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Symposium 3: Non-enzymatic biocatalysts in nature and biotechnology.

Woodson SA, Cech TR, Young M, Perriman R, Kelly L, Graf L, Llewellyn D, Gerlach W, Plückthun A, Collins J.

Fresenius J Anal Chem. 1990;337(1):12-14. doi: 10.1007/BF00325711. No abstract available.


Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid.

Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT.

Nucleic Acids Res. 2020 Apr 6;48(6):2969-2981. doi: 10.1093/nar/gkaa073.


Regulation of histone methylation by automethylation of PRC2.

Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR.

Genes Dev. 2019 Oct 1;33(19-20):1416-1427. doi: 10.1101/gad.328849.119. Epub 2019 Sep 5.


Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

Rowland TJ, Dumbović G, Hass EP, Rinn JL, Cech TR.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18488-18497. doi: 10.1073/pnas.1908275116. Epub 2019 Aug 26.


C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms.

Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR.

RNA. 2019 Aug;25(8):935-947. doi: 10.1261/rna.071191.119. Epub 2019 May 2.


A Lifelong Passion for All Things Ribonucleic.

Cech TR.

Cell. 2018 Sep 20;175(1):14-17. doi: 10.1016/j.cell.2018.08.037. Epub 2018 Sep 11.


Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.

Greenwood J, Patel H, Cech TR, Cooper JP.

Nucleic Acids Res. 2018 Sep 28;46(17):8865-8875. doi: 10.1093/nar/gky605.


In Crystallo Selection to Establish New RNA Crystal Contacts.

Shoffner GM, Wang R, Podell E, Cech TR, Guo F.

Structure. 2018 Sep 4;26(9):1275-1283.e3. doi: 10.1016/j.str.2018.05.005. Epub 2018 Jun 14.


Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.

Youmans DT, Schmidt JC, Cech TR.

Genes Dev. 2018 Jun 1;32(11-12):794-805. doi: 10.1101/gad.311936.118. Epub 2018 Jun 11.


Dynamics of human telomerase recruitment depend on template- telomere base pairing.

Schmidt JC, Zaug AJ, Kufer R, Cech TR.

Mol Biol Cell. 2018 Jan 31. pii: mbc.E17-11-0637. doi: 10.1091/mbc.E17-11-0637. [Epub ahead of print]


Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.

Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR.

Cell Rep. 2017 Dec 26;21(13):3700-3707. doi: 10.1016/j.celrep.2017.12.001.


Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.

Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X.

Elife. 2017 Nov 29;6. pii: e31558. doi: 10.7554/eLife.31558.


Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.

Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR.

Nat Struct Mol Biol. 2017 Dec;24(12):1028-1038. doi: 10.1038/nsmb.3487. Epub 2017 Oct 23.


Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.

Lim CJ, Zaug AJ, Kim HJ, Cech TR.

Nat Commun. 2017 Oct 20;8(1):1075. doi: 10.1038/s41467-017-01313-w.


How do lncRNAs regulate transcription?

Long Y, Wang X, Youmans DT, Cech TR.

Sci Adv. 2017 Sep 27;3(9):eaao2110. doi: 10.1126/sciadv.aao2110. eCollection 2017 Sep. Review.


Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.

Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C.

Mol Cell. 2017 Mar 16;65(6):1056-1067.e5. doi: 10.1016/j.molcel.2017.02.003.


Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

Goldfarb KC, Cech TR.

Genes Dev. 2017 Jan 1;31(1):59-71. doi: 10.1101/gad.286963.116. Epub 2017 Jan 23.


Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.

Schmidt JC, Zaug AJ, Cech TR.

Cell. 2016 Aug 25;166(5):1188-1197.e9. doi: 10.1016/j.cell.2016.07.033. Epub 2016 Aug 11.


RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.

Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY.

Cell. 2016 May 19;165(5):1267-1279. doi: 10.1016/j.cell.2016.04.028. Epub 2016 May 12.


Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.

Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R.

Nat Struct Mol Biol. 2016 Apr;23(4):286-92. doi: 10.1038/nsmb.3184. Epub 2016 Mar 7.


Protein-RNA interaction restricts telomerase from running through the stop sign.

Xi L, Cech TR.

Nat Struct Mol Biol. 2015 Nov;22(11):835-6. doi: 10.1038/nsmb.3118. No abstract available.


The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.

Davidovich C, Cech TR.

RNA. 2015 Dec;21(12):2007-22. doi: 10.1261/rna.053918.115. Review.


A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR.

Genome Biol. 2015 Nov 10;16:231. doi: 10.1186/s13059-015-0791-1.


Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR.

Genes Dev. 2015 Nov 1;29(21):2219-24. doi: 10.1101/gad.269498.115. Epub 2015 Oct 29.


Nucleic acid-binding specificity of human FUS protein.

Wang X, Schwartz JC, Cech TR.

Nucleic Acids Res. 2015 Sep 3;43(15):7535-43. doi: 10.1093/nar/gkv679. Epub 2015 Jul 6.


Human telomerase: biogenesis, trafficking, recruitment, and activation.

Schmidt JC, Cech TR.

Genes Dev. 2015 Jun 1;29(11):1095-105. doi: 10.1101/gad.263863.115. Review.


RNA World research-still evolving.

Cech TR.

RNA. 2015 Apr;21(4):474-5. doi: 10.1261/rna.049965.115. No abstract available.


Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.

Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR.

Science. 2015 Feb 27;347(6225):1006-10. doi: 10.1126/science.1260200. Epub 2015 Feb 5.


Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.

Dalby AB, Hofr C, Cech TR.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1291-1303. doi: 10.1016/j.jmb.2015.01.008. Epub 2015 Jan 23.


Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA.

Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR.

Mol Cell. 2015 Feb 5;57(3):552-8. doi: 10.1016/j.molcel.2014.12.017. Epub 2015 Jan 15.


Biochemical Properties and Biological Functions of FET Proteins.

Schwartz JC, Cech TR, Parker RR.

Annu Rev Biochem. 2015;84:355-79. doi: 10.1146/annurev-biochem-060614-034325. Epub 2014 Dec 8. Review.


Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.

Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z.

J Cell Sci. 2015 Jan 15;128(2):331-41. doi: 10.1242/jcs.159467. Epub 2014 Nov 21.


Academia and industry: Companies on campus.

Watson-Capps JJ, Cech TR.

Nature. 2014 Oct 16;514(7522):297-8. doi: 10.1038/514297a. No abstract available.


Identification of human TERT elements necessary for telomerase recruitment to telomeres.

Schmidt JC, Dalby AB, Cech TR.

Elife. 2014 Oct 1;3. doi: 10.7554/eLife.03563.


FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR.

Mol Biol Cell. 2014 Sep 1;25(17):2571-8. doi: 10.1091/mbc.E14-05-1007. Epub 2014 Jul 9.


A dimeric state for PRC2.

Davidovich C, Goodrich KJ, Gooding AR, Cech TR.

Nucleic Acids Res. 2014 Aug;42(14):9236-48. doi: 10.1093/nar/gku540. Epub 2014 Jul 3.


Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.

Xi L, Cech TR.

Nucleic Acids Res. 2014 Jul;42(13):8565-77. doi: 10.1093/nar/gku560. Epub 2014 Jul 2.


The noncoding RNA revolution-trashing old rules to forge new ones.

Cech TR, Steitz JA.

Cell. 2014 Mar 27;157(1):77-94. doi: 10.1016/j.cell.2014.03.008. Review.


Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA.

McKay DB, Xi L, Barthel KKB, Cech TR.

J Mol Biol. 2014 Apr 17;426(8):1766-1785. doi: 10.1016/j.jmb.2014.01.006. Epub 2014 Jan 30.


RNA seeds higher-order assembly of FUS protein.

Schwartz JC, Wang X, Podell ER, Cech TR.

Cell Rep. 2013 Nov 27;5(4):918-25. doi: 10.1016/j.celrep.2013.11.017. Epub 2013 Nov 21.


Telomerase in bladder cancer: back to a better future?

Theodorescu D, Cech TR.

Eur Urol. 2014 Feb;65(2):370-1. doi: 10.1016/j.eururo.2013.10.019. Epub 2013 Oct 28. No abstract available.


Inhibition of telomerase recruitment and cancer cell death.

Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR.

J Biol Chem. 2013 Nov 15;288(46):33171-80. doi: 10.1074/jbc.M113.518175. Epub 2013 Oct 4.


Promiscuous RNA binding by Polycomb repressive complex 2.

Davidovich C, Zheng L, Goodrich KJ, Cech TR.

Nat Struct Mol Biol. 2013 Nov;20(11):1250-7. doi: 10.1038/nsmb.2679. Epub 2013 Sep 29.


3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.

Goldfarb KC, Cech TR.

BMC Mol Biol. 2013 Sep 21;14:23. doi: 10.1186/1471-2199-14-23.


Many disease-associated variants of hTERT retain high telomerase enzymatic activity.

Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR.

Nucleic Acids Res. 2013 Oct;41(19):8969-78. doi: 10.1093/nar/gkt653. Epub 2013 Jul 30.


RNA recognition by the DNA end-binding Ku heterodimer.

Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR.

RNA. 2013 Jun;19(6):841-51. doi: 10.1261/rna.038703.113. Epub 2013 Apr 22.


Finding the end: recruitment of telomerase to telomeres.

Nandakumar J, Cech TR.

Nat Rev Mol Cell Biol. 2013 Feb;14(2):69-82. doi: 10.1038/nrm3505. Epub 2013 Jan 9. Review.


FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.

Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR.

Genes Dev. 2012 Dec 15;26(24):2690-5. doi: 10.1101/gad.204602.112.


How a chemist looks at RNA.

Cech TR.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):75-8. doi: 10.1002/anie.201205427. Epub 2012 Dec 3.


SnapShot: telomeres and telomerase.

Berman AJ, Cech TR.

Cell. 2012 Nov 21;151(5):1138-1138.e1. doi: 10.1016/j.cell.2012.11.008. No abstract available.

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