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Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.

Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170072. doi: 10.1098/rstb.2017.0072.


Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.

Peng G, McEwen AG, Olieric V, Schmitt C, Albrecht S, Cavarelli J, Tarnus C.

Proteins. 2017 Aug;85(8):1413-1421. doi: 10.1002/prot.25301. Epub 2017 Apr 22.


Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.

van Haren MJ, Marechal N, Troffer-Charlier N, Cianciulli A, Sbardella G, Cavarelli J, Martin NI.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630. doi: 10.1073/pnas.1618401114. Epub 2017 Mar 22.


SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.

Gribling-Burrer AS, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer-Charlier N, Cura V, Barkats M, Cavarelli J, Massenet S, Allmang C.

Nucleic Acids Res. 2017 May 19;45(9):5399-5413. doi: 10.1093/nar/gkx031.


Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J.

FEBS J. 2017 Jan;284(1):77-96. doi: 10.1111/febs.13953. Epub 2016 Nov 23.


TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J.

Sci Rep. 2016 Jan 27;6:19725. doi: 10.1038/srep19725.


Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.

Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianférani S, Cavarelli J.

J Struct Biol. 2015 Aug;191(2):175-83. doi: 10.1016/j.jsb.2015.06.017. Epub 2015 Jun 18.


Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.

Kolaj-Robin O, McEwen AG, Cavarelli J, Séraphin B.

FEBS J. 2015 Mar;282(5):819-33. doi: 10.1111/febs.13199. Epub 2015 Feb 4.


Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.

Cura V, Troffer-Charlier N, Wurtz JM, Bonnefond L, Cavarelli J.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2401-12. doi: 10.1107/S1399004714014278. Epub 2014 Aug 29.


Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M.

J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20.


Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.

Cura V, Troffer-Charlier N, Lambert MA, Bonnefond L, Cavarelli J.

Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):80-6. doi: 10.1107/S2053230X13032871. Epub 2013 Dec 24.


Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C.

PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26.


Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, Poussin-Courmontagne P, Cura V, Brimer N, Babah KO, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Travé G.

Science. 2013 Feb 8;339(6120):694-8. doi: 10.1126/science.1229934.


Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G.

J Med Chem. 2012 Nov 26;55(22):9875-90. doi: 10.1021/jm301097p. Epub 2012 Nov 2.


On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.

Schaub P, Yu Q, Gemmecker S, Poussin-Courmontagne P, Mailliot J, McEwen AG, Ghisla S, Al-Babili S, Cavarelli J, Beyer P.

PLoS One. 2012;7(6):e39550. doi: 10.1371/journal.pone.0039550. Epub 2012 Jun 22.


Structural insights into transcription complexes.

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D, Poterszman A.

J Struct Biol. 2011 Aug;175(2):135-46. doi: 10.1016/j.jsb.2011.04.015. Epub 2011 May 6. Review.


Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Schüle R, Bedford MT, Sippl W, Jung M.

Bioorg Med Chem. 2011 Jun 15;19(12):3717-31. doi: 10.1016/j.bmc.2011.02.032. Epub 2011 Feb 27.


The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.

Diebold ML, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, Romier C.

EMBO J. 2010 Dec 1;29(23):3979-91. doi: 10.1038/emboj.2010.272. Epub 2010 Nov 5.


Noncanonical tandem SH2 enables interaction of elongation factor Spt6 with RNA polymerase II.

Diebold ML, Loeliger E, Koch M, Winston F, Cavarelli J, Romier C.

J Biol Chem. 2010 Dec 3;285(49):38389-98. doi: 10.1074/jbc.M110.146696. Epub 2010 Oct 6.


Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.

Kainov DE, Cura V, Vitorino M, Nierengarten H, Poussin P, Kieffer B, Cavarelli J, Poterszman A.

Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):745-55. doi: 10.1107/S0907444910009844. Epub 2010 Jun 19.


Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi.

Koch M, Diebold ML, Cavarelli J, Romier C.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):207-10. doi: 10.1107/S1744309109052749. Epub 2010 Jan 28.


Structural basis for group A trichothiodystrophy.

Kainov DE, Vitorino M, Cavarelli J, Poterszman A, Egly JM.

Nat Struct Mol Biol. 2008 Sep;15(9):980-4.


TCTP protects from apoptotic cell death by antagonizing bax function.

Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A.

Cell Death Differ. 2008 Aug;15(8):1211-20. doi: 10.1038/cdd.2008.18. Epub 2008 Feb 15.


Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains.

Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J.

EMBO J. 2007 Oct 17;26(20):4391-401. Epub 2007 Sep 20.


Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1.

Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):330-3. Epub 2007 Mar 30.


Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.

Romier C, James N, Birck C, Cavarelli J, Vivarès C, Collart MA, Moras D.

J Mol Biol. 2007 May 18;368(5):1292-306. Epub 2007 Feb 22.


Cloning, purification and crystallization of a Walker-type Pyrococcus abyssi ATPase family member.

Uhring M, Bey G, Lecompte O, Cavarelli J, Moras D, Poch O.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):925-7. Epub 2005 Sep 30.


Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetase.

Cura V, Olieric N, Guichard A, Wang ED, Moras D, Eriani G, Cavarelli J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):899-901. Epub 2005 Sep 13.


Expression, purification, and characterization of a new heterotetramer structure of leucyl-tRNA synthetase from Aquifex aeolicus in Escherichia coli.

Olieric N, Bey G, Nierengarten H, Wang ED, Moras D, Eriani G, Cavarelli J.

Protein Expr Purif. 2006 May;47(1):1-9. Epub 2005 Oct 7.


Biochemical and NMR mapping of the interface between CREB-binding protein and ligand binding domains of nuclear receptor: beyond the LXXLL motif.

Klein FA, Atkinson RA, Potier N, Moras D, Cavarelli J.

J Biol Chem. 2005 Feb 18;280(7):5682-92. Epub 2004 Nov 12.


Translationally controlled tumor protein is a target of tumor reversion.

Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, Moras D, Amson R, Telerman A.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15364-9. Epub 2004 Oct 15.


Mutation and evolution of the magnesium-binding site of a class II aminoacyl-tRNA synthetase.

Ador L, Jaeger S, Geslain R, Martin F, Cavarelli J, Eriani G.

Biochemistry. 2004 Jun 8;43(22):7028-37.


Limited set of amino acid residues in a class Ia aminoacyl-tRNA synthetase is crucial for tRNA binding.

Geslain R, Bey G, Cavarelli J, Eriani G.

Biochemistry. 2003 Dec 30;42(51):15092-101.


Evidence for assembly-dependent folding of protein and RNA in an icosahedral virus.

Lin T, Cavarelli J, Johnson JE.

Virology. 2003 Sep 15;314(1):26-33.


Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site.

Troffer-Charlier N, Ogier J, Moras D, Cavarelli J.

J Mol Biol. 2002 Apr 19;318(1):179-88.


Crucial role of the high-loop lysine for the catalytic activity of arginyl-tRNA synthetase.

Sekine S, Shimada A, Nureki O, Cavarelli J, Moras D, Vassylyev DG, Yokoyama S.

J Biol Chem. 2001 Feb 9;276(6):3723-6. Epub 2000 Dec 5.


tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding.

Delagoutte B, Moras D, Cavarelli J.

EMBO J. 2000 Nov 1;19(21):5599-610.


In vivo selection of lethal mutations reveals two functional domains in arginyl-tRNA synthetase.

Geslain R, Martin F, Delagoutte B, Cavarelli J, Gangloff J, Eriani G.

RNA. 2000 Mar;6(3):434-48.


Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes.

Delagoutte B, Keith G, Moras D, Cavarelli J.

Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):492-4.


Aminoacyl-tRNA synthetases: a new image for a classical family.

Martinis SA, Plateau P, Cavarelli J, Florentz C.

Biochimie. 1999 Jul;81(7):683-700. Review.


Aminoacyl-tRNA synthetases: a family of expanding functions. Mittelwihr, France, October 10-15, 1999.

Martinis SA, Plateau P, Cavarelli J, Florentz C.

EMBO J. 1999 Sep 1;18(17):4591-6. No abstract available.


Active site mapping of yeast aspartyl-tRNA synthetase by in vivo selection of enzyme mutations lethal for cell growth.

Ador L, Camasses A, Erbs P, Cavarelli J, Moras D, Gangloff J, Eriani G.

J Mol Biol. 1999 Apr 30;288(2):231-42.


Crystallogenesis studies on yeast aspartyl-tRNA synthetase: use of phase diagram to improve crystal quality.

Sauter C, Lorber B, Kern D, Cavarelli J, Moras D, Giegé R.

Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):149-56. Epub 1999 Jan 1.


L-arginine recognition by yeast arginyl-tRNA synthetase.

Cavarelli J, Delagoutte B, Eriani G, Gangloff J, Moras D.

EMBO J. 1998 Sep 15;17(18):5438-48.


Structures of RNA-binding proteins.

Arnez JG, Cavarelli J.

Q Rev Biophys. 1997 Aug;30(3):195-240. Review. No abstract available.


The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolution.

Cavarelli J, Prévost G, Bourguet W, Moulinier L, Chevrier B, Delagoutte B, Bilwes A, Mourey L, Rifai S, Piémont Y, Moras D.

Structure. 1997 Jun 15;5(6):813-24.


Genomic organization of the rat aspartyl-tRNA synthetase gene family: a single active gene and several retropseudogenes.

Lazard M, Agou F, Cavarelli J, Latreille MT, Moras D, Mirande M.

Gene. 1996 Nov 21;180(1-2):197-205.


The 2.8 A structure of a T = 4 animal virus and its implications for membrane translocation of RNA.

Munshi S, Liljas L, Cavarelli J, Bomu W, McKinney B, Reddy V, Johnson JE.

J Mol Biol. 1996 Aug 9;261(1):1-10.


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