Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 69

1.

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases.

Gomes P, Leal H, Mendes AF, Reis F, Cavadas C.

Trends Pharmacol Sci. 2019 Nov 5. pii: S0165-6147(19)30214-7. doi: 10.1016/j.tips.2019.09.003. [Epub ahead of print] Review.

PMID:
31704173
2.

The importance of determining circadian parameters in pharmacological studies.

Gaspar LS, Álvaro AR, Carmo-Silva S, Mendes AF, Relógio A, Cavadas C.

Br J Pharmacol. 2019 Aug;176(16):2827-2847. doi: 10.1111/bph.14712. Epub 2019 Jul 6. Review.

PMID:
31099023
3.

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.

Costa S, Cavadas C, Cavaleiro C, Salgueiro L, do Céu Sousa M.

Exp Parasitol. 2018 Jul;190:34-40. doi: 10.1016/j.exppara.2018.05.002. Epub 2018 May 18.

PMID:
29778466
4.

Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.

Nóbrega C, Simões AT, Duarte-Neves J, Duarte S, Vasconcelos-Ferreira A, Cunha-Santos J, Pereira D, Santana M, Cavadas C, de Almeida LP.

Adv Exp Med Biol. 2018;1049:349-367. doi: 10.1007/978-3-319-71779-1_18. Review.

PMID:
29427113
5.

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice.

Marques AP, Cunha-Santos J, Leal H, Sousa-Ferreira L, Pereira de Almeida L, Cavadas C, Rosmaninho-Salgado J.

Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):403-413. doi: 10.1016/j.bbagen.2017.11.012. Epub 2017 Dec 22.

PMID:
29154902
6.

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.

Spadari RC, Cavadas C, de Carvalho AETS, Ortolani D, de Moura AL, Vassalo PF.

Cell Mol Neurobiol. 2018 Jan;38(1):109-120. doi: 10.1007/s10571-017-0557-2. Epub 2017 Oct 24. Review.

PMID:
29063982
7.

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.

Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.

Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298.

PMID:
28973648
8.

Hypothalamic Dysfunction in Obesity and Metabolic Disorders.

Carmo-Silva S, Cavadas C.

Adv Neurobiol. 2017;19:73-116. doi: 10.1007/978-3-319-63260-5_4. Review.

PMID:
28933062
9.

Obstructive Sleep Apnea and Hallmarks of Aging.

Gaspar LS, Álvaro AR, Moita J, Cavadas C.

Trends Mol Med. 2017 Aug;23(8):675-692. doi: 10.1016/j.molmed.2017.06.006. Epub 2017 Jul 21. Review.

PMID:
28739207
10.

Unraveling the Role of Ataxin-2 in Metabolism.

Carmo-Silva S, Nobrega C, Pereira de Almeida L, Cavadas C.

Trends Endocrinol Metab. 2017 Apr;28(4):309-318. doi: 10.1016/j.tem.2016.12.006. Epub 2017 Jan 21. Review.

PMID:
28117213
11.

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line.

Marques AP, Rosmaninho-Salgado J, Estrada M, Cortez V, Nobre RJ, Cavadas C.

Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):673-682. doi: 10.1016/j.bbagen.2016.12.005. Epub 2016 Dec 9.

PMID:
27939617
12.

The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing.

Cavadas C, Aveleira CA, Souza GF, Velloso LA.

Nat Rev Endocrinol. 2016 Dec;12(12):723-733. doi: 10.1038/nrendo.2016.107. Epub 2016 Jul 8. Review.

PMID:
27388987
13.

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases.

Duarte-Neves J, Pereira de Almeida L, Cavadas C.

Neurobiol Dis. 2016 Nov;95:210-24. doi: 10.1016/j.nbd.2016.07.022. Epub 2016 Jul 25. Review.

PMID:
27461050
14.

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Ferreira-Marques M, Aveleira CA, Carmo-Silva S, Botelho M, Pereira de Almeida L, Cavadas C.

Aging (Albany NY). 2016 Jul;8(7):1470-84. doi: 10.18632/aging.100996.

15.

Antileishmanial activity of antiretroviral drugs combined with miltefosine.

Costa S, Machado M, Cavadas C, do Céu Sousa M.

Parasitol Res. 2016 Oct;115(10):3881-7. doi: 10.1007/s00436-016-5153-8. Epub 2016 Jun 1.

PMID:
27249967
16.

Corrigendum to "Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes" [neuropeptides 46/6 (2012) 359-366].

Rosmaninho-Salgado J, Cortez V, Estrada M, Santana MM, Gonçalves A, Marques AP, Cavadas C.

Neuropeptides. 2016 Jun;57:101. doi: 10.1016/j.npep.2015.11.089. Epub 2015 Dec 10. No abstract available.

PMID:
27245106
17.

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C.

Nat Commun. 2016 May 11;7:11445. doi: 10.1038/ncomms11445.

18.

The Adenosinergic System in Diabetic Retinopathy.

Vindeirinho J, Santiago AR, Cavadas C, Ambrósio AF, Santos PF.

J Diabetes Res. 2016;2016:4270301. doi: 10.1155/2016/4270301. Epub 2016 Feb 29. Review.

19.

Neuropeptide Y: An Anti-Aging Player?

Botelho M, Cavadas C.

Trends Neurosci. 2015 Nov;38(11):701-711. doi: 10.1016/j.tins.2015.08.012. Review.

PMID:
26549884
20.

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.

Gomes P, Fleming Outeiro T, Cavadas C.

Trends Pharmacol Sci. 2015 Nov;36(11):756-768. doi: 10.1016/j.tips.2015.08.001. Epub 2015 Nov 1. Review.

PMID:
26538315
21.

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.

Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, Tralhão P, Gøtzsche CR, Cavadas C, Castelo-Branco M, Woldbye DP, Picaud S, Santiago AR, Ambrósio AF.

ASN Neuro. 2015 Aug 26;7(4). pii: 1759091415598292. doi: 10.1177/1759091415598292. Print 2015 Jul-Aug.

22.

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.

Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L.

Hum Mol Genet. 2015 Oct 1;24(19):5451-63. doi: 10.1093/hmg/ddv271. Epub 2015 Jul 27.

PMID:
26220979
23.

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress.

Santana MM, Rosmaninho-Salgado J, Cortez V, Pereira FC, Kaster MP, Aveleira CA, Ferreira M, Álvaro AR, Cavadas C.

Eur Neuropsychopharmacol. 2015 Oct;25(10):1753-66. doi: 10.1016/j.euroneuro.2015.06.013. Epub 2015 Jul 2.

PMID:
26187454
24.

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Aveleira CA, Botelho M, Cavadas C.

Autophagy. 2015;11(8):1431-3. doi: 10.1080/15548627.2015.1062202.

25.

Neuropeptide Y system in the retina: From localization to function.

Santos-Carvalho A, Ambrósio AF, Cavadas C.

Prog Retin Eye Res. 2015 Jul;47:19-37. doi: 10.1016/j.preteyeres.2015.03.001. Epub 2015 Mar 19. Review.

PMID:
25797468
26.

Neuropeptide Y stimulates autophagy in hypothalamic neurons.

Aveleira CA, Botelho M, Carmo-Silva S, Pascoal JF, Ferreira-Marques M, Nóbrega C, Cortes L, Valero J, Sousa-Ferreira L, Álvaro AR, Santana M, Kügler S, Pereira de Almeida L, Cavadas C.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1642-51. doi: 10.1073/pnas.1416609112. Epub 2015 Mar 16.

27.

Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress.

Faria R, Santana MM, Aveleira CA, Simões C, Maciel E, Melo T, Santinha D, Oliveira MM, Peixoto F, Domingues P, Cavadas C, Domingues MR.

Neuroscience. 2014 Jul 25;273:1-11. doi: 10.1016/j.neuroscience.2014.04.042. Epub 2014 May 6.

PMID:
24814727
28.

Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.

Sousa-Ferreira L, Aveleira C, Botelho M, Álvaro AR, Pereira de Almeida L, Cavadas C.

PLoS One. 2014 Mar 5;9(3):e88917. doi: 10.1371/journal.pone.0088917. eCollection 2014.

29.

Progenitor cells in chromospheres: in response to Arthur S. Tischler.

Santana MM, Ehrhart-Bornstein M, Cavadas C.

Stem Cells Transl Med. 2013 Dec;2(12):1020-1. doi: 10.5966/sctm.2013-0062. No abstract available.

30.

Role of hypothalamic neurogenesis in feeding regulation.

Sousa-Ferreira L, de Almeida LP, Cavadas C.

Trends Endocrinol Metab. 2014 Feb;25(2):80-8. doi: 10.1016/j.tem.2013.10.005. Epub 2013 Nov 12. Review.

PMID:
24231724
31.

Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection.

Santos-Carvalho A, Álvaro AR, Martins J, Ambrósio AF, Cavadas C.

Prog Neurobiol. 2014 Jan;112:70-9. doi: 10.1016/j.pneurobio.2013.10.002. Epub 2013 Oct 30. Review.

PMID:
24184719
32.

Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system.

Vindeirinho J, Costa GN, Correia MB, Cavadas C, Santos PF.

PLoS One. 2013 Jun 28;8(6):e67499. doi: 10.1371/journal.pone.0067499. Print 2013.

33.

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.

Santos-Carvalho A, Elvas F, Alvaro AR, Ambrósio AF, Cavadas C.

Cell Death Dis. 2013 May 16;4:e636. doi: 10.1038/cddis.2013.160.

34.

Neuropeptide Y receptors Y1 and Y2 are present in neurons and glial cells in rat retinal cells in culture.

Santos-Carvalho A, Aveleira CA, Elvas F, Ambrósio AF, Cavadas C.

Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):429-43. doi: 10.1167/iovs.12-10776.

PMID:
23211819
35.

Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla.

Santana MM, Chung KF, Vukicevic V, Rosmaninho-Salgado J, Kanczkowski W, Cortez V, Hackmann K, Bastos CA, Mota A, Schrock E, Bornstein SR, Cavadas C, Ehrhart-Bornstein M.

Stem Cells Transl Med. 2012 Nov;1(11):783-91. doi: 10.5966/sctm.2012-0022. Epub 2012 Oct 29.

36.

Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes.

Rosmaninho-Salgado J, Cortez V, Estrada M, Santana MM, Gonçalves A, Marques AP, Cavadas C.

Neuropeptides. 2012 Dec;46(6):359-66. doi: 10.1016/j.npep.2012.08.006. Epub 2012 Sep 13.

PMID:
22981159
37.

Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-γ expression.

Rosmaninho-Salgado J, Marques AP, Estrada M, Santana M, Cortez V, Grouzmann E, Cavadas C.

Peptides. 2012 Sep;37(1):49-54. doi: 10.1016/j.peptides.2012.06.014. Epub 2012 Jul 20.

PMID:
22819773
38.

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose.

Costa GN, Vindeirinho J, Cavadas C, Ambrósio AF, Santos PF.

Mol Cell Neurosci. 2012 May;50(1):113-23. doi: 10.1016/j.mcn.2012.04.003. Epub 2012 Apr 10.

PMID:
22522145
39.

Regulation of catecholamine release in human adrenal chromaffin cells by β-adrenoceptors.

Cortez V, Santana M, Marques AP, Mota A, Rosmaninho-Salgado J, Cavadas C.

Neurochem Int. 2012 Mar;60(4):387-93. doi: 10.1016/j.neuint.2011.12.018. Epub 2012 Jan 12.

PMID:
22261351
40.

Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat.

Martins J, Castelo-Branco M, Batista A, Oliveiros B, Santiago AR, Galvão J, Fernandes E, Carvalho F, Cavadas C, Ambrósio AF.

PLoS One. 2011;6(12):e29583. doi: 10.1371/journal.pone.0029583. Epub 2011 Dec 27.

41.

Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats.

Sousa-Ferreira L, Garrido M, Nascimento-Ferreira I, Nobrega C, Santos-Carvalho A, Alvaro AR, Rosmaninho-Salgado J, Kaster M, Kügler S, de Almeida LP, Cavadas C.

PLoS One. 2011;6(7):e22333. doi: 10.1371/journal.pone.0022333. Epub 2011 Jul 22.

42.

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

Sousa-Ferreira L, Álvaro AR, Aveleira C, Santana M, Brandão I, Kügler S, de Almeida LP, Cavadas C.

PLoS One. 2011 May 11;6(5):e19745. doi: 10.1371/journal.pone.0019745.

43.

Neuropeptide Y inhibits [Ca2+]i changes in rat retinal neurons through NPY Y1, Y4, and Y5 receptors.

Alvaro AR, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C.

J Neurochem. 2009 Jun;109(5):1508-15. doi: 10.1111/j.1471-4159.2009.06079.x. Epub 2009 Apr 1.

44.

Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide.

Rosmaninho-Salgado J, Araújo IM, Alvaro AR, Mendes AF, Ferreira L, Grouzmann E, Mota A, Duarte EP, Cavadas C.

J Neurochem. 2009 May;109(3):911-22. doi: 10.1111/j.1471-4159.2009.06023.x. Epub 2009 Mar 2.

45.

Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide Y in noradrenergic neurons.

Ruohonen ST, Savontaus E, Rinne P, Rosmaninho-Salgado J, Cavadas C, Ruskoaho H, Koulu M, Pesonen U.

Neuroendocrinology. 2009;89(3):351-60. doi: 10.1159/000188602. Epub 2008 Dec 20.

PMID:
19122447
46.

Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia.

Xapelli S, Bernardino L, Ferreira R, Grade S, Silva AP, Salgado JR, Cavadas C, Grouzmann E, Poulsen FR, Jakobsen B, Oliveira CR, Zimmer J, Malva JO.

Eur J Neurosci. 2008 Apr;27(8):2089-102. doi: 10.1111/j.1460-9568.2008.06172.x.

PMID:
18412629
47.

Neuropeptide Y stimulates retinal neural cell proliferation--involvement of nitric oxide.

Alvaro AR, Martins J, Araújo IM, Rosmaninho-Salgado J, Ambrósio AF, Cavadas C.

J Neurochem. 2008 Jun 1;105(6):2501-10. doi: 10.1111/j.1471-4159.2008.05334.x.

48.

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy.

Alvaro AR, Martins J, Costa AC, Fernandes E, Carvalho F, Ambrósio AF, Cavadas C.

Neuroscience. 2008 Mar 3;152(1):97-105. doi: 10.1016/j.neuroscience.2007.12.027.

PMID:
18249070
49.

Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells.

Rosmaninho-Salgado J, Araújo IM, Alvaro AR, Duarte EP, Cavadas C.

J Neurochem. 2007 Nov;103(3):896-903. Epub 2007 Sep 6.

50.

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells.

Alvaro AR, Rosmaninho-Salgado J, Santiago AR, Martins J, Aveleira C, Santos PF, Pereira T, Gouveia D, Carvalho AL, Grouzmann E, Ambrósio AF, Cavadas C.

Neurochem Int. 2007 Apr;50(5):757-63. Epub 2007 Feb 8.

PMID:
17353067

Supplemental Content

Loading ...
Support Center