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Items: 39

1.

The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta.

Karahoda R, Ceckova M, Staud F.

Toxicol Appl Pharmacol. 2019 Feb 5. pii: S0041-008X(19)30043-2. doi: 10.1016/j.taap.2019.02.002. [Epub ahead of print]

PMID:
30735677
2.

Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters.

Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F.

Biochem Pharmacol. 2019 Feb 2;163:60-70. doi: 10.1016/j.bcp.2019.01.024. [Epub ahead of print]

PMID:
30716294
3.

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F.

PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018.

4.

Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta.

Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F.

Drug Metab Dispos. 2018 Nov;46(11):1817-1826. doi: 10.1124/dmd.118.083329. Epub 2018 Aug 10.

PMID:
30097436
5.

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

Široká J, Čečková M, Urbánek L, Kryštof V, Gucký T, Hofman J, Strnad M, Štaud F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:24-32. doi: 10.1016/j.jchromb.2018.04.049. Epub 2018 May 1.

PMID:
29753211
6.

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro.

Sorf A, Hofman J, Kučera R, Staud F, Ceckova M.

Biochem Pharmacol. 2018 Aug;154:10-17. doi: 10.1016/j.bcp.2018.04.013. Epub 2018 Apr 16.

PMID:
29673999
7.

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K.

Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657.

PMID:
29332594
8.

Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine.

Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F.

Placenta. 2017 Dec;60:86-92. doi: 10.1016/j.placenta.2017.10.011. Epub 2017 Nov 10.

PMID:
29208244
9.

MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption.

Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00837-17. doi: 10.1128/AAC.00837-17. Print 2017 Sep.

10.

Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.

Zelena L, Reznicek J, Ceckova M, Sklenarova H.

J Pharm Biomed Anal. 2017 Apr 15;137:70-77. doi: 10.1016/j.jpba.2017.01.012. Epub 2017 Jan 11.

PMID:
28092857
11.

Etravirine inhibits ABCG2 drug transporter and affects transplacental passage of tenofovir disoproxil fumarate.

Reznicek J, Ceckova M, Tupova L, Staud F.

Placenta. 2016 Nov;47:124-129. doi: 10.1016/j.placenta.2016.09.019. Epub 2016 Sep 29.

PMID:
27780535
12.

Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5563-72. doi: 10.1128/AAC.00648-16. Print 2016 Sep.

13.

Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters.

Reznicek J, Ceckova M, Cerveny L, Müller F, Staud F.

Xenobiotica. 2017 Jan;47(1):77-85. doi: 10.3109/00498254.2016.1158886. Epub 2016 Apr 6.

PMID:
27052107
14.

Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

Biopharm Drug Dispos. 2016 Jan;37(1):28-38. doi: 10.1002/bdd.1993.

PMID:
26390406
15.

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F.

Xenobiotica. 2016;46(5):416-23. doi: 10.3109/00498254.2015.1086039. Epub 2015 Sep 12.

PMID:
26364927
16.

Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro.

Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F.

Biochem Pharmacol. 2015 Dec 1;98(3):465-72. doi: 10.1016/j.bcp.2015.08.099. Epub 2015 Aug 20.

PMID:
26300056
17.

Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir.

Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F.

Reprod Toxicol. 2015 Nov;57:176-82. doi: 10.1016/j.reprotox.2015.07.070. Epub 2015 Jul 10.

PMID:
26169552
18.

Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.

Cihalova D, Staud F, Ceckova M.

Cancer Chemother Pharmacol. 2015 Jul;76(1):105-16. doi: 10.1007/s00280-015-2772-1. Epub 2015 May 19.

PMID:
25986678
19.

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms.

Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S.

Toxicol Appl Pharmacol. 2015 May 15;285(1):12-22. doi: 10.1016/j.taap.2015.03.004. Epub 2015 Mar 12.

PMID:
25771127
20.

Regulation of drug transporter expression and function in the placenta.

Staud F, Ceckova M.

Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):533-55. doi: 10.1517/17425255.2015.1005073. Epub 2015 Jan 20. Review.

PMID:
25600150
21.

Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.

Neumanova Z, Cerveny L, Ceckova M, Staud F.

AIDS. 2014 Jan 2;28(1):9-17. doi: 10.1097/QAD.0000000000000112.

PMID:
24413260
22.

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro.

Cihalova D, Hofman J, Ceckova M, Staud F.

PLoS One. 2013 Dec 23;8(12):e83467. doi: 10.1371/journal.pone.0083467. eCollection 2013.

23.

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1).

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F.

PLoS One. 2013 Oct 8;8(10):e75520. doi: 10.1371/journal.pone.0075520. eCollection 2013.

24.

Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics.

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M.

Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11. doi: 10.1016/j.biocel.2013.06.022. Epub 2013 Jul 5. Review.

PMID:
23831838
25.

Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages of gestation.

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovský M, Micuda S, Staud F.

Biol Reprod. 2013 Mar 7;88(3):55. doi: 10.1095/biolreprod.112.105064. Print 2013 Mar.

PMID:
23303678
26.

Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms.

Cerveny L, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J.

Infect Immun. 2013 Mar;81(3):629-35. doi: 10.1128/IAI.01035-12. Epub 2012 Dec 21. Review.

27.

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.

Staud F, Cerveny L, Ceckova M.

J Drug Target. 2012 Nov;20(9):736-63. doi: 10.3109/1061186X.2012.716847. Epub 2012 Sep 20. Review.

PMID:
22994411
28.

Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F.

Toxicol Sci. 2012 Aug;128(2):471-81. doi: 10.1093/toxsci/kfs160. Epub 2012 Apr 26.

PMID:
22543277
29.

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F.

Pharmacol Res. 2012 Mar;65(3):312-9. doi: 10.1016/j.phrs.2011.11.017. Epub 2011 Dec 6.

PMID:
22173067
30.

Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy.

Hahnova-Cygalova L, Ceckova M, Staud F.

Drug Metab Rev. 2011 Feb;43(1):53-68. doi: 10.3109/03602532.2010.512293. Epub 2010 Sep 20. Review.

PMID:
20854129
31.

Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics.

Staud F, Ceckova M, Micuda S, Pavek P.

Methods Mol Biol. 2010;596:199-222. doi: 10.1007/978-1-60761-416-6_10.

PMID:
19949926
32.

Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.

Cygalova LH, Hofman J, Ceckova M, Staud F.

J Pharmacol Exp Ther. 2009 Dec;331(3):1118-25. doi: 10.1124/jpet.109.160564. Epub 2009 Sep 24.

PMID:
19779128
33.

Variation of drug kinetics in pregnancy.

Pavek P, Ceckova M, Staud F.

Curr Drug Metab. 2009 Jun;10(5):520-9. Review.

PMID:
19689248
34.

Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F.

Toxicol In Vitro. 2008 Dec;22(8):1846-52. doi: 10.1016/j.tiv.2008.09.001. Epub 2008 Sep 9.

PMID:
18801423
35.

Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat.

Cygalova L, Ceckova M, Pavek P, Staud F.

Toxicol Lett. 2008 May 30;178(3):176-80. doi: 10.1016/j.toxlet.2008.03.007. Epub 2008 Mar 21.

PMID:
18450391
36.

Salicylanilide acetates: synthesis and antibacterial evaluation.

Vinsova J, Imramovsky A, Buchta V, Ceckova M, Dolezal M, Staud F, Jampilek J, Kaustova J.

Molecules. 2007 Jan 1;12(1):1-12.

37.

Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line.

Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, Cygalova L, Nachtigal P, Fendrich Z.

J Pharmacol Exp Ther. 2006 Oct;319(1):53-62. Epub 2006 Jun 29.

PMID:
16809480
38.

Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di-tert-butylbenzoxazoles.

Vinsova J, Cermakova K, Tomeckova A, Ceckova M, Jampilek J, Cermak P, Kunes J, Dolezal M, Staud F.

Bioorg Med Chem. 2006 Sep 1;14(17):5850-65. Epub 2006 Jun 19.

PMID:
16784871
39.

Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo.

Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F.

Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):58-65.

PMID:
16445700

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