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Yellow fever cases in French Guiana, evidence of an active circulation in the Guiana Shield, 2017 and 2018.

Sanna A, Andrieu A, Carvalho L, Mayence C, Tabard P, Hachouf M, Cazaux CM, Enfissi A, Rousset D, Kallel H.

Euro Surveill. 2018 Sep;23(36). doi: 10.2807/1560-7917.ES.2018.23.36.1800471.


DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status.

Grgurevic S, Montilla-Perez P, Bradbury A, Gilhodes J, Queille S, Pelofy S, Bancaud A, Filleron T, Ysebaert L, Récher C, Laurent G, Fournié JJ, Cazaux C, Quillet-Mary A, Hoffmann JS.

Haematologica. 2018 Jun;103(6):1038-1046. doi: 10.3324/haematol.2017.174243. Epub 2018 Mar 22.


Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress.

Bétous R, Renoud ML, Hoede C, Gonzalez I, Jones N, Longy M, Sensebé L, Cazaux C, Hoffmann JS.

Stem Cells Transl Med. 2017 Jan;6(1):68-76. doi: 10.5966/sctm.2015-0401. Epub 2016 Aug 2.


Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.

Mansilla SF, Bertolin AP, Bergoglio V, Pillaire MJ, González Besteiro MA, Luzzani C, Miriuka SG, Cazaux C, Hoffmann JS, Gottifredi V.

Elife. 2016 Oct 14;5. pii: e18020. doi: 10.7554/eLife.18020.


CHK1 as a therapeutic target to bypass chemoresistance in AML.

David L, Fernandez-Vidal A, Bertoli S, Grgurevic S, Lepage B, Deshaies D, Prade N, Cartel M, Larrue C, Sarry JE, Delabesse E, Cazaux C, Didier C, Récher C, Manenti S, Hoffmann JS.

Sci Signal. 2016 Sep 13;9(445):ra90. doi: 10.1126/scisignal.aac9704.


Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.

Goullet de Rugy T, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS.

Biol Open. 2016 Oct 15;5(10):1485-1492. doi: 10.1242/bio.018028.


3R gene expression in chronic lymphocytic leukemia reveals insight into disease evolution.

Grgurevic S, Berquet L, Quillet-Mary A, Laurent G, Récher C, Ysebaert L, Cazaux C, Hoffmann JS.

Blood Cancer J. 2016 Jun 3;6(6):e429. doi: 10.1038/bcj.2016.39. No abstract available.


The LMO2 oncogene regulates DNA replication in hematopoietic cells.

Sincennes MC, Humbert M, Grondin B, Lisi V, Veiga DF, Haman A, Cazaux C, Mashtalir N, Affar el B, Verreault A, Hoang T.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1393-8. doi: 10.1073/pnas.1515071113. Epub 2016 Jan 13.


A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.

Brandalize AP, Schüler-Faccini L, Hoffmann JS, Caleffi M, Cazaux C, Ashton-Prolla P.

BMC Cancer. 2014 Nov 19;14:850. doi: 10.1186/1471-2407-14-850.


A role for DNA polymerase θ in the timing of DNA replication.

Fernandez-Vidal A, Guitton-Sert L, Cadoret JC, Drac M, Schwob E, Baldacci G, Cazaux C, Hoffmann JS.

Nat Commun. 2014 Jul 3;5:4285. doi: 10.1038/ncomms5285.


Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.

Rouquier S, Pillaire MJ, Cazaux C, Giorgi D.

Dis Markers. 2014;2014:798170. doi: 10.1155/2014/798170. Epub 2014 Apr 30.


Impact of chromosomal instability on colorectal cancer progression and outcome.

Orsetti B, Selves J, Bascoul-Mollevi C, Lasorsa L, Gordien K, Bibeau F, Massemin B, Paraf F, Soubeyran I, Hostein I, Dapremont V, Guimbaud R, Cazaux C, Longy M, Theillet C.

BMC Cancer. 2014 Feb 22;14:121. doi: 10.1186/1471-2407-14-121.


The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity.

Boyer AS, Grgurevic S, Cazaux C, Hoffmann JS.

J Mol Biol. 2013 Nov 29;425(23):4767-81. doi: 10.1016/j.jmb.2013.09.022. Epub 2013 Oct 3. Review.


DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS.

EMBO J. 2013 Jul 31;32(15):2172-85. doi: 10.1038/emboj.2013.148. Epub 2013 Jun 25.


DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.

Bergoglio V, Boyer AS, Walsh E, Naim V, Legube G, Lee MY, Rey L, Rosselli F, Cazaux C, Eckert KA, Hoffmann JS.

J Cell Biol. 2013 Apr 29;201(3):395-408. doi: 10.1083/jcb.201207066. Epub 2013 Apr 22.


DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions.

Schamber-Reis BL, Nardelli S, Régis-Silva CG, Campos PC, Cerqueira PG, Lima SA, Franco GR, Macedo AM, Pena SD, Cazaux C, Hoffmann JS, Motta MC, Schenkman S, Teixeira SM, Machado CR.

Mol Biochem Parasitol. 2012 Jun;183(2):122-31. doi: 10.1016/j.molbiopara.2012.02.007. Epub 2012 Feb 24.


DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.

Allera-Moreau C, Rouquette I, Lepage B, Oumouhou N, Walschaerts M, Leconte E, Schilling V, Gordien K, Brouchet L, Delisle MB, Mazieres J, Hoffmann JS, Pasero P, Cazaux C.

Oncogenesis. 2012 Oct 22;1:e30. doi: 10.1038/oncsis.2012.29.


[Genetic instability as a driver for oncogenesis].

Cazaux C.

Bull Cancer. 2010 Nov;97(11):1241-51. doi: 10.1684/bdc.2010.1202. Review. French.


Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer.

Hoffmann JS, Cazaux C.

Semin Cancer Biol. 2010 Oct;20(5):312-9. doi: 10.1016/j.semcancer.2010.10.001. Epub 2010 Oct 8. Review.


The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway.

Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, Canitrot Y.

Carcinogenesis. 2010 Oct;31(10):1742-7. doi: 10.1093/carcin/bgq166. Epub 2010 Aug 6.


DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

Lemée F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire MJ, Bieth A, Gentil C, Baker L, Martin AL, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roché H, Bourdon JC, Wood RD, Hoffmann JS, Cazaux C.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13390-5. doi: 10.1073/pnas.0910759107. Epub 2010 Jul 12.


A 'DNA replication' signature of progression and negative outcome in colorectal cancer.

Pillaire MJ, Selves J, Gordien K, Gourraud PA, Gentil C, Danjoux M, Do C, Negre V, Bieth A, Guimbaud R, Trouche D, Pasero P, Méchali M, Hoffmann JS, Cazaux C.

Oncogene. 2010 Feb 11;29(6):876-87. doi: 10.1038/onc.2009.378. Epub 2009 Nov 9. Erratum in: Oncogene. 2010 Apr 8;29(14):2160. Gouraud, P-A [corrected to Gourraud, P-A].


Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

Terrados G, Capp JP, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsocq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L.

PLoS One. 2009 Oct 6;4(10):e7290. doi: 10.1371/journal.pone.0007290.


Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.

Faumont N, Le Clorennec C, Teira P, Goormachtigh G, Coll J, Canitrot Y, Cazaux C, Hoffmann JS, Brousset P, Delsol G, Feuillard J, Meggetto F.

Cancer Res. 2009 Jun 15;69(12):5177-85. doi: 10.1158/0008-5472.CAN-08-2866. Epub 2009 Jun 2.


Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Rey L, Sidorova JM, Puget N, Boudsocq F, Biard DS, Monnat RJ Jr, Cazaux C, Hoffmann JS.

Mol Cell Biol. 2009 Jun;29(12):3344-54. doi: 10.1128/MCB.00115-09. Epub 2009 Apr 20.


Isolation and characterization of HC1: a novel human DNA repair gene.

Lopes DO, Falconi FC, Goes AM, Canitrot Y, Hoffmann JS, Cazaux C, Franco GR, Macedo AM, Pena SD, Machado CR.

Genet Mol Res. 2009;8(1):247-60.


The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.

Mattera L, Escaffit F, Pillaire MJ, Selves J, Tyteca S, Hoffmann JS, Gourraud PA, Chevillard-Briet M, Cazaux C, Trouche D.

Oncogene. 2009 Mar 26;28(12):1506-17. doi: 10.1038/onc.2008.499. Epub 2009 Jan 26.


Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

Bétous R, Rey L, Wang G, Pillaire MJ, Puget N, Selves J, Biard DS, Shin-ya K, Vasquez KM, Cazaux C, Hoffmann JS.

Mol Carcinog. 2009 Apr;48(4):369-78. doi: 10.1002/mc.20509.


Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance.

Lopes Dde O, Schamber-Reis BL, Regis-da-Silva CG, Rajão MA, Darocha WD, Macedo AM, Franco GR, Nardelli SC, Schenkman S, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

DNA Repair (Amst). 2008 Nov 1;7(11):1882-92. doi: 10.1016/j.dnarep.2008.07.018. Epub 2008 Sep 11.


Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta.

Brondello JM, Pillaire MJ, Rodriguez C, Gourraud PA, Selves J, Cazaux C, Piette J.

Oncogene. 2008 Oct 16;27(47):6093-101. doi: 10.1038/onc.2008.212. Epub 2008 Jul 14.


Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.

Hazan C, Boudsocq F, Gervais V, Saurel O, Ciais M, Cazaux C, Czaplicki J, Milon A.

BMC Struct Biol. 2008 Apr 16;8:22. doi: 10.1186/1472-6807-8-22.


Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation.

Balin-Gauthier D, Delord JP, Pillaire MJ, Rochaix P, Hoffman JS, Bugat R, Cazaux C, Canal P, Allal BC.

Br J Cancer. 2008 Jan 15;98(1):120-8. doi: 10.1038/sj.bjc.6604134. Epub 2008 Jan 8.


Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer.

Lopes DO, Regis-da-Silva CG, Machado-Silva A, Macedo AM, Franco GR, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

Genet Mol Res. 2007 May 7;6(2):250-5.


Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells.

Capp JP, Boudsocq F, Besnard AG, Lopez BS, Cazaux C, Hoffmann JS, Canitrot Y.

Nucleic Acids Res. 2007;35(11):3551-60. Epub 2007 May 5.


In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery.

Golzio M, Mazzolini L, Ledoux A, Paganin A, Izard M, Hellaudais L, Bieth A, Pillaire MJ, Cazaux C, Hoffmann JS, Couderc B, Teissié J.

Gene Ther. 2007 May;14(9):752-9. Epub 2007 Mar 8.


Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint.

Pillaire MJ, Betous R, Conti C, Czaplicki J, Pasero P, Bensimon A, Cazaux C, Hoffmann JS.

Cell Cycle. 2007 Feb 15;6(4):471-7. Epub 2007 Feb 19.


Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.

Lemée F, Bavoux C, Pillaire MJ, Bieth A, Machado CR, Pena SD, Guimbaud R, Selves J, Hoffmann JS, Cazaux C.

Oncogene. 2007 May 17;26(23):3387-94. Epub 2006 Nov 13.


Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation.

Regis-da-Silva CG, Freitas JM, Passos-Silva DG, Furtado C, Augusto-Pinto L, Pereira MT, DaRocha WD, Franco GR, Macedo AM, Hoffmann JS, Cazaux C, Pena SD, Teixeira SM, Machado CR.

Mol Biochem Parasitol. 2006 Oct;149(2):191-200. Epub 2006 Jun 21.


Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.

Canitrot Y, Laurent G, Astarie-Dequeker C, Bordier C, Cazaux C, Hoffmann JS.

Anticancer Res. 2006 Jan-Feb;26(1B):523-5.


The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.

Capp JP, Boudsocq F, Bertrand P, Laroche-Clary A, Pourquier P, Lopez BS, Cazaux C, Hoffmann JS, Canitrot Y.

Nucleic Acids Res. 2006 May 31;34(10):2998-3007. Print 2006.


Acylphloroglucinol derivatives from Mahurea palustris.

Massiot G, Long C, David B, Serrano MJ, Daubié F, Alby F, Ausseil F, Knibiehler M, Moretti C, Hoffmann JS, Cazaux C, Lavaud C.

J Nat Prod. 2005 Jul;68(7):979-84.


Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa.

Bavoux C, Hoffmann JS, Cazaux C.

Biochimie. 2005 Jul;87(7):637-46. Epub 2005 Mar 18. Review.


Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta.

Boudsocq F, Benaim P, Canitrot Y, Knibiehler M, Ausseil F, Capp JP, Bieth A, Long C, David B, Shevelev I, Frierich-Heinecken E, Hübscher U, Amalric F, Massiot G, Hoffmann JS, Cazaux C.

Mol Pharmacol. 2005 May;67(5):1485-92. Epub 2005 Feb 9.


Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

Bavoux C, Leopoldino AM, Bergoglio V, O-Wang J, Ogi T, Bieth A, Judde JG, Pena SD, Poupon MF, Helleday T, Tagawa M, Machado C, Hoffmann JS, Cazaux C.

Cancer Res. 2005 Jan 1;65(1):325-30.


DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.

Canitrot Y, Capp JP, Puget N, Bieth A, Lopez B, Hoffmann JS, Cazaux C.

Nucleic Acids Res. 2004 Sep 27;32(17):5104-12. Print 2004.


Evidence of finely tuned expression of DNA polymerase beta in vivo using transgenic mice.

Bergoglio V, Fréchet M, Philippe M, Bieth A, Mercier P, Morello D, Lacroix-Tricki M, Delsol G, Hoffmann JS, Cazaux C.

FEBS Lett. 2004 May 21;566(1-3):147-50.


DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA.

Bergoglio V, Ferrari E, Hübscher U, Cazaux C, Hoffmann JS.

J Mol Biol. 2003 Aug 29;331(5):1017-23.


p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.

Canitrot Y, Falinski R, Louat T, Laurent G, Cazaux C, Hoffmann JS, Lautier D, Skorski T.

Blood. 2003 Oct 1;102(7):2632-7. Epub 2003 Jun 26.


Localisation of human DNA polymerase kappa to replication foci.

Bergoglio V, Bavoux C, Verbiest V, Hoffmann JS, Cazaux C.

J Cell Sci. 2002 Dec 1;115(Pt 23):4413-8.


A role for DNA polymerase beta in mutagenic UV lesion bypass.

Servant L, Cazaux C, Bieth A, Iwai S, Hanaoka F, Hoffmann JS.

J Biol Chem. 2002 Dec 20;277(51):50046-53. Epub 2002 Oct 17.

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