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The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.

Cavallone LF, Montana MC, Frey K, Kallogjeri D, Wages JM, Rodebaugh T, Doshi T, Kharasch ED, Gereau RW 4th.

Pain. 2019 Sep 14. doi: 10.1097/j.pain.0000000000001695. [Epub ahead of print]


A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.

Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, Légaré S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M.

Mol Cancer Res. 2019 Sep 19. doi: 10.1158/1541-7786.MCR-19-0264. [Epub ahead of print]


Precision Medicine Tools to Guide Therapy and Monitor Response to Treatment in a HER-2+ Gastric Cancer Patient: Case Report.

Aguilar-Mahecha A, Joseph S, Cavallone L, Buchanan M, Krzemien U, Batist G, Basik M.

Front Oncol. 2019 Aug 6;9:698. doi: 10.3389/fonc.2019.00698. eCollection 2019.


Homologous recombination DNA repair defects in PALB2-associated breast cancers.

Li A, Geyer FC, Blecua P, Lee JY, Selenica P, Brown DN, Pareja F, Lee SSK, Kumar R, Rivera B, Bi R, Piscuoglio S, Wen HY, Lozada JR, Gularte-Mérida R, Cavallone L; kConFab Investigators, Rezoug Z, Nguyen-Dumont T, Peterlongo P, Tondini C, Terkelsen T, Rønlund K, Boonen SE, Mannerma A, Winqvist R, Janatova M, Rajadurai P, Xia B, Norton L, Robson ME, Ng PS, Looi LM, Southey MC, Weigelt B, Soo-Hwang T, Tischkowitz M, Foulkes WD, Reis-Filho JS.

NPJ Breast Cancer. 2019 Aug 8;5:23. doi: 10.1038/s41523-019-0115-9. eCollection 2019.


A Study of Pre-Analytical Variables and Optimization of Extraction Method for Circulating Tumor DNA Measurements by Digital Droplet PCR.

Cavallone L, Aldamry M, Lafleur J, Lan C, Gonzalez Ginestet P, Alirezaie N, Ferrario C, Aguilar-Mahecha A, Basik M.

Cancer Epidemiol Biomarkers Prev. 2019 May;28(5):909-916. doi: 10.1158/1055-9965.EPI-18-0586. Epub 2019 Mar 1.


In Response.

Vannucci A, Kallogjeri D, Helsten DL, Cavallone LF.

Anesth Analg. 2018 Nov;127(5):e82-e83. doi: 10.1213/ANE.0000000000003730. No abstract available.


Modifiable and Nonmodifiable Factors Associated With Perioperative Failure of Extraglottic Airway Devices.

Vannucci A, Rossi IT, Prifti K, Kallogjeri D, Rangrass G, DeCresce D, Brenner D, Lakshman N, Helsten DL, Cavallone LF.

Anesth Analg. 2018 Jun;126(6):1959-1967. doi: 10.1213/ANE.0000000000002659.


Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits.

Alcaide M, Yu S, Davidson J, Albuquerque M, Bushell K, Fornika D, Arthur S, Grande BM, McNamara S, Tertre MCD, Batist G, Huntsman DG, Cavallone L, Aguilar A, Basik M, Johnson NA, Deyell RJ, Rassekh SR, Morin RD.

Sci Rep. 2017 Sep 5;7(1):10574. doi: 10.1038/s41598-017-10269-2.


Airway management and the unstable cervical spine: it is time to assess outcomes that matter to patients.

Cavallone LF.

Minerva Anestesiol. 2017 Aug;83(8):781-783. doi: 10.23736/S0375-9393.17.11943-7. Epub 2017 Apr 11. No abstract available.


The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers.

Légaré S, Cavallone L, Mamo A, Chabot C, Sirois I, Magliocco A, Klimowicz A, Tonin PN, Buchanan M, Keilty D, Hassan S, Laperrière D, Mader S, Aleynikova O, Basik M.

Cancer Res. 2015 Oct 15;75(20):4351-63. doi: 10.1158/0008-5472.CAN-14-3475. Epub 2015 Aug 21.


Percutaneous tracheostomy in animal models: it's the year of the sheep!

Cavallone LF, Vannucci A.

Minerva Anestesiol. 2016 Feb;82(2):151-3. Epub 2015 May 26. No abstract available.


Bedside predictors of difficult intubation: a systematic review.

Vannucci A, Cavallone LF.

Minerva Anestesiol. 2016 Jan;82(1):69-83. Epub 2015 May 20. Review.


Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.

Hartley T, Cavallone L, Sabbaghian N, Silva-Smith R, Hamel N, Aleynikova O, Smith E, Hastings V, Pinto P, Tischkowitz M, Tomiak E, Foulkes WD.

Hered Cancer Clin Pract. 2014 Aug 28;12(1):19. doi: 10.1186/1897-4287-12-19. eCollection 2014.


Prognosis and patterns of failure for the extubation of patients who remain intubated after head and neck surgery.

Graboyes EM, Bradley JP, Kallogjeri D, Cavallone LF, Nussenbaum B.

Ann Otol Rhinol Laryngol. 2015 Mar;124(3):179-86. doi: 10.1177/0003489414549576. Epub 2014 Sep 9.


Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant.

Schrader KA, Stratton KL, Murali R, Laitman Y, Cavallone L, Offit L, Wen YH, Thomas T, Shah S, Rau-Murthy R, Manschreck C, Salo-Mullen E, Otegbeye E, Corines M, Zhang L, Norton L, Hudis C, Klein RJ, Kauff ND, Robson M, Stadler ZK, Haber DA, Lipkin SM, Friedman E, Foulkes WD, Altshuler D, Vijai J, Offit K.

J Clin Oncol. 2016 Mar 10;34(8):e61-7. doi: 10.1200/JCO.2013.50.0272. Epub 2014 Jun 30. No abstract available.


Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers.

Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RW 4th.

J Pain Res. 2013 Nov 7;6:771-84. doi: 10.2147/JPR.S53437. eCollection 2013.


A move in the right direction?

Cavallone LF, Hantler CB.

Minerva Anestesiol. 2013 Oct;79(10):1103-4. Epub 2013 Jul 15. No abstract available.


Familial rhabdoid tumour 'avant la lettre'--from pathology review to exome sequencing and back again.

Witkowski L, Lalonde E, Zhang J, Albrecht S, Hamel N, Cavallone L, May ST, Nicholson JC, Coleman N, Murray MJ, Tauber PF, Huntsman DG, Schönberger S, Yandell D, Hasselblatt M, Tischkowitz MD, Majewski J, Foulkes WD.

J Pathol. 2013 Sep;231(1):35-43. doi: 10.1002/path.4225.


Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient.

Zhang J, Shi Y, Lalonde E, Li L, Cavallone L, Ferenczy A, Gotlieb WH, Foulkes WD, Majewski J.

BMC Cancer. 2013 Mar 22;13:146. doi: 10.1186/1471-2407-13-146.


Review article: Extubation of the difficult airway and extubation failure.

Cavallone LF, Vannucci A.

Anesth Analg. 2013 Feb;116(2):368-83. doi: 10.1213/ANE.0b013e31827ab572. Epub 2013 Jan 9. Review.


Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.

Montana MC, Conrardy BA, Cavallone LF, Kolber BJ, Rao LK, Greco SC, Gereau RW 4th.

Anesthesiology. 2011 Dec;115(6):1239-50. doi: 10.1097/ALN.0b013e318238c051.


Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.

Ha KC, Lalonde E, Li L, Cavallone L, Natrajan R, Lambros MB, Mitsopoulos C, Hakas J, Kozarewa I, Fenwick K, Lord CJ, Ashworth A, Vincent-Salomon A, Basik M, Reis-Filho JS, Majewski J, Foulkes WD.

BMC Med Genomics. 2011 Oct 27;4:75. doi: 10.1186/1755-8794-4-75.


Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.

Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK.

Nat Med. 2011 Sep 25;17(10):1275-82. doi: 10.1038/nm.2459. Erratum in: Nat Med. 2011 Nov;17(11):1521. Nat Med. 2011 Oct;17(10):2 p following 1282.


An integrated genomic approach identifies ARID1A as a candidate tumor-suppressor gene in breast cancer.

Mamo A, Cavallone L, Tuzmen S, Chabot C, Ferrario C, Hassan S, Edgren H, Kallioniemi O, Aleynikova O, Przybytkowski E, Malcolm K, Mousses S, Tonin PN, Basik M.

Oncogene. 2012 Apr 19;31(16):2090-100. doi: 10.1038/onc.2011.386. Epub 2011 Sep 5.


Postoperative myocardial injury after major head and neck cancer surgery.

Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF.

Head Neck. 2011 Aug;33(8):1085-91. doi: 10.1002/hed.21577. Epub 2010 Sep 30.


Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.

Cavallone L, Arcand SL, Maugard CM, Nolet S, Gaboury LA, Mes-Masson AM, Ghadirian P, Provencher D, Tonin PN.

Fam Cancer. 2010 Dec;9(4):507-17. doi: 10.1007/s10689-010-9372-3.


The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

Montana MC, Cavallone LF, Stubbert KK, Stefanescu AD, Kharasch ED, Gereau RW 4th.

J Pharmacol Exp Ther. 2009 Sep;330(3):834-43. doi: 10.1124/jpet.109.154138. Epub 2009 Jun 10.


Dreaming of patients' satisfaction.

Cavallone LF.

Minerva Anestesiol. 2009 Jun;75(6):355-6. Epub 2009 Feb 10. No abstract available.


Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis.

Di Bona D, Plaia A, Vasto S, Cavallone L, Lescai F, Franceschi C, Licastro F, Colonna-Romano G, Lio D, Candore G, Caruso C.

Brain Res Rev. 2008 Nov;59(1):155-63. doi: 10.1016/j.brainresrev.2008.07.003. Epub 2008 Jul 21. Review.


A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism.

Cardelli M, Cavallone L, Marchegiani F, Oliveri F, Dato S, Montesanto A, Lescai F, Lisa R, De Benedictis G, Franceschi C.

J Gerontol A Biol Sci Med Sci. 2008 May;63(5):454-60.


Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.

Cavallone L, Arcand SL, Maugard C, Ghadirian P, Mes-Masson AM, Provencher D, Tonin PN.

BMC Cancer. 2008 Apr 10;8:96. doi: 10.1186/1471-2407-8-96.


A novel sampling design to explore gene-longevity associations: the ECHA study.

De Rango F, Dato S, Bellizzi D, Rose G, Marzi E, Cavallone L, Franceschi C, Skytthe A, Jeune B, Cournil A, Robine JM, Gampe J, Vaupel JW, Mari V, Feraco E, Passarino G, Novelletto A, De Benedictis G.

Eur J Hum Genet. 2008 Feb;16(2):236-42. Epub 2007 Nov 7.


A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.

Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C.

J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):547-56.


Paraoxonase activity and genotype predispose to successful aging.

Marchegiani F, Marra M, Spazzafumo L, James RW, Boemi M, Olivieri F, Cardelli M, Cavallone L, Bonfigli AR, Franceschi C.

J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):541-6.


Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly.

Olivieri F, Antonicelli R, Cardelli M, Marchegiani F, Cavallone L, Mocchegiani E, Franceschi C.

Mech Ageing Dev. 2006 Jun;127(6):552-9. Epub 2006 Mar 6. Review.


Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers.

Antonicelli R, Olivieri F, Cavallone L, Spazzafumo L, Bonafè M, Marchegiani F, Cardelli M, Galeazzi R, Giovagnetti S, Perna GP, Franceschi C.

Coron Artery Dis. 2005 Dec;16(8):489-93.


The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients.

Antonicelli R, Olivieri F, Bonafè M, Cavallone L, Spazzafumo L, Marchegiani F, Cardelli M, Recanatini A, Testarmata P, Boemi M, Parati G, Franceschi C.

Int J Cardiol. 2005 Sep 1;103(3):266-71.


Aging, longevity, inflammation, and cancer.

Caruso C, Lio D, Cavallone L, Franceschi C.

Ann N Y Acad Sci. 2004 Dec;1028:1-13. Review.


Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.

Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D.

Mech Ageing Dev. 2005 Feb;126(2):351-61. Review.


The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.

Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Stecconi R, Molendini C, Trapassi C, De Benedictis G, Kletsas D, Franceschi C.

Aging Cell. 2004 Dec;3(6):443-8.


Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, Hoffmann E, Caruso M, Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C.

J Med Genet. 2004 Oct;41(10):790-4. No abstract available.


Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily.

Listì F, Candore G, Lio D, Cavallone L, Colonna-Romano G, Caruso M, Hoffmann E, Caruso C.

Eur J Immunogenet. 2004 Aug;31(4):175-8.


A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.

Giampieri C, Centurelli M, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Cavallone L, Giovagnetti S, Mugianesi E, Carrieri G, Lisa R, Cenerelli S, Testa R, Boemi M, Petropoulou C, Gonos ES, Franceschi C.

Gene. 2004 Mar 3;327(2):215-9.


Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain.

Licastro F, Grimaldi LM, Bonafè M, Martina C, Olivieri F, Cavallone L, Giovanietti S, Masliah E, Franceschi C.

Neurobiol Aging. 2003 Nov;24(7):921-6.


In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.

Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C.

Mech Ageing Dev. 2003 Apr;124(4):549-53.


The role of IL-1 gene cluster in longevity: a study in Italian population.

Cavallone L, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Giovagnetti S, Di Stasio G, Giampieri C, Mugianesi E, Stecconi R, Sciacca F, Grimaldi LM, De Benedictis G, Lio D, Caruso C, Franceschi C.

Mech Ageing Dev. 2003 Apr;124(4):533-8.


Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP.

Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafé M, Cavallone L, Marchegiani F, Olivieri F, Franceschi C, Caruso C.

J Med Genet. 2003 Apr;40(4):296-9. No abstract available.


Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.

Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C.

Eur J Hum Genet. 2002 May;10(5):292-6.


Gender-specific association between -1082 IL-10 promoter polymorphism and longevity.

Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafè M, Cavallone L, Franceschi C, Caruso C.

Genes Immun. 2002 Feb;3(1):30-3.


The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.

Olivieri F, Bonafè M, Cavallone L, Giovagnetti S, Marchegiani F, Cardelli M, Mugianesi E, Giampieri C, Moresi R, Stecconi R, Lisa R, Franceschi C.

Exp Gerontol. 2002 Jan-Mar;37(2-3):309-14.


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