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Comprehensive pan-cancer analysis reveals CCDC58 as a carcinogenic factor related to immune infiltration.
Wu H, Geng Q, Shi W, Qiu C. Wu H, et al. Apoptosis. 2024 Apr;29(3-4):536-555. doi: 10.1007/s10495-023-01919-0. Epub 2023 Dec 8. Apoptosis. 2024. PMID: 38066393
We aimed to assess the significance of CCDC58 in pan-cancer. We utilized the TCGA, GTEx, and UALCAN databases to perform the differential expression of CCDC58 at both mRNA and protein levels. ...The mutation frequency of CCDC58 was found to be increased in 25 …
We aimed to assess the significance of CCDC58 in pan-cancer. We utilized the TCGA, GTEx, and UALCAN databases to perform the differen …
Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis.
Wang Z, Li Y, Yang J, Liang Y, Wang X, Zhang N, Kong X, Chen B, Wang L, Zhao W, Yang Q. Wang Z, et al. Cell Death Dis. 2022 Sep 8;13(9):776. doi: 10.1038/s41419-022-05216-7. Cell Death Dis. 2022. PMID: 36075896 Free PMC article.
Mechanistically, a dual luciferase reporter assay and RNA immunoprecipitation were performed and indicated that circ-TRIO could combine with miR-432-5p to regulate the expression of coiled-coil domain containing 58 (CCDC58). In summary, our study illustrates that circ-TRIO …
Mechanistically, a dual luciferase reporter assay and RNA immunoprecipitation were performed and indicated that circ-TRIO could combine with …
CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer.
Yang K, Ma Y, Chen W, Liu L, Yang Z, He C, Zheng N, Liu X, Cheng X, Song J, Chen Y, Qiao H, Zhang R. Yang K, et al. Sci Rep. 2024 Apr 13;14(1):8575. doi: 10.1038/s41598-024-59154-9. Sci Rep. 2024. PMID: 38609450 Free PMC article.
Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. ...In addition, the correlation analysis of CCDC58 with the level of immune i …
Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits po …
Coiled-coil domain-containing protein 58 (CCDC58) is a novel prognostic biomarker correlated with mitochondrial functions in hepatocellular carcinoma.
Chen L, Zhang J, Yang Y, Shu J, Zheng J, Zhan X, Guo M. Chen L, et al. Am J Transl Res. 2023 Apr 15;15(4):2568-2584. eCollection 2023. Am J Transl Res. 2023. PMID: 37193151 Free PMC article.
Immunohistochemistry was adopted to detect protein expression of CCDC58 in HCC patients. RESULTS: This study indicated that CCDC58 protein expression level was obviously higher in HCC than that in paired paracancerous tissues. ...It is reliable for CCDC58 to …
Immunohistochemistry was adopted to detect protein expression of CCDC58 in HCC patients. RESULTS: This study indicated that CCDC58
SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, Allen C, Sun Y, Venkatesan M, Madaris TR, Chiem K, Truitt R, Vishnu N, Aune G, Anderson A, Martinez-Sobrido L, Yang W, Stockand JD, Singh BB, Srikantan S, Reeves WB, Madesh M. Ramachandran K, et al. iScience. 2022 Jan 1;25(1):103722. doi: 10.1016/j.isci.2021.103722. eCollection 2022 Jan 21. iScience. 2022. PMID: 35005527 Free PMC article.
M-protein, NSP6, ORF3A, ORF9C, and ORF10 bind to mitochondrial PTP complex components cyclophilin D, SPG-7, ANT, ATP synthase, and a previously undescribed CCDC58 (coiled-coil domain containing protein 58). Knockdown of CCDC58 or mPTP blocker cyclosporin A pretreatm …
M-protein, NSP6, ORF3A, ORF9C, and ORF10 bind to mitochondrial PTP complex components cyclophilin D, SPG-7, ANT, ATP synthase, and a previou …
Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections.
Von Ohlen T, Luce-Fedrow A, Ortega MT, Ganta RR, Chapes SK. Von Ohlen T, et al. Infect Immun. 2012 Oct;80(10):3576-86. doi: 10.1128/IAI.00670-12. Epub 2012 Jul 30. Infect Immun. 2012. PMID: 22851751 Free PMC article.
Ten fly lines carrying mutations in the genes CG6479, separation anxiety, chitinase 11, CG6364 (Uck2), CG6543 (Echs1), withered (whd), CG15881 (Ccdc58), CG14806 (Apop1), CG11875 (Nup37), and dumpy (dp) had increased resistance to infection with Ehrlichia. Analysis of RNA b …
Ten fly lines carrying mutations in the genes CG6479, separation anxiety, chitinase 11, CG6364 (Uck2), CG6543 (Echs1), withered (whd), CG158 …
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor.
Zöller E, Laborenz J, Krämer L, Boos F, Räschle M, Alexander RT, Herrmann JM. Zöller E, et al. J Biol Chem. 2020 Oct 23;295(43):14686-14697. doi: 10.1074/jbc.RA120.014247. Epub 2020 Aug 21. J Biol Chem. 2020. PMID: 32826315 Free PMC article.
Mix23 is evolutionarily conserved and a homolog of the human protein CCDC58. We found that, like the subunits of the proteasome, Mix23 is under control of the transcription factor Rpn4. ...
Mix23 is evolutionarily conserved and a homolog of the human protein CCDC58. We found that, like the subunits of the proteasome, Mix2 …
Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis.
Elsherbini AM, Alsamman AM, Elsherbiny NM, El-Sherbiny M, Ahmed R, Ebrahim HA, Bakkach J. Elsherbini AM, et al. Int J Environ Res Public Health. 2022 Oct 26;19(21):13890. doi: 10.3390/ijerph192113890. Int J Environ Res Public Health. 2022. PMID: 36360783 Free PMC article.
The analysis revealed 135 significant DEGs, of which CEACAM6, ENPP4, HDAC5, HPCAL1, PARVG, STYXL1, VPS28, ZBTB33, ZFP37 and CCDC58 were the top 10 DEGs. These genes were enriched in aerobic respiration, T-cell antigen receptor pathway, tricarboxylic acid metabolic process, …
The analysis revealed 135 significant DEGs, of which CEACAM6, ENPP4, HDAC5, HPCAL1, PARVG, STYXL1, VPS28, ZBTB33, ZFP37 and CCDC58 we …
Analysis of Competitive Endogenous Mechanism and Survival Prognosis of Serum Exosomes in Ovarian Cancer Patients Based on Sequencing Technology and Bioinformatics.
Li X, Wang Y, Xu C, Reheman X, Wang Y, Xu R, Fan J, Huang X, Long L, Yu S, Huang H. Li X, et al. Front Genet. 2022 Jun 30;13:850089. doi: 10.3389/fgene.2022.850089. eCollection 2022. Front Genet. 2022. PMID: 35910206 Free PMC article.

Results: A total of 117 differentially expressed lncRNAs as well as 513 differentially expressed mRNAs (p < 0.05, |log2 fold change (FC)| 1.0) were obtained by combining sequencing data and raw signal analysis, and 841 predicted target genes were reciprocally mapped by combini

Results: A total of 117 differentially expressed lncRNAs as well as 513 differentially expressed mRNAs (p < 0.05, |log2 fold change (FC)|

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer.
Kunitomi H, Kobayashi Y, Wu RC, Takeda T, Tominaga E, Banno K, Aoki D. Kunitomi H, et al. J Gynecol Oncol. 2020 Mar;31(2):e11. doi: 10.3802/jgo.2020.31.e11. Epub 2019 Aug 21. J Gynecol Oncol. 2020. PMID: 31912669 Free PMC article.
Gene expression microarray analysis identified 8 genes correlated with tumor progression (LZTFL1, TAPT1, SEL1L, PAQR6, NME7, TMEM109, CCDC58, and ANKRD40) that were commonly influenced in HEC50B and SPAC-S by LAMC1 silencing. ...
Gene expression microarray analysis identified 8 genes correlated with tumor progression (LZTFL1, TAPT1, SEL1L, PAQR6, NME7, TMEM109, CCD
11 results