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Items: 14


Functional pathways regulated by microRNA networks in CD8 T-cell aging.

Gustafson CE, Cavanagh MM, Jin J, Weyand CM, Goronzy JJ.

Aging Cell. 2019 Feb;18(1):e12879. doi: 10.1111/acel.12879. Epub 2018 Nov 28.


Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.

Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ.

Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074.


Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.

Qi Q, Cavanagh MM, Le Saux S, Wagar LE, Mackey S, Hu J, Maecker H, Swan GE, Davis MM, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005892. doi: 10.1371/journal.ppat.1005892. eCollection 2016 Oct.


Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination.

Qi Q, Cavanagh MM, Le Saux S, NamKoong H, Kim C, Turgano E, Liu Y, Wang C, Mackey S, Swan GE, Dekker CL, Olshen RA, Boyd SD, Weyand CM, Tian L, Goronzy JJ.

Sci Transl Med. 2016 Mar 30;8(332):332ra46. doi: 10.1126/scitranslmed.aaf1725.


Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals.

Fang F, Yu M, Cavanagh MM, Hutter Saunders J, Qi Q, Ye Z, Le Saux S, Sultan W, Turgano E, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

Cell Rep. 2016 Feb 9;14(5):1218-1231. doi: 10.1016/j.celrep.2016.01.002. Epub 2016 Jan 28.


Naive T cell maintenance and function in human aging.

Goronzy JJ, Fang F, Cavanagh MM, Qi Q, Weyand CM.

J Immunol. 2015 May 1;194(9):4073-80. doi: 10.4049/jimmunol.1500046. Review.


B-cell repertoire responses to varicella-zoster vaccination in human identical twins.

Wang C, Liu Y, Cavanagh MM, Le Saux S, Qi Q, Roskin KM, Looney TJ, Lee JY, Dixit V, Dekker CL, Swan GE, Goronzy JJ, Boyd SD.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):500-5. doi: 10.1073/pnas.1415875112. Epub 2014 Dec 22.


OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC, Horwood NJ, Hussell T.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2289-94. doi: 10.1073/pnas.1321071111. Epub 2014 Jan 27.


IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens.

Deshpande P, Cavanagh MM, Le Saux S, Singh K, Weyand CM, Goronzy JJ.

J Immunol. 2013 Feb 15;190(4):1416-23. doi: 10.4049/jimmunol.1201620. Epub 2013 Jan 16.


Systems biology of vaccination in the elderly.

Duraisingham SS, Rouphael N, Cavanagh MM, Nakaya HI, Goronzy JJ, Pulendran B.

Curr Top Microbiol Immunol. 2013;363:117-42. doi: 10.1007/82_2012_250. Review.


Chronic inflammation and aging: DNA damage tips the balance.

Cavanagh MM, Weyand CM, Goronzy JJ.

Curr Opin Immunol. 2012 Aug;24(4):488-93. doi: 10.1016/j.coi.2012.04.003. Epub 2012 May 5. Review.


Finding Balance: T cell Regulatory Receptor Expression during Aging.

Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ.

Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28.


The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia.

Hussell T, Cavanagh MM.

Biochem Soc Trans. 2009 Aug;37(Pt 4):811-3. doi: 10.1042/BST0370811. Review.


Is it wise to target the late costimulatory molecule OX40 as a therapeutic target?

Cavanagh MM, Hussell T.

Arch Immunol Ther Exp (Warsz). 2008 Sep-Oct;56(5):291-7. doi: 10.1007/s00005-008-0032-3. Review.


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