374-6. Epub 2007 Jul 30. No abstract available.

PMID:
17659863
47.

Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes.

Perilli M, Caporale B, Celenza G, Pellegrini C, Docquier JD, Mezzatesta M, Rossolini GM, Stefani S, Amicosante G.

Antimicrob Agents Chemother. 2007 Aug;51(8):2988-90. Epub 2007 Apr 30.

48.

In vitro selection and characterization of mutants in TEM-1-producing Escherichia coli by ceftazidime and ceftibuten.

Perilli M, Segatore B, Tavio M, Setacci D, Celenza G, De Santis F, Pellegrini C, Rossolini GM, Amicosante G.

J Chemother. 2007 Apr;19(2):123-6.

PMID:
17434819
49.

Occurrence of extended spectrum beta-lactamases among isolates of Enterobacteriaceae from urinary tract infections in southern Italy.

Caccamo M, Perilli M, Celenza G, Bonfiglio G, Tempera G, Amicosante G.

Microb Drug Resist. 2006 Winter;12(4):257-64.

PMID:
17227211
50.

Spread of bla(CTX-M-type) and bla(PER-2) beta-lactamase genes in clinical isolates from Bolivian hospitals.

Celenza G, Pellegrini C, Caccamo M, Segatore B, Amicosante G, Perilli M.

J Antimicrob Chemother. 2006 May;57(5):975-8. Epub 2006 Mar 1.

PMID:
16510850

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