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Items: 1 to 50 of 109

1.

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Groups Introduction.

Felicetti T, Cannalire R, Pietrella D, Latacz G, Lubelska A, Manfroni G, Barreca ML, Massari S, Tabarrini O, Kiec-Kononowicz KJ, Schindler BD, Kaatz GW, Cecchetti V, Sabatini S.

J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00791. [Epub ahead of print]

PMID:
30067360
2.

Corrigendum to "Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity" [Eur. J. Med. Chem. 138 (2017) 128-139].

Desantis J, Nannetti G, Massari S, Barreca ML, Manfroni G, Cecchetti V, Palù G, Goracci L, Loregian A, Tabarrini O.

Eur J Med Chem. 2018 Jul 11;156:302-303. doi: 10.1016/j.ejmech.2018.07.009. [Epub ahead of print] No abstract available.

PMID:
30007243
3.

Replenishment of vitamin D status: theoretical and practical considerations.

Minisola S, Pepe J, Donato P, Vigna E, Occhiuto M, Ferrone F, Biamonte F, Cecchetti V, Danese VC, Sonato C, BIondi P, Colangelo L, Cipriani C.

Hormones (Athens). 2018 Jun 12. doi: 10.1007/s42000-018-0040-6. [Epub ahead of print] No abstract available.

4.

Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.

Felicetti T, Cannalire R, Nizi MG, Tabarrini O, Massari S, Barreca ML, Manfroni G, Schindler BD, Cecchetti V, Kaatz GW, Sabatini S.

Eur J Med Chem. 2018 Jul 15;155:428-433. doi: 10.1016/j.ejmech.2018.06.013. Epub 2018 Jun 6.

PMID:
29908437
5.

Reduction of arrhythmias in primary hyperparathyroidism, by parathyroidectomy, evaluated with 24-h ECG monitoring.

Pepe J, Cipriani C, Curione M, Biamonte F, Colangelo L, Danese V, Cecchetti V, Sonato C, Ferrone F, Cilli M, Minisola S.

Eur J Endocrinol. 2018 Aug;179(2):117-124. doi: 10.1530/EJE-17-0948. Epub 2018 Jun 6.

PMID:
29875287
6.

Pharmacological Agents Targeting the Cellular Prion Protein.

Barreca ML, Iraci N, Biggi S, Cecchetti V, Biasini E.

Pathogens. 2018 Mar 7;7(1). pii: E27. doi: 10.3390/pathogens7010027. Review.

7.

A Newly Identified Flower-Specific Splice Variant of AUXIN RESPONSE FACTOR8 Regulates Stamen Elongation and Endothecium Lignification in Arabidopsis.

Ghelli R, Brunetti P, Napoli N, De Paolis A, Cecchetti V, Tsuge T, Serino G, Matsui M, Mele G, Rinaldi G, Palumbo GA, Barozzi F, Costantino P, Cardarelli M.

Plant Cell. 2018 Mar;30(3):620-637. doi: 10.1105/tpc.17.00840. Epub 2018 Mar 7.

PMID:
29514943
8.

A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders.

Astolfi A, Manfroni G, Cecchetti V, Barreca ML.

ChemMedChem. 2018 Jan 8;13(1):7-14. doi: 10.1002/cmdc.201700636. Epub 2017 Dec 18. Review.

PMID:
29210532
9.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V.

Eur J Med Chem. 2018 Jan 1;143:1667-1676. doi: 10.1016/j.ejmech.2017.10.064. Epub 2017 Nov 11.

PMID:
29137867
10.

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium.

Cannalire R, Machado D, Felicetti T, Santos Costa S, Massari S, Manfroni G, Barreca ML, Tabarrini O, Couto I, Viveiros M, Sabatini S, Cecchetti V.

Eur J Med Chem. 2017 Nov 10;140:321-330. doi: 10.1016/j.ejmech.2017.09.014. Epub 2017 Sep 12.

PMID:
28964936
11.

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.

Massari S, Desantis J, Nannetti G, Sabatini S, Tortorella S, Goracci L, Cecchetti V, Loregian A, Tabarrini O.

Org Biomol Chem. 2017 Sep 26;15(37):7944-7955. doi: 10.1039/c7ob02085f.

PMID:
28902220
12.

The XXIV National Meeting in Medicinal Chemistry (NMMC 2016) in Perugia, Italy.

Cecchetti V, Natalini B.

ChemMedChem. 2017 Aug 22;12(16):1226-1234. doi: 10.1002/cmdc.201700465. Epub 2017 Aug 23.

PMID:
28834242
13.

Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.

Desantis J, Nannetti G, Massari S, Barreca ML, Manfroni G, Cecchetti V, Palù G, Goracci L, Loregian A, Tabarrini O.

Eur J Med Chem. 2017 Sep 29;138:128-139. doi: 10.1016/j.ejmech.2017.06.015. Epub 2017 Jun 8. Erratum in: Eur J Med Chem. 2018 Jul 11;156:302-303.

PMID:
28666191
14.

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues.

Felicetti T, Cannalire R, Burali MS, Massari S, Manfroni G, Barreca ML, Tabarrini O, Schindler BD, Sabatini S, Kaatz GW, Cecchetti V.

ChemMedChem. 2017 Aug 22;12(16):1293-1302. doi: 10.1002/cmdc.201700286. Epub 2017 Jul 17.

PMID:
28598572
15.

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

Madia VN, Benedetti R, Barreca ML, Ngo L, Pescatori L, Messore A, Pupo G, Saccoliti F, Valente S, Mai A, Scipione L, Zheng YG, Tintori C, Botta M, Cecchetti V, Altucci L, Di Santo R, Costi R.

ChemMedChem. 2017 Aug 22;12(16):1359-1368. doi: 10.1002/cmdc.201700040. Epub 2017 Apr 12.

PMID:
28346821
16.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V.

J Med Chem. 2017 Feb 23;60(4):1598-1604. doi: 10.1021/acs.jmedchem.6b01439. Epub 2017 Feb 8.

PMID:
28117588
17.

An auxin maximum in the middle layer controls stamen development and pollen maturation in Arabidopsis.

Cecchetti V, Celebrin D, Napoli N, Ghelli R, Brunetti P, Costantino P, Cardarelli M.

New Phytol. 2017 Feb;213(3):1194-1207. doi: 10.1111/nph.14207. Epub 2016 Sep 23.

18.

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.

Tarantino D, Cannalire R, Mastrangelo E, Croci R, Querat G, Barreca ML, Bolognesi M, Manfroni G, Cecchetti V, Milani M.

Antiviral Res. 2016 Oct;134:226-235. doi: 10.1016/j.antiviral.2016.09.007. Epub 2016 Sep 17.

19.

Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium.

Machado D, Cannalire R, Santos Costa S, Manfroni G, Tabarrini O, Cecchetti V, Couto I, Viveiros M, Sabatini S.

ACS Infect Dis. 2015 Dec 11;1(12):593-603. doi: 10.1021/acsinfecdis.5b00052. Epub 2015 Jul 23.

PMID:
27623057
20.

The "racemic approach" in the evaluation of the enantiomeric NorA efflux pump inhibition activity of 2-phenylquinoline derivatives.

Carotti A, Ianni F, Sabatini S, Di Michele A, Sardella R, Kaatz GW, Lindner W, Cecchetti V, Natalini B.

J Pharm Biomed Anal. 2016 Sep 10;129:182-189. doi: 10.1016/j.jpba.2016.07.003. Epub 2016 Jul 4.

PMID:
27429367
21.

Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents.

Kaushik-Basu N, Ratmanova NK, Manvar D, Belov DS, Cevik O, Basu A, Yerukhimovich MM, Lukyanenko ER, Andreev IA, Belov GM, Manfroni G, Cecchetti V, Frick DN, Kurkin AV, Altieri A, Barreca ML.

Eur J Med Chem. 2016 Oct 21;122:319-325. doi: 10.1016/j.ejmech.2016.06.041. Epub 2016 Jun 23.

PMID:
27376494
22.

Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors.

Corona A, Desantis J, Massari S, Distinto S, Masaoka T, Sabatini S, Esposito F, Manfroni G, Maccioni E, Cecchetti V, Pannecouque C, Le Grice SF, Tramontano E, Tabarrini O.

ChemMedChem. 2016 Aug 19;11(16):1709-20. doi: 10.1002/cmdc.201600015. Epub 2016 Mar 16.

PMID:
26990134
23.

Tumour cell population growth inhibition and cell death induction of functionalized 6-aminoquinolone derivatives.

Franci G, Manfroni G, Cannalire R, Felicetti T, Tabarrini O, Salvato A, Barreca ML, Altucci L, Cecchetti V.

Cell Prolif. 2015 Dec;48(6):705-17. doi: 10.1111/cpr.12224.

PMID:
26597381
24.

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.

Astolfi A, Iraci N, Sabatini S, Barreca ML, Cecchetti V.

Molecules. 2015 Aug 31;20(9):15842-61. doi: 10.3390/molecules200915842.

25.

A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.

Cannalire R, Barreca ML, Manfroni G, Cecchetti V.

J Med Chem. 2016 Jan 14;59(1):16-41. doi: 10.1021/acs.jmedchem.5b00825. Epub 2015 Aug 31. Review.

PMID:
26241789
26.

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.

Astolfi A, Iraci N, Manfroni G, Barreca ML, Cecchetti V.

ChemMedChem. 2015 Jun;10(6):957-69. doi: 10.1002/cmdc.201500030. Epub 2015 Apr 9. Review.

PMID:
26012502
27.

Cadmium-inducible expression of the ABC-type transporter AtABCC3 increases phytochelatin-mediated cadmium tolerance in Arabidopsis.

Brunetti P, Zanella L, De Paolis A, Di Litta D, Cecchetti V, Falasca G, Barbieri M, Altamura MM, Costantino P, Cardarelli M.

J Exp Bot. 2015 Jul;66(13):3815-29. doi: 10.1093/jxb/erv185. Epub 2015 Apr 21.

28.

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.

Andreev IA, Manvar D, Barreca ML, Belov DS, Basu A, Sweeney NL, Ratmanova NK, Lukyanenko ER, Manfroni G, Cecchetti V, Frick DN, Altieri A, Kaushik-Basu N, Kurkin AV.

Eur J Med Chem. 2015;96:250-8. doi: 10.1016/j.ejmech.2015.04.022. Epub 2015 Apr 10.

29.

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.

Massari S, Nannetti G, Desantis J, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Palù G, Cruciani G, Loregian A, Goracci L, Tabarrini O.

J Med Chem. 2015 May 14;58(9):3830-42. doi: 10.1021/acs.jmedchem.5b00012. Epub 2015 Apr 20.

PMID:
25856229
30.

ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development.

Cecchetti V, Brunetti P, Napoli N, Fattorini L, Altamura MM, Costantino P, Cardarelli M.

J Integr Plant Biol. 2015 Dec;57(12):1089-98. doi: 10.1111/jipb.12332. Epub 2015 Mar 16.

PMID:
25626615
31.

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

Sabatini S, Manfroni G, Barreca ML, Bauer SM, Gargaro M, Cannalire R, Astolfi A, Brea J, Vacca C, Pirro M, Massari S, Tabarrini O, Loza MI, Fallarino F, Laufer SA, Cecchetti V.

Chem Biol Drug Des. 2015 Oct;86(4):531-45. doi: 10.1111/cbdd.12516. Epub 2015 Feb 19.

PMID:
25589097
32.

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.

Sancineto L, Iraci N, Barreca ML, Massari S, Manfroni G, Corazza G, Cecchetti V, Marcello A, Daelemans D, Pannecouque C, Tabarrini O.

Bioorg Med Chem. 2014 Sep 1;22(17):4658-66. doi: 10.1016/j.bmc.2014.07.018. Epub 2014 Jul 22.

PMID:
25127466
33.

Auxin polar transport in stamen formation and development: how many actors?

Cardarelli M, Cecchetti V.

Front Plant Sci. 2014 Jul 16;5:333. doi: 10.3389/fpls.2014.00333. eCollection 2014. Review.

34.

Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel opener.

Sardella R, Carotti A, Manfroni G, Tedesco D, Martelli A, Bertucci C, Cecchetti V, Natalini B.

J Chromatogr A. 2014 Oct 10;1363:162-8. doi: 10.1016/j.chroma.2014.06.020. Epub 2014 Jun 12.

PMID:
24973806
35.

Ethyl 1,8-naphthyridone-3-carboxylates downregulate human papillomavirus-16 E6 and E7 oncogene expression.

Donalisio M, Massari S, Argenziano M, Manfroni G, Cagno V, Civra A, Sabatini S, Cecchetti V, Loregian A, Cavalli R, Lembo D, Tabarrini O.

J Med Chem. 2014 Jul 10;57(13):5649-63. doi: 10.1021/jm500340h. Epub 2014 Jun 25.

36.

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors.

Manfroni G, Manvar D, Barreca ML, Kaushik-Basu N, Leyssen P, Paeshuyse J, Cannalire R, Iraci N, Basu A, Chudaev M, Zamperini C, Dreassi E, Sabatini S, Tabarrini O, Neyts J, Cecchetti V.

J Med Chem. 2014 Apr 24;57(8):3247-62. doi: 10.1021/jm401688h. Epub 2014 Apr 2.

37.

Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly.

Massari S, Nannetti G, Goracci L, Sancineto L, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Facchini M, Palù G, Cruciani G, Loregian A, Tabarrini O.

J Med Chem. 2013 Dec 27;56(24):10118-31. doi: 10.1021/jm401560v. Epub 2013 Dec 13.

PMID:
24313730
38.

Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity.

Sancineto L, Iraci N, Massari S, Attanasio V, Corazza G, Barreca ML, Sabatini S, Manfroni G, Avanzi NR, Cecchetti V, Pannecouque C, Marcello A, Tabarrini O.

ChemMedChem. 2013 Dec;8(12):1941-53. doi: 10.1002/cmdc.201300287. Epub 2013 Oct 21.

PMID:
24150998
39.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Manfroni G, Cannalire R, Barreca ML, Kaushik-Basu N, Leyssen P, Winquist J, Iraci N, Manvar D, Paeshuyse J, Guhamazumder R, Basu A, Sabatini S, Tabarrini O, Danielson UH, Neyts J, Cecchetti V.

J Med Chem. 2014 Mar 13;57(5):1952-63. doi: 10.1021/jm401362f. Epub 2013 Nov 6.

40.

Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.

Barreca ML, Iraci N, Manfroni G, Gaetani R, Guercini C, Sabatini S, Tabarrini O, Cecchetti V.

J Chem Inf Model. 2014 Feb 24;54(2):481-97. doi: 10.1021/ci400367m. Epub 2013 Sep 5.

PMID:
23952658
41.

Design, synthesis, and evaluation of WC5 analogues as inhibitors of human cytomegalovirus Immediate-Early 2 protein, a promising target for anti-HCMV treatment.

Massari S, Mercorelli B, Sancineto L, Sabatini S, Cecchetti V, Gribaudo G, Palù G, Pannecouque C, Loregian A, Tabarrini O.

ChemMedChem. 2013 Aug;8(8):1403-14. doi: 10.1002/cmdc.201300106. Epub 2013 Jun 11.

PMID:
23757191
42.

Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.

Sabatini S, Gosetto F, Iraci N, Barreca ML, Massari S, Sancineto L, Manfroni G, Tabarrini O, Dimovska M, Kaatz GW, Cecchetti V.

J Med Chem. 2013 Jun 27;56(12):4975-89. doi: 10.1021/jm400262a. Epub 2013 Jun 13.

PMID:
23710549
43.

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions.

Martelli A, Manfroni G, Sabbatini P, Barreca ML, Testai L, Novelli M, Sabatini S, Massari S, Tabarrini O, Masiello P, Calderone V, Cecchetti V.

J Med Chem. 2013 Jun 13;56(11):4718-28. doi: 10.1021/jm400435a. Epub 2013 May 28.

PMID:
23662847
44.

Auxin controls Arabidopsis anther dehiscence by regulating endothecium lignification and jasmonic acid biosynthesis.

Cecchetti V, Altamura MM, Brunetti P, Petrocelli V, Falasca G, Ljung K, Costantino P, Cardarelli M.

Plant J. 2013 May;74(3):411-22. doi: 10.1111/tpj.12130. Epub 2013 Mar 4.

45.

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.

Barreca ML, Manfroni G, Leyssen P, Winquist J, Kaushik-Basu N, Paeshuyse J, Krishnan R, Iraci N, Sabatini S, Tabarrini O, Basu A, Danielson UH, Neyts J, Cecchetti V.

J Med Chem. 2013 Mar 28;56(6):2270-82. doi: 10.1021/jm301643a. Epub 2013 Mar 7.

46.

6-hydrogen-8-methylquinolones active against replicating and non-replicating Mycobacterium tuberculosis.

Tabarrini O, Sabatini S, Massari S, Pieroni M, Franzblau SG, Cecchetti V.

Chem Biol Drug Des. 2012 Nov;80(5):781-6. doi: 10.1111/cbdd.12022. Epub 2012 Sep 10.

PMID:
22889240
47.

Puberty is associated with increased deterioration of renal function in patients with CKD: data from the ItalKid Project.

Ardissino G, Testa S, Daccò V, Paglialonga F, Viganò S, Felice-Civitillo C, Battaglino F, Bettinelli A, Bordugo A, Cecchetti V, De Pascale S, La Manna A, Li Volti S, Maringhini S, Montini G, Pennesi M, Peratoner L.

Arch Dis Child. 2012 Oct;97(10):885-8. doi: 10.1136/archdischild-2011-300685. Epub 2012 Jul 25.

PMID:
22833407
48.

Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.

Sabatini S, Gosetto F, Serritella S, Manfroni G, Tabarrini O, Iraci N, Brincat JP, Carosati E, Villarini M, Kaatz GW, Cecchetti V.

J Med Chem. 2012 Apr 12;55(7):3568-72. doi: 10.1021/jm201446h. Epub 2012 Apr 3.

PMID:
22432682
49.

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

Manfroni G, Meschini F, Barreca ML, Leyssen P, Samuele A, Iraci N, Sabatini S, Massari S, Maga G, Neyts J, Cecchetti V.

Bioorg Med Chem. 2012 Jan 15;20(2):866-76. doi: 10.1016/j.bmc.2011.11.061. Epub 2011 Dec 3.

PMID:
22197397
50.

Synthesis and chromatographic enantioresolution of anti-HIV quinolone derivatives.

Natalini B, Sardella R, Massari S, Ianni F, Tabarrini O, Cecchetti V.

Talanta. 2011 Sep 15;85(3):1392-7. doi: 10.1016/j.talanta.2011.06.047. Epub 2011 Jun 22.

PMID:
21807200

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