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Items: 23

1.

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.

Bussi C, Peralta Ramos JM, Arroyo DS, Gallea JI, Ronchi P, Kolovou A, Wang JM, Florey O, Celej MS, Schwab Y, Ktistakis NT, Iribarren P.

J Cell Sci. 2018 Nov 30;131(23). pii: jcs226241. doi: 10.1242/jcs.226241.

2.

Amyloid oligomerization of the Parkinson's disease related protein α-synuclein impacts on its curvature-membrane sensitivity.

Gallea JI, Ambroggio EE, Vilcaes AA, James NG, Jameson DM, Celej MS.

J Neurochem. 2018 Nov;147(4):541-556. doi: 10.1111/jnc.14573. Epub 2018 Nov 6.

PMID:
30142705
3.

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies.

Abdelkarim H, Marshall MS, Scesa G, Smith RA, Rue E, Marshall J, Elackattu V, Stoskute M, Issa Y, Santos M, Nguyen D, Hauck Z, van Breemen R, Celej MS, Gaponenko V, Bongarzone ER.

Sci Rep. 2018 Aug 20;8(1):12462. doi: 10.1038/s41598-018-30808-9.

4.

Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death.

Bussi C, Peralta Ramos JM, Arroyo DS, Gaviglio EA, Gallea JI, Wang JM, Celej MS, Iribarren P.

Sci Rep. 2017 Mar 3;7:43153. doi: 10.1038/srep43153.

5.

Structural remodeling during amyloidogenesis of physiological Nα-acetylated α-synuclein.

Gallea JI, Sarroukh R, Yunes-Quartino P, Ruysschaert JM, Raussens V, Celej MS.

Biochim Biophys Acta. 2016 May;1864(5):501-10. doi: 10.1016/j.bbapap.2016.01.011. Epub 2016 Feb 2.

PMID:
26845568
6.

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease.

Gustot A, Gallea JI, Sarroukh R, Celej MS, Ruysschaert JM, Raussens V.

Biochem J. 2015 Nov 1;471(3):323-33. doi: 10.1042/BJ20150617. Epub 2015 Aug 13.

PMID:
26272943
7.

Alpha-synuclein levels in blood plasma decline with healthy aging.

Koehler NK, Stransky E, Meyer M, Gaertner S, Shing M, Schnaidt M, Celej MS, Jovin TM, Leyhe T, Laske C, Batra A, Buchkremer G, Fallgatter AJ, Wernet D, Richartz-Salzburger E.

PLoS One. 2015 Apr 6;10(4):e0123444. doi: 10.1371/journal.pone.0123444. eCollection 2015.

8.

Structural insights into amyloid oligomers of the Parkinson disease-related protein α-synuclein.

Gallea JI, Celej MS.

J Biol Chem. 2014 Sep 26;289(39):26733-42. doi: 10.1074/jbc.M114.566695. Epub 2014 Aug 20.

9.

Structural characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase protofibrils preventing α-synuclein oligomeric species toxicity.

Ávila CL, Torres-Bugeau CM, Barbosa LR, Sales EM, Ouidja MO, Socías SB, Celej MS, Raisman-Vozari R, Papy-Garcia D, Itri R, Chehín RN.

J Biol Chem. 2014 May 16;289(20):13838-50. doi: 10.1074/jbc.M113.544288. Epub 2014 Mar 26.

10.

Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.

Smith BR, Santos MB, Marshall MS, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, van Breemen R, Claycomb KI, Gallea JI, Celej MS, Crocker SJ, Givogri MI, Bongarzone ER.

J Pathol. 2014 Apr;232(5):509-21. doi: 10.1002/path.4328. Epub 2014 Feb 20.

11.

Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.

Koehler NK, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, Leyhe T, Laske C, Maetzler W, Kahle P, Celej MS, Jovin TM, Fallgatter AJ, Batra A, Buchkremer G, Schott K, Richartz-Salzburger E.

PLoS One. 2013 May 31;8(5):e64649. doi: 10.1371/journal.pone.0064649. Print 2013.

12.

Imaging nanometer-sized α-synuclein aggregates by superresolution fluorescence localization microscopy.

Roberti MJ, Fölling J, Celej MS, Bossi M, Jovin TM, Jares-Erijman EA.

Biophys J. 2012 Apr 4;102(7):1598-607. doi: 10.1016/j.bpj.2012.03.010. Epub 2012 Apr 3.

13.

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure.

Celej MS, Sarroukh R, Goormaghtigh E, Fidelio GD, Ruysschaert JM, Raussens V.

Biochem J. 2012 May 1;443(3):719-26. doi: 10.1042/BJ20111924.

PMID:
22316405
14.

Binding of the highly toxic tetracycline derivative, anhydrotetracycline, to bovine serum albumin.

Burgos MI, Fernández RA, Celej MS, Rossi LI, Fidelio GD, Dassie SA.

Biol Pharm Bull. 2011;34(8):1301-6.

15.

Small molecule fluorescent probes for the detection of amyloid self-assembly in vitro and in vivo.

Bertoncini CW, Celej MS.

Curr Protein Pept Sci. 2011 May;12(3):205-20. Review.

PMID:
21348839
16.

A triple-emission fluorescent probe reveals distinctive amyloid fibrillar polymorphism of wild-type alpha-synuclein and its familial Parkinson's disease mutants.

Celej MS, Caarls W, Demchenko AP, Jovin TM.

Biochemistry. 2009 Aug 11;48(31):7465-72. doi: 10.1021/bi9003843.

PMID:
19586054
17.

Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.

Heise H, Celej MS, Becker S, Riedel D, Pelah A, Kumar A, Jovin TM, Baldus M.

J Mol Biol. 2008 Jul 11;380(3):444-50. doi: 10.1016/j.jmb.2008.05.026. Epub 2008 May 17.

PMID:
18539297
18.

Fluorescent N-arylaminonaphthalene sulfonate probes for amyloid aggregation of alpha-synuclein.

Celej MS, Jares-Erijman EA, Jovin TM.

Biophys J. 2008 Jun;94(12):4867-79. doi: 10.1529/biophysj.107.125211. Epub 2008 Mar 13.

19.

Differential scanning calorimetry as a tool to estimate binding parameters in multiligand binding proteins.

Celej MS, Dassie SA, González M, Bianconi ML, Fidelio GD.

Anal Biochem. 2006 Mar 15;350(2):277-84. Epub 2006 Jan 6.

PMID:
16434020
20.

Ligand-induced thermostability in proteins: thermodynamic analysis of ANS-albumin interaction.

Celej MS, Dassie SA, Freire E, Bianconi ML, Fidelio GD.

Biochim Biophys Acta. 2005 Jun 30;1750(2):122-33.

PMID:
15972267
21.

Conformational flexibility of avidin: the influence of biotin binding.

Celej MS, Montich GG, Fidelio GD.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):922-7. Erratum in: Biochem Biophys Res Commun. 2005 Feb 4;327(1):372.

PMID:
15541378
22.

Superactivity and conformational changes on alpha-chymotrypsin upon interfacial binding to cationic micelles.

Celej MS, D'Andrea MG, Campana PT, Fidelio GD, Bianconi ML.

Biochem J. 2004 Mar 15;378(Pt 3):1059-66.

23.

Protein stability induced by ligand binding correlates with changes in protein flexibility.

Celej MS, Montich GG, Fidelio GD.

Protein Sci. 2003 Jul;12(7):1496-506.

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