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Items: 1 to 50 of 164

1.

Determining gestational age using genome methylation profile: A novel approach for fetal medicine.

Falick Michaeli T, Spiro A, Sabag O, Karavani G, Yagel S, Eventov-Friedman S, Cedar H, Bergman Y, Gielchinsky Y.

Prenat Diagn. 2019 Oct;39(11):1005-1010. doi: 10.1002/pd.5535. Epub 2019 Aug 12.

PMID:
31330572
2.

Role of transcription complexes in the formation of the basal methylation pattern in early development.

Greenfield R, Tabib A, Keshet I, Moss J, Sabag O, Goren A, Cedar H.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10387-10391. doi: 10.1073/pnas.1804755115. Epub 2018 Sep 26.

3.

Principles of DNA methylation and their implications for biology and medicine.

Dor Y, Cedar H.

Lancet. 2018 Sep 1;392(10149):777-786. doi: 10.1016/S0140-6736(18)31268-6. Epub 2018 Aug 9. Review.

PMID:
30100054
4.

Postnatal DNA demethylation and its role in tissue maturation.

Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H.

Nat Commun. 2018 May 23;9(1):2040. doi: 10.1038/s41467-018-04456-6.

5.

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers.

Neiman D, Moss J, Hecht M, Magenheim J, Piyanzin S, Shapiro AMJ, de Koning EJP, Razin A, Cedar H, Shemer R, Dor Y.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13525-13530. doi: 10.1073/pnas.1713736114. Epub 2017 Dec 4.

6.

Programming asynchronous replication in stem cells.

Masika H, Farago M, Hecht M, Condiotti R, Makedonski K, Buganim Y, Burstyn-Cohen T, Bergman Y, Cedar H.

Nat Struct Mol Biol. 2017 Dec;24(12):1132-1138. doi: 10.1038/nsmb.3503. Epub 2017 Nov 13.

PMID:
29131141
7.

Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome.

Hecht M, Tabib A, Kahan T, Orlanski S, Gropp M, Tabach Y, Yanuka O, Benvenisty N, Keshet I, Cedar H.

Int J Dev Biol. 2017;61(3-4-5):285-292. doi: 10.1387/ijdb.170022hc.

8.

Annotating the genome by DNA methylation.

Cedar H, Razin A.

Int J Dev Biol. 2017;61(3-4-5):137-148. doi: 10.1387/ijdb.160270hc.

9.

Clonally stable Vκ allelic choice instructs Igκ repertoire.

Levin-Klein R, Fraenkel S, Lichtenstein M, Matheson LS, Bartok O, Nevo Y, Kadener S, Corcoran AE, Cedar H, Bergman Y.

Nat Commun. 2017 May 30;8:15575. doi: 10.1038/ncomms15575.

10.

Contribution of epigenetic mechanisms to variation in cancer risk among tissues.

Klutstein M, Moss J, Kaplan T, Cedar H.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2230-2234. doi: 10.1073/pnas.1616556114. Epub 2017 Feb 13.

11.

DNA Methylation in Cancer and Aging.

Klutstein M, Nejman D, Greenfield R, Cedar H.

Cancer Res. 2016 Jun 15;76(12):3446-50. doi: 10.1158/0008-5472.CAN-15-3278. Epub 2016 Jun 2. Review.

12.

Maintenance of Epigenetic Information.

Almouzni G, Cedar H.

Cold Spring Harb Perspect Biol. 2016 May 2;8(5). pii: a019372. doi: 10.1101/cshperspect.a019372. Review.

13.

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.

Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5018-23. doi: 10.1073/pnas.1604365113. Epub 2016 Apr 18.

14.

Identification of tissue-specific cell death using methylation patterns of circulating DNA.

Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14.

15.

Gender-specific postnatal demethylation and establishment of epigenetic memory.

Reizel Y, Spiro A, Sabag O, Skversky Y, Hecht M, Keshet I, Berman BP, Cedar H.

Genes Dev. 2015 May 1;29(9):923-33. doi: 10.1101/gad.259309.115.

16.

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.

Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi RF, Vertino PM, Cedar H, Galun E, Goldenberg D.

Oncotarget. 2015 May 10;6(13):11047-60.

17.

A novel pax5-binding regulatory element in the igκ locus.

Levin-Klein R, Kirillov A, Rosenbluh C, Cedar H, Bergman Y.

Front Immunol. 2014 May 23;5:240. doi: 10.3389/fimmu.2014.00240. eCollection 2014.

18.

Aberrant DNA methylation in ES cells.

Ludwig G, Nejman D, Hecht M, Orlanski S, Abu-Remaileh M, Yanuka O, Sandler O, Marx A, Roberts D, Benvenisty N, Bergman Y, Mendelsohn M, Cedar H.

PLoS One. 2014 May 22;9(5):e96090. doi: 10.1371/journal.pone.0096090. eCollection 2014.

19.

Molecular rules governing de novo methylation in cancer.

Nejman D, Straussman R, Steinfeld I, Ruvolo M, Roberts D, Yakhini Z, Cedar H.

Cancer Res. 2014 Mar 1;74(5):1475-83. doi: 10.1158/0008-5472.CAN-13-3042. Epub 2014 Jan 22.

20.

Establishment of methylation patterns in ES cells.

Sabag O, Zamir A, Keshet I, Hecht M, Ludwig G, Tabib A, Moss J, Cedar H.

Nat Struct Mol Biol. 2014 Jan;21(1):110-2. doi: 10.1038/nsmb.2734. Epub 2013 Dec 15.

PMID:
24336222
21.

DNA methylation dynamics in health and disease.

Bergman Y, Cedar H.

Nat Struct Mol Biol. 2013 Mar;20(3):274-81. doi: 10.1038/nsmb.2518. Review. Erratum in: Nat Struct Mol Biol. 2013 Oct;20(10):1236.

PMID:
23463312
22.

Clonal allelic predetermination of immunoglobulin-κ rearrangement.

Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y.

Nature. 2012 Oct 25;490(7421):561-5. doi: 10.1038/nature11496. Epub 2012 Sep 30.

PMID:
23023124
23.

Programming of DNA methylation patterns.

Cedar H, Bergman Y.

Annu Rev Biochem. 2012;81:97-117. doi: 10.1146/annurev-biochem-052610-091920. Epub 2012 Feb 23. Review.

PMID:
22404632
24.

Epigenetics of haematopoietic cell development.

Cedar H, Bergman Y.

Nat Rev Immunol. 2011 Jun 10;11(7):478-88. doi: 10.1038/nri2991. Review.

PMID:
21660052
25.

Genome-wide de novo methylation in epithelial ovarian cancer.

Michaelson-Cohen R, Keshet I, Straussman R, Hecht M, Cedar H, Beller U.

Int J Gynecol Cancer. 2011 Feb;21(2):269-79. doi: 10.1097/IGC.0b013e31820e5cda.

PMID:
21270610
26.

Epigenetic control of recombination in the immune system.

Bergman Y, Cedar H.

Semin Immunol. 2010 Dec;22(6):323-9. doi: 10.1016/j.smim.2010.07.003. Epub 2010 Sep 15. Review.

27.

Epigenetic silencing during early lineage commitment.

Cedar H, Bergman Y.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2009 Apr 30.

28.

Reprogramming of DNA replication timing.

Shufaro Y, Lacham-Kaplan O, Tzuberi BZ, McLaughlin J, Trounson A, Cedar H, Reubinoff BE.

Stem Cells. 2010 Mar 31;28(3):443-9. doi: 10.1002/stem.303.

29.

Allelic inactivation of rDNA loci.

Schlesinger S, Selig S, Bergman Y, Cedar H.

Genes Dev. 2009 Oct 15;23(20):2437-47. doi: 10.1101/gad.544509.

30.

Shifts in replication timing actively affect histone acetylation during nucleosome reassembly.

Lande-Diner L, Zhang J, Cedar H.

Mol Cell. 2009 Jun 26;34(6):767-74. doi: 10.1016/j.molcel.2009.05.027.

31.

Developmental programming of CpG island methylation profiles in the human genome.

Straussman R, Nejman D, Roberts D, Steinfeld I, Blum B, Benvenisty N, Simon I, Yakhini Z, Cedar H.

Nat Struct Mol Biol. 2009 May;16(5):564-71. doi: 10.1038/nsmb.1594. Epub 2009 Apr 19.

PMID:
19377480
32.

Linking DNA methylation and histone modification: patterns and paradigms.

Cedar H, Bergman Y.

Nat Rev Genet. 2009 May;10(5):295-304. doi: 10.1038/nrg2540. Review.

PMID:
19308066
33.

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes.

Epsztejn-Litman S, Feldman N, Abu-Remaileh M, Shufaro Y, Gerson A, Ueda J, Deplus R, Fuks F, Shinkai Y, Cedar H, Bergman Y.

Nat Struct Mol Biol. 2008 Nov;15(11):1176-1183. doi: 10.1038/nsmb.1476. Epub 2008 Oct 26.

34.

DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin.

Goren A, Tabib A, Hecht M, Cedar H.

Genes Dev. 2008 May 15;22(10):1319-24. doi: 10.1101/gad.468308. Epub 2008 Apr 28.

35.

Choreography of Ig allelic exclusion.

Cedar H, Bergman Y.

Curr Opin Immunol. 2008 Jun;20(3):308-17. doi: 10.1016/j.coi.2008.02.002. Epub 2008 Apr 9. Review.

PMID:
18400481
36.

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.

Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.

Nat Immunol. 2007 Jul;8(7):715-22. Epub 2007 Jun 3.

PMID:
17546032
37.

Role of DNA methylation in stable gene repression.

Lande-Diner L, Zhang J, Ben-Porath I, Amariglio N, Keshet I, Hecht M, Azuara V, Fisher AG, Rechavi G, Cedar H.

J Biol Chem. 2007 Apr 20;282(16):12194-200. Epub 2007 Feb 20.

38.

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H.

Nat Genet. 2007 Feb;39(2):232-6. Epub 2006 Dec 31.

PMID:
17200670
39.

Fine tuning of globin gene expression by DNA methylation.

Goren A, Simchen G, Fibach E, Szabo PE, Tanimoto K, Chakalova L, Pfeifer GP, Fraser PJ, Engel JD, Cedar H.

PLoS One. 2006 Dec 20;1:e46.

40.

Evidence for an instructive mechanism of de novo methylation in cancer cells.

Keshet I, Schlesinger Y, Farkash S, Rand E, Hecht M, Segal E, Pikarski E, Young RA, Niveleau A, Cedar H, Simon I.

Nat Genet. 2006 Feb;38(2):149-53.

PMID:
16444255
41.

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y.

Nat Cell Biol. 2006 Feb;8(2):188-94. Epub 2006 Jan 15.

PMID:
16415856
42.

Gene repression paradigms in animal cells.

Lande-Diner L, Zhang J, Hashimshony T, Goren A, Keshet I, Cedar H.

Cold Spring Harb Symp Quant Biol. 2004;69:131-8. Review. No abstract available.

PMID:
16117642
43.

Silence of the genes--mechanisms of long-term repression.

Lande-Diner L, Cedar H.

Nat Rev Genet. 2005 Aug;6(8):648-54. Review.

PMID:
16012529
44.

Epigenetic ontogeny of the Igk locus during B cell development.

Goldmit M, Ji Y, Skok J, Roldan E, Jung S, Cedar H, Bergman Y.

Nat Immunol. 2005 Feb;6(2):198-203. Epub 2004 Dec 26.

PMID:
15619624
45.

A stepwise epigenetic process controls immunoglobulin allelic exclusion.

Bergman Y, Cedar H.

Nat Rev Immunol. 2004 Oct;4(10):753-61. Review.

PMID:
15459667
46.

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.

Rand E, Ben-Porath I, Keshet I, Cedar H.

Curr Biol. 2004 Jun 8;14(11):1007-12.

47.

A multistep mechanism for the activation of rearrangement in the immune system.

Ji Y, Zhang J, Lee AI, Cedar H, Bergman Y.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7557-62. Epub 2003 Jun 11.

48.

The role of DNA methylation in setting up chromatin structure during development.

Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H.

Nat Genet. 2003 Jun;34(2):187-92.

PMID:
12740577
49.

Epigenetic mechanisms that regulate antigen receptor gene expression.

Bergman Y, Fisher A, Cedar H.

Curr Opin Immunol. 2003 Apr;15(2):176-81. Review.

PMID:
12633667
50.

Biallelic germline transcription at the kappa immunoglobulin locus.

Singh N, Bergman Y, Cedar H, Chess A.

J Exp Med. 2003 Mar 17;197(6):743-50. Epub 2003 Mar 10.

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