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Items: 43

1.

Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.

Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, Straatman K, Luo J, Balmanno K, Jones DTW, Collins VP, Cook SJ, Caunt CJ, Pritchard C.

Heliyon. 2018 Dec 20;4(12):e01065. doi: 10.1016/j.heliyon.2018.e01065. eCollection 2018 Dec.

2.

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD.

Bioconjug Chem. 2017 Jun 21;28(6):1677-1683. doi: 10.1021/acs.bioconjchem.7b00152. Epub 2017 May 12.

PMID:
28449575
3.

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.

Kidger AM, Rushworth LK, Stellzig J, Davidson J, Bryant CJ, Bayley C, Caddye E, Rogers T, Keyse SM, Caunt CJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E317-E326. doi: 10.1073/pnas.1614684114. Epub 2017 Jan 4. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7651.

4.

Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs).

Caunt CJ, Kidger AM, Keyse SM.

Methods Mol Biol. 2016;1447:197-215. doi: 10.1007/978-1-4939-3746-2_12.

PMID:
27514808
5.

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.

Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT.

Mol Cell Biol. 2016 Aug 26;36(18):2403-17. doi: 10.1128/MCB.00292-16. Print 2016 Sep 15.

6.

Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING.

Garner KL, Perrett RM, Voliotis M, Bowsher C, Pope GR, Pham T, Caunt CJ, Tsaneva-Atanasova K, McArdle CA.

J Biol Chem. 2016 Jan 29;291(5):2246-59. doi: 10.1074/jbc.M115.686964. Epub 2015 Dec 7.

7.

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD, Cook SJ.

Nat Rev Cancer. 2015 Oct;15(10):577-92. doi: 10.1038/nrc4000. Review.

PMID:
26399658
8.

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.

Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72. doi: 10.1073/pnas.1420159112. Epub 2014 Dec 8.

9.

BRAF inhibitor resistance: are holidays and cocktails the answer?

Bryant CJ, Keyse SM, Caunt CJ.

Pigment Cell Melanoma Res. 2014 Sep;27(5):693-5. doi: 10.1111/pcmr.12291. Epub 2014 Jul 21. No abstract available.

PMID:
24995574
10.

CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited.

Helsby MA, Leader PM, Fenn JR, Gulsen T, Bryant C, Doughton G, Sharpe B, Whitley P, Caunt CJ, James K, Pope AD, Kelly DH, Chalmers AD.

BMC Cell Biol. 2014 Feb 14;15:6. doi: 10.1186/1471-2121-15-6.

11.

Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase C: feedback, heterogeneity, and gating.

Perrett RM, Fowkes RC, Caunt CJ, Tsaneva-Atanasova K, Bowsher CG, McArdle CA.

J Biol Chem. 2013 Jul 19;288(29):21001-14. doi: 10.1074/jbc.M113.455345. Epub 2013 Jun 10.

12.

Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis.

Pereira Morais MP, Marshall D, Flower SE, Caunt CJ, James TD, Williams RJ, Waterfield NR, van den Elsen JM.

Sci Rep. 2013;3:1437. doi: 10.1038/srep01437.

13.

Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.

Caunt CJ, Keyse SM.

FEBS J. 2013 Jan;280(2):489-504. doi: 10.1111/j.1742-4658.2012.08716.x. Epub 2012 Aug 28. Review.

14.

Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization.

Caunt CJ, Perett RM, Fowkes RC, McArdle CA.

PLoS One. 2012;7(7):e40077. doi: 10.1371/journal.pone.0040077. Epub 2012 Jul 12.

15.

Decoding neurohormone pulse frequency by convergent signalling modules.

Tsaneva-Atanasova K, Caunt CJ, Armstrong SP, Perrett RM, McArdle CA.

Biochem Soc Trans. 2012 Feb;40(1):273-8. doi: 10.1042/BST20110645. Review.

PMID:
22260704
16.

ERK phosphorylation and nuclear accumulation: insights from single-cell imaging.

Caunt CJ, McArdle CA.

Biochem Soc Trans. 2012 Feb;40(1):224-9. doi: 10.1042/BST20110662.

PMID:
22260695
17.

Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases.

Finch AR, Caunt CJ, Perrett RM, Tsaneva-Atanasova K, McArdle CA.

Cell Signal. 2012 May;24(5):1002-11. doi: 10.1016/j.cellsig.2011.12.021. Epub 2012 Jan 3.

18.

Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.

Dukes JD, Fish L, Richardson JD, Blaikley E, Burns S, Caunt CJ, Chalmers AD, Whitley P.

Mol Biol Cell. 2011 Sep;22(17):3192-205. doi: 10.1091/mbc.E11-04-0343. Epub 2011 Jul 14. Erratum in: Mol Biol Cell. 2014 Aug 15;25(16):2537.

19.

Decoding GnRH neurohormone pulse frequency by convergent signalling modules.

Tsaneva-Atanasova K, Mina P, Caunt CJ, Armstrong SP, McArdle CA.

J R Soc Interface. 2012 Jan 7;9(66):170-82. doi: 10.1098/rsif.2011.0215. Epub 2011 Jun 15.

20.
21.

Insulin signaling to the glomerular podocyte is critical for normal kidney function.

Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM.

Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015.

22.

Using high-content microscopy to study gonadotrophin-releasing hormone regulation of ERK.

Caunt CJ, Armstrong SP, McArdle CA.

Methods Mol Biol. 2010;661:507-24. doi: 10.1007/978-1-60761-795-2_32.

PMID:
20812005
23.

Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function.

Armstrong SP, Caunt CJ, Finch AR, McArdle CA.

Mol Cell Endocrinol. 2011 Jan 15;331(2):194-204. doi: 10.1016/j.mce.2010.07.008. Epub 2010 Aug 3. Review.

24.

Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the ERK signaling pathway decode GnRH pulse frequency?

Armstrong SP, Caunt CJ, Fowkes RC, Tsaneva-Atanasova K, McArdle CA.

J Biol Chem. 2010 Aug 6;285(32):24360-71. doi: 10.1074/jbc.M110.115964. Epub 2010 May 27.

25.

Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists.

Finch AR, Caunt CJ, Armstrong SP, McArdle CA.

Mol Endocrinol. 2010 Feb;24(2):423-35. doi: 10.1210/me.2009-0343. Epub 2009 Dec 15.

26.

Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach.

Finch AR, Sedgley KR, Armstrong SP, Caunt CJ, McArdle CA.

Br J Pharmacol. 2010 Feb;159(4):751-60. doi: 10.1111/j.1476-5381.2009.00413.x. Epub 2009 Nov 3. Review.

27.

Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?

Armstrong SP, Caunt CJ, Fowkes RC, Tsaneva-Atanasova K, McArdle CA.

J Biol Chem. 2009 Dec 18;284(51):35746-57. doi: 10.1074/jbc.M109.063917.

28.

Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors.

Finch AR, Caunt CJ, Armstrong SP, McArdle CA.

Am J Physiol Cell Physiol. 2009 Sep;297(3):C591-600. doi: 10.1152/ajpcell.00166.2009. Epub 2009 Jul 8.

29.

Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.

Bailey CP, Oldfield S, Llorente J, Caunt CJ, Teschemacher AG, Roberts L, McArdle CA, Smith FL, Dewey WL, Kelly E, Henderson G.

Br J Pharmacol. 2009 Sep;158(1):157-64. doi: 10.1111/j.1476-5381.2009.00140.x. Epub 2009 Mar 20.

30.

Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases.

Armstrong SP, Caunt CJ, McArdle CA.

Mol Endocrinol. 2009 Apr;23(4):510-9. doi: 10.1210/me.2008-0333. Epub 2009 Jan 29.

31.

Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity.

Maru BS, Tobias JH, Rivers C, Caunt CJ, Norman MR, McArdle CA.

Bone. 2009 Jan;44(1):102-12. doi: 10.1016/j.bone.2008.09.016. Epub 2008 Oct 11. Erratum in: Bone. 2009 Jun;44(6):1191-2.

PMID:
18976723
32.

Spatiotemporal regulation of ERK2 by dual specificity phosphatases.

Caunt CJ, Armstrong SP, Rivers CA, Norman MR, McArdle CA.

J Biol Chem. 2008 Sep 26;283(39):26612-23. doi: 10.1074/jbc.M801500200. Epub 2008 Jul 23.

33.

Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines.

Finch AR, Sedgley KR, Caunt CJ, McArdle CA.

J Endocrinol. 2008 Feb;196(2):353-67. doi: 10.1677/JOE-07-0471.

34.

Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.

Caunt CJ, Rivers CA, Conway-Campbell BL, Norman MR, McArdle CA.

J Biol Chem. 2008 Mar 7;283(10):6241-52. doi: 10.1074/jbc.M706624200. Epub 2008 Jan 3.

35.

Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus.

Vasuta C, Caunt C, James R, Samadi S, Schibuk E, Kannangara T, Titterness AK, Christie BR.

Hippocampus. 2007;17(12):1201-8.

PMID:
17879376
36.

Intracellular gonadotropin-releasing hormone receptors in breast cancer and gonadotrope lineage cells.

Sedgley KR, Finch AR, Caunt CJ, McArdle CA.

J Endocrinol. 2006 Dec;191(3):625-36.

PMID:
17170220
37.

GnRH receptor signalling to ERK: kinetics and compartmentalization.

Caunt CJ, Finch AR, Sedgley KR, McArdle CA.

Trends Endocrinol Metab. 2006 Oct;17(8):308-13. Epub 2006 Aug 21. Review.

PMID:
16919966
38.

Seven-transmembrane receptor signalling and ERK compartmentalization.

Caunt CJ, Finch AR, Sedgley KR, McArdle CA.

Trends Endocrinol Metab. 2006 Sep;17(7):276-83. Epub 2006 Aug 4. Review.

PMID:
16890451
39.

Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.

Caunt CJ, Finch AR, Sedgley KR, Oakley L, Luttrell LM, McArdle CA.

J Biol Chem. 2006 Feb 3;281(5):2701-10. Epub 2005 Nov 28.

40.

Internalization of gonadotropin-releasing hormone receptors (GnRHRs): does arrestin binding to the C-terminal tail target GnRHRs for dynamin-dependent internalization?

Hislop JN, Caunt CJ, Sedgley KR, Kelly E, Mundell S, Green LD, McArdle CA.

J Mol Endocrinol. 2005 Aug;35(1):177-89.

PMID:
16087731
41.

Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations.

Caunt CJ, Hislop JN, Kelly E, Matharu AL, Green LD, Sedgley KR, Finch AR, McArdle CA.

Endocrinology. 2004 Aug;145(8):3594-602. Epub 2004 Apr 1.

PMID:
15059960
42.
43.

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