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Items: 28

1.

rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.

Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin WL, Deture M, Rodríguez-Lebrón E, Dickson DW, Chakrabarty P, Levites Y, Giasson BI, Golde TE.

J Exp Med. 2019 Feb 15. pii: jem.20182184. doi: 10.1084/jem.20182184. [Epub ahead of print]

PMID:
30770411
2.

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.

Sorrentino ZA, Xia Y, Funk C, Riffe CJ, Rutherford NJ, Ceballos Diaz C, Sacino AN, Price ND, Golde TE, Giasson BI, Chakrabarty P.

Neurobiol Dis. 2018 Dec;120:98-106. doi: 10.1016/j.nbd.2018.09.005. Epub 2018 Sep 6.

PMID:
30195075
3.

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.

Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, Moore BD, Liu X, Ceballos-Diaz C, Rosario AM, Medway C, Janus C, Li HD, Dickson DW, Giasson BI, Price ND, Younkin SG, Ertekin-Taner N, Golde TE.

J Exp Med. 2018 Sep 3;215(9):2247-2264. doi: 10.1084/jem.20180484.

PMID:
30158114
4.

Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE.

J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5.

5.

Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.

Strickland MR, Koller EJ, Deng DZ, Ceballos-Diaz C, Golde TE, Chakrabarty P.

Neurobiol Dis. 2018 Feb;110:133-141. doi: 10.1016/j.nbd.2017.11.007. Epub 2017 Nov 28.

6.

Microglia-specific targeting by novel capsid-modified AAV6 vectors.

Rosario AM, Cruz PE, Ceballos-Diaz C, Strickland MR, Siemienski Z, Pardo M, Schob KL, Li A, Aslanidi GV, Srivastava A, Golde TE, Chakrabarty P.

Mol Ther Methods Clin Dev. 2016 Apr 13;3:16026. doi: 10.1038/mtm.2016.26. eCollection 2016.

7.

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI.

Mol Neurodegener. 2015 Jul 30;10:32. doi: 10.1186/s13024-015-0029-4.

8.

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.

Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE.

Mol Neurodegener. 2015 Jul 14;10:29. doi: 10.1186/s13024-015-0021-z.

9.

IFN-γ promotes τ phosphorylation without affecting mature tangles.

Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P.

FASEB J. 2015 Oct;29(10):4384-98. doi: 10.1096/fj.15-275834. Epub 2015 Jul 8.

10.

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.

Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR.

Mol Neurodegener. 2015 Jul 8;10:25. doi: 10.1186/s13024-015-0026-7.

11.

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.

Ran Y, Ladd GZ, Ceballos-Diaz C, Jung JI, Greenbaum D, Felsenstein KM, Golde TE.

PLoS One. 2015 Jun 5;10(6):e0128619. doi: 10.1371/journal.pone.0128619. eCollection 2015.

12.

The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.

Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM.

EMBO J. 2015 Jun 12;34(12):1674-86. doi: 10.15252/embj.201488795. Epub 2015 May 11.

13.

IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, Golde TE.

Neuron. 2015 Feb 4;85(3):519-33. doi: 10.1016/j.neuron.2014.11.020. Epub 2015 Jan 22.

14.

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y.

Mol Ther. 2015 Jan;23(1):53-62. doi: 10.1038/mt.2014.180. Epub 2014 Sep 17.

15.

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI.

Acta Neuropathol. 2014 May;127(5):645-65. Erratum in: Acta Neuropathol. 2014 Dec;128(6):897-8.

16.

Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.

Chakrabarty P, Rosario A, Cruz P, Siemienski Z, Ceballos-Diaz C, Crosby K, Jansen K, Borchelt DR, Kim JY, Jankowsky JL, Golde TE, Levites Y.

PLoS One. 2013 Jun 25;8(6):e67680. doi: 10.1371/journal.pone.0067680. Print 2013.

17.

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE.

Mol Neurodegener. 2013 May 28;8:17. doi: 10.1186/1750-1326-8-17.

18.

The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence.

Chu J, Li JG, Ceballos-Diaz C, Golde T, Praticò D.

Biol Psychiatry. 2013 Sep 1;74(5):321-8. doi: 10.1016/j.biopsych.2012.12.012. Epub 2013 Jan 23.

19.

Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo.

Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL.

Eur J Neurosci. 2013 Apr;37(8):1203-20. doi: 10.1111/ejn.12126. Epub 2013 Jan 24.

20.

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.

Verbeeck C, Deng Q, Dejesus-Hernandez M, Taylor G, Ceballos-Diaz C, Kocerha J, Golde T, Das P, Rademakers R, Dickson DW, Kukar T.

Mol Neurodegener. 2012 Oct 10;7:53. doi: 10.1186/1750-1326-7-53.

21.

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.

Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D.

Ann Neurol. 2012 Sep;72(3):442-54. doi: 10.1002/ana.23642.

22.

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.

Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE.

Mol Neurodegener. 2012 Jul 29;7:36. doi: 10.1186/1750-1326-7-36.

23.

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.

Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratico D.

Mol Neurodegener. 2012 Jan 5;7(1):1. doi: 10.1186/1750-1326-7-1.

24.

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.

Chakrabarty P, Ceballos-Diaz C, Lin WL, Beccard A, Jansen-West K, McFarland NR, Janus C, Dickson D, Das P, Golde TE.

Nat Neurosci. 2011 Jun;14(6):694-6. doi: 10.1038/nn.2829. Epub 2011 May 15.

25.

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo.

Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE.

Mol Neurodegener. 2011 Feb 16;6:16. doi: 10.1186/1750-1326-6-16.

26.

Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain.

Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K.

J Neurosci Methods. 2010 Dec 15;194(1):144-53. doi: 10.1016/j.jneumeth.2010.10.010. Epub 2010 Oct 15.

27.

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.

Chakrabarty P, Ceballos-Diaz C, Beccard A, Janus C, Dickson D, Golde TE, Das P.

J Immunol. 2010 May 1;184(9):5333-43. doi: 10.4049/jimmunol.0903382. Epub 2010 Apr 5.

28.

Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.

Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P.

FASEB J. 2010 Feb;24(2):548-59. doi: 10.1096/fj.09-141754. Epub 2009 Oct 13.

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