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Items: 20


Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, Dalvie D, Denies S, Dillon CP, Fantin VR, Guo J, Letellier MC, Li W, Maegley K, Marillier R, Miller N, Pirson R, Rabolli V, Ray C, Streiner N, Torti VR, Tsaparikos K, Van den Eynde BJ, Wythes M, Yao LC, Zheng X, Tumang J, Kraus M.

Mol Cancer Ther. 2018 Dec;17(12):2530-2542. doi: 10.1158/1535-7163.MCT-17-1104. Epub 2018 Sep 19.


Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, Dalvie D, Deroose F, Feng JL, Gomes B, Greasley S, Kaiser SE, Kraus M, Négrerie M, Maegley K, Miller N, Murray BW, Schneider M, Soloweij J, Stewart AE, Tumang J, Torti VR, Van Den Eynde B, Wythes M.

J Med Chem. 2017 Dec 14;60(23):9617-9629. doi: 10.1021/acs.jmedchem.7b00974. Epub 2017 Nov 21.


Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy?

Schoors S, Cantelmo AR, Georgiadou M, Stapor P, Wang X, Quaegebeur A, Cauwenberghs S, Wong BW, Bifari F, Decimo I, Schoonjans L, De Bock K, Dewerchin M, Carmeliet P.

Cell Cycle. 2014;13(1):16-22. doi: 10.4161/cc.27519. Epub 2013 Dec 13.


Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, Bifari F, Wang X, Blanco R, Tembuyser B, Cornelissen I, Bouché A, Vinckier S, Diaz-Moralli S, Gerhardt H, Telang S, Cascante M, Chesney J, Dewerchin M, Carmeliet P.

Cell Metab. 2014 Jan 7;19(1):37-48. doi: 10.1016/j.cmet.2013.11.008. Epub 2013 Dec 12.


Role of PFKFB3-driven glycolysis in vessel sprouting.

De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P.

Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037.


Aging- and activation-induced platelet microparticles suppress apoptosis in monocytic cells and differentially signal to proinflammatory mediator release.

Vasina EM, Cauwenberghs S, Staudt M, Feijge MA, Weber C, Koenen RR, Heemskerk JW.

Am J Blood Res. 2013 May 5;3(2):107-23. Print 2013.


Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia.

Postea O, Vasina EM, Cauwenberghs S, Projahn D, Liehn EA, Lievens D, Theelen W, Kramp BK, Butoi ED, Soehnlein O, Heemskerk JW, Ludwig A, Weber C, Koenen RR.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1186-93. doi: 10.1161/ATVBAHA.111.243485. Epub 2012 Mar 1.


Microparticles from apoptotic platelets promote resident macrophage differentiation.

Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR.

Cell Death Dis. 2011 Sep 29;2:e211. doi: 10.1038/cddis.2011.94.


Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.

Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P.

Cancer Cell. 2011 Jun 14;19(6):740-53. doi: 10.1016/j.ccr.2011.05.007.


Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications.

De Bock K, Cauwenberghs S, Carmeliet P.

Curr Opin Genet Dev. 2011 Feb;21(1):73-9. doi: 10.1016/j.gde.2010.10.008. Epub 2010 Nov 22. Review.


Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow.

van Lier M, Verhoef S, Cauwenberghs S, Heemskerk JW, Akkerman JW, Heijnen HF.

Thromb Haemost. 2008 Jun;99(6):1068-78. doi: 10.1160/TH07-08-0528.


Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.

Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M.

J Exp Med. 2008 Jun 9;205(6):1435-46. doi: 10.1084/jem.20070846. Epub 2008 Jun 2.


Hemostatic and signaling functions of transfused platelets.

Cauwenberghs S, van Pampus E, Curvers J, Akkerman JW, Heemskerk JW.

Transfus Med Rev. 2007 Oct;21(4):287-94. Review.


Novel methodology for assessment of prophylactic platelet transfusion therapy by measuring increased thrombus formation and thrombin generation.

Cauwenberghs S, Feijge MA, Theunissen E, Heemskerk JW, van Pampus EC, Curvers J.

Br J Haematol. 2007 Feb;136(3):480-90. Epub 2006 Dec 14.


Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton.

Cauwenberghs S, Feijge MA, Harper AG, Sage SO, Curvers J, Heemskerk JW.

FEBS Lett. 2006 Oct 2;580(22):5313-20. Epub 2006 Sep 12.


Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation.

Daubie V, Cauwenberghs S, Senden NH, Pochet R, Lindhout T, Buurman WA, Heemskerk JW.

Biochim Biophys Acta. 2006 Aug;1763(8):860-9. Epub 2006 May 6.


Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.

Cauwenberghs S, Feijge MA, Hageman G, Hoylaerts M, Akkerman JW, Curvers J, Heemskerk JW.

Transfusion. 2006 Jun;46(6):1018-28.


Platelet ADP response deteriorates in synthetic storage media.

Keuren JF, Cauwenberghs S, Heeremans J, de Kort W, Heemskerk JW, Curvers J.

Transfusion. 2006 Feb;46(2):204-12.


Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count.

Lisman T, Adelmeijer J, Cauwenberghs S, Van Pampus EC, Heemskerk JW, De Groot PG.

J Thromb Haemost. 2005 Apr;3(4):742-51.


von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha is influenced by the HPA-2 polymorphism.

Ulrichts H, Vanhoorelbeke K, Cauwenberghs S, Vauterin S, Kroll H, Santoso S, Deckmyn H.

Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1302-7. Epub 2003 May 29.


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