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Linkage of national soil quality measurements to primary care medical records in England and Wales: a new resource for investigating environmental impacts on human health.

Gibson JE, Ander EL, Cave M, Bath-Hextall F, Musah A, Leonardi-Bee J.

Popul Health Metr. 2018 Jul 16;16(1):12. doi: 10.1186/s12963-018-0168-2.


Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients.

Vatsalya V, Kong M, Cave MC, Liu N, Schwandt ML, George DT, Ramchandani VA, McClain CJ.

J Nutr Biochem. 2018 May 12;59:49-55. doi: 10.1016/j.jnutbio.2018.05.003. [Epub ahead of print]


Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-stage Liver Disease Scores Compared With Placebo.

Frenette CT, Morelli G, Shiffman ML, Frederick RT, Rubin RA, Fallon MB, Cheng JT, Cave M, Khaderi SA, Massoud O, Pyrsopoulos N, Park JS, Robinson JM, Yamashita M, Spada AP, Chan JL, Hagerty DT.

Clin Gastroenterol Hepatol. 2018 Jun 15. pii: S1542-3565(18)30622-0. doi: 10.1016/j.cgh.2018.06.012. [Epub ahead of print]


Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures.

Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC.

Toxicol Sci. 2018 Jul 1;164(1):39-49. doi: 10.1093/toxsci/kfy076.


Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals.

Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC.

Toxicol Sci. 2018 Apr 1;162(2):622-634. doi: 10.1093/toxsci/kfy004.


In vitro prediction of polycyclic aromatic hydrocarbon bioavailability of 14 different incidentally ingested soils in juvenile swine.

James K, Peters RE, Cave MR, Wickstrom M, Siciliano SD.

Sci Total Environ. 2018 Mar 15;618:682-689. doi: 10.1016/j.scitotenv.2017.07.244. Epub 2017 Oct 20.


Dietary copper-fructose interactions alter gut microbial activity in male rats.

Song M, Li X, Zhang X, Shi H, Vos MB, Wei X, Wang Y, Gao H, Rouchka EC, Yin X, Zhou Z, Prough RA, Cave MC, McClain CJ.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G119-G130. doi: 10.1152/ajpgi.00378.2016. Epub 2017 Oct 12.


Role of Zinc in the Development/Progression of Alcoholic Liver Disease.

McClain C, Vatsalya V, Cave M.

Curr Treat Options Gastroenterol. 2017 Jun;15(2):285-295. doi: 10.1007/s11938-017-0132-4. Review.


In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids.

Pelfrêne A, Cave MR, Wragg J, Douay F.

Int J Environ Res Public Health. 2017 Jan 24;14(2). pii: E112. doi: 10.3390/ijerph14020112.


The relationship between historical development and potentially toxic element concentrations in urban soils.

McIlwaine R, Doherty R, Cox SF, Cave M.

Environ Pollut. 2017 Jan;220(Pt B):1036-1049. doi: 10.1016/j.envpol.2016.11.040. Epub 2016 Nov 19.


Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome.

Guardiola JJ, Beier JI, Falkner KC, Wheeler B, McClain CJ, Cave M.

Toxicol Appl Pharmacol. 2016 Dec 15;313:47-56. doi: 10.1016/j.taap.2016.10.001. Epub 2016 Oct 17.


Narrative inquiry: a relational research methodology for medical education.

Clandinin DJ, Cave MT, Berendonk C.

Med Educ. 2017 Jan;51(1):89-96. doi: 10.1111/medu.13136. Epub 2016 Nov 2.


Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice.

Anders LC, Yeo H, Kaelin BR, Lang AL, Bushau AM, Douglas AN, Cave M, Arteel GE, McClain CJ, Beier JI.

Toxicol Appl Pharmacol. 2016 Nov 15;311:34-41. doi: 10.1016/j.taap.2016.09.026. Epub 2016 Sep 28.


Safety Assessment of Liver Injury with Quetiapine Fumarate XR Management in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ.

Clin Drug Investig. 2016 Nov;36(11):935-944.


Metabolism disrupting chemicals and metabolic disorders.

Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R, Vandenberg LN, Vom Saal F.

Reprod Toxicol. 2017 Mar;68:3-33. doi: 10.1016/j.reprotox.2016.10.001. Epub 2016 Oct 17. Review.


Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ.

Alcohol Clin Exp Res. 2016 Oct;40(10):2085-2093. doi: 10.1111/acer.13197. Epub 2016 Sep 2.


Source and pathway analysis of lead and polycyclic aromatic hydrocarbons in Lisbon urban soils.

Marinho Reis AP, Shepherd T, Nowell G, Cachada A, Duarte AC, Cave M, Wragg J, Patinha C, Dias A, Rocha F, da Silva EF, Sousa AJ, Prazeres C, Batista MJ.

Sci Total Environ. 2016 Dec 15;573:324-336. doi: 10.1016/j.scitotenv.2016.08.119. Epub 2016 Aug 26.


Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury.

Liu Y, Zhao C, Xiao J, Liu L, Zhang M, Wang C, Wu G, Zheng MH, Xu LM, Chen YP, Mohammadi M, Chen SY, Cave M, McClain C, Li X, Feng W.

Sci Rep. 2016 Aug 8;6:31026. doi: 10.1038/srep31026.


New Insights into the Reliability of Automatic Dynamic Methods for Oral Bioaccessibility Testing: A Case Study for BGS102 soil.

Cave MR, Rosende M, Mounteney I, Gardner A, Miró M.

Environ Sci Technol. 2016 Sep 6;50(17):9479-86. doi: 10.1021/acs.est.6b02387. Epub 2016 Aug 23.


Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling.

Hardesty JE, Wahlang B, Falkner KC, Clair HB, Clark BJ, Ceresa BP, Prough RA, Cave MC.

Xenobiotica. 2017 Sep;47(9):807-820. doi: 10.1080/00498254.2016.1217572. Epub 2017 Jun 21.


Indoor radon measurements in south west England explained by topsoil and stream sediment geochemistry, airborne gamma-ray spectroscopy and geology.

Ferreira A, Daraktchieva Z, Beamish D, Kirkwood C, Lister TR, Cave M, Wragg J, Lee K.

J Environ Radioact. 2018 Jan;181:152-171. doi: 10.1016/j.jenvrad.2016.05.007. Epub 2016 May 20.


China's soil and groundwater management challenges: Lessons from the UK's experience and opportunities for China.

Coulon F, Jones K, Li H, Hu Q, Gao J, Li F, Chen M, Zhu YG, Liu R, Liu M, Canning K, Harries N, Bardos P, Nathanail P, Sweeney R, Middleton D, Charnley M, Randall J, Richell M, Howard T, Martin I, Spooner S, Weeks J, Cave M, Yu F, Zhang F, Jiang Y, Longhurst P, Prpich G, Bewley R, Abra J, Pollard S.

Environ Int. 2016 May;91:196-200. doi: 10.1016/j.envint.2016.02.023. Epub 2016 Mar 10.


Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice.

Anders LC, Lang AL, Anwar-Mohamed A, Douglas AN, Bushau AM, Falkner KC, Hill BG, Warner NL, Arteel GE, Cave M, McClain CJ, Beier JI.

Toxicol Sci. 2016 Jun;151(2):312-23. doi: 10.1093/toxsci/kfw045. Epub 2016 Mar 8.


Nuclear receptors and nonalcoholic fatty liver disease.

Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA.

Biochim Biophys Acta. 2016 Sep;1859(9):1083-1099. doi: 10.1016/j.bbagrm.2016.03.002. Epub 2016 Mar 4. Review.


Simeprevir and sofosbuvir with or without ribavirin to treat recurrent genotype 1 hepatitis C virus infection after orthotopic liver transplantation.

Crittenden NE, Buchanan LA, Pinkston CM, Cave B, Barve A, Marsano L, McClain CJ, Jones CM, Marvin MR, Davis EG, Kuns-Adkins CB, Gedaly R, Brock G, Shah MB, Rosenau J, Cave MC.

Liver Transpl. 2016 May;22(5):635-43. doi: 10.1002/lt.24422.


Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response.

Song M, Chen T, Prough RA, Cave MC, McClain CJ.

Alcohol Clin Exp Res. 2016 Mar;40(3):518-28. doi: 10.1111/acer.12994. Epub 2016 Feb 9.


Is received dose from ingested soil independent of soil PAH concentrations?-Animal model results.

Peters RE, James K, Cave M, Wickstrom M, Siciliano SD.

Environ Toxicol Chem. 2016 Sep;35(9):2261-9. doi: 10.1002/etc.3384. Epub 2016 Jun 13.


Alcoholic Liver Disease: Update on the Role of Dietary Fat.

Kirpich IA, Miller ME, Cave MC, Joshi-Barve S, McClain CJ.

Biomolecules. 2016 Jan 6;6(1):1. doi: 10.3390/biom6010001. Review.


Predicting Polycyclic Aromatic Hydrocarbon Bioavailability to Mammals from Incidentally Ingested Soils Using Partitioning and Fugacity.

James K, Peters RE, Cave MR, Wickstrom M, Lamb EG, Siciliano SD.

Environ Sci Technol. 2016 Feb 2;50(3):1338-46. doi: 10.1021/acs.est.5b05317. Epub 2016 Jan 19.


A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil.

Beriro DJ, Cave MR, Wragg J, Thomas R, Wills G, Evans F.

J Hazard Mater. 2016 Mar 15;305:240-259. doi: 10.1016/j.jhazmat.2015.11.010. Epub 2015 Nov 18. Review.


Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.

Wahlang B, Prough RA, Falkner KC, Hardesty JE, Song M, Clair HB, Clark BJ, States JC, Arteel GE, Cave MC.

Toxicol Sci. 2016 Feb;149(2):396-410. doi: 10.1093/toxsci/kfv250. Epub 2015 Nov 25.


Linking selective chemical extraction of iron oxyhydroxides to arsenic bioaccessibility in soil.

Palumbo-Roe B, Wragg J, Cave M.

Environ Pollut. 2015 Dec;207:256-65. doi: 10.1016/j.envpol.2015.09.026. Epub 2015 Sep 25.


Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism.

Wahlang B, Falkner KC, Cave MC, Prough RA.

Adv Pharmacol. 2015;74:1-33. doi: 10.1016/bs.apha.2015.04.004. Epub 2015 May 29. Review.


Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease.

Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W.

J Hepatol. 2016 Jan;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. Epub 2015 Jul 26.


At the precipice: a prospective exploration of medical students' expectations of the pre-clerkship to clerkship transition.

Soo J, Brett-MacLean P, Cave MT, Oswald A.

Adv Health Sci Educ Theory Pract. 2016 Mar;21(1):141-62. doi: 10.1007/s10459-015-9620-2. Epub 2015 Jul 12.


Investigating relationships between biomarkers of exposure and environmental copper and manganese levels in house dusts from a Portuguese industrial city.

Reis AP, Costa S, Santos I, Patinha C, Noack Y, Wragg J, Cave M, Sousa AJ.

Environ Geochem Health. 2015 Aug;37(4):725-44. doi: 10.1007/s10653-015-9724-x. Epub 2015 Jun 9.


Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences.

Joshi-Barve S, Kirpich I, Cave MC, Marsano LS, McClain CJ.

Cell Mol Gastroenterol Hepatol. 2015 Jun 3;1(4):356-367. doi: 10.1016/j.jcmgh.2015.05.006. eCollection 2015 Jul. Review.


Lead bioaccessibility in 12 contaminated soils from China: Correlation to lead relative bioavailability and lead in different fractions.

Li J, Li K, Cave M, Li HB, Ma LQ.

J Hazard Mater. 2015 Sep 15;295:55-62. doi: 10.1016/j.jhazmat.2015.03.061. Epub 2015 Mar 30.


Measuring the solid-phase fractionation of lead in urban and rural soils using a combination of geochemical survey data and chemical extractions.

Cave M, Wragg J, Gowing C, Gardner A.

Environ Geochem Health. 2015 Aug;37(4):779-90. doi: 10.1007/s10653-015-9697-9. Epub 2015 Apr 4.


The effects of lead sources on oral bioaccessibility in soil and implications for contaminated land risk management.

Palmer S, McIlwaine R, Ofterdinger U, Cox SF, McKinley JM, Doherty R, Wragg J, Cave M.

Environ Pollut. 2015 Mar;198:161-71. doi: 10.1016/j.envpol.2015.01.004. Epub 2015 Jan 17.


Liver diseases.

Obert J, Cave M, Marsano L.

World Rev Nutr Diet. 2015;111:146-50. doi: 10.1159/000362314. Epub 2014 Nov 17. No abstract available.


Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents.

Al-Eryani L, Wahlang B, Falkner KC, Guardiola JJ, Clair HB, Prough RA, Cave M.

Toxicol Pathol. 2015 Jun;43(4):482-97. doi: 10.1177/0192623314549960. Epub 2014 Oct 16. Review.


Treating Every Needle in the Haystack: Hyperammonemic Encephalopathy and Severe Malnutrition After Bariatric Surgery-A Case Report and Review of the Literature.

Singh S, Suresh S, McClave SA, Cave M.

JPEN J Parenter Enteral Nutr. 2015 Nov;39(8):977-85. doi: 10.1177/0148607114546900. Epub 2014 Sep 2. Review.


The mobility and human oral bioaccessibility of Zn and Pb in urban dusts of Estarreja (N Portugal).

Patinha C, Reis AP, Dias AC, Abduljelil AA, Noack Y, Robert S, Cave M, Ferreira da Silva E.

Environ Geochem Health. 2015 Feb;37(1):115-31. doi: 10.1007/s10653-014-9634-3. Epub 2014 Jul 16.


Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease.

Wahlang B, Song M, Beier JI, Cameron Falkner K, Al-Eryani L, Clair HB, Prough RA, Osborne TS, Malarkey DE, Christopher States J, Cave MC.

Toxicol Appl Pharmacol. 2014 Sep 15;279(3):380-90. doi: 10.1016/j.taap.2014.06.019. Epub 2014 Jul 3.


Effects of drying and comminution type on the quantification of Polycyclic Aromatic Hydrocarbons (PAH) in a homogenised gasworks soil and the implications for human health risk assessment.

Beriro DJ, Vane CH, Cave MR, Nathanail CP.

Chemosphere. 2014 Sep;111:396-404. doi: 10.1016/j.chemosphere.2014.03.077. Epub 2014 May 14.


Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells.

Ghare SS, Joshi-Barve S, Moghe A, Patil M, Barker DF, Gobejishvili L, Brock GN, Cave M, McClain CJ, Barve SS.

J Immunol. 2014 Jul 1;193(1):412-21. doi: 10.4049/jimmunol.1400055. Epub 2014 Jun 4.


Geochemistry, mineralogy, solid-phase fractionation and oral bioaccessibility of lead in urban soils of Lisbon.

Reis AP, Patinha C, Wragg J, Dias AC, Cave M, Sousa AJ, Costa C, Cachada A, Ferreira da Silva E, Rocha F, Duarte A.

Environ Geochem Health. 2014 Oct;36(5):867-81. doi: 10.1007/s10653-014-9605-8. Epub 2014 May 10.


Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.

Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC.

Toxicol Sci. 2014 Aug 1;140(2):283-97. doi: 10.1093/toxsci/kfu083. Epub 2014 May 8.


The importance of solid-phase distribution on the oral bioaccessibility of Ni and Cr in soils overlying Palaeogene basalt lavas, Northern Ireland.

Cox SF, Chelliah MC, McKinley JM, Palmer S, Ofterdinger U, Young ME, Cave MR, Wragg J.

Environ Geochem Health. 2013 Oct;35(5):553-67. doi: 10.1007/s10653-013-9539-6. Epub 2013 Jul 3.


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