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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.


Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T.

J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15.


Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.

Harzallah A, Hammami M, Kępczyńska MA, Hislop DC, Arch JR, Cawthorne MA, Zaibi MS.

Arch Physiol Biochem. 2016;122(2):75-87. doi: 10.3109/13813455.2016.1148053. Epub 2016 Feb 26.


5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE.

Dis Model Mech. 2016 Apr;9(4):401-12. doi: 10.1242/dmm.023903. Epub 2016 Jan 14.


Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases.

Christiansen E, Watterson KR, Stocker CJ, Sokol E, Jenkins L, Simon K, Grundmann M, Petersen RK, Wargent ET, Hudson BD, Kostenis E, Ejsing CS, Cawthorne MA, Milligan G, Ulven T.

Br J Nutr. 2015 Jun 14;113(11):1677-88. doi: 10.1017/S000711451500118X. Epub 2015 Apr 28.


Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes.

Wargent ET, Zaibi MS, O'Dowd JF, Cawthorne MA, Wang SJ, Arch JR, Stocker CJ.

PeerJ. 2015 Feb 5;3:e753. doi: 10.7717/peerj.753. eCollection 2015.


The effects of sarcolipin over-expression in mouse skeletal muscle on metabolic activity.

Butler J, Smyth N, Broadbridge R, Council CE, Lee AG, Stocker CJ, Hislop DC, Arch JR, Cawthorne MA, Malcolm East J.

Arch Biochem Biophys. 2015 Mar 1;569:26-31. doi: 10.1016/ Epub 2015 Feb 7.


A MATLAB tool for pathway enrichment using a topology-based pathway regulation score.

Ibrahim M, Jassim S, Cawthorne MA, Langlands K.

BMC Bioinformatics. 2014 Nov 4;15:358. doi: 10.1186/s12859-014-0358-2.


Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3.

Ngala RA, Zaibi MS, Langlands K, Stocker CJ, Arch JR, Cawthorne MA.

PeerJ. 2014 Oct 7;2:e614. doi: 10.7717/peerj.614. eCollection 2014.


Circulating levels of the cytokines IL10, IFNγ and resistin in an obese mouse model of developmental programming.

Kępczyńska MA, Wargent ET, Cawthorne MA, Arch JR, O'Dowd JF, Stocker CJ.

J Dev Orig Health Dis. 2013 Dec;4(6):491-8. doi: 10.1017/S2040174413000263.


A novel automated image analysis method for accurate adipocyte quantification.

Osman OS, Selway JL, Kępczyńska MA, Stocker CJ, O'Dowd JF, Cawthorne MA, Arch JR, Jassim S, Langlands K.

Adipocyte. 2013 Jul 1;2(3):160-4. doi: 10.4161/adip.24652. Epub 2013 Apr 16.


A novel method to assess collagen architecture in skin.

Osman OS, Selway JL, Harikumar PE, Stocker CJ, Wargent ET, Cawthorne MA, Jassim S, Langlands K.

BMC Bioinformatics. 2013 Aug 26;14:260. doi: 10.1186/1471-2105-14-260.


The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.

Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA.

Nutr Diabetes. 2013 May 27;3:e68. doi: 10.1038/nutd.2013.9.


Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.

Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T.

ACS Med Chem Lett. 2013 May 9;4(5):441-445. Epub 2013 Apr 8.


β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling.

Ngala RA, O'Dowd JF, Stocker CJ, Cawthorne MA, Arch JR.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):761-73. doi: 10.1007/s00210-013-0860-5. Epub 2013 Apr 6.


Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.

Stolarczyk E, Vong CT, Perucha E, Jackson I, Cawthorne MA, Wargent ET, Powell N, Canavan JB, Lord GM, Howard JK.

Cell Metab. 2013 Apr 2;17(4):520-33. doi: 10.1016/j.cmet.2013.02.019.


Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T.

J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22.


Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice.

Wargent ET, O'Dowd JF, Zaibi MS, Gao D, Bing C, Trayhurn P, Cawthorne MA, Arch JR, Stocker CJ.

J Endocrinol. 2013 Jan 18;216(2):157-68. doi: 10.1530/JOE-12-0402. Print 2013 Feb.


Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.

Bellahcene M, O'Dowd JF, Wargent ET, Zaibi MS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR.

Br J Nutr. 2013 May 28;109(10):1755-64. doi: 10.1017/S0007114512003923. Epub 2012 Oct 31.


Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schröder R, Hudson BD, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T.

J Med Chem. 2012 Jul 26;55(14):6624-8. doi: 10.1021/jm3002026. Epub 2012 Jul 13.


A topology-based score for pathway enrichment.

Ibrahim MA, Jassim S, Cawthorne MA, Langlands K.

J Comput Biol. 2012 May;19(5):563-73. doi: 10.1089/cmb.2011.0182. Epub 2012 Apr 2.


Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y.

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O'Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR.

Int J Obes (Lond). 2012 Aug;36(8):1040-6. doi: 10.1038/ijo.2011.226. Epub 2011 Nov 29.


Dual acting and pan-PPAR activators as potential anti-diabetic therapies.

Heald M, Cawthorne MA.

Handb Exp Pharmacol. 2011;(203):35-51. doi: 10.1007/978-3-642-17214-4_2. Review.


A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice.

Ngala RA, Stocker CJ, Roy AG, Hislop D, Wargent E, Bell R, Hassall DG, Harling JD, Billin AN, Willson TM, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2011 May;13(5):455-64. doi: 10.1111/j.1463-1326.2011.01371.x. Epub 2011 Jan 27.


Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.

Zaibi MS, Stocker CJ, O'Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM, Arch JR.

FEBS Lett. 2010 Jun 3;584(11):2381-6. doi: 10.1016/j.febslet.2010.04.027. Epub 2010 Apr 20.


Taspoglutide, an analog of human glucagon-like Peptide-1 with enhanced stability and in vivo potency.

Sebokova E, Christ AD, Wang H, Sewing S, Dong JZ, Taylor J, Cawthorne MA, Culler MD.

Endocrinology. 2010 Jun;151(6):2474-82. doi: 10.1210/en.2009-1459. Epub 2010 Apr 9.


Chemerin, a novel adipokine in the regulation of angiogenesis.

Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB.

J Clin Endocrinol Metab. 2010 May;95(5):2476-85. doi: 10.1210/jc.2010-0042. Epub 2010 Mar 17.


Beta2-adrenoceptors and non-beta-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice.

Ngala RA, O'Dowd J, Wang SJ, Stocker C, Cawthorne MA, Arch JR.

Br J Pharmacol. 2009 Dec;158(7):1676-82. doi: 10.1111/j.1476-5381.2009.00472.x.


Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.

Cornick CL, Strongitharm BH, Sassano G, Rawlins C, Mayes AE, Joseph AN, O'Dowd J, Stocker C, Wargent E, Cawthorne MA, Brown AL, Arch JR.

J Nutr Biochem. 2009 Oct;20(10):806-15. doi: 10.1016/j.jnutbio.2008.07.010. Epub 2008 Oct 15.


The influence of leptin on early life programming of obesity.

Stocker CJ, Cawthorne MA.

Trends Biotechnol. 2008 Oct;26(10):545-51. doi: 10.1016/j.tibtech.2008.06.004. Epub 2008 Aug 14.


Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms.

Ngala RA, O'Dowd J, Wang SJ, Agarwal A, Stocker C, Cawthorne MA, Arch JR.

Br J Pharmacol. 2008 Oct;155(3):395-406. doi: 10.1038/bjp.2008.244. Epub 2008 Jun 16.


Opportunities and challenges for the development of pharmacological therapies for obesity treatment.

Cawthorne MA.

Obes Rev. 2007 Mar;8 Suppl 1:131-6. Review. No abstract available.


Inhibition of insulin secretion by betagranin, an N-terminal chromogranin A fragment.

Schmid GM, Meda P, Caille D, Wargent E, O'Dowd J, Hochstrasser DF, Cawthorne MA, Sanchez JC.

J Biol Chem. 2007 Apr 27;282(17):12717-24. Epub 2007 Feb 8.


Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.

Wang SJ, Cornick C, O'Dowd J, Cawthorne MA, Arch JR.

Lipids Health Dis. 2007 Jan 19;6:2.


Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers.

Stocker CJ, Wargent E, O'Dowd J, Cornick C, Speakman JR, Arch JR, Cawthorne MA.

Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1810-8. Epub 2007 Jan 18.


Fetal origins of insulin resistance and obesity.

Stocker CJ, Arch JR, Cawthorne MA.

Proc Nutr Soc. 2005 May;64(2):143-51. Review.


Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2005 Mar;7(2):170-81.


Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation.

Wargent E, Sennitt MV, Stocker C, Mayes AE, Brown L, O'Dowd J, Wang S, Einerhand AW, Mohede I, Arch JR, Cawthorne MA.

Lipids Health Dis. 2005 Jan 10;4:3.


Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice.

Schmid GM, Converset V, Walter N, Sennitt MV, Leung KY, Byers H, Ward M, Hochstrasser DF, Cawthorne MA, Sanchez JC.

Proteomics. 2004 Aug;4(8):2270-82.


Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation.

Stocker C, O'Dowd J, Morton NM, Wargent E, Sennitt MV, Hislop D, Glund S, Seckl JR, Arch JR, Cawthorne MA.

Int J Obes Relat Metab Disord. 2004 Jan;28(1):129-36.


Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle.

Wang S, Subramaniam A, Cawthorne MA, Clapham JC.

Diabetes Obes Metab. 2003 Sep;5(5):295-301.


Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice.

Sanchez JC, Converset V, Nolan A, Schmid G, Wang S, Heller M, Sennitt MV, Hochstrasser DF, Cawthorne MA.

Proteomics. 2003 Aug;3(8):1500-20.


Effect of rosiglitazone on the differential expression of diabetes-associated proteins in pancreatic islets of C57Bl/6 lep/lep mice.

Sanchez JC, Converset V, Nolan A, Schmid G, Wang S, Heller M, Sennitt MV, Hochstrasser DF, Cawthorne MA.

Mol Cell Proteomics. 2002 Jul;1(7):509-16.


Enhanced diabetogenic effect of streptozotocin in mice overexpressing UCP-3 in skeletal muscle.

Wang S, Cawthorne MA, Clapham JC.

Ann N Y Acad Sci. 2002 Jun;967:112-9.


Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.

Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M, Clapham JC, Arch JR.

Regul Pept. 2002 Mar 15;104(1-3):153-9.


The mouse SWISS-2D PAGE database: a tool for proteomics study of diabetes and obesity.

Sanchez JC, Chiappe D, Converset V, Hoogland C, Binz PA, Paesano S, Appel RD, Wang S, Sennitt M, Nolan A, Cawthorne MA, Hochstrasser DF.

Proteomics. 2001 Jan;1(1):136-63.


Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells.

Emilsson V, O'Dowd J, Nolan AL, Cawthorne MA.

Endocrinology. 2001 Oct;142(10):4414-9.


The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.

Emilsson V, O'Dowd J, Wang S, Liu YL, Sennitt M, Heyman R, Cawthorne MA.

Metabolism. 2000 Dec;49(12):1610-5.


BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro.

Board M, Doyle P, Cawthorne MA.

Eur J Pharmacol. 2000 Oct 6;406(1):33-40.


Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.

Liu YL, Sennitt MV, Hislop DC, Crombie DL, Heyman RA, Cawthorne MA.

Int J Obes Relat Metab Disord. 2000 Aug;24(8):997-1004.


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